Treatment Planning: comparing techniques and standards
ConclusionsPT shows many dosimetric advantages but emphasizes challenges like range uncertainty. RBE modelling plays a crucial role, and LET-based optimization introduces new possibilities. Addressing uncertainties and embracing innovation are vital for enhancing PT ’s efficacy. (Source: Health and Technology)
Source: Health and Technology - April 5, 2024 Category: Information Technology Source Type: research
Lived experiences of healthcare. Putting the person in person centred care in the medical radiation sciences
Contemporary healthcare models recognise person-centred care (PCC) as a fundamental principle of quality, safe care. While substantial literature exists on PCC in healthcare generally, there is less evidence on how this relates to medical imaging and radiation therapy.Embedding patient-lived experiences of healthcare into healthcare education has promise in enhancing students ’ confidence in delivering PCC. Digital storytelling (DST) of patient-lived experiences can help improve reflection, understanding, critical thinking and empathy. (Source: Radiography)
Source: Radiography - April 5, 2024 Category: Radiology Authors: K. Auld, I. Devaparanam, S. Roberts, J. McInerney Source Type: research
Treatment Planning: comparing techniques and standards
ConclusionsPT shows many dosimetric advantages but emphasizes challenges like range uncertainty. RBE modelling plays a crucial role, and LET-based optimization introduces new possibilities. Addressing uncertainties and embracing innovation are vital for enhancing PT ’s efficacy. (Source: Health and Technology)
Source: Health and Technology - April 5, 2024 Category: Information Technology Source Type: research
Current issues in dose-finding designs: A response to the US Food and Drug Adminstrations's oncology center of excellence project optimus
Clin Trials. 2024 Apr 3:17407745241234652. doi: 10.1177/17407745241234652. Online ahead of print.ABSTRACTWith the advent of targeted agents and immunological therapies, the medical research community has become increasingly aware that conventional methods for determining the best dose or schedule of a new agent are inadequate. It has been well established that conventional phase I designs cannot reliably identify safe and effective doses. This problem applies, generally, for cytotoxic agents, radiation therapy, targeted agents, and immunotherapies. To address this, the US Food and Drug Administration's Oncology Center of E...
Source: Clinical Trials - April 4, 2024 Category: Research Authors: Peter F Thall Elizabeth Garrett-Mayer Nolan A Wages Susan Halabi Ying Kuen Cheung Source Type: research
Current issues in dose-finding designs: A response to the US Food and Drug Adminstrations's oncology center of excellence project optimus
Clin Trials. 2024 Apr 3:17407745241234652. doi: 10.1177/17407745241234652. Online ahead of print.ABSTRACTWith the advent of targeted agents and immunological therapies, the medical research community has become increasingly aware that conventional methods for determining the best dose or schedule of a new agent are inadequate. It has been well established that conventional phase I designs cannot reliably identify safe and effective doses. This problem applies, generally, for cytotoxic agents, radiation therapy, targeted agents, and immunotherapies. To address this, the US Food and Drug Administration's Oncology Center of E...
Source: Clinical Trials - April 4, 2024 Category: Research Authors: Peter F Thall Elizabeth Garrett-Mayer Nolan A Wages Susan Halabi Ying Kuen Cheung Source Type: research
A vocal cord palsy caused by the uterine cancer metastatic tumor in the mediastinum revealed in a patient with a thyroid lesion: a case report and review of the literature
ConclusionA history of the disease should always be kept in mind when assessing a patient ’s complaints. VCP in case of thyroid pathology and previous secondary malignancy may be caused by metastatic tumor anywhere along the RLN pathway. Such a rare case shows the importance of additional methods of examination which may avoid unnecessary thyroid surgeries. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - April 4, 2024 Category: General Medicine Source Type: research
Newly Diagnosed Mental Health Disorders in Patients with Breast Cancer Receiving Radiation Therapy
Patients with a mental health disorder (MHD) have higher age-adjusted mortality compared to the general population. Few reports investigate factors contributing to MHD among breast cancer patients receiving radiotherapy. Here, we report the incidence of acquired MHD after the diagnosis of breast cancer and treatment with radiotherapy. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 4, 2024 Category: Radiology Authors: Bailey A. Loving, Muayad F. Almahariq, Shaveena Sivapalan, Ronald Levitin, Lihua Qu, Siddharth Ramanathan, Zainab Ijaz, Joshua T. Dilworth Tags: Clinical Investigation Source Type: research
A low-cost phantom design for evaluating spine SABR calculations in the presence of prosthetic vertebral stabilization
We present an initial design for a low-cost phantom to evaluate spine stereotactic ablative radiotherapy (SABR) in the presence of prosthetic vertebral stabilization. The phantom is modular, allowing the prosthetic at the centre of the phantom to be removed by exchanging the central block. It also includes space to insert ion chamber and film. The agreement of the RayStation TPS (v8.0B) collapsed cone convolution (CCC) calculation and measurement was determined for phantom versions with and without prosthetic. There was little to no change in the agreement between the measured and calculated dose when introducing metallic ...
