Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD
This study also found significant associations of various infections with the risk of AD, but not with the risks of other dementias. This indicates that vulnerability to infections may play a more significant role in AD than in other types of dementia, which warrants further investigation.PMID:38548241 | DOI:10.1016/j.exger.2024.112411 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 28, 2024 Category: Geriatrics Authors: Svetlana Ukraintseva Arseniy P Yashkin Igor Akushevich Konstantin Arbeev Hongzhe Duan Galina Gorbunova Eric Stallard Anatoliy Yashin Source Type: research
Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD
This study also found significant associations of various infections with the risk of AD, but not with the risks of other dementias. This indicates that vulnerability to infections may play a more significant role in AD than in other types of dementia, which warrants further investigation.PMID:38548241 | DOI:10.1016/j.exger.2024.112411 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 28, 2024 Category: Geriatrics Authors: Svetlana Ukraintseva Arseniy P Yashkin Igor Akushevich Konstantin Arbeev Hongzhe Duan Galina Gorbunova Eric Stallard Anatoliy Yashin Source Type: research
Paediatric meningitis in the conjugate vaccine era and a novel clinical decision model to predict bacterial aetiology
The aims of this study were to assess aetiology and clinical characteristics in childhood meningitis, and develop clinical decision rules to distinguish bacterial meningitis from other similar clinical syndromes. (Source: Journal of Infection)
Source: Journal of Infection - March 26, 2024 Category: Infectious Diseases Authors: Martin NG, Defres S, Willis L, Beckley R, Hardwick H, Coxon A, Kadambari S, Yu L-M, Liu X, Galal U, Conlin K, Griffiths MJ, Kneen R, Nadel S, Heath PT, Kelly DF, Solomon T, Sadarangani M, Pollard AJ, on behalf of the UK-ChiMES and ENCEPH-UK study groups Source Type: research
Pneumococcal conjugate vaccination schedules in infants —acquisition, immunogenicity, and pneumococcal conjugate and yellow fever vaccine co-administration study: statistical analysis plan
The effectiveness of immunisation with pneumococcal conjugate vaccine (PCV) has been demonstrated in many countries. However, the global impact of PCV is limited by its cost, which has prevented its introducti... (Source: Trials)
Source: Trials - March 26, 2024 Category: General Medicine Authors: Grant A. Mackenzie, Isaac Osei, Rasheed Salaudeen, Paul V. Licciardi, Brian Greenwood, Kim Mulholland and Cattram Nguyen Tags: Update Source Type: research
Concurrent Outbreaks of Hepatitis A, Invasive Meningococcal Disease, and Mpox, Florida, USA, 2021-2022
Emerg Infect Dis. 2024 Apr;30(4). doi: 10.3201/eid3004.231392.ABSTRACTIn 2022, concurrent outbreaks of hepatitis A, invasive meningococcal disease (IMD), and mpox were identified in Florida, USA, primarily among men who have sex with men. The hepatitis A outbreak (153 cases) was associated with hepatitis A virus genotype IA. The IMD outbreak (44 cases) was associated with Neisseria meningitidis serogroup C, sequence type 11, clonal complex 11. The mpox outbreak in Florida (2,845 cases) was part of a global epidemic. The hepatitis A and IMD outbreaks were concentrated in Central Florida and peaked during March--June, wherea...
Source: Emerging Infectious Diseases - March 25, 2024 Category: Infectious Diseases Authors: Timothy J Doyle Megan Gumke Danielle Stanek Joshua Moore Brian Buck Timothy Locksmith Kelly Tomson Sarah Schmedes George Churchwell Shan Justin Hubsmith Baskar Krishnamoorthy Karalee Poschman Brandi Danforth Daniel Chacreton outbreak investigation team1 Source Type: research
Concurrent Outbreaks of Hepatitis A, Invasive Meningococcal Disease, and Mpox, Florida, USA, 2021-2022
Emerg Infect Dis. 2024 Apr;30(4). doi: 10.3201/eid3004.231392.ABSTRACTIn 2022, concurrent outbreaks of hepatitis A, invasive meningococcal disease (IMD), and mpox were identified in Florida, USA, primarily among men who have sex with men. The hepatitis A outbreak (153 cases) was associated with hepatitis A virus genotype IA. The IMD outbreak (44 cases) was associated with Neisseria meningitidis serogroup C, sequence type 11, clonal complex 11. The mpox outbreak in Florida (2,845 cases) was part of a global epidemic. The hepatitis A and IMD outbreaks were concentrated in Central Florida and peaked during March--June, wherea...
