Effects of oral/enteral nutrition alone versus plus pantoprazole on gastrointestinal bleeding in critically ill patients with low risk factor: A multicenter, randomized controlled trial.
CONCLUSIONS: Our findings seems to indicate that in patients who are at low risk for GI bleeding and under oral/enteral nutritional support, the use of PPIs may not reduce the risk of bleeding, however these results are imprecise because of low event (GI bleeding) rate and limited power. PMID: 32151119 [PubMed - as supplied by publisher] (Source: Turkish Journal of Medical Sciences)
Source: Turkish Journal of Medical Sciences - March 12, 2020 Category: General Medicine Tags: Turk J Med Sci Source Type: research

Effects of Low-Dose Amitriptyline on Epigastric Pain Syndrome in Functional Dyspepsia Patients
AbstractAimTo observe the therapeutic effect of low-dose amitriptyline (AMT) on epigastric pain syndrome (EPS) in patients with functional dyspepsia.MethodsSixty patients with EPS were randomly divided into the following two groups for a four-week clinical trial: routine treatment with pantoprazole (RT group) and the AMT group. The RT group was treated with 40  mg of pantoprazole once daily. The AMT group received 25 mg of AMT once daily before bedtime. The Nepean Dyspepsia Index (NDI) checklist, Hamilton Rating Scale of Anxiety/Depression (HAMA/HAMD), and Pittsburgh Sleep Quality Index (PSQI) were employed to ev...
Source: Digestive Diseases and Sciences - March 12, 2020 Category: Gastroenterology Source Type: research

Inappropriate Medication Use and cost comparison analysis of Proton pump inhibitors: Evidence from an Indian tertiary care facility.
CONCLUSION: The study inferred that irrational drug use of PPI still prevalent, that too without considering the economic impact of it on general populations. Healthcare practitioners should be aware and cautious while prescribing the PPI to identify the actual need and to choose with the most cost-effective alternative. PMID: 32160850 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - March 11, 2020 Category: Drugs & Pharmacology Authors: Venkataraman R, Rashid M, Shrestha H Tags: Curr Drug Saf Source Type: research

Effect of proton pump inhibitors on voriconazole concentrations in Chinese patients with malignant hematological diseases
AbstractPurposeTo evaluate the influence of three proton pump inhibitors (PPIs) on plasma voriconazole (VOR) concentrations and characterize potential drug-drug interactions (DDIs) between VOR and three PPIs (omeprazole, lansoprazole, and pantoprazole) in Chinese patients with malignant hematological diseases.MethodsA simple and reliable 2D-HPLC with internal quality control method was used to ensure accurate concentration measurements. A total of 194 patients in this retrospective study were divided into control (N = 59), omeprazole (OME,N = 57), lansoprazole (LAN,N = 26), and pan...
Source: European Journal of Clinical Pharmacology - March 10, 2020 Category: Drugs & Pharmacology Source Type: research

Cancers, Vol. 12, Pages 640: Proton Pump Inhibitors Reduce Pancreatic Adenocarcinoma Progression by Selectively Targeting H+, K+-ATPases in Pancreatic Cancer and Stellate Cells
Arcangeli Ivana Novak Pancreatic duct cells are equipped with acid/base transporters important for exocrine secretion. Pancreatic ductal adenocarcinoma (PDAC) cells may utilize such transporters to acidify extracellular tumor microenvironment, creating a niche favoring cell proliferation, fibrosis and resistance to chemotherapy—all contributing to the notoriously bad prognosis of this disease. Here, we report that gastric and non-gastric H+, K+-ATPases (coded by ATP4A and ATP12A) are overexpressed in human and murine pancreatic cancer and that we can target them specifically with proton pump inhibitors...
Source: Cancers - March 10, 2020 Category: Cancer & Oncology Authors: Marco Tozzi Christiane E. S ørensen Lara Magni Nynne M. Christensen Rayhana Bouazzi Caroline M. Buch Matteo Stefanini Claudia Duranti Annarosa Arcangeli Ivana Novak Tags: Article Source Type: research

