Medication Overuse Headache: an Updated Review and Clinical Recommendations on Management
AbstractOverviewMedication overuse headache (MOH) is highly prevalent among individuals with primary headache disorders.Purpose of Review(1) Provide an update on epidemiology, risk factors, and treatment strategies of MOH and (2) provide recommendations on the management of MOH.Recent FindingsThe prevalence of MOH ranges from 0.5 to 7.2%. Risk factors for MOH include female sex, lower socioeconomic status, some psychiatric conditions, and substance use disorders, among others. Recent large clinical trials support preventative therapy as an integral component of MOH management. Emerging clinical trial evidence supports anti...
Source: Current Neurology and Neuroscience Reports - June 5, 2023 Category: Neuroscience Source Type: research
Supporting Post-Stroke Language and Cognition with Pharmacotherapy: Tools for Each Phase of Care
AbstractPurpose of ReviewThere is enormous enthusiasm for the possibility of pharmacotherapies to treat language deficits that can arise after stroke. Speech language therapy remains the most frequently utilized and most strongly evidenced treatment, but the numerous barriers to patients receiving the therapy necessary to recover have motivated the creation of a relatively modest, yet highly cited, body of evidence to support the use of pharmacotherapy to treat post-stroke aphasia directly or to augment traditional post-stroke aphasia treatment. In this review, we survey the use of pharmacotherapy to preserve and support l...
Source: Current Neurology and Neuroscience Reports - June 5, 2023 Category: Neuroscience Source Type: research
Analyzing the effect of the COVID-19 vaccine on Parkinson ’s disease symptoms
ConclusionThere was strong evidence of worsening of PD symptoms post COVID-19 vaccination, however it was mostly mild and limited to a couple of days. The worsening had statistically significant moderate positive correlation with vaccine hesitancy and post-vaccine general side effects. A possible causative mechanism of PD symptom worsening using existing scientific knowledge would be stress and anxiety associated with vaccine hesitancy and the extent of post-vaccine general side effects (fever, chills, pain), likely via simulating a mild systemic infection/inflammation the latter already established causes of PD symptom wo...
Source: Frontiers in Immunology - June 5, 2023 Category: Allergy & Immunology Source Type: research
Global trends in COVID-19 Alzheimer's related research: a bibliometric analysis
ConclusionThe disease caused by the COVID-19 virus infection related to Alzheimer's disease has attracted significant attention worldwide. The major hot topics in 2020 were: “Alzheimer' disease,” COVID-19,” risk factors,” care,” and “Parkinson's disease.” During the 2 years 2021 and 2022, researchers were also interested in “neurodegenerative diseases,” “cognitive impairment,” and “quality of life,” which require further investigation. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - June 5, 2023 Category: Neurology Source Type: research
The role of high-sensitivity C-reactive protein serum levels in the prognosis for patients with stroke: a meta-analysis
ConclusionHs-CRP levels are strongly associated with mortality, risk of stroke recurrence and poor prognosis in stroke patients. Therefore, hs-CRP levels may contribute to the prognosis prediction of these patients. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - June 5, 2023 Category: Neurology Source Type: research
The effects of layer-wise relevance propagation-based feature selection for EEG classification: a comparative study on multiple datasets
In this study, we design a layer-wise relevance propagation (LRP)-based feature selection method which can be easily integrated into deep learning (DL)-based models. We assess its effectiveness for reliable class-discriminative EEG feature selection on two different publicly available EEG datasets with various DL-based backbone models in the subject-dependent scenario.Results and discussionThe results show that LRP-based feature selection enhances the performance for MI classification on both datasets for all DL-based backbone models. Based on our analysis, we believe that it can broad its capability to different research ...
