Chronic nicotine exposure is associated with electrophysiological and sympathetic remodeling in the intact rabbit heart
Am J Physiol Heart Circ Physiol. 2024 Mar 29. doi: 10.1152/ajpheart.00749.2023. Online ahead of print.ABSTRACTNicotine is the primary addictive component in tobacco products. Through its actions on the heart and autonomic nervous system, nicotine exposure is associated with electrophysiological changes and increased arrhythmia susceptibility. To assess underlying mechanisms, we treated rabbits with transdermal nicotine (NIC, 21 mg/day) or control (CT) patches for 28 days prior to performing dual optical mapping of transmembrane potential (RH237) and intracellular Ca2+ (Rhod-2 AM) in isolated hearts with intact sympathetic ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 29, 2024 Category: Physiology Authors: Amanda Guevara Charlotte E R Smith Jessica L Caldwell Lena Ngo Lilian R Mott I-Ju Lee Srinivas Tapa Zhen Wang Lianguo Wang William R Woodward G Andre Ng Beth A Habecker Crystal M Ripplinger Source Type: research
Effects of nicotine on microRNA-124 expression in bile duct ligation-induced liver fibrosis in rats
CONCLUSION: Considering that miRNA-124 is an anti-inflammatory miRNA, it can be concluded that the decrease in its expression due to nicotine exposure leads to an increase in inflammatory processes and subsequently to an increase in liver fibrosis.PMID:38549169 | PMC:PMC10976767 | DOI:10.1186/s40360-024-00749-3 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - March 29, 2024 Category: Drugs & Pharmacology Authors: Khalil Hajiasgharzadeh Parviz Shahabi Elham Karimi-Sales Mohammad Reza Alipour Source Type: research
Article Retraction
The News Brief titled “E-Cigarettes May Be Better Than Nicotine Gum for Quitting Smoking,” in the March 5, 2024, issue of JAMA, was published before the related article was retracted. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - March 29, 2024 Category: General Medicine Source Type: research
Notice of Retraction: Lin HX et al. Efficacy of Electronic Cigarettes vs Varenicline and Nicotine Chewing Gum as an Aid to Stop Smoking: A Randomized Clinical Trial. JAMA Intern Med . 2024;184(3):291-299.
To the Editor On behalf of my coauthors, I write to formally request retraction of the Original Investigation, “Efficacy of Electronic Cigarettes vs Varenicline and Nicotine Chewing Gum as an Aid to Stop Smoking: A Randomized Clinical Trial,” published online January 29, 2024, and in the March 2024 issue of JAMA Internal Medicine. Unfortunately, we have found significant coding errors that are difficult to rectify. We also discovered discrepancies in the calculation process that cast doubt on the accuracy and reliability of the reported findings. Consequently, we believe it is necessary to retract the article to uphold...
Source: JAMA Internal Medicine - March 29, 2024 Category: Internal Medicine Source Type: research
First experience with nicotine products and transition to regular tobacco use: a secondary data analysis in 28 European countries
Conclusions
Although this study cannot infer causality, the findings show that odds of becoming a regular tobacco user differs widely depending on the first product used. Better understanding of the associations between first product use and regular tobacco use could be informative to tobacco control policy-makers and help tailor prevention programmes. (Source: BMJ Open)
Source: BMJ Open - March 28, 2024 Category: General Medicine Authors: Rajani, N. B., Goyal, J., Filippidis, F. T. Tags: Open access, Public health Source Type: research
The Impact of Marijuana Use on Postoperative Outcomes in Abdominal-based Free Flap Breast Reconstruction
Conclusion Marijuana use increases the risks of postoperative VTE and increased postoperative narcotic requirements in patients who underwent abdominal-based free flap breast reconstruction. Future prospective cohort study is required to further understand marijuana-associated risks in microsurgical procedures. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Journal of Reconstructive Microsurgery)
Source: Journal of Reconstructive Microsurgery - March 28, 2024 Category: Surgery Authors: Lu, Yi-Hsueh Mahajan, Lakshmi Rudy, Hayeem Yan, Yufan Ricci, Joseph A. Tags: Original Article Source Type: research
