Decoding cocaine-induced proteomic adaptations in the mouse nucleus accumbens
Sci Signal. 2024 Apr 16;17(832):eadl4738. doi: 10.1126/scisignal.adl4738. Epub 2024 Apr 16.ABSTRACTCocaine use disorder (CUD) is a chronic neuropsychiatric condition that results from enduring cellular and molecular adaptations. Among substance use disorders, CUD is notable for its rising prevalence and the lack of approved pharmacotherapies. The nucleus accumbens (NAc), a region that is integral to the brain's reward circuitry, plays a crucial role in the initiation and continuation of maladaptive behaviors that are intrinsic to CUD. Leveraging advancements in neuroproteomics, we undertook a proteomic analysis that spanne...
Source: Science Signaling - April 16, 2024 Category: Biomedical Science Authors: Philipp Mews Lucas Sosnick Ashik Gurung Simone Sidoli Eric J Nestler Source Type: research
RFC1: Motifs and phenotypes
Rev Neurol (Paris). 2024 Apr 15:S0035-3787(24)00484-3. doi: 10.1016/j.neurol.2024.03.006. Online ahead of print.ABSTRACTBiallelic intronic expansions (AAGGG)exp in intron 2 of the RFC1 gene have been shown to be a common cause of late-onset ataxia. Since their first description, the phenotypes, neurological damage, and pathogenic variants associated with the RFC1 gene have been frequently updated. Here, we review the various motifs, genetic variants, and phenotypes associated with the RFC1 gene. We searched PubMed for scientific articles published between March 1st, 2019, and January 15th, 2024. The motifs and phenotypes a...
Source: Revue Neurologique - April 16, 2024 Category: Neurology Authors: V Delforge C Tard J-B Davion K Dujardin A Wissocq C-M Dhaenens E Mutez V Huin Source Type: research
Functional Connectivity Alterations in Patients with Post-stroke Epilepsy Based on Source-level EEG and Graph Theory
Brain Topogr. 2024 Apr 16. doi: 10.1007/s10548-024-01048-0. Online ahead of print.ABSTRACTWe investigated the differences in functional connectivity based on the source-level electroencephalography (EEG) analysis between stroke patients with and without post-stroke epilepsy (PSE). Thirty stroke patients with PSE and 35 stroke patients without PSE were enrolled. EEG was conducted during a resting state period. We used a Brainstorm program for source estimation and the connectivity matrix. Data were processed according to EEG frequency bands. We used a BRAPH program to apply a graph theoretical analysis. In the beta band, ra...
Source: Brain Topography - April 16, 2024 Category: Neuroscience Authors: Dong Ah Lee Taeik Jang Jaeho Kang Seongho Park Kang Min Park Min Kang None Park Source Type: research
Neural signatures of imaginary motivational states: desire for music, movement and social play
Brain Topogr. 2024 Apr 16. doi: 10.1007/s10548-024-01047-1. Online ahead of print.ABSTRACTThe literature has demonstrated the potential for detecting accurate electrical signals that correspond to the will or intention to move, as well as decoding the thoughts of individuals who imagine houses, faces or objects. This investigation examines the presence of precise neural markers of imagined motivational states through the combining of electrophysiological and neuroimaging methods. 20 participants were instructed to vividly imagine the desire to move, listen to music or engage in social activities. Their EEG was recorded fro...
Source: Brain Topography - April 16, 2024 Category: Neuroscience Authors: Giada Della Vedova Alice Mado Proverbio Source Type: research
Contributions of the left and right thalami to language: A meta-analytic approach
CONCLUSION: The current findings show that the language-relevant network extends beyond the classical left perisylvian cortices and spans bilateral cortical, bilateral subcortical (bilateral thalamus, bilateral basal ganglia) and right cerebellar regions.PMID:38625556 | DOI:10.1007/s00429-024-02795-3 (Source: Brain Structure and Function)
Source: Brain Structure and Function - April 16, 2024 Category: Neuroscience Authors: Talat Bulut Peter Hagoort Source Type: research
The degeneration of locus coeruleus occurring during Alzheimer's disease clinical progression: a neuroimaging follow-up investigation
In this study, we report the results of a follow-up neuroradiological assessment, in which we evaluated the LC degeneration overtime in a group of cognitively impaired patients, submitted to MRI both at baseline and at the end of a 2.5-year follow-up. We found that a progressive LC disruption can be observed also in vivo, involving the entire nucleus and associated with clinical diagnosis. Our findings parallel neuropathological ones, which showed a continuous increase of neuronal death and volumetric atrophy within the LC with the progression of Braak's stages for neurofibrillary pathology. This supports the reliability o...
