Proton Pump Inhibitor Exposure and Acute Myocardial Infarction Risk: A Nested Cohort Study
CONCLUSIONS: Our study demonstrated long-term or high-dose PPI exposure associated with increased new-onset AMI risk in patients without a history of any ischemic heart disease. The underlying mechanisms of PPI-related cardiovascular effects deserve more investigation.PMID:33625647 | DOI:10.1007/s12012-021-09637-2 (Source: Cardiovascular Toxicology)
Source: Cardiovascular Toxicology - February 24, 2021 Category: Cardiology Authors: Hsiang-Jung Tseng Chih-Ming Cheng Shih-Jen Tsai Wei-Chen Lin Ya-Mei Bai Chia-Fen Tsai Tung-Ping Su Cheng-Ta Li Tzeng-Ji Chen Mu-Hong Chen Source Type: research

Proton Pump Inhibitor Exposure and Acute Myocardial Infarction Risk: A Nested Cohort Study
CONCLUSIONS: Our study demonstrated long-term or high-dose PPI exposure associated with increased new-onset AMI risk in patients without a history of any ischemic heart disease. The underlying mechanisms of PPI-related cardiovascular effects deserve more investigation.PMID:33625647 | DOI:10.1007/s12012-021-09637-2 (Source: Cardiovascular Toxicology)
Source: Cardiovascular Toxicology - February 24, 2021 Category: Cardiology Authors: Hsiang-Jung Tseng Chih-Ming Cheng Shih-Jen Tsai Wei-Chen Lin Ya-Mei Bai Chia-Fen Tsai Tung-Ping Su Cheng-Ta Li Tzeng-Ji Chen Mu-Hong Chen Source Type: research

Proton Pump Inhibitor Exposure and Acute Myocardial Infarction Risk: A Nested Cohort Study
CONCLUSIONS: Our study demonstrated long-term or high-dose PPI exposure associated with increased new-onset AMI risk in patients without a history of any ischemic heart disease. The underlying mechanisms of PPI-related cardiovascular effects deserve more investigation.PMID:33625647 | DOI:10.1007/s12012-021-09637-2 (Source: Cardiovascular Toxicology)
Source: Cardiovascular Toxicology - February 24, 2021 Category: Cardiology Authors: Hsiang-Jung Tseng Chih-Ming Cheng Shih-Jen Tsai Wei-Chen Lin Ya-Mei Bai Chia-Fen Tsai Tung-Ping Su Cheng-Ta Li Tzeng-Ji Chen Mu-Hong Chen Source Type: research

Do the types and routes of proton pump inhibitor treatments affect Clostridium difficile in ICU patients?: A retrospective cohort study.
Authors: Lee P, Fike D, Yang H, Hall RG, Pass S, Alvarez CA Abstract Background: Proton pump inhibitor (PPI) exposure is associated with Clostridium difficile infection (CDI). The impact of the route of administration is unknown. RESEARCH DESIGN AND METHODS: Patients in the Multiparameter Intelligent Monitoring in Intensive Care II database (MIMIC-II) from 2001-2008 who were>18 years old, admitted to medical, surgical, or cardiac ICUs were included. PPI exposure types were omeprazole, esomeprazole, lansoprazole, and pantoprazole. PPI administration routes were oral or intravenous. Patients who received hista...
Source: Expert Review of Clinical Pharmacology - February 14, 2021 Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research

Comparison of the Efficacy of Polaprezinc Plus Proton Pump Inhibitor and Rebamipide Plus Proton Pump Inhibitor Treatments for Endoscopic Submucosal Dissection-induced Ulcers
Conclusion: The polaprezinc plus PPI treatment showed noninferiority to rebamipide plus PPI treatment in the ulcer healing rate at 4 weeks after ESD. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - February 12, 2021 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Pharmacokinetics and pharmacodynamics of tegoprazan co-administered with amoxicillin and clarithromycin in healthy subjects.
In conclusion, the exposure of tegoprazan was increased after co-administration of amoxicillin/clarithromycin, which led to increase pharmacodynamic response measured by intragastric pH compared to tegoprazan alone. Therefore, tegoprazan-based triple therapy would be effective therapeutic regimen to manage intragastric pH in terms of gastric or duodenal ulcers healing, treatment of gastroesophageal reflux disease, and Helicobacter pylori eradication. This article is protected by copyright. All rights reserved. PMID: 33341955 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Pharmacology)
Source: The Journal of Clinical Pharmacology - December 20, 2020 Category: Drugs & Pharmacology Authors: Ghim JL, Chin MC, Jung J, Lee J, Kim S, Kim B, Song GS, Choi YK, Shin JG Tags: J Clin Pharmacol Source Type: research