Clinical Impact of Co-Medication of Levetiracetam and Clobazam with Proton Pump Inhibitors: A Drug Interaction Study.
CONCLUSION: The effect of comedication with PPIs on the plasma concentration of clobazam is more pronounced for pantoprazole in greater extent when compared to esomeprazole and rabeprazole. When pantoprazole is used in combination with clobazam, dose reduction of clobazam should be considered or significance of PPIs is seen to avoid adverse effects. PMID: 32067615 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - February 18, 2020 Category: Drugs & Pharmacology Authors: Pasupuleti B, Gone V, Baddam R, Venisetty RK, Prasad OP Tags: Curr Drug Metab Source Type: research

Therapeutic drugs modulate ATP-Binding cassette transporter-mediated transport of amyloid beta(1-42) in brain microvascular endothelial cells.
Abstract Deposition of amyloid-β peptide (Aβ(1-42)) is a hallmark of Alzheimer's disease. Clearance of Aβ(1-42), across the blood-brain barrier (BBB), is mediated by ATP-binding Cassette (ABC) efflux transporters. Many therapeutic drugs inhibit ABC transporters, but little is known of the effect of therapeutic drugs on Aβ(1-42) transport across BBB endothelial cells. The effects of selected, widely prescribed, therapeutic drugs on ABCB1, ABCC5 and ABCG2 activities were determined by measuring intracellular levels of calcein, GS-MF, and Hoechst 33342 respectively in primary porcine brain endothe...
Source: European Journal of Pharmacology - February 13, 2020 Category: Drugs & Pharmacology Authors: Shubbar MH, Penny JI Tags: Eur J Pharmacol Source Type: research

Signal amplification for simultaneous determination of two proton pump inhibitors in biological matrix based on newly synthesized metal organic framework and polymeric film
Publication date: Available online 1 February 2020Source: Journal of Electroanalytical ChemistryAuthor(s): Nastran Arab, Lida Fotouhi, Parisa Seyed Dorraji, Ghasem SargaziAbstractIn this work, by incorporation of newly synthesized metal–organic framework (MOF) into the carbon paste matrix, and electropolymerization of melamine at the resulted electrode, a new sensor was designed for enhanced sensing of omeprazole (OMZ) and pantoprazole (PNZ). Characterization of MOF was accomplished by X-ray diffraction, scanning electron microscopy, Brunauer-Emmett-Teller (BET) surface area analysis, and FT-IR. The influence of affe...
Source: Journal of Electroanalytical Chemistry - February 2, 2020 Category: Chemistry Source Type: research

Protective Effect of Asacol in Combination with Pantoprazole in Ulcerative Colitis Patients Who Defecate Asacol Tablets Intactly: A Clinical Trial Study
(Source: Clinical and Experimental Gastroenterology)
Source: Clinical and Experimental Gastroenterology - January 23, 2020 Category: Gastroenterology Tags: Clinical and Experimental Gastroenterology Source Type: research

Facile fabrication of g-C3N4 supported Fe3O4 nanoparticles/ZnO nanorods: A superlative visible light responsive architecture for express degradation of pantoprazole
Publication date: 1 May 2020Source: Chemical Engineering Journal, Volume 387Author(s): Sauvik Raha, M. AhmaruzzamanAbstractFe3O4/ZnO nanorods were first fabricated through a facile chemical route and then anchored on g-C3N4 sheets. X-ray diffraction (XRD), transmission electron microscopy (TEM), high resolution transmission electron microscopy (HRTEM), selected area electron diffraction (SAED), field emission scanning electron microscopy (FESEM), energy dispersive X-ray (EDX) spectroscopy, elemental mapping, X-ray photoelectron spectroscopy (XPS), UV–visible (UV–vis) spectrophotometry and photoluminescence (PL)...
Source: Chemical Engineering Journal - January 23, 2020 Category: Chemistry Source Type: research

Influence of proton pump inhibitor therapy on occurrence of voice prosthesis complications
ConclusionAlthough reflux was proposed to be associated with VP complications and pepsin was proven as a most sensitive and specific marker of EER, we did not find any statistically significant correlation between pepsin levels and occurrence of VP complications. A 3  months 40 mg pantoprazole therapy was ineffective in reduction of VP complications in our study group. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - January 17, 2020 Category: ENT & OMF Source Type: research