Source: Brain Structure and Function - April 16, 2024 Category: Neuroscience Authors: Alessandro Galgani Francesco Lombardo Francesca Frijia Nicola Martini Gloria Tognoni Nicola Pavese Filippo Sean Giorgi Source Type: research
Correction: Orientin Modulates Nrf2-ARE, PI3K/Akt, JNK-ERK1/2, and TLR4/NF-kB Pathways to Produce Neuroprotective Benefits in Parkinson's Disease
Neurochem Res. 2024 Apr 16. doi: 10.1007/s11064-024-04138-4. Online ahead of print.NO ABSTRACTPMID:38625635 | DOI:10.1007/s11064-024-04138-4 (Source: Neurochemical Research)
Source: Neurochemical Research - April 16, 2024 Category: Neuroscience Authors: Deepak Vasudevan Sajini Praveen Thaggikuppe Krishnamurthy Amritha Chakkittukandiyil Ravi Naik Mudavath Source Type: research
Role of the Cerebellum in the Construction of Functional and Geometrical Spaces
Cerebellum. 2024 Apr 16. doi: 10.1007/s12311-024-01693-y. Online ahead of print.ABSTRACTThe perceptual and motor systems appear to have a set of movement primitives that exhibit certain geometric and kinematic invariances. Complex patterns and mental representations can be produced by (re)combining some simple motor elements in various ways using basic operations, transformations, and respecting a set of laws referred to as kinematic laws of motion. For example, point-to-point hand movements are characterized by straight hand paths with single-peaked-bell-shaped velocity profiles, whereas hand speed profiles for curved tra...
Source: Cerebellum - April 16, 2024 Category: Neuroscience Authors: Eya Torkhani Langlois Daniel Bennequin Giovanni de Marco Source Type: research
A Comprehensive Examination of Prediction-Based Error as a Mechanism for Syntactic Development: Evidence From Syntactic Priming
Cogn Sci. 2024 Apr;48(4):e13431. doi: 10.1111/cogs.13431.ABSTRACTPrediction-based accounts of language acquisition have the potential to explain several different effects in child language acquisition and adult language processing. However, evidence regarding the developmental predictions of such accounts is mixed. Here, we consider several predictions of these accounts in two large-scale developmental studies of syntactic priming of the English dative alternation. Study 1 was a cross-sectional study (N = 140) of children aged 3-9 years, in which we found strong evidence of abstract priming and the lexical boost, but littl...
Source: Cognitive Science - April 16, 2024 Category: Neuroscience Authors: Seamus Donnelly Caroline Rowland Franklin Chang Evan Kidd Source Type: research
Autistic traits and anthropomorphism: the case of vehicle fascia perception
Cogn Process. 2024 Apr 16. doi: 10.1007/s10339-024-01187-z. Online ahead of print.ABSTRACTIndividuals high in autistic traits can have difficulties with social interactions which may stem from difficulties with mentalizing abilities, yet findings from research investigating anthropomorphism of non-human objects in high trait individuals are inconsistent. Measuring emotions and attributes of front-facing vehicles, individuals scoring high versus low on the AQ-10 were compared for ratings of angry-happy, hostile-friendly, masculine-feminine, and submissive-dominant, as a function of vehicle size (large versus small). Our res...