Clinical pathologic conference case 3: multiple deep oral ulcers
Clinical Presentation: An 87-year-old woman reported a history of “canker sores” so painful she was unable to eat. Large ulcerations were present on the right buccal mucosa, left ventral tongue (Figure 1A and B), left hard palate, and right soft palate. Recently she developed 3 lesions on her scalp (Figure 2). The patient's medications include levothyroxine (S ynthroid), pantoprazole (Protonix), furosemide (Lasix), and sucralfate (Carafate).Differential Diagnosis: Close examination of the patient's medications and clinical history was essential to developing a working diagnosis. (Source: Oral Surgery, Oral Medi...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - December 17, 2020 Category: ENT & OMF Authors: Mark L. Bernstein, Stephanie L. Wetzel Source Type: research

Laparoscopic Clip Gastroplasty with the BariClip
In conclusion, the BariClip accomplishes almost similar weight loss as a SG, without a gastrectomy, without risks of leaks, and without causing reflux, and at the same ,time the BariClip is reversible [5]. (Source: Obesity Surgery)
Source: Obesity Surgery - December 1, 2020 Category: Surgery Source Type: research

Modified quadruple therapy or bismuth-containing quadruple therapy in the first-line treatment of Helicobacter Pylori in Turkey.
CONCLUSION: Both bismuth-containing treatment regimens, quadruple therapy and modified quadruple therapy were highly effective and safe in H. pylori eradication in Turkey. Adverse events were lower in the modified quadruple therapy group. Modified quadruple therapy should be kept in mind in H. Pylori first-line therapy in regions with high resistance of metronidazole and clarithromycin treatment. PMID: 33233910 [PubMed - as supplied by publisher] (Source: Revista Espanola de Enfermedades Digestivas)
Source: Revista Espanola de Enfermedades Digestivas - November 26, 2020 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

A Sensitive, Simple and Direct Determination of Pantoprazole Based on a "Turn off-on" Fluorescence Nanosensor by Using Terbium-1,10-phenanthroline-silver Nanoparticles.
A Sensitive, Simple and Direct Determination of Pantoprazole Based on a "Turn off-on" Fluorescence Nanosensor by Using Terbium-1,10-phenanthroline-silver Nanoparticles. Anal Sci. 2020;36(11):1345-1352 Authors: Shaghaghi M, Rashtbari S, Abdollahi A, Dehghan G, Jouyban A Abstract A new sensitive, simple, rapid, reliable and selective fluorometric method for the determination of pantoprazole (PAN) in human plasma and a pharmaceutical formulation has been developed. This technique is based on a quenching effect of silver nanoparticles (AgNPs) on the emission intensity of a fluorescent probe, ter...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - November 14, 2020 Category: Chemistry Authors: Shaghaghi M, Rashtbari S, Abdollahi A, Dehghan G, Jouyban A Tags: Anal Sci Source Type: research

Molecules, Vol. 25, Pages 5287: Role of Daucus carota in Enhancing Antiulcer Profile of Pantoprazole in Experimental Animals
This study was performed to evaluate the role of carrot when administered concurrently with a conventional antiulcer treatment, pantoprazole, in alleviating gastric and duodenal ulcers in female experimental animals. The study involved standard animal models to determine the ulcer preventive effect using pylorus ligation, ethanol, and stress induced acute gastric ulcer models and duodenal ulcer models involving cysteamine. Acetic acid-induced chronic gastric ulcer and indomethacin-induced gastric ulcer models were used to evaluate the ulcer healing effect. Carrot fruit (500 mg/kg) and its co-administration with pantoprazol...
Source: Molecules - November 13, 2020 Category: Chemistry Authors: Syed Mohammed Basheeruddin Asdaq Earla Swathi Sunil S Dhamanigi Mohammed Asad Yahya Ali Mohzari Ahmed A. Alrashed Abdulrahman S. Alotaibi Batool Mohammed Alhassan Sreeharsha Nagaraja Tags: Article Source Type: research

A retrospective study on prescribing pattern and cost analysis of proton ‐pump inhibitors used among adults of Saudi Arabia
ConclusionIn our study, among all the PPIs Pantoprazole was prescribed to the highest number of patients also it was costliest; hence, their safe and effective use must be warranted. Current study will also help in to develop nation database regarding utilization of proton ‐pump inhibitors. (Source: Journal of Pharmaceutical Health Services Research)
Source: Journal of Pharmaceutical Health Services Research - November 9, 2020 Category: Drugs & Pharmacology Authors: Mohammad Daud Ali, Ayaz Ahmad Tags: Research Paper Source Type: research

