4CMenB Vaccination to Prevent Meningococcal B Disease in Vietnam: Expert Review and Opinion
AbstractAn advisory board meeting was held with experts in Vietnam (Hanoi, August 2022), to review the evidence on invasive meningococcal disease (IMD) epidemiology, clinical management, and meningococcal vaccines to reach a consensus on recommendations for meningococcal vaccination in Vietnam. IMD is a severe disease, with the highest burden in infants and children. IMD presents as meningitis and/or meningococcemia and can progress extremely rapidly. Almost 90% of deaths in children occur within the first 24 h, and disabling sequelae (e.g., limb amputations and neurological damage) occur in up to 20% of survivors. IMD p...
Source: Infectious Diseases and Therapy - March 2, 2024 Category: Infectious Diseases Source Type: research
Construction of an aerolysin-based multi-epitope vaccine against Aeromonas hydrophila: an in silico machine learning and artificial intelligence-supported approach
Aeromonas hydrophila, a gram-negative coccobacillus bacterium, can cause various infections in humans, including septic arthritis, diarrhea (traveler’s diarrhea), gastroenteritis, skin and wound infections, meningitis, fulminating septicemia, enterocolitis, peritonitis, and endocarditis. It frequently occurs in aquatic environments and readily contacts humans, leading to high infection rates. This bacterium has exhibited resistance to numerous commercial antibiotics, and no vaccine has yet been developed. Aiming to combat the alarmingly high infection rate, this study utilizes in silico techniques to design a multi-epito...
Source: Frontiers in Immunology - March 1, 2024 Category: Allergy & Immunology Source Type: research
Meningococcal Vaccination of Adolescents in the United States: Past Successes and Future Considerations
Invasive meningococcal disease (IMD) is a rare but serious illness, and adolescents and young adults in the United States are at increased risk. Here, we discuss US IMD history and how successful disease prevention through routine vaccination against the most common disease-causing serogroups (A, B, C, W, and Y) can inform future recommendations. Before the introduction of quadrivalent meningococcal conjugate (MenACWY) vaccines, most US cases of IMD were caused by serogroups B, C, and Y. After recommendation by the Advisory Committee on Immunization Practices for routine MenACWY vaccination of 11 −12-year-olds in 2005, f...
Source: Journal of Adolescent Health - March 1, 2024 Category: Child Development Authors: Jessica Presa, Jamie Findlow, Gregory D. Zimet Tags: Review article Source Type: research
Prevalence, serogroup distribution and risk factors of Neisseria meningitidis carriage in high school and university students in Hungary
In conclusion, we have found high asymptomatic meningococcus carriage rate among high school students and young adults, however, the majority of the colonizing meningococci were non-typable.PMID:38423809 | DOI:10.1016/j.vaccine.2024.02.064 (Source: Vaccine)
Source: Vaccine - February 29, 2024 Category: Allergy & Immunology Authors: Annam ária Huber Eszter Kov ács Andrea Horv áth Judit Sahin-T óth Ákos Kaptás Emese Juh ász Katalin Krist óf Orsolya Dobay Source Type: research
Co-administration of the adjuvanted recombinant zoster vaccine with other adult vaccines: An overview
CONCLUSIONS: Co-administration of RZV with routine vaccines does not significantly alter the reactogenicity, immunogenicity or safety of RZV or the co-administered vaccine. Healthcare practitioners should consider routine co-administration of RZV with other adult vaccines to improve vaccination coverage.PMID:38423814 | DOI:10.1016/j.vaccine.2024.02.035 (Source: Vaccine)
Source: Vaccine - February 29, 2024 Category: Allergy & Immunology Authors: S Omar Ali Christophe Dessart Raunak Parikh Source Type: research
Co-administration of the adjuvanted recombinant zoster vaccine with other adult vaccines: An overview
CONCLUSIONS: Co-administration of RZV with routine vaccines does not significantly alter the reactogenicity, immunogenicity or safety of RZV or the co-administered vaccine. Healthcare practitioners should consider routine co-administration of RZV with other adult vaccines to improve vaccination coverage.PMID:38423814 | DOI:10.1016/j.vaccine.2024.02.035 (Source: Herpes)
Source: Herpes - February 29, 2024 Category: Infectious Diseases Authors: S Omar Ali Christophe Dessart Raunak Parikh Source Type: research
Co-administration of the adjuvanted recombinant zoster vaccine with other adult vaccines: An overview
CONCLUSIONS: Co-administration of RZV with routine vaccines does not significantly alter the reactogenicity, immunogenicity or safety of RZV or the co-administered vaccine. Healthcare practitioners should consider routine co-administration of RZV with other adult vaccines to improve vaccination coverage.PMID:38423814 | DOI:10.1016/j.vaccine.2024.02.035 (Source: Vaccine)
Source: Vaccine - February 29, 2024 Category: Allergy & Immunology Authors: S Omar Ali Christophe Dessart Raunak Parikh Source Type: research
Prevalence, serogroup distribution and risk factors of Neisseria meningitidis carriage in high school and university students in Hungary
In conclusion, we have found high asymptomatic meningococcus carriage rate among high school students and young adults, however, the majority of the colonizing meningococci were non-typable.PMID:38423809 | DOI:10.1016/j.vaccine.2024.02.064 (Source: Vaccine)
Source: Vaccine - February 29, 2024 Category: Allergy & Immunology Authors: Annam ária Huber Eszter Kov ács Andrea Horv áth Judit Sahin-T óth Ákos Kaptás Emese Juh ász Katalin Krist óf Orsolya Dobay Source Type: research
High diversity within and low but significant genetic differentiation among geographic and temporal populations of the global Streptococcus pneumoniae
In this study, we investigated the spatial and temporal patterns of genetic variation of S. pneumoniae based on archived multilocus sequence typing data from PubMLST.org. Our analyses demonstrated both shared and unique distributions of sequence types (STs) and allele types among regional populations. Among the 17 915 global STs, 36 representing 15 263 isolates were broadly shared among all six continents, consistent with recent clonal dispersal and expansion of this pathogen. The analysis of molecular variance revealed that >96% genetic variations were found within individual regional populations. However, though...
