Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: J Physiol Pharmacol - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: Journal of Physiology and Pharmacology - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: J Physiol Pharmacol - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: Journal of Physiology and Pharmacology - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: J Physiol Pharmacol - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: Journal of Physiology and Pharmacology - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: J Physiol Pharmacol - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: Journal of Physiology and Pharmacology - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: J Physiol Pharmacol - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: Journal of Physiology and Pharmacology - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: J Physiol Pharmacol - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: Journal of Physiology and Pharmacology - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: J Physiol Pharmacol - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: Journal of Physiology and Pharmacology - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: J Physiol Pharmacol - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