Pharmacokinetics, Bioequivalence, and Safety Studies of Pantoprazole Sodium Enteric ‐Coated Tablets in Healthy Subjects
This study aimed to evaluate the bioequivalence of 2 pantoprazole sodium enteric ‐coated tablet formulations, a generic formulation and a branded formulation, and to investigate their pharmacokinetic and safety profiles. The study was designed as a single‐center, randomized, open‐label, single‐dose, dual‐period, and 2‐sequence crossover trial, and was divided into fa sting and postprandial human bioequivalence trials. In the first trial, 36 subjects were fasted overnight before they were given generic or branded tablets (during 2 separate administration periods). Separately, 42 subjects were provided a high‐f...
Source: Clinical Pharmacology in Drug Development - October 31, 2020 Category: Drugs & Pharmacology Authors: Zhimin Chen, Fangliang Gan, Xiali Rao, Xiaoxiao Huang, Huafang Chen Tags: Original Manuscript Source Type: research

Efficacy of DA-5204 (Stillen 2X) for patients with gastroesophageal reflux disease: A randomized, double-blind, placebo-controlled pilot study
Conclusion: Combined therapy with PPI and DA-5204 has no additional effect on the endoscopic healing rate compared to PPI alone. However, it may be beneficial in resolving minimal change. (Source: Medicine)
Source: Medicine - October 29, 2020 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

Probable Drug Eruption Eosinophilia and Systemic Symptoms Due to Colistimethate Sodium: A Challenging Case Report
A 28-year-old male patient was admitted to our hospital with an altered mental status. During his hospitalization, he experienced 2 events of ventilator-associated pneumonia. Acinetobacter baumannii and Pseudomonas aeruginosa were separated from sputum culture in the first and second episodes, respectively. Two events of drug reactions with eosinophilia and systemic symptoms also occurred during hospitalization. Generalized morbilliform rash, high fever, eosinophilia, and increases in liver aminotransferase and bilirubin were observed in the first episode. Initially, medications with a higher likelihood of skin eruption in...
Source: Infectious Diseases in Clinical Practice - October 29, 2020 Category: Infectious Diseases Tags: Case Reports Source Type: research

Revaprazan prevented indomethacin-induced intestinal damages by enhancing tight junction related mechanisms.
We examined intestinal permeability-related molecular changes in in vitro Caco-2 cell models and in an in vivo indomethacin-induced enteropathy rat model. Indomethacin alone or in combination with pantoprazole significantly increased relative lucifer yellow dye flux and decreased relative trans-epithelial electrical resistance and tight junction protein (TJP) expression compare to normal cells. In contrast, indomethacin combined with revaprazan significantly preserved TJPs compare to indomethacin-treated cells. MLC phosphorylation, Rho activation, and ERK activation responsible for TJP were significantly increased by indom...
Source: Biochemical Pharmacology - October 16, 2020 Category: Drugs & Pharmacology Authors: Han YM, Park JM, Her S, Sun Kim M, Jin Park Y, Baik Hahm K Tags: Biochem Pharmacol Source Type: research

Pattern of systemic antibiotic use and potential drug interactions: Evaluations through a point prevalence study in Ankara University Hospitals.
Conclusions A dramatic variance existed amongst antibiotics prescribed by different departments. This indicated indicated the requirement for a centralized role of an infectious diseases specialist. Especially for the hospitalized patient, prophylactic coverage with at least one antibiotic brought about a number of drug interactions. A precise evaluation by a clinical pharmacist -currently none on duty- of orders in terms of drug interactions will reduce possible drug-related hazards. PMID: 32927931 [PubMed - as supplied by publisher] (Source: Turkish Journal of Medical Sciences)
Source: Turkish Journal of Medical Sciences - September 16, 2020 Category: General Medicine Tags: Turk J Med Sci Source Type: research

Use of Proton Pump Inhibitors in Hungary: Mixed-Method Study to Reveal Scale and Characteristics
ConclusionsOur data suggests that Hungarian patients receive proton pump inhibitors in high doses and for a long time. Use of proton pump inhibitors beyond their recommended indications was also found. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 7, 2020 Category: Drugs & Pharmacology Source Type: research

Evaluation of the prescribing of proton pump inhibitors as stress ulcer prophylaxis for non-ICU patients in a Malaysian tertiary hospital
ConclusionOur findings indicated a high prevalence of inappropriate prescribing of PPIs as SUP for non-ICU patients. Interventions to reduce the unnecessary use of PPIs in Malaysian hospital settings are desperately required. The need for national criteria that address the proper indications and dosing regimens for PPIs as SUP in ICU and non-ICU patients is high. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - August 30, 2020 Category: Drugs & Pharmacology Source Type: research

