Tribute: Edward ‘Ned’ Lally
Molecular Oral Microbiology, EarlyView. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - October 21, 2019 Category: Microbiology Authors: Bruce J. Shenker, Kathleen Boesze ‐Battaglia, Caroline A. Genco, Ann Progulske‐Fox Tags: Tribute Source Type: research

Streptococcal peptides that signal Enterococcus faecalis cells carrying the pheromone ‐responsive conjugative plasmid pAM373
AbstractPheromone ‐mediated conjugative transfer of enterococcal plasmids can contribute to the dissemination of genes involved in antibiotic resistance, fitness, and virulence among co‐residents of mixed microbial communities. We have previously shown that intergeneric signaling by theStreptococcus gordonii strain Challis heptapeptide s.g.cAM373 (SVFILAA) induces an aggregation ‐substance‐mediated mating response and facilitates plasmid transfer fromEnterococcus faecalis cells carrying the pheromone ‐responsive plasmid pAM373 to both pheromone producing and non‐pheromone producing oral streptococcal recipients...
Source: Molecular Oral Microbiology - October 14, 2019 Category: Microbiology Authors: M. Margaret Vickerman, Jillian M. Mansfield Tags: ORIGINAL ARTICLE Source Type: research

Type I Interferon and Interferon ‐stimulated Gene Expression in Oral Epithelial Cells
AbstractOral epithelial cells (OEC) represent the first site of host interaction with viruses that infect the body through the oral route, however their innate antiviral defense mechanisms have yet to be defined. Previous studies have determined that OEC express pathogen ‐, damage‐ or danger‐associated molecular patterns (PAMPs, or DAMPs), but their expression of key antiviral innate immune mediators, including type I interferons (type I IFN) and interferon‐stimulated genes (ISGs) has not been studied extensively. We used the oral keratinocyte cell line, OKF 6/TERT1 in the presence and absence of the viral mimics p...
Source: Molecular Oral Microbiology - September 13, 2019 Category: Microbiology Authors: David C. Brice, Erika Figgins, Fahong Yu, Gill Diamond Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
Molecular Oral Microbiology, Volume 34, Issue 5, Page i-iv, October 2019. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - September 12, 2019 Category: Microbiology Tags: ISSUE INFORMATION Source Type: research

Type IX secretion system is pivotal for expression of gingipain ‐associated virulence of Porphyromonas gingivalis
This article is protected by copyright. All rights reserved. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - August 20, 2019 Category: Microbiology Authors: Malgorzata Benedyk, Agata Marczyk, Barbara Chru ścicka Tags: Original Article Source Type: research

Peptide and non ‐peptide mimetics as potential therapeutics targeting oral bacteria and oral biofilms
This article is protected by copyright. All rights reserved. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - August 7, 2019 Category: Microbiology Authors: Maryta N. Sztukowska, Mohammad Roky, Donald R. Demuth Tags: Invited Review Source Type: research

Sortase A ‐mediated modification of the Streptococcus mutans transcriptome and virulence traits
This article is protected by copyright. All rights reserved. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - July 25, 2019 Category: Microbiology Authors: Xuan Chen, Yuanli He, Haixia Liu, Ying Song, Kaixin Xiong, Xian Peng, Chengcheng Liu, Ling Zou Tags: Original Article Source Type: research

Regulation of IL ‐24 in human oral keratinocytes stimulated with Tannerella forsythia
This article is protected by copyright. All rights reserved. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - July 22, 2019 Category: Microbiology Authors: Yeon ‐Kyeong Ko, Sun‐Jin An, Na‐Young Han, Hookeun Lee, Bong‐Kyu Choi Tags: Original Article Source Type: research

Issue Information
Molecular Oral Microbiology, Volume 34, Issue 4, Page i-iv, August 2019. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - July 11, 2019 Category: Microbiology Tags: ISSUE INFORMATION Source Type: research

EzrA, a cell shape regulator contributing to biofilm formation and competitiveness in Streptococcus mutans
This article is protected by copyright. All rights reserved. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - July 9, 2019 Category: Microbiology Authors: Zhenting Xiang, Zongbo Li, Zhi Ren, Jumei Zeng, Xian Peng, Yuqing Li, Jiyao Li Tags: ORIGINAL ARTICLE Source Type: research

Differential responses of endothelial cells on three ‐dimensional scaffolds to lipopolysaccharides from periodontopathogens
This article is protected by copyright. All rights reserved. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - July 4, 2019 Category: Microbiology Authors: Diego Fernando Gualtero, Gloria Ines Lafaurie, Marta Raquel Fontanilla Tags: Original Article Source Type: research

