Streptococcus salivarius ameliorates the destructive effect on the epithelial barrier by inhibiting the growth of Prevotella melaninogenica via metabolic acid production
ConclusionsThese results suggest that liveS. salivarius or its cell-free supernatant significantly ameliorated the disruption of epithelial tight junctions induced byP. melaninogenica, likely through the inhibition ofP. melaninogenica growth mediated by metabolic acid production. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - May 1, 2024 Category: Microbiology Authors: Pingyi Zhu,
Ruru Shao,
Pan Xu,
Ruowen Zhao,
Chen Zhao,
Jian Fei,
Yuan He Tags: ORIGINAL ARTICLE Source Type: research
Use of oxazolidinones (linezolid or tedizolid) for the treatment of breast infections. A case series from a tertiary referral hospital
ConclusionsOxazolidinones could be considered as an alternative for treating breast infections. (Source: Infection)
Source: Infection - May 1, 2024 Category: Infectious Diseases Source Type: research
Mycobacterium immunogenum acquisition from hospital tap water: a genomic and epidemiologic analysis
Journal of Clinical Microbiology, Ahead of Print. (Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - May 1, 2024 Category: Microbiology Authors: Arthur W. BakerSophie E. NickFan JiaAmanda M. GravesBobby G. WarrenSofia ZavalaJason E. StoutMark J. LeeBarbara D. AlexanderRebecca M. DavidsonDeverick J. Anderson1Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina Source Type: research
Validation of a qualitative real-time PCR assay for the detection of Candida auris in hospital inpatient screening
Journal of Clinical Microbiology, Ahead of Print. (Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - May 1, 2024 Category: Microbiology Authors: Lauren C. FrancoMahmoud AhmedChristopher G. KendraR. Matthew SperlingKayla Van BentenJohn-Paul LavikChristopher L. EmeryRyan F. RelichKenneth Gavina1Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indi Source Type: research
Tunable Release of Ions from Graphene Oxide Laminates for Sustained Antibacterial Activity in a Biomimetic Environment
In this study, the tunable, slow, and longer-term release of silver ions from the two -dimensional (2D) nanocapillaries of graphene oxide (GO) laminates incorporated with silver ions (Ag-GO) for antimicrobial applications are successfully demonstrated. To closely mimic a physiologically relevant serum-based environment, a novel in vitro study model using 100% fetal bovine serum (FBS) is introduced as the test medium for microbiology, biocompatibility, and bioactivity studies. To emulate fluid circulation in a physiological environment, the in vitro studies are challenged with serum exchange protocols on different days. The...
Source: Small - April 30, 2024 Category: Nanotechnology Authors: Swathi Suran,
Negin Kamyar,
Kun Huang,
Farzad Foroutan,
Premlal Balakrishna Pillai,
Xuzhao Liu,
John Vaughan,
Darren Wilson,
Philip J. Day,
Rahul R. Nair Tags: Research Article Source Type: research
Characterization of tongue coating microbiome from patients with colorectal cancer
CONCLUSION: These results elucidate the use of tongue coating microbiome in CRC patients firstly, and the fur-types observed contribute to a better understanding of the microbial community in human. Furthermore, the tongue coating microbiota-based biomarkers provide a valuable reference for CRC prediction and diagnosis.PMID:38686186 | PMC:PMC11057396 | DOI:10.1080/20002297.2024.2344278 (Source: Journal of Oral Microbiology)
Source: Journal of Oral Microbiology - April 30, 2024 Category: Microbiology Authors: Qubo Chen Xiaoting Huang Haiyan Zhang Xuanting Jiang Xuan Zeng Wanhua Li Hairong Su Ying Chen Fengye Lin Man Li Xiangyu Gu Huihui Jin Ruohan Wang Dechang Diao Wei Wang Jin Li Sufen Wei Weizheng Zhang Wofeng Liu Zhiping Huang Yusheng Deng Wen Luo Zuofeng L Source Type: research
Outcomes of Adjunctive Therapy with Open Arthrotomy for Patients with Septic Arthritis Due to Melioidosis: A Retrospective Study
Am J Trop Med Hyg. 2024 Apr 30:tpmd230812. doi: 10.4269/ajtmh.23-0812. Online ahead of print.ABSTRACTMelioidosis is a potentially fatal infection caused by the bacterium Burkholderia pseudomallei. Septic arthritis caused by this infection is uncommon and difficult to treat. The role of adjunctive open arthrotomy in this type of infection has not yet been elucidated. We conducted a retrospective study of patients with microbiologically confirmed melioidosis between January 2002 and December 2022. Patients with a clinical condition of septic arthritis and positive cultures for B. pseudomallei were included. Comparisons were ...