Source: Emerging Infectious Diseases - March 25, 2024 Category: Infectious Diseases Authors: Timothy J Doyle Megan Gumke Danielle Stanek Joshua Moore Brian Buck Timothy Locksmith Kelly Tomson Sarah Schmedes George Churchwell Shan Justin Hubsmith Baskar Krishnamoorthy Karalee Poschman Brandi Danforth Daniel Chacreton outbreak investigation team1 Source Type: research
Concurrent Outbreaks of Hepatitis A, Invasive Meningococcal Disease, and Mpox, Florida, USA, 2021-2022
Emerg Infect Dis. 2024 Apr;30(4). doi: 10.3201/eid3004.231392.ABSTRACTIn 2022, concurrent outbreaks of hepatitis A, invasive meningococcal disease (IMD), and mpox were identified in Florida, USA, primarily among men who have sex with men. The hepatitis A outbreak (153 cases) was associated with hepatitis A virus genotype IA. The IMD outbreak (44 cases) was associated with Neisseria meningitidis serogroup C, sequence type 11, clonal complex 11. The mpox outbreak in Florida (2,845 cases) was part of a global epidemic. The hepatitis A and IMD outbreaks were concentrated in Central Florida and peaked during March--June, wherea...
Source: Emerging Infectious Diseases - March 25, 2024 Category: Infectious Diseases Authors: Timothy J Doyle Megan Gumke Danielle Stanek Joshua Moore Brian Buck Timothy Locksmith Kelly Tomson Sarah Schmedes George Churchwell Shan Justin Hubsmith Baskar Krishnamoorthy Karalee Poschman Brandi Danforth Daniel Chacreton outbreak investigation team1 Source Type: research
Concurrent Outbreaks of Hepatitis A, Invasive Meningococcal Disease, and Mpox, Florida, USA, 2021-2022
Emerg Infect Dis. 2024 Apr;30(4). doi: 10.3201/eid3004.231392.ABSTRACTIn 2022, concurrent outbreaks of hepatitis A, invasive meningococcal disease (IMD), and mpox were identified in Florida, USA, primarily among men who have sex with men. The hepatitis A outbreak (153 cases) was associated with hepatitis A virus genotype IA. The IMD outbreak (44 cases) was associated with Neisseria meningitidis serogroup C, sequence type 11, clonal complex 11. The mpox outbreak in Florida (2,845 cases) was part of a global epidemic. The hepatitis A and IMD outbreaks were concentrated in Central Florida and peaked during March--June, wherea...
Source: Emerging Infectious Diseases - March 25, 2024 Category: Infectious Diseases Authors: Timothy J Doyle Megan Gumke Danielle Stanek Joshua Moore Brian Buck Timothy Locksmith Kelly Tomson Sarah Schmedes George Churchwell Shan Justin Hubsmith Baskar Krishnamoorthy Karalee Poschman Brandi Danforth Daniel Chacreton outbreak investigation team1 Source Type: research
Concurrent Outbreaks of Hepatitis A, Invasive Meningococcal Disease, and Mpox, Florida, USA, 2021-2022
Emerg Infect Dis. 2024 Apr;30(4):633-43. doi: 10.3201/eid3004.231392.ABSTRACTIn 2022, concurrent outbreaks of hepatitis A, invasive meningococcal disease (IMD), and mpox were identified in Florida, USA, primarily among men who have sex with men. The hepatitis A outbreak (153 cases) was associated with hepatitis A virus genotype IA. The IMD outbreak (44 cases) was associated with Neisseria meningitidis serogroup C, sequence type 11, clonal complex 11. The mpox outbreak in Florida (2,845 cases) was part of a global epidemic. The hepatitis A and IMD outbreaks were concentrated in Central Florida and peaked during March--June,...
Source: Emerging Infectious Diseases - March 25, 2024 Category: Infectious Diseases Authors: Timothy J Doyle Megan Gumke Danielle Stanek Joshua Moore Brian Buck Timothy Locksmith Kelly Tomson Sarah Schmedes George Churchwell Shan Justin Hubsmith Baskar Krishnamoorthy Karalee Poschman Brandi Danforth Daniel Chacreton outbreak investigation team1 Source Type: research
Concurrent Outbreaks of Hepatitis A, Invasive Meningococcal Disease, and Mpox, Florida, USA, 2021-2022
Emerg Infect Dis. 2024 Apr;30(4):633-43. doi: 10.3201/eid3004.231392.ABSTRACTIn 2022, concurrent outbreaks of hepatitis A, invasive meningococcal disease (IMD), and mpox were identified in Florida, USA, primarily among men who have sex with men. The hepatitis A outbreak (153 cases) was associated with hepatitis A virus genotype IA. The IMD outbreak (44 cases) was associated with Neisseria meningitidis serogroup C, sequence type 11, clonal complex 11. The mpox outbreak in Florida (2,845 cases) was part of a global epidemic. The hepatitis A and IMD outbreaks were concentrated in Central Florida and peaked during March--June,...
