PaSTe. Blockade of the Lipid Phenotype of Prostate Cancer as Metabolic Therapy: A Theoretical Proposal
CONCLUSION: We conclude that this regimen deserves to be preclinically evaluated because of its clinical potential for the treatment of prostate cancer.PMID:37287286 | DOI:10.2174/0929867330666230607104441 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - June 8, 2023 Category: Chemistry Authors: Adriana Romo-Perez Guadalupe Dom ínguez-Gómez Alma Ch ávez-Blanco Aurora Gonz ález-Fierro Jos é Correa-Basurto Alfonso Due ñas-González Source Type: research
PaSTe. Blockade of the Lipid Phenotype of Prostate Cancer as Metabolic Therapy: A Theoretical Proposal
CONCLUSION: We conclude that this regimen deserves to be preclinically evaluated because of its clinical potential for the treatment of prostate cancer.PMID:37287286 | DOI:10.2174/0929867330666230607104441 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - June 8, 2023 Category: Chemistry Authors: Adriana Romo-Perez Guadalupe Dom ínguez-Gómez Alma Ch ávez-Blanco Aurora Gonz ález-Fierro Jos é Correa-Basurto Alfonso Due ñas-González Source Type: research
The impact of CYP2C19 genotype on phenoconversion by concomitant medication
Conclusion: This study suggests that the differential outcome of CYP2C19-mediated DDIs between genotypes are primarily dictated by basal CYP2C19 activity, that may in part be predicted by CYP2C19 genotype but likely also depends on disease-related factors. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - June 8, 2023 Category: Drugs & Pharmacology Source Type: research
Avoiding incompatible drug pairs in central-venous catheters of patients receiving critical care: an algorithm-based analysis and a staff survey
ConclusionsAlthough incompatibilities were common, the staff rarely felt unsafe when administering drugs. Knowledge deficits correlated well with the incompatibilities identified. All recommendations were fully accepted. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - June 7, 2023 Category: Drugs & Pharmacology Source Type: research
Effect of morning versus night-time administration of proton pump inhibitor (pantoprazole) on thyroid function test in levothyroxine-treated primary hypothyroidism: a prospective cross-over study
ConclusionsConcomitant use of pantoprazole, even for 6 weeks, leads to significant elevation in serum TSH in levothyroxine-treated patients who are biochemically euthyroid, irrespective of timing of pantoprazole intake. Early morning and night-time administration of pantoprazole have similar effect on TFT in these patients. (Source: Thyroid Research)
Source: Thyroid Research - June 1, 2023 Category: Endocrinology Source Type: research
Upper digestive bleeding secondary to duodenal infiltration due to pancreatic cancer: a therapeutic challenge
Rev Esp Enferm Dig. 2023 May 26;115. doi: 10.17235/reed.2023.9738/2023. Online ahead of print.ABSTRACTA 68-year-old woman with stage IV pancreatic adenocarcinoma (liver and lymph node metastases) on first-line treatment with gemcitabine. As a non-oncological comorbidity, the patient was anticoagulated with enoxaparin 8000 IU/24 hours because she had a mitral valve prosthesis. The patient made a medical consultation for presenting vomits which looked like coffee grounds and melaena. In the complete blood count, a hemoglobin of 7.5 g/dL was detected. Transfusion support, pantoprazole infusion (80 mg in 500 cc of 0.9% SSF eve...
Source: Revista Espanola de Enfermedades Digestivas - May 26, 2023 Category: Gastroenterology Authors: Jos é García Flores Manuel S ánchez Cánovas Emilio Torrella Cort és Source Type: research
