Hepatitis C viral clearance with coadministration of crushed sofosbuvir/velpatasvir and high-dose pantoprazole after liver transplantation
CONCLUSION: A liver transplant patient exhibited viral clearance of hepatitis C following administration of crushed sofosbuvir/velpatasvir in the setting of multiple absorption concerns.PMID:35675479 | DOI:10.1093/ajhp/zxac153 (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - June 8, 2022 Category: Drugs & Pharmacology Authors: Dawn M Pluckrose Amanda Szczepanik Sarah E Bova Sari R Freedman Source Type: research
Hepatitis C viral clearance with coadministration of crushed sofosbuvir/velpatasvir and high-dose pantoprazole after liver transplantation
CONCLUSION: A liver transplant patient exhibited viral clearance of hepatitis C following administration of crushed sofosbuvir/velpatasvir in the setting of multiple absorption concerns.PMID:35675479 | DOI:10.1093/ajhp/zxac153 (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - June 8, 2022 Category: Drugs & Pharmacology Authors: Dawn M Pluckrose Amanda Szczepanik Sarah E Bova Sari R Freedman Source Type: research
Role of ADMA/DDAH-1 and iNOS/eNOS signaling in the gastroprotective effect of tadalafil against indomethacin-induced gastric injury
Biomed Pharmacother. 2022 Jun;150:113026. doi: 10.1016/j.biopha.2022.113026. Epub 2022 Apr 28.ABSTRACTNon-steroidal anti-inflammatory drugs (NSAIDs)-induced gastric ulcers represent a significant clinical concern and adversely affect the quality of life. Inducible nitric oxide synthase/endothelial nitric oxide synthase (iNOS/eNOS) and asymmetric dimethylarginine/ dimethylarginine dimethylaminohydrolase-1 (ADMA/DDAH-1) signaling are key players in gastric ulcer pathogenesis. This work was planned to explore the role of iNOS/eNOS and ADMA/DDAH-1 signaling in rats with indomethacin-induced gastric ulcer, as potential pathways...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 5, 2022 Category: Drugs & Pharmacology Authors: Yasmin T Mohamed Ibrahim A Naguib Ali A Abo-Saif Mohammed H Elkomy Badrah S Alghamdi Wafaa R Mohamed Source Type: research
Metronidazole-induced hepatotoxicity in a patient with xeroderma pigmentosum: A case report
We report the case of a 44-year-old man, affected by xeroderma pigmentosum, who was admitted to the hospital presenting aspiration pneumoniae caused by worsening dysphagia and with severe hepatotoxicity during the hospitalization.
Diagnoses:
Acute hepatitis, which was leading to acute liver failure, occurred during antibiotic treatment with metronidazole and ceftazidime with an elevation of liver enzymes consistent with hepatocellular damage pattern.
Interventions:
Hydration with glucose 5% solution, pantoprazole and vitamin K were administered, meanwhile other causes of hepatitis were ruled out and the ongoi...
Source: Medicine - May 27, 2022 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Pantoprazole promotes the sensitivity of cervical cancer cells to cisplatin by inhibiting cisplatin-induced autophagy
Conclusion: PPZ promotes the sensitivity of CC cells to cisplatin by inhibiting cisplatin-induced cell autophagy. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - May 20, 2022 Category: Cancer & Oncology Authors: Guangzhu Su Xiaolu Chen Hongyan Yang Source Type: research
"Nonpolarity paving" in substrate tunnel of a Limnobacter sp. Phenylacetone monooxygenase for efficient single whole-cell synthesis of esomeprazole
Bioorg Chem. 2022 May 11;125:105867. doi: 10.1016/j.bioorg.2022.105867. Online ahead of print.ABSTRACTBaeyer-Villiger monooxygenase (BVMO) mediated sulfoxidation is a sustainable approach for the synthesis of esomeprazole. In this work, a novel phenylacetone monooxygenase from Limnobacter sp. (LnPAMO) was found to have trace activity for synthesis of enantiopure esomeprazole. Through engineering in the substrate tunnel using a mutagenesis strategy called "nonpolarity paving" and some modifications in cofactor binding domains, a mutant harboring 15 mutations (LnPAMO Mu15) was obtained with 6.6 × 103-fold higher activity to...
Source: Bioorganic Chemistry - May 16, 2022 Category: Chemistry Authors: Xinqi Xu Yajiao Zhang Shaoyu Wang Lian Xu Bingmei Su Lichao Wang Juan Lin Source Type: research
"Nonpolarity paving" in substrate tunnel of a Limnobacter sp. Phenylacetone monooxygenase for efficient single whole-cell synthesis of esomeprazole
Bioorg Chem. 2022 May 11;125:105867. doi: 10.1016/j.bioorg.2022.105867. Online ahead of print.ABSTRACTBaeyer-Villiger monooxygenase (BVMO) mediated sulfoxidation is a sustainable approach for the synthesis of esomeprazole. In this work, a novel phenylacetone monooxygenase from Limnobacter sp. (LnPAMO) was found to have trace activity for synthesis of enantiopure esomeprazole. Through engineering in the substrate tunnel using a mutagenesis strategy called "nonpolarity paving" and some modifications in cofactor binding domains, a mutant harboring 15 mutations (LnPAMO Mu15) was obtained with 6.6 × 103-fold higher activity to...
Source: Bioorganic Chemistry - May 16, 2022 Category: Chemistry Authors: Xinqi Xu Yajiao Zhang Shaoyu Wang Lian Xu Bingmei Su Lichao Wang Juan Lin Source Type: research
Effects of CYP3A Inhibition, CYP3A Induction, and Gastric Acid Reduction on the Pharmacokinetics of Ripretinib, a Switch Control KIT Tyrosine Kinase Inhibitor
AbstractRipretinib is a switch control KIT kinase inhibitor approved for treatment of adults with advanced gastrointestinal stromal tumors who received prior treatment with 3 or more kinase inhibitors, including imatinib. Ripretinib and its active metabolite (DP-5439) are cleared mainly via cytochrome P450 enzyme 3A4/5 (CYP3A4/5), and ripretinib solubility is pH-dependent, thus the drug –drug interaction potentials of ripretinib with itraconazole (strong CYP3A inhibitor), rifampin (strong CYP3A inducer), and pantoprazole (proton pump inhibitor) were each evaluated in open-label, fixed-sequence study designs. Overall, 20 ...
Source: Clinical Pharmacology in Drug Development - May 13, 2022 Category: Drugs & Pharmacology Authors: Xiaoyan Li,
Mark J Shelton,
Jing Wang,
Julie Meade,
Rodrigo Ruiz ‐Soto Tags: Original Article Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: Journal of Physiology and Pharmacology - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: J Physiol Pharmacol - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: Journal of Physiology and Pharmacology - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: J Physiol Pharmacol - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: Journal of Physiology and Pharmacology - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: J Physiol Pharmacol - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