Source: Emerging Infectious Diseases - March 25, 2024 Category: Infectious Diseases Authors: Timothy J Doyle Megan Gumke Danielle Stanek Joshua Moore Brian Buck Timothy Locksmith Kelly Tomson Sarah Schmedes George Churchwell Shan Justin Hubsmith Baskar Krishnamoorthy Karalee Poschman Brandi Danforth Daniel Chacreton outbreak investigation team1 Source Type: research
A randomized, blind, parallel controlled phase I clinical trial to evaluate the safety and preliminary immunogenicity of 23-valent pneumococcal polysaccharide vaccine in healthy people aged 2 years and older
CONCLUSION: This clinical study showed good safety of the PPV23 vaccine candidate produced by Ab&b Biotechnology Co., Ltd.JS had good safety after vaccination in people aged 2 years and older. At the same time, good immunogenicity was also demonstrated.PMID:38519344 | DOI:10.1016/j.vaccine.2024.03.044 (Source: Vaccine)
Source: Vaccine - March 22, 2024 Category: Allergy & Immunology Authors: Yuhui Zhang Yanxia Wang Guangfu Li Xue Zhao Kai Wang Chunyu Jia Yongli Yang Lili Huang Jiebing Tan Xiaofen Chen Wenna Leng Zhiqiang Xie Wei Zhang Juan Zong Kang Chen Qin Li Xiaocan Jia Dongyang Zhao Youcai An Yaodong Zhang Source Type: research
Meningococcal meningitis in Spain in the Horizon 2030: A position paper
Rev Esp Quimioter. 2024 Mar 22:moraga22mar2024. doi: 10.37201/req/023.2024. Online ahead of print.ABSTRACTMeningococcal meningitis (MM) and invasive meningococcal disease remain a major public health problem that generates enormous public alarm. It is caused by Neisseria meningitidis, a Gram-negative diplococcus with an enormous capacity for acute and rapidly progressive disease, both episodic and epidemic in nature, with early diagnosis and treatment playing a major role. It occurs at any age, but is most common in children under 5 years of age followed by adolescents. Although most cases occur in healthy people, the inci...
Source: Revista Espanola de Quimioterapia - March 22, 2024 Category: Drugs & Pharmacology Authors: F Moraga-Llop E Andradas L C Blesa-Baviera R Cant ón J Gonz ález Del Castillo F Martin ón-Torres E Moya A Trilla J Vazquez R J Villena J Ruiz-Galiana P De Lucas Ramos A Garc ía-Botella A Garc ía-Lledó T Hern ández-Sampelayo J G ómez-Pavón M C Mar Source Type: research
A randomized, blind, parallel controlled phase I clinical trial to evaluate the safety and preliminary immunogenicity of 23-valent pneumococcal polysaccharide vaccine in healthy people aged 2 years and older
CONCLUSION: This clinical study showed good safety of the PPV23 vaccine candidate produced by Ab&b Biotechnology Co., Ltd.JS had good safety after vaccination in people aged 2 years and older. At the same time, good immunogenicity was also demonstrated.PMID:38519344 | DOI:10.1016/j.vaccine.2024.03.044 (Source: Vaccine)
Source: Vaccine - March 22, 2024 Category: Allergy & Immunology Authors: Yuhui Zhang Yanxia Wang Guangfu Li Xue Zhao Kai Wang Chunyu Jia Yongli Yang Lili Huang Jiebing Tan Xiaofen Chen Wenna Leng Zhiqiang Xie Wei Zhang Juan Zong Kang Chen Qin Li Xiaocan Jia Dongyang Zhao Youcai An Yaodong Zhang Source Type: research
Meningococcal meningitis in Spain in the Horizon 2030: A position paper
Rev Esp Quimioter. 2024 Mar 22:moraga22mar2024. doi: 10.37201/req/023.2024. Online ahead of print.ABSTRACTMeningococcal meningitis (MM) and invasive meningococcal disease remain a major public health problem that generates enormous public alarm. It is caused by Neisseria meningitidis, a Gram-negative diplococcus with an enormous capacity for acute and rapidly progressive disease, both episodic and epidemic in nature, with early diagnosis and treatment playing a major role. It occurs at any age, but is most common in children under 5 years of age followed by adolescents. Although most cases occur in healthy people, the inci...
Source: Revista Espanola de Quimioterapia - March 22, 2024 Category: Drugs & Pharmacology Authors: F Moraga-Llop E Andradas L C Blesa-Baviera R Cant ón J Gonz ález Del Castillo F Martin ón-Torres E Moya A Trilla J Vazquez R J Villena J Ruiz-Galiana P De Lucas Ramos A Garc ía-Botella A Garc ía-Lledó T Hern ández-Sampelayo J G ómez-Pavón M C Mar Source Type: research
Strategies for pneumococcal vaccination in older adults in the coming era
Volume 20, Issue 1, December 2024 . (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - March 22, 2024 Category: Allergy & Immunology Authors: Kei NakashimaWakaba Fukushimaa Department of Pulmonology, Kameda Medical Center, Kamogawa, Japanb Department of Public Health, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japanc Research Center for Infectious Disease Sciences, Osaka Source Type: research