Source: Canadian Journal of Microbiology - February 29, 2024 Category: Microbiology Authors: Jezreel Dalmieda Megan Hitchcock Jianping Xu Source Type: research
A conserved antigen induces respiratory Th17-mediated broad serotype protection against pneumococcal superinfection
Cell Host Microbe. 2024 Feb 21:S1931-3128(24)00037-4. doi: 10.1016/j.chom.2024.02.002. Online ahead of print.ABSTRACTSeveral vaccines targeting bacterial pathogens show reduced efficacy upon concurrent viral infection, indicating that a new vaccinology approach is required. To identify antigens for the human pathogen Streptococcus pneumoniae that are effective following influenza infection, we performed CRISPRi-seq in a murine model of superinfection and identified the conserved lafB gene as crucial for virulence. We show that LafB is a membrane-associated, intracellular protein that catalyzes the formation of galactosyl-g...
Source: Cell Host and Microbe - February 28, 2024 Category: Microbiology Authors: Xue Liu Laurye Van Maele Laura Matarazzo Daphn ée Soulard Vinicius Alves Duarte da Silva Vincent de Bakker Julien D énéréaz Florian P Bock Michael Taschner Jinzhao Ou Stephan Gruber Victor Nizet Jean-Claude Sirard Jan-Willem Veening Source Type: research
A conserved antigen induces respiratory Th17-mediated broad serotype protection against pneumococcal superinfection
Cell Host Microbe. 2024 Feb 21:S1931-3128(24)00037-4. doi: 10.1016/j.chom.2024.02.002. Online ahead of print.ABSTRACTSeveral vaccines targeting bacterial pathogens show reduced efficacy upon concurrent viral infection, indicating that a new vaccinology approach is required. To identify antigens for the human pathogen Streptococcus pneumoniae that are effective following influenza infection, we performed CRISPRi-seq in a murine model of superinfection and identified the conserved lafB gene as crucial for virulence. We show that LafB is a membrane-associated, intracellular protein that catalyzes the formation of galactosyl-g...
Source: Cell Host and Microbe - February 28, 2024 Category: Microbiology Authors: Xue Liu Laurye Van Maele Laura Matarazzo Daphn ée Soulard Vinicius Alves Duarte da Silva Vincent de Bakker Julien D énéréaz Florian P Bock Michael Taschner Jinzhao Ou Stephan Gruber Victor Nizet Jean-Claude Sirard Jan-Willem Veening Source Type: research
How common is otogenic meningitis? A retrospective study in southern Sweden over 18 years
ConclusionAOM is an important cause of meningitis in children and adults. Though bacterial meningitis almost disappeared in children < 2 years after the introduction of PCV, the incidence of pneumococcal meningitis in adults seems to have increased. (Source: Infection)
Source: Infection - February 28, 2024 Category: Infectious Diseases Source Type: research
Effect of Pneumococcal Conjugate Vaccine on Pneumonia Incidence Rates among Children 2-59 Months of Age, Mongolia, 2015-2021
Emerg Infect Dis. 2024 Mar;30(3):490-498. doi: 10.3201/eid3003.230864.ABSTRACTStarting in June 2016, the 13-valent pneumococcal conjugate vaccine (PCV13) was introduced into the routine immunization program of Mongolia by using a 2+1 dosing schedule, phased by district. We used prospective hospital surveillance to evaluate the vaccine's effect on pneumonia incidence rates among children 2-59 months of age over a 6-year period. Of 17,607 children with pneumonia, overall adjusted incidence rate ratios showed decreased primary endpoint pneumonia, very severe pneumonia, and probable pneumococcal pneumonia until June 2021. Resu...
Source: Emerging Infectious Diseases - February 26, 2024 Category: Infectious Diseases Authors: Claire von Mollendorf Munkhchuluun Ulziibayar Cattram D Nguyen Purevsuren Batsaikhan Bujinlkham Suuri Dashtseren Luvsantseren Dorj Narangerel John de Campo Margaret de Campo Bilegtsaikhan Tsolmon Sodbayar Demberelsuren Eileen M Dunne Catherine Satzke Tuya Source Type: research
