Anaphylactic reaction to omeprazole after negative pantoprazole allergy testing
Proton pump inhibitors (PPIs) are widely used inhibitors of gastric acid secretion. PPIs are generally well tolerated with very few side effects and hypersensitivity reactions are rarely described. Here we present an adult man who reports anaphylaxis upon treatment with oral omeprazole. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: C. Wilson, K. Hannett, S. Hauk, S. Fowler, B. McGoey, M. Younus Tags: M015 Source Type: research
Clinical outcomes of concomitant use of proton pump inhibitors and regorafenib in patients with metastatic colorectal cancer: a multicenter study
ConclusionThis study found no worse outcome in the combined use of PPI and regorafenib among patients with mCRC. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 21, 2022 Category: Drugs & Pharmacology Source Type: research
Clinical outcomes of concomitant use of proton pump inhibitors and regorafenib in patients with metastatic colorectal cancer: a multicenter study
CONCLUSION: This study found no worse outcome in the combined use of PPI and regorafenib among patients with mCRC.PMID:36266366 | DOI:10.1007/s00228-022-03403-1 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - October 20, 2022 Category: Cancer & Oncology Authors: Emre Yeked üz Mehmet Fatih Özbay Dilek Çağlayan Atila Y ıldırım Cihan Erol Hasan Çağrı Yıldırım Sezai Tun ç Neslihan Özyurt Feyyaz Özdemir Mehmet Ali Nahit Şendur Abdurrahman I şıkdoğan Saadettin K ılıçkap Y üksel Ürün Şuayib Ya Source Type: research
Clinical outcomes of concomitant use of proton pump inhibitors and regorafenib in patients with metastatic colorectal cancer: a multicenter study
CONCLUSION: This study found no worse outcome in the combined use of PPI and regorafenib among patients with mCRC.PMID:36266366 | DOI:10.1007/s00228-022-03403-1 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - October 20, 2022 Category: Cancer & Oncology Authors: Emre Yeked üz Mehmet Fatih Özbay Dilek Çağlayan Atila Y ıldırım Cihan Erol Hasan Çağrı Yıldırım Sezai Tun ç Neslihan Özyurt Feyyaz Özdemir Mehmet Ali Nahit Şendur Abdurrahman I şıkdoğan Saadettin K ılıçkap Y üksel Ürün Şuayib Ya Source Type: research
Proton pump inhibitor-induced risk of chronic kidney disease is associated with increase of indoxyl sulfate synthesis via inhibition of CYP2E1 protein degradation
In conclusion, PPIs induced IS synthesis via increased hepatic CYP2E1 protein level, subsequently leading to increased IS exposure. These findings present a plausible biological mechanism to explain the association of PPI use with the increased risk of CKD.PMID:36243147 | DOI:10.1016/j.cbi.2022.110219 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - October 15, 2022 Category: Molecular Biology Authors: Shuanghui Lu Jieping Zhao Xiu Chen Shuyu Xu Xi Yang Yingqiong Zhang Zhiyuan Ma Huidi Jiang Hui Zhou Source Type: research
Proton pump inhibitor-induced risk of chronic kidney disease is associated with increase of indoxyl sulfate synthesis via inhibition of CYP2E1 protein degradation
In conclusion, PPIs induced IS synthesis via increased hepatic CYP2E1 protein level, subsequently leading to increased IS exposure. These findings present a plausible biological mechanism to explain the association of PPI use with the increased risk of CKD.PMID:36243147 | DOI:10.1016/j.cbi.2022.110219 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - October 15, 2022 Category: Molecular Biology Authors: Shuanghui Lu Jieping Zhao Xiu Chen Shuyu Xu Xi Yang Yingqiong Zhang Zhiyuan Ma Huidi Jiang Hui Zhou Source Type: research
Intracellular pH-Regulating Nanoparticles to Improve Anticancer Drug Efficacy for Cancer Treatment
Biomacromolecules. 2022 Oct 12. doi: 10.1021/acs.biomac.2c00952. Online ahead of print.ABSTRACTHere, we describe an intracellular pH-regulating nanoparticle (IPRN), coencapsulated with chemosensitizers and anticancer agents for effective and safe cancer treatment. IPRN contains a tubulysin derivative (TUB), a hydrophobic anticancer drug, and pantoprazole (PTZ), a hydrophilic proton-pump inhibitor. IPRN with a size of 62 nm has an anionic surface charge and is stable for at least two weeks under storage conditions, though PTZ and TUB encapsulated in IPRN showed different drug release patterns. PTZ was released before TUB, c...
