A Phase 3 Randomized Study to Evaluate Safety and Immunogenicity of 20-Valent Pneumococcal Conjugate Vaccine in Healthy Japanese Infants
Streptococcus pneumoniae is a leading cause of bacteremia, bacterial meningitis, pneumonia, and acute otitis media [1 –3]. Serious pneumococcal disease may occur at any age; however, children (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - January 17, 2024 Category: Infectious Diseases Authors: Yasunori Ishihara, Mitsuru Fukazawa, Shinya Enomoto, Richard de Solom, Masako Yamaji, Mary Kline, Masakazu Aizawa, Yahong Peng, Osamu Kogawara, Peter C. Giardina, Noor Tamimi, William C. Gruber, Wendy Watson Source Type: research
Serotype-specific quantification of residual free polysaccharide in multivalent pneumococcal conjugate vaccines
AbstractTheStreptococcus pneumoniae bacteria has over 100 known serotypes that display a continuous change in prevalence by patients ’ age and geographical location and therefore necessitate continued efforts toward development of new vaccines with broader protection. Glycoconjugate vaccines have been instrumental in reducing global morbidity and mortality caused byStreptococcus pneumoniae infections. In these vaccines, the bacterial polysaccharide is conjugated to a carrier protein to enhance immunogenicity. To ensure well defined immunogenicity and stability of conjugated vaccines, reliable quantification of non-conjug...
Source: Glycoconjugate Journal - January 15, 2024 Category: Biochemistry Source Type: research
Impact of Meningococcal ACWY Vaccination Program during 2017 –18 Epidemic, Western Australia, Australia
K. Ewe et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - January 11, 2024 Category: Infectious Diseases Source Type: research
Nasopharyngeal carriage of < i > Streptococcus pneumoniae < /i > among children < 5 years of age in Indonesia prior to pneumococcal conjugate vaccine introduction
by Dodi Safari, Wa Ode Dwi Daningrat, Jennifer L. Milucky, Miftahuddin Majid Khoeri, Wisiva Tofriska Paramaiswari, Wisnu Tafroji, Korrie Salsabila, Yayah Winarti, Amin Soebandrio, Sri Rezeki Hadinegoro, Ari Prayitno, Lana Childs, Fabiana C. Pimenta, Maria da Gloria Carvalho, Tamara Pilishvili
Pneumococcal conjugate vaccines (PCVs) prevent nasopharyngeal colonization with vaccine serotypes ofStreptococcus pneumoniae, leading to reduced transmission of pneumococci and stronger population-level impact of PCVs. In 2017 we conducted a cross-sectional pneumococcal carriage study in Indonesia among children aged (Source: PLoS One)
Source: PLoS One - January 11, 2024 Category: Biomedical Science Authors: Dodi Safari Source Type: research
Prevalence and resistance characteristics of multidrug-resistant Streptococcus pneumoniae isolated from the respiratory tracts of hospitalized children in Shenzhen, China
ConclusionThe introduction of PCV13 into China from 2017 has led to a shift in the dominant composition of pneumococcal strains. There has been a notable rise and spread of multidrug-resistant non-vaccine serotypes among children. Specifically, the non-vaccine serotype 6E, which was not widely reported in China previously, has emerged. To comprehend the resistance mechanisms, it is crucial to further investigate the molecular and genetic characteristics of these non-vaccine serotypes. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - January 10, 2024 Category: Microbiology Source Type: research
Serotype 3 Experimental Human Pneumococcal Challenge (EHPC) study protocol: dose ranging and reproducibility in a healthy volunteer population (challenge 3)
This study is approved by the NHS Research and Ethics Committee (reference 22/NW/0051). Findings will be published in peer-reviewed journals and reports will be made available to participants. (Source: BMJ Open)
Source: BMJ Open - January 10, 2024 Category: General Medicine Authors: Hazenberg, P., Robinson, R. E., Farrar, M., Solorzano, C., Hyder-Wright, A., Liatsikos, K., Brunning, J., Fleet, H., Bettam, A., Howard, A., Kenny-Nyazika, T., Urban, B., Mitsi, E., El Safadi, D., Davies, K., Lesosky, M., Gordon, S. B., Ferreira, D. M., C Tags: Open access, Respiratory medicine Source Type: research
Cost-effectiveness of 20-valent pneumococcal conjugate vaccine in US infants
CONCLUSIONS: Infant vaccination with PCV20 is estimated to further reduce pneumococcal disease and associated healthcare system and societal costs compared to both PCV13 and PCV15.PMID:38191278 | DOI:10.1016/j.vaccine.2023.12.057 (Source: Vaccine)