Characterization of a stress tolerance ‐defective mutant of Lactobacillus rhamnosus LRB
In this study we usedL.  rhamnosus LRB to isolate one spontaneous mutant that was sensitive to acid stress. The mutant, which we named RBM1, also displayed sensitivity to a wide range of stresses including osmotic, thermal, and others. Using whole genome sequencing, we mapped the putative mutations in the mutant strain. It appears that three single nucleotide substitutions occurred in the mutant as compared to the wild ‐type LRB strain. Among those, the most relevant mutation occurred in theftsH gene that created a single amino acid change in the protein. We performed a comparative proteomic study to understand the ...
Source: Molecular Oral Microbiology - June 7, 2019 Category: Microbiology Authors: Saswati Biswas, Andrew Keightley, Indranil Biswas Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
Molecular Oral Microbiology, Volume 34, Issue 3, Page i-iv, June 2019. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - May 15, 2019 Category: Microbiology Tags: ISSUE INFORMATION Source Type: research

Characterization of a stress tolerance defective mutant of Lactobacillus rhamnosus LRB
This article is protected by copyright. All rights reserved. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - May 5, 2019 Category: Microbiology Authors: Saswati Biswas, Andrew Keightley, Indranil Biswas Tags: Original Article Source Type: research

Plausible role of bacterial toxin –antitoxin system in persister cell formation and elimination
Targeting toxin ‐antitoxin systems for elimination of persisters:Under the influence of several micro‐environmental factors (temperature, pH etc…), the antitoxin component gets degraded resulting in a proportionate increase of toxin levels (T> A) that induces the formation of persister bacteria (red colour). On three varying conditions (Conditional cooperativity, Cellular detoxification and Use of toxin inhibitors), the antitoxin level becomes high (A> T) resulting in awakening of persister bacteria. After regrowth of persisters (green colour), antimicrobials can be applied to eliminate these pathogens. Al...
Source: Molecular Oral Microbiology - May 2, 2019 Category: Microbiology Authors: Prajita Paul, Bikash R. Sahu, Mrutyunjay Suar Tags: REVIEW ARTICLE Source Type: research

Membrane proteomic analysis reveals overlapping and independent functions of Streptococcus mutans Ffh, YidC1, and YidC2
This article is protected by copyright. All rights reserved. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - April 29, 2019 Category: Microbiology Authors: Surabhi Mishra, Paula J. Crowley, Katherine R. Wright, Sara R. Palmer, Alejandro R. Walker, Susmita Datta, L. Jeannine Brady Tags: Original Article Source Type: research

Resveratrol attenuates the pathogenic and inflammatory properties of Porphyromonas gingivalis
This article is protected by copyright. All rights reserved. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - April 4, 2019 Category: Microbiology Authors: Amel Ben Lagha, Elisoa Andrian, Daniel Grenier Tags: Original Article Source Type: research

Induction and Inhibition of Oral Malodor
This article is protected by copyright. All rights reserved. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - March 30, 2019 Category: Microbiology Authors: Nao Suzuki, Masahiro Yoneda, Toru Takeshita, Takao Hirofuji, Takashi Hanioka Tags: Invited Review Source Type: research

The bare necessities: Uncovering essential and condition ‐critical genes with transposon sequencing
In this article we review transposon ‐sequencing (Tn‐seq) technologies and how they have been applied to the study of oral microbiology. This technology has revealed genes that are essential for bacterial fitness in a multitude of different environments, discovering potential new therapeutic targets for the treatment of oral diseas es. AbstractQuerying gene function in bacteria has been greatly accelerated by the advent of transposon sequencing (Tn ‐seq) technologies (related Tn‐seq strategies are known as TraDIS, INSeq, RB‐TnSeq, and HITS). Pooled populations of transposon mutants are cultured in an environment ...
Source: Molecular Oral Microbiology - March 19, 2019 Category: Microbiology Authors: Robert C. Shields, Paul A. Jensen Tags: INVITED REVIEW Source Type: research