Heterogeneity of treatment effect of prophylactic pantoprazole in adult ICU patients: a post hoc analysis of the SUP-ICU trial
ConclusionsIn this post hoc analysis of the SUP-ICU trial, we found indications of HTE with increased risks of serious adverse events in patients with greater illness severity or more risk factors for CIB allocated to pantoprazole. These findings are hypothesis-generating and warrant further prospective investigation.ClinicalTrials.gov identifierNCT02467621 (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - January 14, 2020 Category: Intensive Care Source Type: research

Interaction of epidermal growth factor with COX-2 products and peroxisome proliferator-activated receptor gamma system in experimental rat Barrett's esophagus.
Abstract Mixed acidic-alkaline refluxate is a major pathogenic factor in chronic esophagitis progressing into Barrett's esophagus (BE) but the involvement of epidermal growth factor (EGF), COX-2 and peroxisome proliferator-activated receptor gamma (PPARg) in BE has not been extensively studied. Rats surgically prepared with esophagogastroduodenal anastomosis (EGDA) with intact or removed salivary glands to deplete salivary EGF were treated either with: 1) vehicle, 2) EGF or pioglitazone with or without tyrphostin A46 or GW9662, respectively, 3) ranitidine or pantoprazole. At three months, the esophageal damage (LI...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - January 13, 2020 Category: Physiology Authors: Majka J, Wierdak M, Szlachcic A, Magierowski M, Targosz A, Urbanczyk K, Krzysiek-Maczka G, Ptak-Belowska A, Bakalarz D, Magierowska K, Chmura A, Brzozowski T Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Proton Pump Inhibitor-Treated H. pylori Adjust Cell Envelope Fatty Acid and Cholesterol Content to Survive.
CONCLUSION: Incorporation of lipophilic PPI into H. pylori cell membrane disrupted lipids and inhibited growth. However, H. pylori adjusted the defected membrane by replacing the lipid components and resisted lysis. PMID: 31910629 [PubMed - in process] (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - January 1, 2020 Category: Middle East Health Authors: Kadkhodaei S, Siavoshi F, Foroumadi A, Sarrafnejad A, Kolahdoozan S Tags: Arch Iran Med Source Type: research

Effect on Bleeding Prevention of an Intravenous Proton Pump Inhibitor During the Fasting Period After Endoscopic Submucosal Dissection: a Prospective, Randomized, Double-Blind, Placebo-Controlled Trial
ConclusionsAdministration of routine IV PPI during the fasting period 48 h after ESD does not reduce delayed post-ESD bleeding. (Source: Journal of Gastrointestinal Surgery)
Source: Journal of Gastrointestinal Surgery - December 16, 2019 Category: Surgery Source Type: research

Nonspecific oral mucositis in a patient with Crohn's disease
ConclusionsThis case demonstrates the simultaneous presentation of multiple conditions. Oral biopsy revealed a solitary focus of granulomatous inflammation, indicative of orofacial granulomatosis. However, the biopsied lesion was also unusual in that inflammation extended into the epithelium, a relatively unusual feature for a granulomatous inflammatory disease and a pattern more commonly seen in vesiculobullous eruptions. Because this patient's CD was well controlled, it is difficult to believe that these oral lesions were associated with CD activity. One reasonable assumption is that the long-time treatment of the patien...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Omeprazole Increases the Efficacy of Acyclovir Against Herpes Simplex Virus Type 1 and 2
In conclusion, proton pump inhibitors increase the anti-HSV activity of acyclovir and are candidates for antiviral therapies in combination with acyclovir, in particular for topical preparations for the treatment of immunocompromised individuals who are more likely to suffer from severe complications. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - December 3, 2019 Category: Microbiology Source Type: research

Reversed-phase HPLC enantioseparation of pantoprazole using a teicoplanin aglycone stationary phase-Determination of the enantiomer elution order using HPLC-CD analyses.
l B, Szabó ZI, Tóth G Abstract A direct HPLC method was developed for the enantioseparation of pantoprazole using macrocyclic glycopeptide-based chiral stationary phases, along with various methods to determine the elution order without isolation of the individual enantiomers. In the preliminary screening, four macrocyclic glycopeptide-based chiral stationary phases containing vancomycin (Chirobiotic V), ristocetin A (Chirobiotic R), teicoplanin (Chirobiotic T), and teicoplanin-aglycone (Chirobiotic TAG) were screened in polar organic and reversed-phase mode. Best results were achieved by using Chiro...
Source: Chirality - December 3, 2019 Category: Molecular Biology Authors: Papp LA, Foroughbakhshfasaei M, Fiser B, Horváth P, Kiss E, Sekkoum K, Gyéresi Á, Hancu G, Noszál B, Szabó ZI, Tóth G Tags: Chirality Source Type: research