Source: Frontiers in Human Neuroscience - June 5, 2023 Category: Neuroscience Source Type: research
DeePay: deep learning decodes EEG to predict consumer ’s willingness to pay for neuromarketing
In conclusion, we show that DLNs may be the superior method to perform EEG-based predictions, to the benefit of decision-making researchers and marketing practitioners alike. (Source: Frontiers in Human Neuroscience)
Source: Frontiers in Human Neuroscience - June 5, 2023 Category: Neuroscience Source Type: research
Pregnane X receptor (PXR) deficiency protects against spinal cord injury by activating NRF2/HO-1 pathway
CONCLUSION: PXR is involved in the recovery of motor function after SCI by regulating NRF2/HO-1 pathway.PMID:37269088 | DOI:10.1111/cns.14279 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 3, 2023 Category: Neuroscience Authors: Li-Na Xuan Zhen-Xin Hu Zhen-Fu Jiang Cong Zhang Xiao-Wan Sun Wen-Hua Ming Hui-Tao Liu Rong-Fang Qiao Lin-Jie Shen Shao-Bo Liu Guan-Yu Wang Lin Wen Zhi-Lin Luan Jian Yin Source Type: research
Single-cell RNA-sequencing analysis reveals enhanced non-canonical neurotrophic factor signaling in the subacute phase of traumatic brain injury
CONCLUSION: The non-canonical neurotrophic factors MDK, PTN, and PSAP were upregulated in the subacute phase of TBI and played a crucial role in neuroregeneration.PMID:37269057 | DOI:10.1111/cns.14278 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 3, 2023 Category: Neuroscience Authors: Xuecheng Qiu Yaling Guo Ming-Feng Liu Bingge Zhang Jingzhen Li Jian-Feng Wei Meng Li Source Type: research
Comprehensive analyses of brain cell communications based on multiple scRNA-seq and snRNA-seq datasets for revealing novel mechanism in neurodegenerative diseases
CONCLUSION: This research provided a comprehensive study to explore brain cell communications, which could reveal novel biological mechanisms involved in normal brain function and neurodegenerative diseases such as AD.PMID:37269061 | DOI:10.1111/cns.14280 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 3, 2023 Category: Neuroscience Authors: Chunlong Zhang Guiyuan Tan Yuxi Zhang Xiaoling Zhong Ziyan Zhao Yunyi Peng Qian Cheng Ke Xue Yanjun Xu Xia Li Feng Li Yunpeng Zhang Source Type: research
A preliminary transcriptomic analysis of the orbitofrontal cortex of antisocial individuals
CONCLUSION: These preliminary findings suggest that ASPD and CD feature a complex array of functional deficits in the pyramidal neurons and astrocytes of the OFC. In turn, these aberrances may contribute to the reduced OFC connectivity observed in antisocial subjects. Future analyses on larger cohorts are needed to validate these results.PMID:37269073 | DOI:10.1111/cns.14283 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 3, 2023 Category: Neuroscience Authors: Ignazio S Piras Giulia Braccagni Matthew J Huentelman Marco Bortolato Source Type: research
TL1A promotes the postoperative cognitive dysfunction in mice through NLRP3-mediated A1 differentiation of astrocytes
CONCLUSION: Our results demonstrate that TL1A plays an important role in POCD in mice, which promotes the A1 differentiation of astrocytes through NLRP3, thereby exacerbating the progression of cognitive dysfunction.PMID:37269079 | DOI:10.1111/cns.14290 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 3, 2023 Category: Neuroscience Authors: Genghuan Wang Jian Shen Liping Zhai Yingcong Lin Qiaobing Guan Heping Shen Source Type: research
USP14 inhibition promotes recovery by protecting BBB integrity and attenuating neuroinflammation in MCAO mice
CONCLUSIONS: Our results demonstrate a role for USP14 in disrupting the integrity of the BBB and promoting neuroinflammation after MCAO.PMID:37269080 | DOI:10.1111/cns.14292 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 3, 2023 Category: Neuroscience Authors: Wenzhong Hou Jianping Yao Junjie Liu Xiaohong Lin JueXian Wei Xiaofan Yin Hongbiao Huang Xiaohui Chen Guo-Yuan Yang Xiaosong He Source Type: research
rTMS ameliorates depressive-like behaviors and regulates the gut microbiome and medium- and long-chain fatty acids in mice exposed to chronic unpredictable mild stress
CONCLUSION: These findings revealed that the modulation of gut microbiotas and PUFAs metabolism might partly contribute to the antidepressant effect of rTMS.PMID:37269082 | DOI:10.1111/cns.14287 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 3, 2023 Category: Neuroscience Authors: Cui-Hong Zhou Yi-Huan Chen Shan-Shan Xue Qing-Qing Shi Lin Guo Huan Yu Fen Xue Min Cai Hua-Ning Wang Zheng-Wu Peng Source Type: research
Administration of agmatine prior to physical or psychological stress in pregnant mice ameliorates behavioural and cognitive deficits in female offspring
In this study, we aimed to assess whether prenatal agmatine exposure could ameliorate behavioural and cognitive deficits in female offspring born to prenatally stressed mice. Pregnant Swiss Webster (SW) mice were exposed to physical or psychological stress from the 11th to 17th days of gestation. Agmatine (37.5 mg/kg, i.p.) was administrated 30 min before the induction of stress for seven consecutive days. The pups were assessed using a variety of behavioural tests and molecular assays on postnatal days 40 to 47. Agmatine attenuated impairments in locomotor activity, anxiety-like behaviour, and drug-seeking behaviour assoc...
Source: International Journal of Developmental Neuroscience - June 3, 2023 Category: Neuroscience Authors: Amin Hassanshahi Mahyar Janahmadi Moazamehosadat Razavinasab Mehran Ilaghi Kristi A Kohlmeier Elham Hassanshahi Mohammad Shabani Source Type: research