The roles of NADPH oxidase in modulating neutrophil effector responses
Activation of neutrophil NADPH oxidase (NOX2) enzyme complex generates reactive oxygen species (ROS). ROS generated play critical roles in the activation and redox modulation of neutrophil antimicrobial capacity and effector functions. Neutrophils are phagocytic innate immune cells essential for killing bacteria via activation of a wide variety of effector responses and generation of large amounts of reactive oxygen species (ROS). Majority of the ROS in neutrophils is generated by activation of the superoxide ‐generating enzyme nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. Independent of their anti‐micro...
Source: Molecular Oral Microbiology - March 19, 2019 Category: Microbiology Authors: Melody Y. Zeng, Irina Miralda, Cortney L. Armstrong, Silvia M. Uriarte, Juhi Bagaitkar Tags: INVITED REVIEW Source Type: research

Issue Information
Molecular Oral Microbiology, Volume 34, Issue 2, Page i-iv, April 2019. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - March 19, 2019 Category: Microbiology Tags: ISSUE INFORMATION Source Type: research

Global analysis of lysine succinylome in the periodontal pathogen Porphyromonas gingivalis
In this study, we used a highly sensitive proteomics approach combining affinity enrichment with high ‐resolution liquid chromatography coupled with tandem mass spectrometry to examine Ksuc inP gingivalis. In total, 345 Ksuc sites in 233 proteins were identified and determined to be involved in a variety of cellular processes. In the region surrounding Ksuc sites, lysine residues were drastically overrepresented and sequence motifs with succinyl ‐lysine flanked by a lysine at the +3 or +6 positions appear to be unique to this pathogen. Additionally, our results suggest a crosstalk between Ksuc and glycosylation, but th...
Source: Molecular Oral Microbiology - March 19, 2019 Category: Microbiology Authors: Leng Wu, Tao Gong, Xuedong Zhou, Jumei Zeng, Ruijie Huang, Yafei Wu, Yuqing Li Tags: ORIGINAL ARTICLE Source Type: research

Streptococcus mutans serotypes and collagen ‐binding proteins Cnm/Cbm in children with caries analysed by PCR
This study is the first to report on the prevalence ofS. mutans serotypes in a United States population using the PCR based identification approach with 3 sample types. The prevalence ofS. mutans serotypek reported herein is the highest reported to date and strains with both collagen ‐binding proteins Cbm and Cnm were observed. This study highlights the need for further study ofS. mutans serotypek and collagen ‐binding proteins in the overall health of patients in the United States. Streptococcus mutans, a primary bacterium associated with dental caries, has four known clinical serotypes (c, e, fandk). Certain serotype...
Source: Molecular Oral Microbiology - March 19, 2019 Category: Microbiology Authors: Stephanie S. Momeni, Tariq Ghazal, Hernan Grenett, Jennifer Whiddon, Stephen A. Moser, Noel K. Childers Tags: ORIGINAL ARTICLE Source Type: research

Regulation of water ‐soluble glucan synthesis by the Streptococcus mutans dexA gene effects biofilm aggregation and cariogenic pathogenicity
In this study, we identify the role of theS mutans dexAgene in dextran ‐dependent aggregation in biofilm formation. Our results show that deletion ofdexA (SmudexA) results in increased transcription of EPS synthesis ‐related genes, includinggtfB, gtfD, andftf. Interestingly, we reveal that inactivating thedexA gene may lead to elevated WSG synthesis inS mutans , which results in dysregulated cariogenicity in vivo. Furthermore, structural analysis provides new insights regarding the lack of mannose monosaccharides, especially in the WSG synthesis of theSmudexA mutants. The biofilm phenotypes that are associated with the...
Source: Molecular Oral Microbiology - March 19, 2019 Category: Microbiology Authors: Yan Yang, Mengying Mao, Lei Lei, Meng Li, Jiaxin Yin, Xinrong Ma, Xiang Tao, Yingming Yang, Tao Hu Tags: ORIGINAL ARTICLE Source Type: research

Plausible role of bacterial toxin anti ‐toxin system in persister cell formation and elimination
This article is protected by copyright. All rights reserved. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - March 19, 2019 Category: Microbiology Authors: Prajita Paul, Bikash R. Sahu, Mrutyunjay Suar Tags: Review Article Source Type: research

Issue Information
Molecular Oral Microbiology, Volume 34, Issue 2, Page i-iv, April 2019. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - March 19, 2019 Category: Microbiology Tags: ISSUE INFORMATION Source Type: research

Plausible role of bacterial toxin anti ‐toxin system in persister cell formation and elimination
This article is protected by copyright. All rights reserved. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - March 19, 2019 Category: Microbiology Authors: Prajita Paul, Bikash R. Sahu, Mrutyunjay Suar Tags: Review Article Source Type: research