Source: Vaccine - January 8, 2024 Category: Allergy & Immunology Authors: Mark H Rozenbaum Liping Huang Johnna Perdrizet Alejandro Cane Adriano Arguedas Kyla Hayford Maria J Tort Ruth Chapman Desmond Dillon-Murphy Vincenza Snow Erica Chilson Raymond A Farkouh Source Type: research
Vaccination coverage of primary care providers against seasonal influenza, tetanus, pneumococcal pneumonia and herpes zoster: A cross-sectional study in Greece
CONCLUSIONS: The results revealed suboptimal vaccination rates among health providers who are in the frontline of adult immunization. Individualized and targeted measures to improve their vaccination coverage and indirectly the vaccination coverage of their patients, are therefore required.PMID:38187900 | PMC:PMC10764975 | DOI:10.3934/publichealth.2023061 (Source: Herpes)
Source: Herpes - January 8, 2024 Category: Infectious Diseases Authors: Panagiota Kalatzi Antonios K Travlos Nickos Geladas Maria Iliadou Chara Tzavara Costas Chryssanthopoulos Alexandros Mihopoulos Styliani Tziaferi Source Type: research
Considerations for the development of adult vaccination in China
This article focuses on elaborating the values of adult vaccination, introducing the current status of adult vaccination abroad, and analyzing the challenges and existing foundations for China to provide adult vaccination, and makes suggestions for the building and development of adult vaccination.PMID:38186149 | DOI:10.3760/cma.j.cn112150-20230703-00502 (Source: Herpes)
Source: Herpes - January 8, 2024 Category: Infectious Diseases Authors: L Li C S Xu L J Liu L Cao Y F Song Z N Zhang J K Ye W Z Yu Z D Yin Source Type: research
Long-term surveillance of invasive pneumococcal disease: The impact of 10-valent pneumococcal conjugate vaccine in the metropolitan region of Salvador, Brazil
CONCLUSION: Significant declines in IPD, including among adults not eligible for vaccination, suggest direct and indirect protection up to nine years after PCV10 introduction, without evidence of significant replacement disease. Continued surveillance is needed to monitor changes in non-vaccine serotypes and inform decisions about introducing higher valent PCVs.PMID:38184393 | DOI:10.1016/j.vaccine.2023.12.055 (Source: Vaccine)
Source: Vaccine - January 6, 2024 Category: Allergy & Immunology Authors: Joice Neves Reis Jailton Azevedo Aisla M ércia Lazaro de Oliveira Ana Paula de Oliveira Menezes Mayara Pedrosa Milena Soares Dos Santos Laise Carvalho Ribeiro Humberto Fonseca de Freitas Edilane Lins Gouveia Marcelo Bastos Teles Maria da Gl ória Carvalh Source Type: research
Long-term surveillance of invasive pneumococcal disease: The impact of 10-valent pneumococcal conjugate vaccine in the metropolitan region of Salvador, Brazil
CONCLUSION: Significant declines in IPD, including among adults not eligible for vaccination, suggest direct and indirect protection up to nine years after PCV10 introduction, without evidence of significant replacement disease. Continued surveillance is needed to monitor changes in non-vaccine serotypes and inform decisions about introducing higher valent PCVs.PMID:38184393 | DOI:10.1016/j.vaccine.2023.12.055 (Source: Vaccine)
Source: Vaccine - January 6, 2024 Category: Allergy & Immunology Authors: Joice Neves Reis Jailton Azevedo Aisla M ércia Lazaro de Oliveira Ana Paula de Oliveira Menezes Mayara Pedrosa Milena Soares Dos Santos Laise Carvalho Ribeiro Humberto Fonseca de Freitas Edilane Lins Gouveia Marcelo Bastos Teles Maria da Gl ória Carvalh Source Type: research
Lifecycle model-based evaluation of infant 4CMenB vaccination in the UK
ConclusionsHALM-based CBA provides an empirically richer, more utility –theoretically grounded approach to vaccine evaluation than CUA, demonstrating good value for money for legislatures (based on private values) and for all decision-makers (based on social values). (Source: The European Journal of Health Economics)
Source: The European Journal of Health Economics - January 5, 2024 Category: Health Management Source Type: research
Compliance with recommended pneumococcal vaccination schedule in patients treated for rheumatoid arthritis: A retrospective cohort study in the Veterans Affairs population
CONCLUSIONS: Providers should identify barriers to pneumococcal vaccination in RA patients to improve compliance. Efforts to increase vaccination should be tailored to specific high-risk groups.PMID:38177030 | DOI:10.1016/j.vaccine.2023.12.075 (Source: Vaccine)
Source: Vaccine - January 4, 2024 Category: Allergy & Immunology Authors: Carlos A Alvarez Ronald G Hall Suzy Lin Aaron R Perkins Eric M Mortensen Source Type: research