The Effects of Proton Pump Inhibitors (Pantoprazole) on Pentylenetetrazole-Induced Epileptic Seizures in Rats and Neurotoxicity in the SH-SY5Y Human Neuroblastoma Cell Line.
In this study, it was aimed to investigate the effect of pantoprazole on pentylenetetrazole-induced epileptic seizures in rats and neurotoxicity in the SH-SY5Y cell line. Animals were divided into three groups: control, saline (1 mL/kg serum physiologic), and pantoprazole (10 mg/kg). Pentylenetetrazole (45 mg/kg) was given to induce a seizure and a passive avoidance test trial was carried out to evaluate memory function. 8-hydroxy-2'-deoxyguanosine (8-OHdG), caspase-3, and brain-derived neurotrophic factor (BDNF) levels were measured in the brain by commercial kits. SH-SY5Y cells were treated with saline or ...
Source: Cellular and Molecular Neurobiology - August 28, 2020 Category: Cytology Authors: Taskiran AS, Ergul M, Gunes H, Ozturk A, Sahin B, Ozdemir E Tags: Cell Mol Neurobiol Source Type: research

Current status of Helicobacter pylori eradication and risk factors for eradication failure.
Abstract BACKGROUND: The Helicobacter pylori (H. pylori) eradication rate is decreasing in the general population of China. AIM: To evaluate the H. pylori eradication status in real-world clinical practice and to explore factors related to eradication failure. METHODS: Patients with H. pylori infection who were treated with standard 14-d quadruple therapy and received a test of cure at a provincial medical institution between June 2018 and May 2019 were enrolled. Demographic and clinical data were recorded. Eradication rates were calculated and compared between regimens and subgroups. Multivariate analys...
Source: World Journal of Gastroenterology : WJG - August 27, 2020 Category: Gastroenterology Authors: Yan TL, Gao JG, Wang JH, Chen D, Lu C, Xu CF Tags: World J Gastroenterol Source Type: research

Prevalence of polypharmacy in Denmark.
CONCLUSIONS: Polypharmacy is prevalent in Denmark with no relevant regional differences. The prevalence of polypharmacy increased with age, and more than half of the population aged ≥ 75 years redeemed prescriptions for> 5 different medicines. The most redeemed medicines among older citizens were against pain and cardiovascular disease. FUNDING: none. TRIAL REGISTRATION: not relevant. PMID: 32741431 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - August 5, 2020 Category: General Medicine Tags: Dan Med J Source Type: research

Dose and time-dependent toxicological impact of pantoprazole on vascular endothelium and renal tissue.
Abstract Proton pump inhibitors (PPIs) have wide pleiotropic action in addition to their therapeutic potential in gastroesophageal reflux diseases. Conversely, recent reports revealed a significant incidence of toxic events of PPIs including nephritis, osteoporosis, and cardiac damage. Thus, the study was designed to reconcile the deceptive contraindications. The present investigation targeted to reveal the toxic impact of sub-acute and sub-chronic administration of pantoprazole (PPZ) with different concentrations (low dose 4 mg/kg, medium-dose 8 mg/kg and high dose 16 mg/kg once a day) on normal vascular en...
Source: Toxicology Letters - August 3, 2020 Category: Toxicology Authors: Taneja G, Thanikachalam PV, Rajput SK Tags: Toxicol Lett Source Type: research

Epidermoid Metaplasia of the Esophagus
A 76-year-old man presented with a 1.5-year history of intermittent globus sensation and rare episodes of solid food dysphagia. He reported no heartburn or regurgitation. Two months previously, he had undergone esophagoduodenoscopy that revealed Los Angeles classification grade C esophagitis with a nonobstructing peptic stricture. Treatment with pantoprazole, 40 mg twice daily, was initiated. Repeated esophagoduodenoscopy at the current presentation revealed healing of the prior erosive esophagitis and well-demarcated, white plaques with altered texture in the distal esophagus (Figure  1). (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - July 31, 2020 Category: Internal Medicine Authors: Amrit K. Kamboj, Rondell P. Graham, Joseph A. Murray Tags: Medical image Source Type: research

