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The impact of diabetic glucose concentration on viability and cardiac differentiation of mesenchymal stem cells
CONCLUSION: Diabetic glucose concentration inhibits normal proliferation and cardiac differentiation of MSCs. This effect should be considered in stem cell therapy of cardiovascular patients who are concurrently affected by hyperglycemia, a common comorbidity in such individuals. Why carry out this study? What was learned from the study?PMID:38502970 | DOI:10.1016/j.tice.2024.102361 (Source: Tissue and Cell)
Source: Tissue and Cell - March 19, 2024 Category: Cytology Authors: Shadi Nosrati Maryam Gheisari Shahrokh Zare Mahintaj Dara Samaneh Zolghadri Iman Razeghian-Jahromi Source Type: research

Medical societies in Germany call for a ban on flavors in e-cigarettes - A Position Paper of the German Respiratory Society (DGP) in cooperation with other professional associations and organizations
Pneumologie. 2024 Mar 19. doi: 10.1055/a-2282-9908. Online ahead of print.ABSTRACTE-cigarettes are primarily used by teenagers and young adults. Flavors in e-cigarettes increase their attractiveness and encourage young people and adults to start using them. This exposes young people in particular to the risk of nicotine addiction and various toxic substances from the aerosol of e-cigarettes. There are indications that various flavors in e-cigarettes are harmful to health, although toxicological studies are still lacking for the majority of flavors. There is a need for independent scientific investigations in this area. The...
Source: Pneumologie - March 19, 2024 Category: Respiratory Medicine Authors: Alexander Rupp Natascha Sommer Stefan Andreas Wulf Pankow Reiner Hanewinkel Harm Wienbergen Anil Batra Tilman Sauerbruch Peter Kardos Sabina Ulbricht Folke Brinkmann Robert Scheubel Claus Vogelmeier Wolfram Windisch in Zusammenarbeit mit medizinischen Fac Source Type: research

Factors Associated With Successful E-Cigarette Cessation Among a Convenience Sample of Adult Users
Conclusions: These results suggests that cigarette use, other tobacco use, and quit method used may significantly influence the likelihood of e-cigarette cessation. Future research is needed to determine the effectiveness of interventions for e-cigarette cessation using nicotine replacement therapy.PMID:38503709 | DOI:10.1080/10826084.2024.2320395 (Source: Substance Use and Misuse)
Source: Substance Use and Misuse - March 19, 2024 Category: Addiction Authors: Geronimo Bejarano Meagan A Bluestein Alayna P Tackett Jaimie C Duano Shelby Grace Rawls Jasjit S Ahluwalia Elizabeth A Vandewater Emily T H ébert Source Type: research

Dynamic changes in fungal communities and functions in different air-curing stages of cigar tobacco leaves
ConclusionThis study provides a deeper understanding of the dynamic changes in fungal communities during the AC process in cigar tobacco leaves and offers theoretical guidance for the application of microorganisms during the AC process. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - March 19, 2024 Category: Microbiology Source Type: research

Epistle
The alarming rise in vaping and the use of e-cigarettes by children and young persons (CYP) is a topical issue.1 Although vaping nicotine and its toxic by-products have been established to have many harmful effects, e-cigarette use has been misleadingly advertised as a viable strategy in aiding smoking cessation. There is, however, limited evidence to support this suggestion. This perception that vaping products are safe and harmless compared with combustible tobacco, together with attractive advertising and media influences, have contributed to the growing popularity of e-cigarettes among the young. Over the years, approp...
Source: Archives of Disease in Childhood - Education and Practice - March 19, 2024 Category: Pediatrics Authors: Gupta, N. Tags: Highlights from this issue Source Type: research

How do people who smoke perceive a tobacco retail outlet reduction policy in Aotearoa New Zealand? A qualitative analysis
Conclusions Many participants hoped to become smoke-free and thought retail reduction measures would prompt quit attempts and reduce relapse. Adopting a holistic well-being perspective, such as those developed by Māori, could address concerns about unintended adverse outcomes and provide comprehensive support to people who smoke as they adjust to a fundamental change in tobacco availability. (Source: Tobacco Control)
Source: Tobacco Control - March 19, 2024 Category: Respiratory Medicine Authors: Graham-DeMello, A., Hoek, J. Tags: Open access Original research Source Type: research