Pantoprazole
(Source: Reactions Weekly)
Source: Reactions Weekly - December 1, 2019 Category: Drugs & Pharmacology Source Type: research

Optimization of the coating process of minitablets in two different lab-scale fluid bed systems.
Authors: Szczepanska M, Paduszynski P, Kotlowska H, Sznitowska M Abstract The optimization of the coating process for minitablets is extremely important in fluidized bed systems, and allows knowledge acquisition about the process for modern multiparticulate forms. The coating of minitablets allows the development of modified-release pediatric drugs. In our study, 3-mm minitablets with pantoprazole were coated to obtain an enteric product. The experiments were designed to evaluate the quality of the enteric product by efficiency and quality of film coating. Four process parameters at two levels were examined, and 16...
Source: Drug Development and Industrial Pharmacy - November 29, 2019 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Alanyl-glutamine Heals Indomethacin-induced Gastric Ulceration in Rats Via Antisecretory and Anti-apoptotic Mechanisms
Conclusions: AG confers its antiulcerogenic/antisecretory potentials by repressing the proton pump to increase the gastric juice pH via boosting p-CREB, p-Akt, p-GSK-3β, and GLP-1. Also, it inhibits apoptosis through suppressing nuclear factor-kappa B/tumor necrosis factor-α/H2O2/claudin-1 cue. This trajectory contributes to loosen the tight junction priming AG-mediated GLP-1/β-catenin/cyclin-D1 that results in pronounced increase in gastric mucosa proliferation. Therefore, the crosstalk between multiple pathways orchestrates the action of AG against gastric ulceration. (Source: Journal of Pediatric Gastr...
Source: Journal of Pediatric Gastroenterology and Nutrition - November 21, 2019 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

Pantoprazole in Prevention of Gastroduodenal Events in Patients Receiving Rivaroxaban and/or Aspirin: A Short Word of Caution
(Source: Gastroenterology)
Source: Gastroenterology - November 5, 2019 Category: Gastroenterology Authors: Michiel Bronswijk Source Type: research

Pantoprazole in COMPASS: no prevention of gastroduodenal events, nor other useful net results
(Source: Gastroenterology)
Source: Gastroenterology - November 5, 2019 Category: Gastroenterology Authors: Alberto Donzelli, Giulia Giudicatti Source Type: research

Pantoprazole in COMPASS — No Prevention of Gastroduodenal Events or Other Useful Net Results
The authors ’ conclusions are that “routine use of proton pump inhibitors [PPIs] in patients receiving low-dose anticoagulation and/or aspirin for stable cardiovascular disease does not reduce upper gastrointestinal events, but may reduce bleeding from gastroduodenal lesions.”1 We deem the latter statemen t questionable and a forcing of the data.Indeed, the primary outcome was an “upper GI event,” which includes a composite of overt bleeding (hematemesis and/or melena) with a gastroduodenal lesion (peptic ulcer or neoplasia confirmed by endoscopy or radiology) that is bleeding at the time of t...
Source: Gastroenterology - November 5, 2019 Category: Gastroenterology Authors: Alberto Donzelli, Giulia Giudicatti Tags: Correspondence Source Type: research

Reply
. We are grateful for Dr Donzelli et  al and Dr Bronswijk for their interest in our randomized controlled trial evaluating the efficacy1 as well as the safety2 of pantoprazole in reducing gastroduodenal events in patients taking rivaroxaban or aspirin. Dr Bronswijk states that the dose of rivaroxaban is low and perhaps we would have s een more upper gastrointestinal (GI) events if we had evaluated a higher dose. However, the present regimen of low dose rivaroxaban (2.5 mg twice daily) plus low-dose aspirin was effective in reducing cardiovascular events and deaths in the population studied and this has led to approval...
Source: Gastroenterology - November 5, 2019 Category: Gastroenterology Authors: Paul Moayyedi, John W. Eikelboom, Salim Yusuf Tags: Correspondence Source Type: research

