Tuberculosis (TB) Aftermath: study protocol for a hybrid type I effectiveness-implementation non-inferiority randomized trial in India comparing two active case finding (ACF) strategies among individuals treated for TB and their household contacts
DiscussionThis novel trial will guide India ’s scale-up of post-treatment ACF and provide an evidence base for designing strategies to detect recurrent and new TB in other high burden settings.Trial registrationNCT04333485, registered April 3, 2020.CTRI/2020/05/025059 [Clinical Trials Registry of India], registered May 6 2020. (Source: Trials)
Source: Trials - August 5, 2022 Category: Research Source Type: clinical trials
GeneXpert or chest-X-ray or tuberculin skin testing for household contact assessment (GXT): protocol for a cluster-randomized trial
DiscussionThis randomized trial is meant to provide high-quality evidence to inform WHO recommendations on investigation of household contacts, as currently these are based on very low-quality evidence.Trial registrationClinicalTrials.gov NCT04528823. (Source: Trials)
Source: Trials - August 2, 2022 Category: Research Source Type: clinical trials
Impact of rapid molecular testing on diagnosis, treatment and management of community-acquired pneumonia in Norway: a pragmatic randomised controlled trial (CAPNOR)
DiscussionWe will examine if rapid use of FAPplus panel in hospitalized patients with suspected CAP can improve both the time to and the proportion of patients receiving pathogen-directed treatment, thereby shortening the exposure to unnecessary antibiotics and the length of hospital admission, compared to the standard-of-care arm. The pragmatic design together with broad inclusion criteria and a straightforward intervention could make our results generalizable to other similar centres.Trial registrationClinicalTrials.govNCT04660084. Registered on December 9, 2020 (Source: Trials)
Source: Trials - August 1, 2022 Category: Research Source Type: clinical trials
Microbiology in Obstructive BIliary Disease
Condition: Biliary Disease Intervention: Diagnostic Test: ERCP biliary culture Sponsor: Hospital Universitario Dr. Jose E. Gonzalez Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 19, 2022 Category: Research Source Type: clinical trials
