Brain activation and connection across resting and motor-task states in patients with generalized tonic-clonic seizures
CONCLUSION: Convergent findings suggested the over-response of activation and connection of the brain to motor execution in GTCS, providing new clues to uncover motor susceptibility underlying the disease.PMID:38644561 | PMC:PMC11033329 | DOI:10.1111/cns.14672 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 22, 2024 Category: Neuroscience Authors: Sisi Jiang Yuehan Wang Haonan Pei Hechun Li Junxia Chen Yutong Yao Qifu Li Dezhong Yao Cheng Luo Source Type: research
USP19 regulates DNA methylation damage repair and confers temozolomide resistance through MGMT stabilization
CONCLUSION: The regulation of MGMT ubiquitination by USP19 plays a critical role in DNA methylation damage repair and GBM patients' temozolomide chemotherapy response.PMID:38644551 | PMC:PMC11033335 | DOI:10.1111/cns.14711 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 22, 2024 Category: Neuroscience Authors: Jiaqi Liu Kaikai Wang Qian Zhu Yixin Zhang Yuping Chen Zhenkun Lou Jian Yuan Source Type: research
Role of the medial agranular cortex in unilateral spatial neglect
Exp Brain Res. 2024 Apr 22. doi: 10.1007/s00221-024-06817-8. Online ahead of print.ABSTRACTUnilateral spatial neglect (USN) results from impaired attentional networks and can affect various sensory modalities, such as visual and somatosensory. The rodent medial agranular cortex (AGm), located in the medial part of the forebrain from rostral to caudal direction, is considered a region associated with spatial attention. The AGm selectively receives multisensory input with the rostral AGm receiving somatosensory input and caudal part receiving visual input. Our previous study showed slower recovery from neglect with anterior ...
Source: Experimental Brain Research - April 22, 2024 Category: Neuroscience Authors: Daisuke Ishii Hironobu Osaki Arito Yozu Tatsuya Yamamoto Satoshi Yamamoto Mariko Miyata Yutaka Kohno Source Type: research
Navigating the Alzheimer's Treatment Landscape: Unraveling Amyloid-Beta Complexities and Pioneering Precision Medicine Approaches
Curr Top Med Chem. 2024 Apr 19. doi: 10.2174/0115680266295495240415114919. Online ahead of print.ABSTRACTA variety of cutting-edge methods and good knowledge of the illness's complex causes are causing a sea change in the field of Alzheimer's Disease (A.D.) research and treatment. Precision medicine is at the vanguard of this change, where individualized treatment plans based on genetic and biomarker profiles give a ray of hope for customized therapeutics. Combination therapies are becoming increasingly popular as a way to address the multifaceted pathology of Alzheimer's by simultaneously attacking Aβ plaques, tau tangle...
Source: Current Topics in Medicinal Chemistry - April 22, 2024 Category: Chemistry Authors: Mohsina Patwekar Faheem Patwekar Shahzad Khan Rohit Sharma Dileep Kumar Source Type: research
Stilbenes: a journey from folklore to pharmaceutical innovation
Arch Microbiol. 2024 Apr 22;206(5):229. doi: 10.1007/s00203-024-03939-z.ABSTRACTIn modern times, medicine is predominantly based on evidence-based practices, whereas in ancient times, indigenous people relied on plant-based medicines with factual evidence documented in ancient books or folklore that demonstrated their effectiveness against specific infections. Plants and microbes account for 70% of drugs approved by the USFDA (U.S. Food and Drug Administration). Stilbenes, polyphenolic compounds synthesized by plants under stress conditions, have garnered significant attention for their therapeutic potential, bridging anci...
Source: Archives of Microbiology - April 22, 2024 Category: Microbiology Authors: Gursharan Kaur Rajinder Kaur Gurleen Kaur Sodhi Nancy George Santosh Kumar Rath Harleen Kaur Walia Vagish Dwibedi Sanjai Saxena Source Type: research
Analysis of mechanism of core points in acupuncture and moxibustion treatment for epilepsy based on data mining
CONCLUSIONS: The core acupoint prescription of acupuncture and moxibustion intervention for epilepsy can act on multiple targets and multiple pathways to exert anti-epileptic effects, which can provide a theoretical basis for further clinical application and mechanism research.PMID:38649211 | DOI:10.13702/j.1000-0607.20230019 (Source: Atherosclerosis)
Source: Atherosclerosis - April 22, 2024 Category: Cardiology Authors: Yi-Wen Zhang Guang-Yu Cheng Xuan Wang Wei-Ping Cheng Source Type: research
Personality changes related to presence and treatment of substance use (disorders): a systematic review
Psychol Med. 2024 Apr 22:1-25. doi: 10.1017/S003329172400093X. Online ahead of print.ABSTRACTHeavy substance use (SU) and substance use disorders (SUD) have complex etiologies and often severe consequences. Certain personality traits have been associated with an increased risk for SU(D), but far less is known about personality changes related to SU(D). This review aims to synthesize the existing literature on this research question. A systematic literature search was conducted from November 2022 to February 2023 in PubMed, EbscoHost, and Web of Science. Peer-reviewed original papers on SU(D)-related personality changes wer...