Pantoprazole did not reduce risk for a composite of upper gastrointestinal events in stable arterial disease.
PMID: 31610558 [PubMed - in process] (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - October 15, 2019 Category: Internal Medicine Authors: Dayanand P, Borzak S Tags: Ann Intern Med Source Type: research

The Effects of Co-prescription of Pantoprazole on the Clozapine Metabolism
Pharmacopsychiatry DOI: 10.1055/a-1021-8827 Background Polypharmacy including somatic medications such as proton pump inhibitors is a common phenomenon in psychiatric care. The aim of this study was to evaluate the pantoprazole effects on clozapine metabolism. Methods A large therapeutic drug-monitoring database containing plasma concentrations of CLZ was analyzed. The results were stratified into four groups: a non-smoking (n=250) and a smoking group (n=326), and two groups co-medicated with pantoprazole: non-smokers (n=26) and smokers (n=29). The analysis was based on the non-parametrical Mann-Whitney U test (M-W-U) with...
Source: Pharmacopsychiatry - October 15, 2019 Category: Psychiatry Authors: Kuzin, Maxim Schoretsanitis, Georgios Haen, Ekkehard Dammann, Gerhard Hiemke, Christoph Gr ünder, Gerhard Paulzen, Michael Tags: Original Paper Source Type: research

Non-operative management of perforated peptic ulcer: A single-center experience.
CONCLUSION: Standard treatment of peptic ulcer perforation in most of the patients is still surgical repair. Non-surgical treatment should be kept in mind as an option in the selected patients who had normal vital parameters and did not have any findings of generalized peritonitis in the abdominal examination. In this way, it may be possible to avoid unnecessary surgery and reduce the possible morbidity and mortality associated with the operation. PMID: 31701498 [PubMed - in process] (Source: Turkish Journal of Trauma and Emergency Surgery : TJTES)
Source: Turkish Journal of Trauma and Emergency Surgery : TJTES - October 1, 2019 Category: Emergency Medicine Authors: Karabulut K, Dinçer M, Liman RK, Usta S Tags: Ulus Travma Acil Cerrahi Derg Source Type: research

Pantoprazole pretreatment elevates sensitivity to vincristine in drug-resistant oral epidermoid carcinoma in vitro and in vivo
In conclusion, our study demonstrated that PPZ could be included in new combined therapy of human oral cancer (especially on VCR-resistant therapy) together with VCR. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - September 28, 2019 Category: Drugs & Pharmacology Source Type: research

Comparison of concomitant therapy versus standard triple-drug therapy for eradication of Helicobacter pylori infection: A prospective open-label randomized controlled trial
ConclusionAlthough the rate of  eradication ofH. pylori infection with   concomitant therapy was higher than that with triple therapy, the rate of concomitant therapy was still less than expected. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - September 14, 2019 Category: Gastroenterology Source Type: research

Protective effect of pantoprazole against sepsis-induced acute lung and kidney injury in rats.
Authors: Yan XX, Zheng AD, Zhang ZE, Pan GC, Zhou W Abstract To investigate the effect of pantoprazole on acute lung and kidney injury with sepsis and its possible mechanism. Rats were randomly divided into six groups, the status and lung wet/dry weight ratio were determined at various time points. Hematoxylin Eosin staining (HE) for pathological changes in the lungs and kidneys of rats with sepsis. Western blot (WB) and immunohistochemistry were used to detect the pulmonary surfactant protein A(SPA) and D(SPD). The levels of markers for kidney damage in serum and urine various time points were measured by ELISA. T...
Source: American Journal of Translational Research - September 11, 2019 Category: Research Tags: Am J Transl Res Source Type: research