Source: Cognitive Processing - April 16, 2024 Category: Neuroscience Authors: Leilani Forby Farid Pazhoohi Alan Kingstone Source Type: research
Recruitment of hippocampal and thalamic pathways to the central amygdala in the control of feeding behavior under novelty
Brain Struct Funct. 2024 Apr 16. doi: 10.1007/s00429-024-02791-7. Online ahead of print.ABSTRACTIt is adaptive to restrict eating under uncertainty, such as during habituation to novel foods and unfamiliar environments. However, sustained restrictive eating can become maladaptive. Currently, the neural substrates of restrictive eating are poorly understood. Using a model of feeding avoidance under novelty, our recent study identified forebrain activation patterns and found evidence that the central nucleus of the amygdala (CEA) is a core integrating node. The current study analyzed the activity of CEA inputs in male and fe...
Source: Brain Structure and Function - April 16, 2024 Category: Neuroscience Authors: Eliza M Greiner Gorica D Petrovich Source Type: research
Brain structural covariances in the ageing brain in the UK Biobank
We examined 84 cortical thickness covariances and subcortical covariances. Our findings include: (1) there were significant differences in the variability of structural covariance in the ageing process, including an increased variance, and a decreased entropy. (2) significant enrichment in pairwise correlations between brain regions within the occipital lobe was observed in all age groups; (3) structural covariance in older age, especially after the age of around 64, was significantly different from that in the youngest group (median age 48 years); (4) sixty-two of the total 528 pairs of cortical thickness correlations and...
Source: Brain Structure and Function - April 16, 2024 Category: Neuroscience Authors: Chao Dong Anbupalam Thalamuthu Jiyang Jiang Karen A Mather Perminder S Sachdev Wei Wen Source Type: research
Learned switch readiness via concurrent activation of task sets: Evidence from task specificity and memory load
Mem Cognit. 2024 Apr 16. doi: 10.3758/s13421-024-01560-5. Online ahead of print.ABSTRACTCognitive flexibility increases when switch demands increase. In task switching experiments, repeated pairing of flexibility-demanding situations with specific contexts leads subjects to become more prepared to adapt to changing task demands in those contexts. One form of such upregulated cognitive flexibility has been demonstrated with a list-wide switch probability (LWSP) effect, where switch costs are smaller in lists with frequent switches than in lists with rare switches. According to a recent proposal, the LWSP effect is supported...
Source: Memory and Cognition - April 16, 2024 Category: Neuroscience Authors: Corey A Nack Yu-Chin Chiu Source Type: research
The days we never forget: Flashbulb memories across the life span in Alzheimer's disease
We examined the frequency, characteristics, and the temporal distribution of flashbulb memories across the life span. To this aim, 28 older adults diagnosed with AD and a matched sample of 29 healthy older controls were probed for flashbulb memories for two historical events from each decade of their lives. They also estimated the subjective degree of reexperiencing for the memories reported. AD participants showed impaired access to flashbulb memories, the frequency of reported memories being lower than for healthy older adults. However, qualitative aspects of AD participants' flashbulb memories were quite similar to thos...
Source: Memory and Cognition - April 16, 2024 Category: Neuroscience Authors: Katrine W Rasmussen Marie Kirk Susanne B Overgaard Dorthe Berntsen Source Type: research
Review of COVID-19 Therapeutics by Mechanism: From Discovery to Approval
J Korean Med Sci. 2024 Apr 15;39(14):e134. doi: 10.3346/jkms.2024.39.e134.ABSTRACTThe global research and pharmaceutical community rapidly mobilized to develop treatments for coronavirus disease 2019 (COVID-19). Existing treatments have been repurposed and new drugs have emerged. Here we summarize mechanisms and clinical trials of COVID-19 therapeutics approved or in development. Two reviewers, working independently, reviewed published data for approved COVID-19 vaccines and drugs, as well as developmental pipelines, using databases from the following organizations: United States Food and Drug Administration (US-FDA), Euro...
Source: Journal of Korean Medical Science - April 16, 2024 Category: Biomedical Science Authors: Hee Sun Choi A Young Choi Jeffrey B Kopp Cheryl A Winkler Sung Kweon Cho Source Type: research
