Impact of radiation dose distribution on nutritional supplementation needs in head and neck cancer radiotherapy: a voxel-based machine learning approach
ConclusionsMachine learning modeling of voxel-level doses enables identification of subregions within organs that correlate with toxicity. For HN radiotherapy, doses to the superior-middle pharyngeal constrictors are most predictive of feeding tube use/weight loss followed by the doses to superior portion of the larynx. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - February 28, 2024 Category: Cancer & Oncology Source Type: research
Role of MRI in Evaluation of Tongue and Hypopharyngeal Lesions
AbstractTongue is a complex, principally muscular structure extending from oral cavity to oropharynx. Hypopharynx extends from the level of hyoid bone and to the level of inferior margin of cricoid cartilage and is divided into pyriform sinus, posterior cricoid region and posterior pharyngeal wall. Lesions that can affect the tongue and hypopharynx include neoplastic, congenital, vascular and infectious etiologies. Imaging provides crucial details for diagnosis and the appropriate management of these lesions. To evaluate the role of MRI in characterisation of benign and malignant lesions of tongue, malignant lesions of hyp...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - February 24, 2024 Category: ENT & OMF Source Type: research
Disease and toxicity outcomes for a modern cohort of patients with squamous cell carcinoma of cutaneous origin involving the parotid gland: Comparison of volumetric modulated arc therapy and pencil beam scanning proton therapy
CONCLUSIONS: Cutaneous SCC involving the parotid can be an aggressive clinical entity despite modern multimodal therapy. PBT offers significantly lower dose to organs at risk compared to VMAT, which seemingly yields diminished acute toxicities.PMID:38309587 | DOI:10.1016/j.radonc.2024.110112 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 3, 2024 Category: Radiology Authors: Reza Zarinshenas Peter Campbell Kai Sun Jason K Molitoris Akshar N Patel Matthew E Witek Kevin J Cullen Ranee Mehra Kyle M Hatten Kelly F Moyer Rodney J Taylor Kalpesh T Vakharia Jeffrey S Wolf Matthew J Ferris Source Type: research
Evaluation of DNA methylation levels of < em > SEPT9 < /em > and < em > SHOX2 < /em > in plasma of patients with head and neck squamous cell carcinoma using droplet digital PCR
Oncol Rep. 2024 Mar;51(3):52. doi: 10.3892/or.2024.8711. Epub 2024 Feb 1.ABSTRACTHead and neck squamous cell carcinoma (HNSCC) is the seventh most commonly diagnosed cancer globally. HNSCC develops from the mucosa of the oral cavity, pharynx and larynx. Methylation levels of septin 9 (SEPT9) and short stature homeobox 2 (SHOX2) genes in circulating cell‑free DNA (ccfDNA) are considered epigenetic biomarkers and have shown predictive value in preliminary reports in HNSCC. Liquid biopsy is a non‑invasive procedure that collects tumor‑derived molecules, including ccfDNA. In the present study, a droplet digital PCR (ddPC...
Source: Oncology Reports - February 1, 2024 Category: Cancer & Oncology Authors: Ilaria Grossi Claudia Assoni Luigi Lorini Davide Smussi Cristina Gurizzan Salvatore Grisanti Alberto Paderno Davide Mattavelli Cesare Piazza Iulia Andreea Pelisenco Giuseppina De Petro Alessandro Salvi Paolo Bossi Source Type: research
Prognosis of South Asian Buccal Mucosa Cancer Patients in the United States: Association of Race with Overall Survival
CONCLUSION: South Asians in the US with non-metastatic buccal mucosa or gingiva SCC have better OS compared to Caucasians or African Americans, likely due to younger age at diagnosis (median 59 vs. 71 and 62 years old) and more frequent surgical resection (75% vs. 72% and 64%). In MVA, South Asians have similar OS as Caucasians.PMID:38285790 | DOI:10.31557/APJCP.2024.25.1.241 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - January 29, 2024 Category: Cancer & Oncology Authors: Stephen J Sozio Sachin R Jhawar Shengguo Li Hao Liu Mutlay Sayan Rahul Parikh Anupama Chundury Sung Kim Source Type: research
Cancers, Vol. 16, Pages 529: Diagnostic Performance of a Novel Ultra-Thin Endoscopy under Narrow-Band Imaging for Superficial Squamous Cell Carcinoma of the Pharynx and Esophagus
This study aimed to evaluate the diagnostic utility of the ultra-thin endoscope (UTE) for superficial squamous cell carcinoma (SSCC) compared to magnifying endoscopy (ME) under narrow-band imaging. Participants underwent endoscopic examination, and images of pharyngeal and esophageal SCCs, as along with suspicious SSCC lesions, were collected using UTE and ME on the same day. Three image catalogs (UTE, ME-1, and ME-2) were created and reviewed by three expert endoscopists. ME-1 and ME-2 contained the same endoscopic images. The primary endpoint was the intra-observer agreement for diagnosing SCC. Eighty-six lesions (SCC = ...
Source: Cancers - January 26, 2024 Category: Cancer & Oncology Authors: Akira Dobashi Yuko Hara Hiroto Furuhashi Hiroaki Matsui Naoya Tada Mamoru Ito Toshiki Futakuchi Masakuni Kobayashi Shingo Ono Daisuke Aizawa Takashi Yamauchi Machi Suka Kazuki Sumiyama Tags: Article Source Type: research
