Incidence and risk factors for cancer in people with type 1 diabetes, stratified by stages of diabetic kidney disease: a nationwide Finnish cohort study
Lancet Reg Health Eur. 2024 Mar 16;40:100884. doi: 10.1016/j.lanepe.2024.100884. eCollection 2024 May.ABSTRACTBACKGROUND: Individuals with type 1 diabetes (T1D) have been reported to have increased overall risk of cancer. In addition, individuals with a kidney transplant/transplantation (KT) have markedly increased cancer risk due to chronic use of immunosuppressive agents. However, it has not been elucidated whether the observed excess cancer risk is related to KT or whether diabetic kidney disease (DKD) per se is a risk factor for cancer in individuals with T1D.METHODS: The study included 5035 individuals from the Finnis...
Source: Cancer Control - March 27, 2024 Category: Cancer & Oncology Authors: Maija Feodoroff Valma Harjutsalo Sari M äkimattila Per-Henrik Groop FinnDiane Study Group Source Type: research
The Quantification of Radiation Fibrosis Using Clinically Indicated Magnetic Resonance Imaging for Head and Neck Cancer Patients
AbstractCurrently, no objective method exists to measure the extent of fibrosis in swallowing musculature in head and neck cancer (HNC) patients. We developed and psychometrically tested a method of quantifying fibrosis volume using magnetic resonance imaging (MRI). The overall aim of this study was to determine if clinical MRI is a reliable tool to measure fibrosis of the pharyngeal musculature in patients with HNC managed with RT and to assess its potential to capture changes in fibrosis over time. Eligible participants were adults with HNC treated with rad iation therapy (RT) who received minimally two MRIs and videof...
Source: Dysphagia - March 27, 2024 Category: Speech-Language Pathology Source Type: research
Unlocking the Therapeutic Potential of LncRNA < em > BLACAT1 < /em > in Hypopharynx Squamous Cell Carcinoma
CONCLUSIONS: lncRNA BLACAT1 is highly expressed in HSCC tumor tissues and plays a crucial role in the development of HSCC in vitro and in vivo. This increased expression may be caused by STAT3/AKT pathway activation, consequently inhibiting P21 expression through PHB2.PMID:38531795 | DOI:10.24976/Discov.Med.202436182.51 (Source: Discovery Medicine)
Source: Discovery Medicine - March 26, 2024 Category: Research Authors: Fan-Li Liu Zhan-Cheng Zhang Sheng-Li Zhou Xu-Liang Liu Wei Xu Source Type: research