Source: The American Journal of Tropical Medicine and Hygiene - April 30, 2024 Category: Tropical Medicine Authors: Sorawit Chittrakarn Pisud Siripaitoon Narongdet Kositpantawong Siripen Kanchanasuwan Duangkamol Aiewruengsurat Piyawat Bintachitt Boonsri Charoenmak Monchana Jullangkoon Sarunyou Chusri Source Type: research
Doxycycline, levofloxacin, and moxifloxacin are superior to ciprofloxacin in treating anthrax meningitis in rabbits and NHP
Antimicrob Agents Chemother. 2024 Apr 30:e0161023. doi: 10.1128/aac.01610-23. Online ahead of print.ABSTRACTEfficient treatment of anthrax-related meningitis in patients poses a significant therapeutic challenge. Previously, we demonstrated in our anthrax meningitis rabbit model that ciprofloxacin treatment is ineffective with most of the treated animals succumbing to the infection. Herein we tested the efficacy of doxycycline in our rabbit model and found it highly effective. Since all of our findings are based on a rabbit model, we test the efficacy of ciprofloxacin or doxycycline in a specific central nervous system (CN...
Source: Antimicrobial Agents and Chemotherapy - April 30, 2024 Category: Microbiology Authors: Amir Ben-Shmuel Itai Glinert Assa Sittner Elad Bar-David Josef Schlomovitz Haim Levy Shay Weiss Source Type: research
Efficacy of an oral lipid nanocrystal formulation of amphotericin B (MAT2203) in the neutropenic mouse model of pulmonary mucormycosis
Antimicrob Agents Chemother. 2024 Apr 30:e0154023. doi: 10.1128/aac.01540-23. Online ahead of print.ABSTRACTInvasive mucormycosis (IM) is associated with high mortality and morbidity. MAT2203 is an orally administered lipid nanocrystal formulation of amphotericin B, which has been shown to be safe and effective against other fungal infections. We sought to compare the efficacy of MAT2203 to liposomal amphotericin B (LAMB) treatment in a neutropenic mouse model of IM due to Rhizopus arrhizus var. delemar or Mucor circinelloides f. jenssenii DI15-131. In R. arrhizus var. delemar-infected mice, 15 mg/kg of MAT2203 qd was as e...
Source: Antimicrobial Agents and Chemotherapy - April 30, 2024 Category: Microbiology Authors: Yiyou Gu Teclegiorgis Gebremariam Sondus Alkhazraji Eman Youssef Sabrina El-Gamal Theresa Matkovits Jenel Cobb Raphael Mannino Ashraf S Ibrahim Source Type: research
The nucleoside analog 4'-fluorouridine suppresses the replication of multiple enteroviruses by targeting 3D polymerase
In this study, we found that 4'-fluorouridine (4'-FlU), a nucleoside analog with low cytotoxicity, exhibited broad-spectrum activity against infections of multiple enteroviruses with EC50 values at low micromolar levels, including coxsackievirus A10 (CV-A10), CV-A16, CV-A6, CV-A7, CV-B3, enterovirus A71 (EV-A71), EV-A89, EV-D68, and echovirus 6. With further investigation, the results indicated that 4'-FlU directly interacted with the RNA-dependent RNA polymerase of enterovirus, the 3D pol, and impaired the polymerase activity of 3D pol, hence inhibiting viral RNA synthesis and significantly suppressing viral replication. ...
Source: Antimicrobial Agents and Chemotherapy - April 30, 2024 Category: Microbiology Authors: Yongkang Chen Xiaohong Li Fengyang Han Beihong Ji Yuan Li Jingjing Yan Min Wang Jun Fan Shuye Zhang Lu Lu Peng Zou Source Type: research
The ecto-3'-nucleotidase activity of Acanthamoeba castellanii trophozoites increases their adhesion to host cells through the generation of extracellular adenosine
Eur J Protistol. 2024 Apr 26;94:126086. doi: 10.1016/j.ejop.2024.126086. Online ahead of print.ABSTRACTAcanthamoeba castellanii, a free-living amoeba, can be pathogenic to humans causing a corneal infection named Acanthamoeba keratitis (AK). The mannose-binding protein (MBP) is well established as the major factor related to Acanthamoeba pathogenesis. However, additional factors that participate in the adhesion process and protect trophozoites from cytolytic effects caused by host immune responses remain unknown. Ectonucleotidases, including 3'-nucleotidase/nuclease (3'-NT/NU), a bifunctional enzyme that was recently repor...