Nicotine pouches: a summary of regulatory approaches across 67 countries
Conclusion Our work offers novel insight into nicotine pouch markets and national regulatory approaches. Policy approaches vary from not regulating nicotine pouches at all to banning both forms of nicotine pouches. Policies used by countries regulating both tobacco-derived and synthetic nicotine pouches offer a roadmap for how other jurisdictions can add effective guardrails to the use of these and other non-medicinal nicotine products. (Source: Tobacco Control)
Source: Tobacco Control - March 19, 2024 Category: Respiratory Medicine Authors: Duren, M., Atella, L., Welding, K., Kennedy, R. D. Tags: Editor's choice Original research Source Type: research

Trajectories of ENDS and cigarette use among dual users: analysis of waves 1 to 5 of the PATH Study
Conclusions Most dual users maintained long-term cigarette smoking or dual use, highlighting the need to address cessation of both products. Continued monitoring of trajectories and their predictors is needed, given ongoing changes to the ENDS marketplace. (Source: Tobacco Control)
Source: Tobacco Control - March 19, 2024 Category: Respiratory Medicine Authors: Krishnan, N., Berg, C. J., Elmi, A. F., Klemperer, E. M., Sherman, S. E., Abroms, L. C. Tags: Press releases Original research Source Type: research

Vuse Solo e-cigarettes do not provide net benefits to public health: a scientific analysis of FDAs marketing authorisation
In October 2021, the US Food and Drug Administration (FDA) authorised marketing of RJ Reynolds Vapor Company’s (RJR) Vuse Solo e-cigarette through FDA’s Premarket Tobacco Product Application (PMTA) pathway. FDA concluded that RJR demonstrated Vuse products met the statutory standard of providing a net benefit to public health. A review of FDA’s scientific justification reveals deficiencies: (1) not adequately considering Vuse’s popularity with youth and evidence that e-cigarettes expanded the nicotine market and stimulate cigarette smoking; (2) trading youth addiction for unproven adult benefit with...
Source: Tobacco Control - March 19, 2024 Category: Respiratory Medicine Authors: Glantz, S., Lempert, L. K. Tags: Special communication Source Type: research

Analysis of FDAs Vuse market authorisation: limitations and opportunities
This special communication provides a physicians’ critique of the US Food and Drug Administration (FDA)’s decision to authorise the Vuse Solo (Vuse) Premarket Tobacco Application (PMTA). The PMTA authorisation represents the first time that FDA has authorised an Electronic Nicotine Delivery System (ENDS) for marketing in the USA. Using the FDA Decision Summary, the special communication identifies significant unanswered public health and scientific questions that prevent the authors from reaching FDA’s conclusion that Vuse meets the Appropriate for the Protection of the Public Health (APPH) standard. The ...
Source: Tobacco Control - March 19, 2024 Category: Respiratory Medicine Authors: Meshnick, A. B., Faricy, L. E., Lushniak, B. D. Tags: Special communication Source Type: research

Regulating flavours and flavour delivery technologies: an analysis of menthol cigarettes and RYO tobacco in Aotearoa New Zealand
Conclusions Capsule technologies using menthol flavours work synergistically to enhance the appeal of smoking and appear likely to encourage experimentation among non-smoking young people. Comprehensive policy that regulates menthol flavours and innovations used to deliver flavour sensations will support tobacco endgame goals in NZ and could inform policy in other countries. (Source: Tobacco Control)
Source: Tobacco Control - March 19, 2024 Category: Respiratory Medicine Authors: Gendall, P., Hoek, J. Tags: Brief report Source Type: research

Should menthol e-cigarettes be banned? Reaction of adult smokers and users of e-cigarettes to hypothetical bans
Conclusions Our results indicate that a ban on menthol cigarettes and flavoured cigars would decrease smoking. However, it is unclear if adding a ban of menthol e-cigarettes would lead to additional benefits because without menthol e-cigarettes as an alternative, some smokers and e-cigarette users may switch to non-flavoured tobacco smoking, rather than quit all tobacco use. (Source: Tobacco Control)
Source: Tobacco Control - March 19, 2024 Category: Respiratory Medicine Authors: Yang, Y., Lindblom, E. N., Ward, K. D., Salloum, R. G. Tags: Brief report Source Type: research