Letter to the Editor in regards to the article “Prognosticating acute traumatic spinal cord injury using Neurofilament (NF), Neuron Specific Enolase (NSE), Matrix Metalloproteinases (MMPs), and S-100B as biomarkers”
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 19, 2024 Category: General Medicine Source Type: research
Application of CRISPR/Cas9 System in the Treatment of Alzheimer ’s Disease and Neurodegenerative Diseases
AbstractAlzheimer ’s, Parkinson’s, and Huntington’s are some of the most common neurological disorders, which affect millions of people worldwide. Although there have been many treatments for these diseases, there are still no effective treatments to treat or completely stop these disorders. Perhaps the lack of proper treatment for these diseases can be related to various reasons, but the poor results related to recent clinical research also prompted doctors to look for new treatment approaches. In this regard, various researchers from all over the world have provided many new treatments, one of which is CRISPR/Cas9....
Source: Molecular Neurobiology - April 19, 2024 Category: Neurology Source Type: research
Retraction Note: Hydralazine Promotes Central Nervous System Recovery after Spinal Cord Injury by Suppressing Oxidative Stress and Inflammation through Macrophage Regulation
The Editor-in-Chief has retracted this article on the corresponding authors ’ request. The corresponding author on behalf of all the authors stated that the data presented in this article does not belong to the named authors, but belongs to Prof. Sheng-xi Wu and Prof. Wang Xi of the Department of Neurobiology of the Fourth Military Medical University, Xi’an, China.All Authors agree to this retraction. (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - April 19, 2024 Category: Research Source Type: research
Transparency in Cognitive Training Meta-analyses: A Meta-review
AbstractMeta-analyses often present flexibility regarding their inclusion criteria, outcomes of interest, statistical analyses, and assessments of the primary studies. For this reason, it is necessary to transparently report all the information that could impact the results. In this meta-review, we aimed to assess the transparency of meta-analyses that examined the benefits of cognitive training, given the ongoing controversy that exists in this field. Ninety-seven meta-analytic reviews were included, which examined a wide range of populations with different clinical conditions and ages. Regarding the reporting, informatio...
Source: Neuropsychology Review - April 19, 2024 Category: Neuroscience Source Type: research
Reading Difficulties in Individuals with Homonymous Visual Field Defects: A Systematic Review of Reported Interventions
AbstractReading difficulties are amongst the most commonly reported problems in individuals with homonymous visual field defects (HVFDs). To be able to provide guidance for healthcare professionals considering offering reading training, researchers in this field and interested individuals with HVFDs, this systematic review aims to (1) provide an overview of the contextual and intervention characteristics of all published HVFD interventions and (2) generate insights into the different reading outcome measures that these studies adopted. A search on PsycINFO, MEDLINE and Web of Science was conducted up to February 2, 2023. A...
Source: Neuropsychology Review - April 19, 2024 Category: Neuroscience Source Type: research
Impacts of gait freeze on quality of life in Parkinson ’s disease, from the perspectives of patients and their carers
ConclusionsThis study shows that FoG is a significant detriment to the QoL of PwP, from the perspectives of patients and carers. This method of assessing FoG and QoL using online questionnaires has potential to enhance the reach and flexibility of this type of research. These findings will inform future studies on larger cohorts and highlight unmet clinical needs in PwP. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 19, 2024 Category: General Medicine Source Type: research
Population-level insights into temporal interference for focused deep brain neuromodulation
The ability to stimulate deep brain regions in a focal manner brings new opportunities for treating brain disorders. Temporal interference (TI) stimulation has been suggested as a method to achieve focused stimulation in deep brain targets. Individual-level knowledge of the interferential currents has permitted personalizing TI montage via subject-specific digital human head models, facilitating the estimation of interferential electric currents in the brain. While this individual approach offers a high degree of personalization, the significant intra-and inter-individual variability among specific head models poses challe...