Optimal duration of concomitant nonbismuth quadruple therapy as first-line therapy for Helicobacter pylori: a prospective, open-label, comparative study
Conclusions Ten day concomitant nonbismuth quadruple therapy for H. pylori is highly efficacious and better tolerated than the 14-day regimen. Thus, 10-day therapy may be preferred as first-line treatment in clinical practice. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - September 11, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Pantoprazole Affecting Docetaxel Resistance Pathways via Autophagy (PANDORA): Phase II Trial of High Dose Pantoprazole (Autophagy Inhibitor) with Docetaxel in Metastatic Castration‐Resistant Prostate Cancer (mCRPC)
Conclusion.The combination of docetaxel and pantoprazole was tolerable, but the resultant clinical activity was not sufficient to meet the ambitious predefined target to warrant further testing.Implications for Practice.To date, no docetaxel combination regimen has reported superior efficacy over docetaxel alone in men with metastatic castration‐resistant prostate cancer (mCRPC). The PANDORA trial has demonstrated that the combination of high dose pantoprazole with docetaxel is tolerable, but the clinical activity was not sufficient to warrant further testing. The chemotherapy standard of care for men with mCRPC remains ...
Source: The Oncologist - September 11, 2019 Category: Cancer & Oncology Authors: Aaron R. Hansen, Ian F. Tannock, Arnoud Templeton, Eric Chen, Andrew Evans, Jennifer Knox, Amy Prawira, Srikala S. Sridhar, Susie Tan, Francisco Vera-Badillo, Lisa Wang, Bradly G. Wouters, Anthony M. Joshua Tags: Genitourinary Cancer Source Type: research

Outcomes of Prophylactic Pantoprazole in Adult Intensive Care Unit Patients Receiving Dialysis: Results of a Randomized Trial.
CONCLUSIONS: In adult ICU patients receiving RRT at baseline, we observed high incidences of clinically important GI bleeding, but did not observe effects of pantoprazole versus placebo in this subgroup. PMID: 31480045 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 3, 2019 Category: Urology & Nephrology Authors: Schefold JC, Krag M, Marker S, Perner A, Wetterslev J, Wise MP, Borthwick M, Bendel S, Keus F, Guttormsen AB, Lange T, Møller MH, the SUP-ICU investigators Tags: Am J Nephrol Source Type: research

Comparison of the gastric acid inhibition function among lansoprazole, pantoprazole, and their respective stereoisomers in healthy Chinese subjects 
.
CONCLUSION: After a single dose, the mean gastric pH inhibition value of R-LPZ was the highest, followed by LPZ, then S-PPZ and PPZ. R-LPZ and LPZ provided significantly better pH control compared with PPZ and S-PPZ in healthy subjects. The onset time of R-LPZ was the fastest and R-LPZ can provide better acid inhibition during sleeping time. After multiple doses, the mean values in all PD parameters of R-LPZ were the highest, the values of LPZ, S-PPZ, and PPZ were similar. However, no significant difference was found in acid inhibition among these four drugs after multiple doses.
. PMID: 31397275 [PubMed - as supplie...
Source: International Journal of Clinical Pharmacology and Therapeutics - August 10, 2019 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Brain tumor acidification using drugs simultaneously targeting multiple pH regulatory mechanisms
ConclusionsThe combined drug treatment with glucose produced a large acute CEST MRI contrast indicating tumor acidification, which could be used to help localize brain cancer and monitor tumor response to chemotherapy. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 7, 2019 Category: Cancer & Oncology Source Type: research

MOG antibody-related isolated rhombencephalitis revealed by paroxysmal dysarthria
A 59-year-old female was admitted to the neurology ward with a two-month history of recurrent episodes characterized by an ascending feeling of constriction starting in the lower limbs, followed by speech impairment, dizziness and a lack of strength in both hands. The symptoms lasted 10  s and recurred 30–40 times a day. She did not report a prodromal infectious episode. She suffered from mitral regurgitation and from peptic ulcer and was treated by bisoprolol and pantoprazole. Her clinical neurological examination was unremarkable. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - August 5, 2019 Category: Neurology Authors: Paul Kollmann, Vincent van Pesch Tags: Letter to the Editor Source Type: research

The status of proton pump inhibitor use: a prescription survey of 45 hospitals in China.
CONCLUSION: this survey demonstrated that PPI use was accompanied by unapproved indications and excessive dosages. Comprehensive measures are urgently needed to improve PPI use and reduce unnecessary drug costs. PMID: 31373505 [PubMed - as supplied by publisher] (Source: Revista Espanola de Enfermedades Digestivas)
Source: Revista Espanola de Enfermedades Digestivas - August 3, 2019 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