Source: Australasian Physical and Engineering Sciences in Medicine - April 4, 2024 Category: Biomedical Engineering Source Type: research
Fibrin glue mediated direct delivery of radiation sensitizers results in enhanced efficacy of radiation treatment
ConclusionNon-degraded RS was released from the FG for up to 72 h. FG-released 5FU greatly increased the efficacy of radiation therapy. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 4, 2024 Category: Cancer & Oncology Source Type: research
Does lower dose pilocarpine have a role in radiation-induced xerostomia in the modern radiotherapy era? A single-center experience based on patient-reported outcome measures
ConclusionPilocarpine may be considered at doses lower for late-term dry mouth. With modern radiotherapy techniques effectively preserving the parotid gland, short-term use may be recommended in these patients. Future studies may enhance the development of a more robust patient selection criteria model. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - April 4, 2024 Category: ENT & OMF Source Type: research
Comprehensive radiotherapy for pediatric Ewing Sarcoma: Outcomes of a prospective proton study
Patients with Ewing sarcoma (EWS) are treated with combination therapy, which includes radiation therapy (RT) as a treatment option for the primary tumor site (local control). Historically, the best local control (LC) outcomes have been achieved with surgery alone or combination of surgery with adjuvant RT for patients with high risk factors such as positive tumor margins after surgery or poor response to adjuvant/ induction chemotherapy. Definitive RT is often reserved for large tumors in anatomical locations where surgical resection is considered to be too morbid [1 –3]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - April 4, 2024 Category: Radiology Authors: Julianna K. Bronk, Mary Frances McAleer, Susan L. McGovern, Yasmin Lassen-Ramshad, Akmal Safwat, Najat C. Daw, Nino Rainusso, Anita Mahajan, David R. Grosshans, Arnold C. Paulino Tags: Original Article Source Type: research
Cost of Treatment for Brain Metastases Using Data From a National Health Insurance
CONCLUSIONS: Whole-brain radiation therapy was the least costly radiation technique. Similar per-treatment prices for Gamma Knife and linear accelerator SRS support their use in treating BMs. Stereotactic radiation therapy in general was costlier on a per-use basis than SRS, prompting further scrutiny on its frequent use. Hippocampal avoidance intensity modulated radiation therapy was the costliest radiation therapy on a per-use basis by a moderate amount, prompting further discussion about its comparative cost effectiveness against other radiation modalities. This study underscores the importance of multiple consideration...
Source: Cancer Control - April 3, 2024 Category: Cancer & Oncology Authors: Joseph Crooks Oralia Dominic Matthew Shepard Alexander Yu Yun Liang Stephen M Karlovits Rodney E Wegner Source Type: research
Proapoptotic effects of ceranib-2 in combination with radiation therapy on human breast cancer cells
CONCLUSIONS: The study results suggest that co-treatment of human breast adenocarcinoma cells with a ceramidase inhibitor, ceranib-2, and a high dose of radiation of 20 Gy exerted cytotoxicity and apoptosis and might be a solid, potent alternative to current therapy strategies.PMID:38567595 | DOI:10.26355/eurrev_202403_35736 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - April 3, 2024 Category: Drugs & Pharmacology Authors: F Tu ğrul C Vejselova Sezer H M Kutlu Source Type: research
Clinical Outcome of Chemotherapy and Radiation Therapy Versus Chemotherapy, Radiation Therapy, and Multilevel Vertebroplasty or Kyphoplasty for Multiple Myeloma
CONCLUSION: This study found that performing kyphoplasty and vertebroplasty in addition to conventional therapy for patients with multiple myeloma resulted in enhanced morbidity and functional outcomes. [Orthopedics. 202x;4x(x):xx-xx.].PMID:38568002 | DOI:10.3928/01477447-20240325-06 (Source: Orthopedics)
Source: Orthopedics - April 3, 2024 Category: Orthopaedics Authors: Mohammad Alkhatatba Ala'a Alma' Aiteh Ziad Audat Suhaib Bani Essa Ahmad Radaideh Ziyad Mohaidat Hamzeh Ziad Audat Tarek Manasreh Source Type: research
Outcomes of Simultaneous Versus Staged Resection for Stage IV Colorectal Cancer with Synchronous Liver Metastases
CONCLUSIONS: Practice patterns within Southern California KP hospitals favor minor colorectal and liver resections. However, there were no significant differences in demographics, treatment rates, or outcomes between simultaneous and staged resection. While not statistically significant, our findings of a 11.9% higher major liver resection rate and 7.5-month longer median disease-free survival in the staged resection group may benefit from further study with higher power datasets.PMID:38567700 | DOI:10.1177/00031348241244632 (Source: The American Surgeon)
Source: The American Surgeon - April 3, 2024 Category: Surgery Authors: Harry H Kim Nghiem H Nguyen Claire J Yang Michael S Tam Anna M Leung Vikram Attaluri Source Type: research
