Preventive effects of crocin, a natural compound from saffron, against nicotine ‑induced oxidative stress and neurobehavioral disturbances
In this study, we explore the neuroprotective effects of crocin, a bioactive agent commonly found in saffron - a spice derived from the flower of Crocus sativus - using a rat model. The dose‑dependent effects of crocin were evaluated in nicotine‑induced neurodegeneration and compared with a control group. Neurobehavioral changes, assessed through the elevated plus maze, the open field test, the forced swim test, and the Morris water maze, as well as oxidative stress in the hippocampus, were evaluated. Interestingly, nicotine administration resulted in depression, anxiety, and abnormal motor and cognitive functions, whi...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Majid Motaghinejad Manijeh Motevalian Antoni Sureda Source Type: research
High-risk smoking in the United States: Nicotine staining predicts increased colonic adenomas and advanced adenomas on colonoscopy
CONCLUSION: This marks the first investigation of nicotine staining within gastroenterology. We have demonstrated that the presence of nicotine staining independently predicts numerous adenomas and advanced adenomas.PMID:38583603 | DOI:10.1016/j.ypmed.2024.107950 (Source: Cancer Control)
Source: Cancer Control - April 7, 2024 Category: Cancer & Oncology Authors: Christopher Bouvette Justin Kosirog Bryce Yohannan Alyssa Grossen Ijlal Akbar Ali Mohammad Madhoun Source Type: research
The role of ROS/JNK/caspase 3 axis in apoptosis induction by menthol-favored electronic cigarette liquid in human periodontal ligament stem cells
CONCLUSIONS: ROS/JNK/caspase 3 axis is involved in menthol-favored E-liquid-induced apoptosis of hPDLSCs.PMID:38583023 (Source: Shanghai Journal of Stomatology)
Source: Shanghai Journal of Stomatology - April 7, 2024 Category: Dentistry Authors: Yi-Fen Shen Chao Liu Ying Tang Tao Yang Yong-Chun Gu Source Type: research
The role of ROS/JNK/caspase 3 axis in apoptosis induction by menthol-favored electronic cigarette liquid in human periodontal ligament stem cells
CONCLUSIONS: ROS/JNK/caspase 3 axis is involved in menthol-favored E-liquid-induced apoptosis of hPDLSCs.PMID:38583023 (Source: Shanghai Journal of Stomatology)
Source: Shanghai Journal of Stomatology - April 7, 2024 Category: Dentistry Authors: Yi-Fen Shen Chao Liu Ying Tang Tao Yang Yong-Chun Gu Source Type: research
The role of ROS/JNK/caspase 3 axis in apoptosis induction by menthol-favored electronic cigarette liquid in human periodontal ligament stem cells
CONCLUSIONS: ROS/JNK/caspase 3 axis is involved in menthol-favored E-liquid-induced apoptosis of hPDLSCs.PMID:38583023 (Source: Shanghai Journal of Stomatology)
Source: Shanghai Journal of Stomatology - April 7, 2024 Category: Dentistry Authors: Yi-Fen Shen Chao Liu Ying Tang Tao Yang Yong-Chun Gu Source Type: research
An exploratory, randomised, crossover study to investigate the effect of nicotine on cognitive function in healthy adult smokers who use an electronic cigarette after a period of smoking abstinence
As well as being associated with serious negative health outcomes, smoking has been reported to have an array of physiological and psychological effects, including effects on mood and cognitive function. Post-... (Source: Harm Reduction Journal)
Source: Harm Reduction Journal - April 6, 2024 Category: Drugs & Pharmacology Authors: Harry J. Green, Olivia K. O ’Shea, Jack Cotter, Helen L. Philpott and Nik Newland Tags: Research Source Type: research
Reconstructing axial progenitor field dynamics in mouse stem cell-derived embryoids
Dev Cell. 2024 Apr 3:S1534-5807(24)00192-8. doi: 10.1016/j.devcel.2024.03.024. Online ahead of print.ABSTRACTEmbryogenesis requires substantial coordination to translate genetic programs to the collective behavior of differentiating cells, but understanding how cellular decisions control tissue morphology remains conceptually and technically challenging. Here, we combine continuous Cas9-based molecular recording with a mouse embryonic stem cell-based model of the embryonic trunk to build single-cell phylogenies that describe the behavior of transient, multipotent neuro-mesodermal progenitors (NMPs) as they commit into neur...