Source: Frontiers in Human Neuroscience - April 19, 2024 Category: Neuroscience Source Type: research
Volumetric segmentation in the context of posterior fossa-related pathologies: a systematic review
ConclusionsVarious forms of segmentation techniques have been used to assess posterior fossa volumes/pathologies and each has its advantages and disadvantages. We discuss these nuances and summarize the current state of literature in the context of posterior fossa-associated pathologies. (Source: Neurosurgical Review)
Source: Neurosurgical Review - April 19, 2024 Category: Neurosurgery Source Type: research
Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need | Science
Drugs of abuse are thought to promote addiction in part by “hijacking” brain reward systems, but the underlying mechanisms remain undefined. Using whole-brain FOS mapping and in vivo single-neuron calcium imaging, we found that drugs of abuse augment ... (Source: Science: Current Issue)
Source: Science: Current Issue - April 18, 2024 Category: Science Source Type: research
Simplifying Multimodal With Single EOG Modality for Automatic Sleep Staging
Polysomnography (PSG) recordings have been widely used for sleep staging in clinics, containing multiple modality signals (i.e., EEG and EOG). Recently, many studies have combined EEG and EOG modalities for sleep staging, since they are the most and the second most powerful modality for sleep staging among PSG recordings, respectively. However, EEG is complex to collect and sensitive to environment noise or other body activities, imbedding its use in clinical practice. Comparatively, EOG is much more easily to be obtained. In order to make full use of the powerful ability of EEG and the easy collection of EOG, we propose a...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - April 18, 2024 Category: Neuroscience Source Type: research
Neuroendocrine cells initiate protective upper airway reflexes | Science
Airway neuroendocrine (NE) cells have been proposed to serve as specialized sensory epithelial cells that modulate respiratory behavior by communicating with nearby nerve endings. However, their functional properties and physiological roles in the ... (Source: Science: Current Issue)
Source: Science: Current Issue - April 18, 2024 Category: Science Source Type: research
Reprioritizing motivations in addiction | Science
Drugs of abuse alter neuronal signaling (Source: Science: Current Issue)
Source: Science: Current Issue - April 18, 2024 Category: Science Source Type: research
Association of Air Pollution with Risk and Severity of Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis
CONCLUSION: The findings suggest air pollutants, especially NO2, might play a role in worsening OSA risk and severity, but the evidence isn't definitive. This highlights the variability of different pollutants' effects and the necessity for more research. Understanding these links is vital for shaping public health policies and clinical approaches to address OSA amidst high air pollution.PMID:38636605 | DOI:10.1016/j.neuro.2024.04.005 (Source: Neurotoxicology)
Source: Neurotoxicology - April 18, 2024 Category: Neurology Authors: Tahani Alrahbeni Jeetendra Kumar Gupta Anas Alkhouri Ladi Alik Kumar Ahmed Mahal Khalid Al-Mugheed Prakasini Satapathy Neelima Kukreti Mahalaqua Nazli Khatib Shilpa Gaidhane Abhay M Gaidhane Sarvesh Rustagi Dibyalochan Mohanty Bijaya Kumar Padhi Source Type: research
Conflict Dynamics of Post-Retrieval Extinction: A Comparative Analysis of Unconditional and Conditional Reminders Using Skin Conductance Responses and EEG
This study investigates the impact of two reminder types, mild US-reminder (US-R) and CS-reminder (CS-R), along with a no-reminder extinction, on fear recovery prevention in a categorical fear conditioning paradigm. Scalp EEG recordings during reminder and extinction processes were conducted in a three-day design. Results show that the US-R group exhibits a distinctive extinction learning pattern, characterized by a slowed-down yet successful process and pronounced theta-alpha desynchronization (source-located in the prefrontal cortex) during CS processing, followed by enhanced synchronization (source-located in the anteri...
Source: Brain Topography - April 18, 2024 Category: Neuroscience Authors: Dong-Ni Pan Delhii Hoid Oliver T Wolf Christian J Merz Xuebing Li Source Type: research
DMT1 ubiquitination by Nedd4 protects against ferroptosis after intracerebral hemorrhage
CONCLUSION: The results demonstrated that ferroptosis occurs via the Nedd4/DMT1 pathway during ICH, suggesting it potential as a valuable target to inhibit ferroptosis for the treatment of ICH.PMID:38634270 | PMC:PMC11024684 | DOI:10.1111/cns.14685 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 18, 2024 Category: Neuroscience Authors: Bingchen Lv Ping Fu Miao Wang Likun Cui Lei Bao Xingzhi Wang Lu Yu Chao Zhou Mengxin Zhu Fei Wang Ye Pang Suhua Qi Zuohui Zhang Guiyun Cui Source Type: research