Source: Psychological Medicine - April 22, 2024 Category: Psychiatry Authors: Christina M Juchem Antonia Bendau Leonie C Bandurski Nico J Reich Saskia Baumgardt Eva Asselmann Source Type: research
Does a Healthy Weight Body Mass Index at Onset of Idiopathic Intracranial Hypertension Change the Outcomes? A United Kingdom Prospective Cohort Study
. (Source: Neuro-Ophthalmology)
Source: Neuro-Ophthalmology - April 22, 2024 Category: Opthalmology Authors: Mark ThallerVictoria HomerSally AbbottJonathan HazlehurstSusan P. MollanAlexandra J. Sinclaira Translational Brain Science, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UKb Department of Neurology, University Hospita Source Type: research
Daily briefing: Great Barrier Reef is experiencing its worst mass bleaching event on record
Nature, Published online: 22 April 2024; doi:10.1038/d41586-024-01195-1Iconic coral reef is ‘transforming’ from repeated bleaching events. Plus, researchers face the possibility of animal consciousness and science explores the neurodiversity of visual imagery. (Source: Nature AOP)
Source: Nature AOP - April 22, 2024 Category: Research Authors: Flora Graham Source Type: research
Analysis and prevention strategies of risk factors for postoperative stroke complications in cardiac surgery
. (Source: International Journal of Neuroscience)
Source: International Journal of Neuroscience - April 22, 2024 Category: Neuroscience Authors: Liang WeiJie LiFeng ZhengYan ZhangDepartment of Cardiac and Vascular Surgery, Affiliated Huai ’an Hospital of Yangzhou University, Huai’an, China Source Type: research
Anticipating noxious stimulation rather than afferent nociceptive input may evoke pupil asymmetry
Unilateral nociceptive stimulation is associated with subtle signs of pupil asymmetry that may reflect lateralized activity in the locus coeruleus. To explore drivers of this pupil asymmetry, electrical stimuli, delivered alone or 200 ms before or after an acoustic startle stimulus, were administered to one ankle under four experimental conditions: with or without a 1.6 s anticipatory period, or while the forearm ipsilateral or contralateral to the electrical stimulus was heated tonically to induce moderate pain (15 healthy participants in each condition). (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - April 22, 2024 Category: Neuroscience Authors: Peter D. Drummond Source Type: research
Remote neuropsychological assessment of patients with neurological disorders and injuries--a study protocol for a cross-sectional case-control validation study
This study protocol describes a cross-sectional study aimed at validating the newly developed digitalized neuropsychological test battery Mindmore Remote in patients with neurological disorders and injuries. Diagnoses comprise traumatic brain injury, stroke, Parkinson’s disease, multiple sclerosis, brain tumour and epilepsy. 50 patients in each patient group will be included. In addition, 50 healthy controls will be recruited. All participants will undergo both testing with Mindmore Remote at home and traditional neuropsychological assessment face-to-face in a randomised order. The primary outcome is the association ...
Source: BMJ Open - April 22, 2024 Category: General Medicine Authors: Berginström, N., Andersson, L. Tags: Open access, Neurology Source Type: research
Efficacy and utility of antifibrinolytics in pediatric spine surgery: a systematic review and network meta-analysis
AbstractAntifibrinolytics have gained increasing attention in minimizing blood loss and mitigating the risks associated with massive transfusions, including infection and coagulopathy in pediatric patients undergoing spine surgery. Nevertheless, the selection of optimal agent is still a matter of debate. We aim to review the utility of these agents and compare the efficacy of antifibrinolytics in pediatric and adolescent spine surgeries. A comprehensive search was performed in Scopus, Web of Science, and MEDLINE databases for relevant works. Studies providing quantitative data on predefined outcomes were included. Primary ...
Source: Neurosurgical Review - April 22, 2024 Category: Neurosurgery Source Type: research
The relationship between numerical magnitude processing and math anxiety, and their joint effect on adult math performance, varied by indicators of numerical tasks
Cogn Process. 2024 Apr 22. doi: 10.1007/s10339-024-01186-0. Online ahead of print.ABSTRACTAccording to the hypothesis of Maloney et al. (Cognition 114(2):293-297, 2010. https://doi.org/10.1016/j.cognition.2009.09.013), math anxiety is related to deficits in numerical magnitude processing, which in turn compromises the development of advanced math skills. Because previous studies on this topic are contradictory, which may be due to methodological differences in the measurement of numerical magnitude processing, we tested Maloney et al.'s hypothesis using different tasks and their indicators: numerical magnitude processing (...
Source: Cognitive Processing - April 21, 2024 Category: Neuroscience Authors: Monika Szczygie ł Mehmet Hayri Sar ı Source Type: research
Detecting deception with artificial intelligence: promises and perils
Trends Cogn Sci. 2024 Apr 20:S1364-6613(24)00081-0. doi: 10.1016/j.tics.2024.04.002. Online ahead of print.ABSTRACTRapid advancements in artificial intelligence (AI) have driven interest in its potential application for lie detection. Unfortunately, the current approaches have primarily focused on technical aspects at the expense of a solid methodological and theoretical foundation. We discuss the implications thereof and offer recommendations for the development and regulation of AI-based deception detection.PMID:38644102 | DOI:10.1016/j.tics.2024.04.002 (Source: Trends Cogn Sci)
Source: Trends Cogn Sci - April 21, 2024 Category: Neuroscience Authors: Kristina Suchotzki Matthias Gamer Source Type: research