Source: Developmental Cell - April 5, 2024 Category: Cytology Authors: Adriano Bolondi Benjamin K Law Helene Kretzmer Seher Ipek Gassaloglu Ren é Buschow Christina Riemenschneider Dian Yang Maria Walther Jesse V Veenvliet Alexander Meissner Zachary D Smith Michelle M Chan Source Type: research
Protective effect of enicostemma axillare - swertiamarin on oxidative stress against nicotine-induced liver damage in sd rats
CONCLUSION: The results of the current study show that nicotine can seriously harm liver tissue and that Swertiamarin can prevent the harmful effects of nicotine on rat liver. Future research is necessary to delve deeply into the mechanisms behind Swertiamarin protective impact against nicotine-induced hepatotoxicity.PMID:38579927 | DOI:10.1016/j.pharma.2024.03.009 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - April 5, 2024 Category: Drugs & Pharmacology Authors: Rajini Kolure V Nachammai Sneha Thakur Ramreddy Godela D Sherisha Bhavani S N Manjula Source Type: research
A discrete choice experiment on price and flavour effects on the appeal of nicotine products: a pilot study among young adults in Switzerland
CONCLUSIONS: Our Discrete Choice Experiment suggests that, for the Swiss context, limiting the availability of flavours for alternative smoking products has the potential to reduce their appeal to non-smokers by 86% and that a small but significant increase in prices to CHF 15 for cigarettes, ENDS and HTS could lead to a major (around 66%) decrease in their appeal.PMID:38579318 | DOI:10.57187/s.3733 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Larissa Merz Milo A Puhan Miquel Serra-Burriel Source Type: research
Adaptation and Validation of the Hooked on Nicotine Checklist (HONC) with Spanish Adolescents
CONCLUSION: This study makes the Spanish version of the HONC available to researchers and clinicians, so that it can be used with sufficient psychometric guarantees.PMID:38580487 | DOI:10.1016/j.arbres.2024.03.020 (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - April 5, 2024 Category: Respiratory Medicine Authors: Nuria Garc ía-Couceiro Sion Kim-Harris Patricia G ómez Manuel Isorna Antonio Rial Source Type: research
Reconstructing axial progenitor field dynamics in mouse stem cell-derived embryoids
Dev Cell. 2024 Apr 3:S1534-5807(24)00192-8. doi: 10.1016/j.devcel.2024.03.024. Online ahead of print.ABSTRACTEmbryogenesis requires substantial coordination to translate genetic programs to the collective behavior of differentiating cells, but understanding how cellular decisions control tissue morphology remains conceptually and technically challenging. Here, we combine continuous Cas9-based molecular recording with a mouse embryonic stem cell-based model of the embryonic trunk to build single-cell phylogenies that describe the behavior of transient, multipotent neuro-mesodermal progenitors (NMPs) as they commit into neur...
Source: Developmental Cell - April 5, 2024 Category: Cytology Authors: Adriano Bolondi Benjamin K Law Helene Kretzmer Seher Ipek Gassaloglu Ren é Buschow Christina Riemenschneider Dian Yang Maria Walther Jesse V Veenvliet Alexander Meissner Zachary D Smith Michelle M Chan Source Type: research
Protective effect of enicostemma axillare - swertiamarin on oxidative stress against nicotine-induced liver damage in sd rats
CONCLUSION: The results of the current study show that nicotine can seriously harm liver tissue and that Swertiamarin can prevent the harmful effects of nicotine on rat liver. Future research is necessary to delve deeply into the mechanisms behind Swertiamarin protective impact against nicotine-induced hepatotoxicity.PMID:38579927 | DOI:10.1016/j.pharma.2024.03.009 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - April 5, 2024 Category: Drugs & Pharmacology Authors: Rajini Kolure V Nachammai Sneha Thakur Ramreddy Godela D Sherisha Bhavani S N Manjula Source Type: research
A discrete choice experiment on price and flavour effects on the appeal of nicotine products: a pilot study among young adults in Switzerland
CONCLUSIONS: Our Discrete Choice Experiment suggests that, for the Swiss context, limiting the availability of flavours for alternative smoking products has the potential to reduce their appeal to non-smokers by 86% and that a small but significant increase in prices to CHF 15 for cigarettes, ENDS and HTS could lead to a major (around 66%) decrease in their appeal.PMID:38579318 | DOI:10.57187/s.3733 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Larissa Merz Milo A Puhan Miquel Serra-Burriel Source Type: research
Adaptation and Validation of the Hooked on Nicotine Checklist (HONC) with Spanish Adolescents
CONCLUSION: This study makes the Spanish version of the HONC available to researchers and clinicians, so that it can be used with sufficient psychometric guarantees.PMID:38580487 | DOI:10.1016/j.arbres.2024.03.020 (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - April 5, 2024 Category: Respiratory Medicine Authors: Nuria Garc ía-Couceiro Sion Kim-Harris Patricia G ómez Manuel Isorna Antonio Rial Source Type: research
Protective effect of enicostemma axillare - swertiamarin on oxidative stress against nicotine-induced liver damage in sd rats
CONCLUSION: The results of the current study show that nicotine can seriously harm liver tissue and that Swertiamarin can prevent the harmful effects of nicotine on rat liver. Future research is necessary to delve deeply into the mechanisms behind Swertiamarin protective impact against nicotine-induced hepatotoxicity.PMID:38579927 | DOI:10.1016/j.pharma.2024.03.009 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - April 5, 2024 Category: Drugs & Pharmacology Authors: Rajini Kolure V Nachammai Sneha Thakur Ramreddy Godela D Sherisha Bhavani S N Manjula Source Type: research