Source: Biomacromolecules - October 12, 2022 Category: Biochemistry Authors: Taebum Lee Kyoung Sub Kim Kun Na Source Type: research
Y-site administration of electrolyte solutions and injectable acetaminophen- A physical compatibility study with combinations frequently used in pediatric intensive care and anesthesia
CONCLUSION: Most of the analyzed combinations showed no signs of physical incompatibility and may therefore be administered via the same Y-site. However, diazepam, furosemide, and pantoprazole should not be administered simultaneously with acetaminophen or both electrolyte solutions.PMID:36214581 | DOI:10.1111/pan.14569 (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - October 10, 2022 Category: Anesthesiology Authors: Mona Kleinlein Stephanie Marschler Martina P Neininger Michael Hoeckel Thilo Bertsche Source Type: research
Effects of CYP2C19 genetic polymorphisms on the cure rates of H. pylori in patients treated with the proton pump inhibitors: An updated meta-analysis
Conclusion: Carriers of CYP2C19 loss-of-function variant alleles (IM and PM) exhibit a significantly greater cure rate of H. pylori than noncarriers (EM) regardless of other factors (84.7% vs. 79.2%). In addition, pantoprazole- and rabeprazole-based quadruple therapy for H. pylori treatment is less dependent on the CYP2C19 genotype and should be prioritized in Asian populations with H. pylori. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - October 6, 2022 Category: Drugs & Pharmacology Source Type: research
Pantoprazole Induced Acute Interstitial Nephritis in a Patient with
Diabetic Ketoacidosis
Klin Padiatr DOI: 10.1055/a-1937-0927Childhood-onset type 1 diabetes mellitus (DM) is a common chronic metabolic disease
associated with life-threatening complications. Diabetic ketoacidosis (DKA) is an
acute complication of type 1 DM that has significant mortality mostly due to
cerebral edema. Other putative complications of DKA include hypokalemia,
hypophosphatemia, hypoglycemia, intracerebral and peripheral venous thrombosis,
rhabdomyolysis, acute pancreatitis, and acute kidney injury (AKI) (Murdoch IA et
al., Acta Paediatr 1993; 82:498–500). [...] Georg Thie...
Source: Klinische Padiatrie - September 29, 2022 Category: Pediatrics Authors: Tas, Nesrin Mengen, Eda Goncu, Sultan Tasar, Sercin Kiremitci, Saba Ucakturk, Ahmet Tags: Short Communication Source Type: research
Diffuse Arterial Atherosclerosis Presenting With Acute Ischemic Gastritis
Cureus. 2022 Sep 13;14(9):e29115. doi: 10.7759/cureus.29115. eCollection 2022 Sep.ABSTRACTIschemic gastritis is a rare cause of gastrointestinal bleeding due to the rich blood supply of the stomach. A 66-year-old lady with a history of coronary artery disease and hyperlipidemia presented with acute abdominal pain, diarrhea, and recent coffee-ground emesis. She had diffuse abdominal tenderness on physical exam with mild leukocytosis. A CT scan of the abdomen showed new peripheral wedge-shaped hypoenhancing regions in the spleen and both kidneys, suggestive of embolic infarcts. Posterior pneumatosis of the stomach suggestive...
Source: Atherosclerosis - September 22, 2022 Category: Cardiology Authors: Mohamed Osman Abu-Bekr Mohamed Ahmed Salim Source Type: research
Acid suppressants use and risk of atherosclerotic cardiovascular disease in middle-aged and older adults
CONCLUSIONS: PPIs were associated with increased risk of ASCVD, particularly amongst participants without indications for medication. Our findings are of important practical significance and suggest that clinicians should be cautious in prophylactic use of PPIs.PMID:36113328 | DOI:10.1016/j.atherosclerosis.2022.09.001 (Source: Atherosclerosis)
Source: Atherosclerosis - September 16, 2022 Category: Cardiology Authors: Yue Ma Shu Li Hongxi Yang Yuan Zhang Huiping Li Lihui Zhou Jing Lin Yanchun Chen Yabing Hou Xinyu Zhang Tong Liu Xin Zhou Yaogang Wang Source Type: research
Oxygen desaturation in a transgender man: initial concerns and recommendations regarding the practice of chest binding: a case report
ConclusionIn the clinical narrative, a healthy patient was observed to have prolonged oxygen desaturation after induction of anesthesia. Laryngospasm was suspected clinically owing to the sudden absence of end-tidal carbon dioxide. Prolonged oxygen desaturation despite appropriate interventions suggests the contribution of additional factors. We speculate that the presence of a chest binder intraoperatively predisposed the patient to more rapid oxygen desaturation less responsive to typical therapy. A chest binder would introduce mechanical restriction to the patient ’s breathing owing to its inherent design to compress....
Source: Journal of Medical Case Reports - September 4, 2022 Category: General Medicine Source Type: research
71-Year-Old Man With a New Heart Murmur
A 71-year-old man with a history of hypertension, hyperlipidemia, and bicuspid aortic valve endocarditis treated with prosthetic valve replacement in 2012 presented to the internal medicine clinic for his annual physical examination. His home medications included aspirin (81 mg), pantoprazole (40 mg), paroxetine (37.5 mg), rosuvastatin (20 mg), and terazosin (10 mg) daily. Review of systems was notable for increasing exertional and supine shortness of breath. He also reported occasional chest discomfort on the right side with and without exertion. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - September 1, 2022 Category: Internal Medicine Authors: Zeynep I. Seckin, Goyal Umadat, Richard O. White Tags: Residents ’ clinic Source Type: research
Correction to: Hepatitis C viral clearance with coadministration of crushed sofosbuvir/velpatasvir and high-dose pantoprazole after liver transplantation
Am J Health Syst Pharm. 2022 Aug 30:zxac220. doi: 10.1093/ajhp/zxac220. Online ahead of print.NO ABSTRACTPMID:36039904 | DOI:10.1093/ajhp/zxac220 (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - August 30, 2022 Category: Drugs & Pharmacology Source Type: research