Effect of food on the pharmacokinetics of omeprazole, pantoprazole and rabeprazole.
CONCLUSION: As food delays the absorption of PPIs and increases their variability, it would be better to administer these drugs under fasting conditions. TRIAL REGISTRATION: European Union Drug Regulating Authorities Clinical Trials Database: EudraCT : 2004-003863-59 (registration date 05/MAR/2004), EudraCT 2006-001162-17 (registration date 17-MAR-2006), EudraCT: 2007-002489-37 (registration date 12-JUN-2007), EudraCT: 2007-002490-31 (registration date 12-JUN-2007), EudraCT: 2010-024029-19 (registration date 23-NOV-2010). PMID: 32711578 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - July 29, 2020 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Effect of food on the pharmacokinetics of omeprazole, pantoprazole and rabeprazole
The pharmacokinetics of proton pump inhibitors (PPIs) may be affected by food intake. We aimed to evaluate the effect of food on the pharmacokinetics of omeprazole, rabeprazole, and pantoprazole. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - July 25, 2020 Category: Drugs & Pharmacology Authors: Dolores Ochoa, Manuel Rom án, Teresa Cabaleiro, Miriam Saiz-Rodríguez, Gina Mejía and Francisco Abad-Santos Tags: Research article Source Type: research

Pantoprazole, a proton ‐pump inhibitor, impairs human sperm motility and capacitation in vitro
ConclusionOur results indicate that exposure to pantoprazole has an adverse effect on the physiological competence of human spermatozoa. As the capacitation process takes place within the female tract, our results suggest that PPIs intake by the female partner may impair in vivo sperm maturation and possibly fertilization. Moreover, the absence of adverse effect by PPIs on mouse sperm emphasizes the need to develop reprotox assays using human material to better assess the effects of medication intake on sperm physiology. (Source: Andrology)
Source: Andrology - July 15, 2020 Category: Urology & Nephrology Authors: Jessica Escoffier, Bastien Arnaud, Mayis Kaba, Jean Pascal Hograindleur, Emilie Le Bl évec, Guillaume Martinez, Isabelle Stévant, Pierre F. Ray, Christophe Arnoult, Serge Nef Tags: ORIGINAL ARTICLE Source Type: research

A retrospective study on prescribing pattern and cost analysis of proton ‐pump inhibitors used among adults of Saudi Arabia
ConclusionIn our study, among all the PPIs Pantoprazole was prescribed to the highest number of patients also it was costliest; hence, their safe and effective use must be warranted. Current study will also help in to develop nation database regarding utilization of proton ‐pump inhibitors. (Source: Journal of Pharmaceutical Health Services Research)
Source: Journal of Pharmaceutical Health Services Research - July 11, 2020 Category: Drugs & Pharmacology Authors: Mohammad Daud Ali, Ayaz Ahmad Tags: Research Paper Source Type: research

Evaluation of different proton pump inhibitors combined with bismuth quadruple regimens in Helicobacter pylori eradication
AbstractTo evaluate the efficacy and economics of different proton pump inhibitors (PPIs) combined with bismuth quadruple regimens forHelicobacter pylori (Hp) eradication, a retrospective analysis method was used to collect Hp-positive patients who were treated with a bismuth-containing quadruple regimen (PPIs  + amoxicillin + furazolidone + colloid pectin bismuth) from the outpatient department of gastroenterology in our hospital from January to June 2017. A total of 1410 patients were included in the study and divided into four groups according to different PPIs: group A (pantopr...
Source: Clinical and Experimental Medicine - July 9, 2020 Category: Research Source Type: research

Pantoprazole, a proton pump inhibitor, impairs human sperm motility and capacitation in vitro
Discussion and conclusionOur results indicate that exposure to pantoprazole have an adverse effect on the physiological competence of human sperm. As the capacitation process takes place within the female tract, our results suggest that PPIs intake by the female partner may impairin vivo sperm maturation and possibly fertilization. Moreover, the absence of adverse effect by PPIs on mouse sperm emphasizes the need to develop reprotox assays using human material to better assess the effects of medication intake on sperm physiology. (Source: Andrology)
Source: Andrology - June 30, 2020 Category: Urology & Nephrology Authors: J Escoffier, B Arnaud, M Kaba, JP Hograindleur, E Le Bl évec, G Martinez, I Stévant, PF Ray, C Arnoult, S Nef Tags: ORIGINAL ARTICLE Source Type: research

Impact of pantoprazole on absorption and disposition of hydroxychloroquine, a drug used in Corona Virus Disease-19 (Covid-19): A structured summary of a study protocol for a randomised controlled trial
Primary objective: Evaluation of the effect of the proton pump inhibitor (PPI) pantoprazole on the absorption of hydroxychloroquine (HCQ). (Source: Trials)
Source: Trials - June 29, 2020 Category: General Medicine Authors: Felicitas Stoll, Antje Blank, Gerd Mikus, David Czock, Kathrin I. Foerster, Simon Hermann, Katja H äußler, Amin Muhareb, Simone Hummler, Johanna Weiss, Jürgen Burhenne and Walter E. Haefeli Tags: Letter Source Type: research