DMBT1 involvement in the human aortic endothelial cell response to Streptococcus mutans
This article is protected by copyright. All rights reserved. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - March 12, 2019 Category: Microbiology Authors: Takahiko Oho, Emi Nagata Tags: Original Article Source Type: research

The Bare Necessities: Uncovering Essential and Condition ‐Critical Genes with Transposon Sequencing
This article is protected by copyright. All rights reserved. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - February 9, 2019 Category: Microbiology Authors: Robert C. Shields, Paul A. Jensen Tags: Invited Review Source Type: research

Global Analysis of Lysine Succinylome in the Periodontal Pathogen Porphyromonas gingivalis
This article is protected by copyright. All rights reserved. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - January 23, 2019 Category: Microbiology Authors: Leng Wu, Tao Gong, Xuedong Zhou, Jumei Zeng, Ruijie Huang, Yafei Wu, Yuqing Li Tags: Original Article Source Type: research

Streptococcus mutans serotypes and Collagen ‐Binding Proteins Cnm/Cbm in Children with Caries analyzed by PCR
SummaryStreptococcus mutans, a primary bacterium associated with dental caries, has four known clinical serotypes (c, e, f, andk). Some serotypes, presence of multiple serotypes and strains with collagen ‐binding proteins (CBP, Cnm and Cbm) have been linked with systemic disease. Evaluation ofS. mutans serotype distribution and caries association is needed in the United States. The purpose of this study was to evaluate the prevalence ofS. mutans serotypes from two cohorts of African American children in rural Alabama using 3 sample types (saliva, plaque, and individualS. mutans isolates) by PCR detection for association ...
Source: Molecular Oral Microbiology - January 22, 2019 Category: Microbiology Authors: Stephanie S. Momeni, Tariq Ghazal, Hernan Grenett, Jennifer Whiddon, Stephen A. Moser, Noel K. Childers Tags: Original Article Source Type: research

Regulation of water ‐soluble glucan synthesis by the Streptococcus mutans dexA gene effects biofilm aggregation and cariogenic pathogenicity
This article is protected by copyright. All rights reserved. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - January 19, 2019 Category: Microbiology Authors: Yan Yang, Mengying Mao, Lei Lei, Meng Li, Jiaxin Yin, Xinrong Ma, Xiang Tao, Yingming Yang, Tao Hu Tags: Original Article Source Type: research

Issue Information
Molecular Oral Microbiology, Volume 34, Issue 1, Page i-iv, February 2019. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - January 16, 2019 Category: Microbiology Tags: ISSUE INFORMATION Source Type: research

Biofilm ‐induced profiles of immune response gene expression by oral epithelial cells
This study examined the oral epithelial immunotranscriptome response patterns modulated by oral bacterial planktonic or biofilm challenge. We assessed gene expression patterns when epithelial cells were challenged with a multispecies biofilm composed ofStreptococcus gordonii, Fusobacterium nucleatum, andPorphyromonas gingivalisrepresenting a type of periodontopathic biofilm compared to challenge with the same species of planktonic bacteria. Of the 579 human immunology genes, a substantial signal of the epithelial cells was observed to 181 genes. Biofilm challenged stimulated significant elevations compared to planktonic ba...
Source: Molecular Oral Microbiology - January 16, 2019 Category: Microbiology Authors: Jeffrey L. Ebersole, Rebecca Peyyala, Octavio A. Gonzalez Tags: ORIGINAL ARTICLE Source Type: research

The roles of NADPH oxidase in modulating neutrophil effector responses
This article is protected by copyright. All rights reserved. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - January 11, 2019 Category: Microbiology Authors: Melody Y Zeng, Irina Miralda, Cortney L Armstrong, Silvia M Uriarte, Juhi Bagaitkar Tags: Invited Review Source Type: research

Issue Information
Molecular Oral Microbiology, Volume 33, Issue 6, Page i-iv, December 2018. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - November 20, 2018 Category: Microbiology Tags: ISSUE INFORMATION Source Type: research

Biofilm Induced Profiles of Immune Response Gene Expression by Oral Epithelial Cells
ConclusionsA wide array of immune genes were regulated by oral bacterial challenge of epithelial cells that would be linked to the local activity of innate and adaptive immune response components in the gingival tissues. Incorporating bacterial species into a structured biofilm dramatically altered the number and level of genes expressed. Additionally a specific set of genes were significantly decreased with the multispecies biofilms suggesting that some epithelial cell biologic pathways are down ‐regulated when in contact with this type of pathogenic biofilm.This article is protected by copyright. All rights reserved. (...
Source: Molecular Oral Microbiology - November 8, 2018 Category: Microbiology Authors: J.L Ebersole, R. Peyyala, O.A. Gonzalez Tags: Original Article Source Type: research