A potential risk factor for paraoxonase 1: in silico and in ‐vitro analysis of the biological activity of proton‐pump inhibitors
ConclusionsWe observed that the drugs decreased PON1 activity at low concentrations. The results show that adjusting the dosages of these medications is a crucial case for each patient. The physicians should more carefully interpret whether there is an essential indication before prescribing PPIs and, if there is, to approve the proper dosing for the situation. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 29, 2019 Category: Drugs & Pharmacology Authors: C üneyt Türkeş Tags: Research Paper Source Type: research

Acute esophageal necrosis in association with acute cholecystitis.
We report a unique case of acute esophageal necrosis in association with perforated acute cholecystitis and secondary Klebsiella pneumoniae bacteremia. An 83-year-old male with history of diabetes mellitus, dyslipidemia, ischemic cardiomyopathy and recent right hemicolectomy for colon adenocarcinoma presented to emergency department with acute epigastric pain and hematemesis. The patient appeared cachectic and dehydrated. He was afebrile and hemodynamically stable. Laboratory studies revealed anemia, leukocytosis, hyponatremia and hyperlactatemia. Esophagogastroduodenoscopy displayed characteristic features of acute esopha...
Source: Revista Espanola de Enfermedades Digestivas - July 24, 2019 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

Clopidogrel safety communication impact on histamine ‐2 receptor antagonist and proton‐pump inhibitor use trends
ConclusionsOverall H2RA and PPI use did not change among adults taking clopidogrel from 2007 through 2014. Prescribers must consider acid reducing agents that will not interact with clopidogrel. Future studies should evaluate the use of PPIs and H2RAs with dual antiplatelet therapy and in patients with a high risk of gastrointestinal bleeding. (Source: Journal of Pharmaceutical Health Services Research)
Source: Journal of Pharmaceutical Health Services Research - July 19, 2019 Category: Drugs & Pharmacology Authors: Amie Armbrister, Annette Vidal, Shanique James, Claudia Nunez Chiang, Jennifer G. Steinberg, Alexandra Perez Tags: Research Paper Source Type: research

The Anti-virulence Efficacy of 4-(1,3-Dimethyl-2,3-Dihydro-1H-Benzimidazol-2-yl)Phenol Against Methicillin-Resistant Staphylococcus aureus
Antimicrobial drug discovery against drug-resistant bacteria is an urgent need. Beyond agents with direct antibacterial activity, anti-virulent molecules may also be viable compounds to defend against bacterial pathogenesis. Using a high throughput screen (HTS) that utilized, Caenorhabditis elegans infected with methicillin-resistant Staphylococcus aureus (MRSA) strain of MW2, we identified 4-(1,3-dimethyl-2,3-dihydro-1H-benzimidazol-2-yl)phenol (BIP). Interestingly, BIP had no in vitro inhibition activity against MW2, at least up to 64 µg/mL. The lack of direct antimicrobial activity suggests that BIP could inhibit ...
Source: Frontiers in Microbiology - July 17, 2019 Category: Microbiology Source Type: research

SPME fiber coated by arrayed ZNRs for sampling and concentration of polar residual solvents for further analysis using GC FID
Publication date: Available online 28 June 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Thiago Ilipronti, Sílvia Denofre de Campos, Cristiano Cabral Muller, Élvio Antônio de CamposAbstractIn this work, fused silica coated by arrayed ZNRs were successfully applied as a sorbent for analysis of polar residual solvents in pantoprazole feedstocks. ZnO nanoparticles were produced and deposited on a fused silica surface applying the dip coating technique and hydrothermal growth to synthesize the arrayed nanorods. The ZNRs array fiber coating was characterized by SEM, EDS, XRD, and TG...
Source: Journal of Pharmaceutical and Biomedical Analysis - June 29, 2019 Category: Drugs & Pharmacology Source Type: research

