Effects of Smoking on Clinical and Microbiological Response in Individuals With Periodontitis
Conditions: Periodontitis; Smoking Habit; Subgingival Plaque Interventions: Procedure: Non-surgical periodontal therapy Sponsors: Trakya University Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 25, 2024 Category: Research Source Type: clinical trials

Dynamic Full-field Optical Coherence Tomography for Structural and Microbiological Characterization of Endotracheal Tube Biofilm in Critically Ill Patients
Conditions: Healthcare Associated Infection; Critically Ill; Endotracheal Tube Interventions: Other: •Dynamic Full-Field Optical Coherence Tomography analysis of endotracheal tube Sponsors: Centre Hospitalier Universitaire Dijon Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 23, 2024 Category: Research Source Type: clinical trials

The clinical value of mNGS of bronchoalveolar lavage fluid versus traditional microbiological tests for pathogen identification and prognosis of severe pneumonia (NT-BALF):study protocol for a prospective multi-center randomized clinical trial
DiscussionThe clinical benefits of mNGS are potentially significant, but its limitations should also be considered.Trial registrationChineseClinicalTrialRegistry.org, ChiCTR2300076853. Registered on 22 October 2023. (Source: Trials)
Source: Trials - April 22, 2024 Category: Research Source Type: clinical trials

Clinical and Microbiological Evaluation of Laser Assisted New Attachment Procedure (LANAP) Using Nd:Yag vs. Diode Laser in the Management Of Stage II Periodontitis
Conditions: Periodontal Diseases Interventions: Device: Laser Assisted New Attachment Procedure using ND:YAG laser; Device: Laser Assisted New Attachment Procedure using diode laser; Procedure: Scaling and Root Planing using ultrasonic and curettes Sponsors: Mahmoud Salem Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 11, 2024 Category: Research Source Type: clinical trials

Australasian Malignant PLeural Effusion (AMPLE)-4 trial: study protocol for a multi-centre randomised trial of topical antibiotics prophylaxis for infections of indwelling pleural catheters
DiscussionResults from this trial will determine the efficacy of mupirocin prophylaxis in patients who require IPC for MPE. It will provide data on infection rates, microbiology, and potentially infection pathways associated with IPC-related infections.Ethics and disseminationSir Charles Gairdner and Osborne Park Health Care Group Human Research Ethics Committee has approved the study (RGS0000005920). Results will be published in peer-reviewed journals and presented at scientific conferences.Trial registrationAustralia New Zealand Clinical Trial Registry ACTRN12623000253606. Registered on 9 March 2023. (Source: Trials)
Source: Trials - April 10, 2024 Category: Research Source Type: clinical trials

Microbiological Structure of Pathogens of Periprosthetic Infection of Large Joints in the Post-Covid Period
Conditions: Joint Infection; Periprosthetic Left Knee Joint Infection Interventions: Diagnostic Test: Microbiological examination of the patient ' s biological material and determination of antibiotic resistance Sponsors: Federal State Budgetary Organization, Federal Center for Traumatology, Orthopedics and Arthroplasty Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 20, 2024 Category: Research Source Type: clinical trials

Community-Acquired Pneumonia Diagnosis Through Integrating Novel Microbiological Techniques.
Conditions: Community-acquired Pneumonia Interventions: Diagnostic Test: Multiplex PCR Sponsors: Assiut University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 14, 2024 Category: Research Source Type: clinical trials

Study of the Safety and Tolerability of the Broad-spectrum Probiotic Medicine " AS-Probionorm "
Conditions: Intestinal Infections; Dysbacteriosis Interventions: Drug: " AS-Probionorm " Sponsors: Industrial Microbiology LLP Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 12, 2024 Category: Research Source Type: clinical trials

Dynamic Full-Field Optical Coherence Tomography for Structural and Microbiological Characterization of Central Venous Catheter-deposited Biofilm in Critically Ill Patients
Conditions: Healthcare Associated Infection; Critically Ill; Central Venous Catheter Associated Bloodstream Infection Interventions: Other: D-FF-OCT analysis of CVC Sponsors: Centre Hospitalier William Morey - Chalon sur Sa ône; Centre Hospitalier Universitaire Dijon Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 22, 2024 Category: Research Source Type: clinical trials

Broad-spectrum antibiotic prophylaxis in tumor and infected orthopedic surgery —the prospective-randomized, microbiologist-blinded, stratified, superiority trials: BAPTIST Trials
DiscussionIn selected patients with a high risk for infections due to selection of prophylaxis-resistant SSI, a broad-spectrum combination with vancomycin and gentamycin might prevent SSIs (and other postoperative infections) better than the prophylaxis with cefuroxime.Trial registrationClinicalTrial.gov NCT05502380. Registered on 12 August 2022.  Protocol version: 2 (3 June 2022) (Source: Trials)
Source: Trials - January 19, 2024 Category: Research Source Type: clinical trials

Acurx Announces Positive Comparative Microbiology and Microbiome Data for Ibezapolstat from Phase 2b Clinical Trial in CDI Patients
Ibezapolstat outperformed vancomycin showing eradication of fecal C. difficile at Day 3 of treatment in 15 of 16 treated patients (94%), versus vancomycin which had eradication of C. difficile in 10 of 14 treated patients (71%). Ibezapolstat, but... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - January 17, 2024 Category: Pharmaceuticals Source Type: clinical trials

Epidemiological Study of Vulvovaginal Candidiases Strain Types and Risk Factors Among Gynecological Outpatients in China
Conditions: Vulvovaginal Candidiases Interventions: Diagnostic Test: microbiology testing Sponsors: Beijing Tsinghua Chang Gung Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 11, 2024 Category: Research Source Type: clinical trials

Appropriate Use of Blood Cultures in the Emergency Department Through Machine Learning
Conditions: Artificial Intelligence; Machine Learning; Microbiology; Emergency Service, Hospital; Randomized Controlled Trial Interventions: Device: Blood culture prediction tool Sponsors: Amsterdam UMC, location VUmc Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 11, 2023 Category: Research Source Type: clinical trials

The Surveillance Clinical Study of Rickettsiosis
Conditions: Rickettsiosis Sponsors: Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 8, 2023 Category: Research Source Type: clinical trials

Ultrasound-guided Blood Sampling Drawing for Microbiological Analysis in the Critically Ill
Conditions: Sepsis; Septic Shock; Infections; Diagnosis Interventions: Diagnostic Test: Ultrasound-guided venipuncture Sponsors: Fondazione Policlinico Universitario Agostino Gemelli IRCCS Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 5, 2023 Category: Research Source Type: clinical trials