Omeprazole-induced and pantoprazole-induced asymptomatic hyponatremia: a case report
ConclusionHyponatremia is worrisome and awareness of medication-induced hyponatremia, especially due to proton pump inhibitors, is needed. In our case, sequential hyponatremia occurred with two different proton pump inhibitors, suggesting a class effect. Therefore, when syndrome of inappropriate antidiuretic hormone secretion due to a proton pump inhibitor is diagnosed, preferably no other medication from the same class is prescribed. When after consideration another proton pump inhibitor is prescribed, serum sodium concentrations should be monitored. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - June 28, 2020 Category: General Medicine Source Type: research

Acute interstitial nephritis with only three doses of pantoprazole
Several antibiotics, proton pump inhibitors, and nonsteroidal anti ‐inflammatory drugs can cause acute interstitial nephritis. This is not dose‐dependent, and recurrence can occur with a second exposure of the same drug. Stopping the culprit is critical for successful management. AbstractSeveral antibiotics, proton pump inhibitors, and nonsteroidal anti ‐inflammatory drugs can cause acute interstitial nephritis. This is not dose‐dependent, and recurrence can occur with a second exposure of the same drug. Stopping the culprit is critical for successful management. (Source: Clinical Case Reports)
Source: Clinical Case Reports - June 23, 2020 Category: General Medicine Authors: Subhankar Samal, Namrata Singhania, Saurabh Bansal, Girish Singhania Tags: CLINICAL IMAGE Source Type: research

Effect of Sex, Use of Pantoprazole and Polymorphisms in SLC22A1 , ABCB1 , CES1 , CYP3A5 and CYP2D6 on the Pharmacokinetics and Safety of Dabigatran
AbstractIntroductionDabigatran is a direct oral anticoagulant (DOAC) used for the treatment of several thrombotic conditions. To date, very few pharmacogenetic studies on dabigatran were published. We aimed to investigate the influence of 59 polymorphisms in 15 genes (including CES1, UGT andCYP that encode enzymes andABCB1 andSLC that encode transporters), concomitant treatment with pantoprazole and demographic characteristics (including sex or race) on dabigatran pharmacokinetics and safety.MethodsThis was a candidate gene pharmacogenetic study. The study population comprised 107 volunteers enrolled in two dabigatran bioe...
Source: Advances in Therapy - June 19, 2020 Category: Drugs & Pharmacology Source Type: research

Effect of High-Dose Esomeprazole on CYP1A2, CYP2C19 and CYP3A4 Activities in Humans: Evidence for Substantial and Long-lasting Inhibition of CYP2C19.
In conclusion, high-dose esomeprazole can cause strong inhibition of CYP2C19, but only weakly inhibits CYP3A4 and leads to minor induction of CYP1A2. The enzymatic activity of CYP2C19 recovers gradually in approximately 3-4 days after discontinuation of esomeprazole treatment. PMID: 32558923 [PubMed - as supplied by publisher] (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - June 18, 2020 Category: Drugs & Pharmacology Authors: Kaartinen TJK, Tornio A, Tapaninen T, Launiainen T, Isoherranen N, Niemi M, Backman JT Tags: Clin Pharmacol Ther Source Type: research

Role of Genetic Polymorphisms of Cytochrome P450 2C19 in Pantoprazole Metabolism and Pantoprazole-based Helicobacter pylori Eradication Regimens.
CONCLUSION: The data on cytochrome P450 gene polymorphisms and their role in pantoprazole metabolism and pantoprazole based Helicobacter pylori eradication remain conflicting. Individual differences in pantoprazole metabolism might be partly related to genetic polymorphisms of CYP450 enzymes. Most of the studies support the observation that cytochrome 2C19 polymorphisms have an impact on the pharmacokinetics of pantoprazole and its therapeutic effects: poor metabolizers of PPIs are more likely to have a better response to pantoprazole therapy and achieve better H. pylori eradication rates compared to rapid metabolizers. Th...
Source: Current Drug Metabolism - May 12, 2020 Category: Drugs & Pharmacology Authors: Jonaitis P, Jonaitis L, Kupcinskas J Tags: Curr Drug Metab Source Type: research

Drug-induced enterocolitis syndrome (DIES) with pantoprazole in an adult patient
Publication date: Available online 4 May 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Geneviève Bouvette, Nina Verreault, Nathalie Gagnon, Aubert Lavoie (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - May 4, 2020 Category: Allergy & Immunology Source Type: research