Lipopolysaccharide from Escherichia coli stimulates osteogenic differentiation of human periodontal ligament stem cells through Wnt/ β‐catenin induced TAZ elevation
Molecular Oral Microbiology,Volume 0, Issue ja, -Not available-. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - November 2, 2018 Category: Microbiology Authors: Yixiao Xing, Yunpeng Zhang, Linglu Jia, Xin Xu Source Type: research

Genome editing in Streptococcus mutans through self ‐targeting CRISPR arrays
Molecular Oral Microbiology,Volume 0, Issue ja, -Not available-. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - October 17, 2018 Category: Microbiology Authors: Tao Gong, Boyu Tang, Xuedong Zhou, Jumei Zeng, Miao Lu, Xiaoxin Guo, Xian Peng, Lei Lei, Bo Gong, Yuqing Li Source Type: research

Transcriptional Responses of Streptococcus gordonii and Fusobacterium nucleatum to Coaggregation
Molecular Oral Microbiology,Volume 0, Issue ja, -Not available-. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - October 17, 2018 Category: Microbiology Authors: Naresh V.R. Mutha, Waleed K. Mohammed, Natalio Krasnogor, Geok Y. A. Tan, Siew Woh Choo, Nicholas S. Jakubovics Source Type: research

Characterization and development of SAPP as a specific peptidic inhibitor that targets Porphyromonas gingivalis
Molecular Oral Microbiology,Volume 0, Issue ja, -Not available-. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - October 9, 2018 Category: Microbiology Authors: M. Ho, R. J. Lamont, W. J. Chazin, H. Chen, D. F. Young, P. Kumar, H. Xie Source Type: research

A tripartite toxin ‐antitoxin module induced by quorum sensing is associated with the persistence phenotype in Streptococcus mutans
Molecular Oral Microbiology,Volume 0, Issue ja, -Not available-. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - October 9, 2018 Category: Microbiology Authors: Delphine Dufour, Alexandra Mankovskaia, Yuki Chan, Kamyar Motavaze, Siew ‐Ging Gong, Céline M. Lévesque Source Type: research

Issue Information
Molecular Oral Microbiology,Volume 33, Issue 5, Page i-iv, October 2018. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - September 26, 2018 Category: Microbiology Source Type: research

The contribution of Tannerella forsythia dipeptidyl aminopeptidase IV in the breakdown of collagen
Molecular Oral Microbiology,Volume 0, Issue ja, -Not available-. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - September 1, 2018 Category: Microbiology Authors: Susan Yost , Ana E Duran ‐Pinedo Source Type: research

Lactobacillus rhamnosus LRB mediated inhibition of oral streptococci
Molecular Oral Microbiology,Volume 0, Issue ja, -Not available-. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - August 7, 2018 Category: Microbiology Authors: Saswati Biswas , Lance Turner , Indranil Biswas Source Type: research

Porphyromonas gingivalis inhibits M2 activation of macrophages by suppressing α‐ketoglutarate production in mice
Molecular Oral Microbiology,Volume 0, Issue ja, -Not available-. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - July 14, 2018 Category: Microbiology Authors: Shihui Yu , Luyang Ding , Dongyu Liang , Lijun Luo Source Type: research

Issue Information
Molecular Oral Microbiology,Volume 33, Issue 4, Page i-iv, August 2018. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - July 11, 2018 Category: Microbiology Source Type: research

Potential role for Streptococcus gordonii ‐derived hydrogen peroxide in heme acquisition by Porphyromonas gingivalis
Molecular Oral Microbiology,Volume 33, Issue 4, Page 322-335, August 2018. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - July 11, 2018 Category: Microbiology Authors: J.L. Brown , E.A. Yates , M. Bielecki , T. Olczak , J.W. Smalley Source Type: research

Antibiotics alter the window of competence for natural transformation in streptococci
Molecular Oral Microbiology,Volume 0, Issue ja, -Not available-. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - July 3, 2018 Category: Microbiology Authors: Kjersti Stur ød , Gabriela Salvadori , Roger Junges , Fernanda Petersen Source Type: research