The Effect of Proton Pump Inhibitors on Bone Formation in a Rat Spinal Arthrodesis Model
Conclusion. This study demonstrates that administration of PPIs does not inhibit fusion rates, bone formation, or affect biomechanical integrity of fusion. However, lower fusion scores in the PPI group suggest that a negative impact may still exist. Future studies will explore growth factor and protein expression in the fusion masses as well as utilize higher doses of PPI to fully discern their effect on spine fusion. Level of Evidence: N/A (Source: Spine)
Source: Spine - June 28, 2019 Category: Orthopaedics Tags: BASIC SCIENCE Source Type: research

Covering the Cover
A randomized control trial showed that pantoprazole did not reduce upper gastrointestinal events among patients taking aspirin or rivaroxaban (Source: Gastroenterology)
Source: Gastroenterology - June 25, 2019 Category: Gastroenterology Authors: Andrew T. Chan, Christopher S. Williams Tags: Covering the Cover Source Type: research

Hairy leukoplakia in a patient undergoing anti-retroviral therapy
We report a case of hairy leukoplakia that developed in a patient undergoing anti-retroviral therapy. A 53-year old white male presented with mild erythema in the anterior maxillary gingiva and was managed with clobetasol gel, after excluding the possibility of candidiasis. Patient's medical history was significant for HIV, bipolar disorder, high blood pressure, high cholesterol, chronic bronchitis, smoking, and alcohol. His medications included Androgel, Axiron, atorvastatin, bupropion, clonazepam, finasteride, hydrochlorothiazide, lamotrigine, lisinopril, pantoprazole, Prezcobix, Trazadone, Truvada (200 mg emticitabine, ...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - June 13, 2019 Category: ENT & OMF Source Type: research

Hairy leukoplakia in a patient undergoing anti-retroviral therapy
We report a case of hairy leukoplakia that developed in a patient undergoing anti-retroviral therapy. A 53-year old white male presented with mild erythema in the anterior maxillary gingiva and was managed with clobetasol gel, after excluding the possibility of candidiasis. Patient's medical history was significant for HIV, bipolar disorder, high blood pressure, high cholesterol, chronic bronchitis, smoking, and alcohol. His medications included Androgel, Axiron, atorvastatin, bupropion, clonazepam, finasteride, hydrochlorothiazide, lamotrigine, lisinopril, pantoprazole, Prezcobix, Trazadone, Truvada (200 mg emticitabine, ...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - June 13, 2019 Category: ENT & OMF Authors: Dr. Kelcie Barnts, Dr. Celeste Abraham, Dr. Yi-Shing Lisa Cheng Tags: #124 Source Type: research

A Rare Cause of Postprandial Pain
​BY DHIMITRI A. NIKOLLA, DO; BRENDAN A. MICCIO; MELODY L. MILLIRON; & BRETT FOREHAND, MD, PHDA 49-year-old woman with a past medical history of chronic obstructive pulmonary disease presented to the emergency department with epigastric pain. She said the pain radiated to her chest and had been intermittent for six months, but it had been progressively worsening over the previous three weeks. Her pain was exacerbated by eating, and was associated with early satiety and nausea. She complained of a 30-pound weight loss over the preceding three months.Her vital signs included a blood pressure of 116/80 mm Hg, a heart rat...
Source: The Case Files - June 12, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Effects of proton pump inhibitor use on risk of Clostridium difficile infection: a hospital cohort study
ConclusionsOur study showed that PPI use was associated with an increased risk of developing CDI and the risk of CDI was dose dependent. Therefore, PPIs should only be used at proper doses and only for the necessary indications to avoid CDI risk. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - June 11, 2019 Category: Gastroenterology Source Type: research

Efonidipine-Induced Exanthematic Drug Eruption and Literature Review
We report the case of an elderly woman who developed exanthematic drug eruption after administration of efonidipine. An 84-year-old woman presented to emergency department with complaints of generalized itching and erythema since 4 days. She was on human-soluble insulin since 11 years. In view of her hypertension and left anterior descending artery stenosis, she was initiated on aspirin, clopidogrel, atorvastatin, pantoprazole, nebivolol, aldactone, and efonidipine a week ago. Her presenting complaints were initially managed with parenteral pheniramine maleate and hydrocortisone. She was admitted, and all her medications e...
Source: Journal of Cardiovascular Pharmacology - June 1, 2019 Category: Cardiology Tags: Original Article Source Type: research