A phase I study of the effect of repeated oral doses of pantoprazole on the pharmacokinetics of a single dose of fedratinib in healthy male subjects
ConclusionCoadministration with pantoprazole did not have clinically meaningful effects on fedratinib PK. No new or unexpected safety signals were observed with fedratinib. (Source: Cancer Chemotherapy and Pharmacology)
Source: Cancer Chemotherapy and Pharmacology - April 21, 2020 Category: Cancer & Oncology Source Type: research

Assessment of the utilization pattern of chemotherapy agents in patients with head and neck cancer in an oncology hospital
ConclusionPlatinum analogs and taxanes were highly prescribed chemotherapy agents as they are highly effective in HNSCC. To prevent chemotherapy-induced cytotoxicity, supportive care agents, such as anti-emetics, proton pump inhibitors, anti-infective agents, and colony-stimulating factors, were used along with miscellaneous supplements. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - April 20, 2020 Category: Drugs & Pharmacology Source Type: research

The Effect of Proton Pump Inhibitor Withdrawal on Dabigatran Etexilate Plasma Levels in Patients With Atrial Fibrillation: A Washout Study
Background: Several studies demonstrated that proton pump inhibitors (PPIs) co-administrated with dabigatran in patients with atrial fibrillation (AF) decreased dabigatran trough and peak plasma levels. However, it is still unknown whether this interaction is reversible or not, and whether the withdrawal of PPI would lead to normalization of dabigatran plasma levels. Aim of study: The aim of this study was to determine the effect of PPI withdrawal on dabigatran plasma levels in patients with AF. Methods: This pilot prospective study enrolled 23 AF patients on long-term dabigatran and PPI therapy (omeprazole 20 mg t...
Source: Journal of Cardiovascular Pharmacology - April 1, 2020 Category: Cardiology Tags: Original Article Source Type: research

Evaluation of the Direct Economic Cost per Eradication Treatment Regimen against Helicobacter pylori Infection in Greece: Do National Health Policy-Makers Need to Care?
Abstract Helicobacter pylori (Hp) management has undoubtedly resulted in a notable economic burden on healthcare systems globally, including Greece. Its cost has never been estimated so far, especially during the recent 10-year unprecedented financial crisis. Direct medical and procedural costs for one attempt "outpatient" Hp eradication treatment were estimated as the following: (I) first-line regimens: 10 and 14 days standard triple, 10 and 14 days sequential, 10 and 14 days concomitant non-bismuth quadruple, 14 days hybrid, (II) second-line salvage regimens: 10 and 14 days levofloxacin-containing trip...
Source: Medicina (Kaunas) - March 17, 2020 Category: Universities & Medical Training Authors: Liatsos C, Papaefthymiou A, Kyriakos N, Giakoumis M, Kountouras J, Galanopoulos M, Apostolopoulos P, Georgopoulos SD, Mavrogiannis C, Exadaktylos AK, Srivastava DS, Rokkas T, Doulberis M Tags: Medicina (Kaunas) Source Type: research

Effects of oral/enteral nutrition alone versus plus pantoprazole on gastrointestinal bleeding in critically ill patients with low risk factor: A multicenter, randomized controlled trial.
CONCLUSIONS: Our findings seems to indicate that in patients who are at low risk for GI bleeding and under oral/enteral nutritional support, the use of PPIs may not reduce the risk of bleeding, however these results are imprecise because of low event (GI bleeding) rate and limited power. PMID: 32151119 [PubMed - as supplied by publisher] (Source: Turkish Journal of Medical Sciences)
Source: Turkish Journal of Medical Sciences - March 12, 2020 Category: General Medicine Tags: Turk J Med Sci Source Type: research

Effects of Low-Dose Amitriptyline on Epigastric Pain Syndrome in Functional Dyspepsia Patients
AbstractAimTo observe the therapeutic effect of low-dose amitriptyline (AMT) on epigastric pain syndrome (EPS) in patients with functional dyspepsia.MethodsSixty patients with EPS were randomly divided into the following two groups for a four-week clinical trial: routine treatment with pantoprazole (RT group) and the AMT group. The RT group was treated with 40  mg of pantoprazole once daily. The AMT group received 25 mg of AMT once daily before bedtime. The Nepean Dyspepsia Index (NDI) checklist, Hamilton Rating Scale of Anxiety/Depression (HAMA/HAMD), and Pittsburgh Sleep Quality Index (PSQI) were employed to ev...
Source: Digestive Diseases and Sciences - March 11, 2020 Category: Gastroenterology Source Type: research