Source: European Journal of Protistology - April 30, 2024 Category: Microbiology Authors: Eduarda de Souza-Maciel Luiz Fernando Carvalho-Kelly Anita Leocadio Freitas-Mesquita Jos é Roberto Meyer-Fernandes Source Type: research
Contractile vacuoles: a rapidly expanding (and occasionally diminishing?) understanding
Eur J Protistol. 2024 Mar 26;94:126078. doi: 10.1016/j.ejop.2024.126078. Online ahead of print.ABSTRACTOsmoregulation is the homeostatic mechanism essential for the survival of organisms in hypoosmotic and hyperosmotic conditions. In freshwater or soil dwelling protists this is frequently achieved through the action of an osmoregulatory organelle, the contractile vacuole. This endomembrane organelle responds to the osmotic challenges and compensates by collecting and expelling the excess water to maintain the cellular osmolarity. As compared with other endomembrane organelles, this organelle is underappreciated and under-s...
Source: European Journal of Protistology - April 30, 2024 Category: Microbiology Authors: Kiran J More Harpreet Kaur Alastair G B Simpson Frederick W Spiegel Joel B Dacks Source Type: research
Broadly neutralizing antibodies for HIV prevention: a comprehensive review and future perspectives
Clin Microbiol Rev. 2024 Apr 30:e0015222. doi: 10.1128/cmr.00152-22. Online ahead of print.ABSTRACTSUMMARYThe human immunodeficiency virus (HIV) epidemic remains a formidable global health concern, with 39 million people living with the virus and 1.3 million new infections reported in 2022. Despite anti-retroviral therapy's effectiveness in pre-exposure prophylaxis, its global adoption is limited. Broadly neutralizing antibodies (bNAbs) offer an alternative strategy for HIV prevention through passive immunization. Historically, passive immunization has been efficacious in the treatment of various diseases ranging from onco...
Source: Clinical Microbiology Reviews - April 30, 2024 Category: Microbiology Authors: Sharana Mahomed Source Type: research
< em > Anaerolentibacter hominis < /em > gen. nov. sp. nov., < em > Diplocloster hominis < /em > sp. nov. and < em > Pilosibacter fragilis < /em > gen. nov. sp. nov., isolated from human faeces
Int J Syst Evol Microbiol. 2024 Apr;74(4). doi: 10.1099/ijsem.0.006359.ABSTRACTThree Gram-positive, obligately anaerobic bacterial strains, namely CSJ-1T, CSJ-3T, and CSJ-4T, were isolated from faeces of healthy persons. They were characterized through a combination of whole-genome sequencing, phenotypic traits, and metabolomic analysis. The genome sizes of CSJ-1T, CSJ-4T, and CSJ-3T were 3.3, 3.8, and 6.1 Mbp, with DNA G+C contents of 47.2, 48.3, and 48.8 mol%, respectively. Strain CSJ-3T was identified as representing a novel species, Diplocloster hominis (type strain CSJ-3T=CGMCC 1.18033T=JCM 36512T) of the genus Diploc...
Source: International Journal of Systematic and Evolutionary Microbiology - April 30, 2024 Category: Microbiology Authors: Yang Yan Qing-Hua Zhao Chang Xu Rui-Qi Wei He Jiang Shuang-Jiang Liu Source Type: research
Disease-induced changes in bacterial and fungal communities from plant below- and aboveground compartments
In this study, we investigated the bacterial and fungal communities in bulk soil, rhizosphere soil, root, stem, and leaf of both healthy and infected (Potato virus Y disease, PVY) plants. The results indicated that bacterial and fungal communities showed different recruitment strategies in plant organs. The number and abundance of shared bacterial ASVs between bulk and rhizosphere soils decreased with ascending migration from below- to aboveground compartments, while the number and abundance of fungal ASVs showed no obvious changes. Field type, plant compartments, and PVY infection all affected the diversity and structures...
Source: Applied Microbiology and Biotechnology - April 30, 2024 Category: Microbiology Authors: Mingfeng Cao Songqing Huang Jingjing Li Xiaoming Zhang Yi Zhu Jingzhao Sun Li Zhu Yong Deng Jianqiang Xu Zhihua Zhang Qiang Li Jixiang Ai Tian Xie Hengli Li Huaqun Yin Wuyuan Kong Yabing Gu Source Type: research