Inappropriate Medication Use and cost comparison analysis of Proton pump inhibitors: Evidence from an Indian tertiary care facility.
CONCLUSION: The study inferred that irrational drug use of PPI still prevalent, that too without considering the economic impact of it on general populations. Healthcare practitioners should be aware and cautious while prescribing the PPI to identify the actual need and to choose with the most cost-effective alternative. PMID: 32160850 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - March 10, 2020 Category: Drugs & Pharmacology Authors: Venkataraman R, Rashid M, Shrestha H Tags: Curr Drug Saf Source Type: research

Cancers, Vol. 12, Pages 640: Proton Pump Inhibitors Reduce Pancreatic Adenocarcinoma Progression by Selectively Targeting H+, K+-ATPases in Pancreatic Cancer and Stellate Cells
Arcangeli Ivana Novak Pancreatic duct cells are equipped with acid/base transporters important for exocrine secretion. Pancreatic ductal adenocarcinoma (PDAC) cells may utilize such transporters to acidify extracellular tumor microenvironment, creating a niche favoring cell proliferation, fibrosis and resistance to chemotherapy—all contributing to the notoriously bad prognosis of this disease. Here, we report that gastric and non-gastric H+, K+-ATPases (coded by ATP4A and ATP12A) are overexpressed in human and murine pancreatic cancer and that we can target them specifically with proton pump inhibitors...
Source: Cancers - March 9, 2020 Category: Cancer & Oncology Authors: Marco Tozzi Christiane E. S ørensen Lara Magni Nynne M. Christensen Rayhana Bouazzi Caroline M. Buch Matteo Stefanini Claudia Duranti Annarosa Arcangeli Ivana Novak Tags: Article Source Type: research

Effect of proton pump inhibitors on voriconazole concentrations in Chinese patients with malignant hematological diseases
AbstractPurposeTo evaluate the influence of three proton pump inhibitors (PPIs) on plasma voriconazole (VOR) concentrations and characterize potential drug-drug interactions (DDIs) between VOR and three PPIs (omeprazole, lansoprazole, and pantoprazole) in Chinese patients with malignant hematological diseases.MethodsA simple and reliable 2D-HPLC with internal quality control method was used to ensure accurate concentration measurements. A total of 194 patients in this retrospective study were divided into control (N = 59), omeprazole (OME,N = 57), lansoprazole (LAN,N = 26), and pan...
Source: European Journal of Clinical Pharmacology - March 9, 2020 Category: Drugs & Pharmacology Source Type: research

Oesophageal appearances of eosinophilic oesophagitis
A 33-year-old man presented with recent-onset (1 month) sticking of food in the retrosternal area. The symptoms occurred with the consumption of specific food items like pulses only. He did not have odynophagia, skin rash, asthma or urticaria. Physical examination was unremarkable. Laboratory data showed a normal total white blood count and a slightly elevated absolute eosinophil count of 580/ μl. Endoscopy revealed multiple fixed rings in the esophagus (Figure  1A) starting from 26  cm from incisors and extending up to the gastroesophageal junction, suggestive of eosinophilic esophagitis (EoE). Endoscopic e...
Source: QJM - February 28, 2020 Category: Internal Medicine Source Type: research

Clinical Impact of Co-Medication of Levetiracetam and Clobazam with Proton Pump Inhibitors: A Drug Interaction Study.
CONCLUSION: The effect of comedication with PPIs on the plasma concentration of clobazam is more pronounced for pantoprazole in greater extent when compared to esomeprazole and rabeprazole. When pantoprazole is used in combination with clobazam, dose reduction of clobazam should be considered or significance of PPIs is seen to avoid adverse effects. PMID: 32067615 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - February 17, 2020 Category: Drugs & Pharmacology Authors: Pasupuleti B, Gone V, Baddam R, Venisetty RK, Prasad OP Tags: Curr Drug Metab Source Type: research

Therapeutic drugs modulate ATP-Binding cassette transporter-mediated transport of amyloid beta(1-42) in brain microvascular endothelial cells.
Abstract Deposition of amyloid-β peptide (Aβ(1-42)) is a hallmark of Alzheimer's disease. Clearance of Aβ(1-42), across the blood-brain barrier (BBB), is mediated by ATP-binding Cassette (ABC) efflux transporters. Many therapeutic drugs inhibit ABC transporters, but little is known of the effect of therapeutic drugs on Aβ(1-42) transport across BBB endothelial cells. The effects of selected, widely prescribed, therapeutic drugs on ABCB1, ABCC5 and ABCG2 activities were determined by measuring intracellular levels of calcein, GS-MF, and Hoechst 33342 respectively in primary porcine brain endothe...
Source: European Journal of Pharmacology - February 12, 2020 Category: Drugs & Pharmacology Authors: Shubbar MH, Penny JI Tags: Eur J Pharmacol Source Type: research