State of pneumococcal vaccine immunity
Volume 20, Issue 1, December 2024 . (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - April 3, 2024 Category: Allergy & Immunology Authors: Mustafa AkkoyunluDivision of Bacterial Allergenic and Parasitic Diseases, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA Source Type: research

Declining Invasive Pneumococcal Disease With Pneumococcal Vaccination
(Source: AAP Grand Rounds)
Source: AAP Grand Rounds - April 1, 2024 Category: Pediatrics Source Type: research

Pneumococcal Perplexity: Improving Awareness of Updated Pneumococcal Vaccination Recommendations in Two Large Military Treatment Facilities
CONCLUSIONS: There is a significant knowledge gap regarding ACIP pneumococcal vaccination recommendations among military providers and a low pneumococcal vaccination rate for adults aged 19 to 64 years with asthma at Joint Base-San Antonio MTFs. Focused education sessions were effective in increasing providers' knowledge of updated pneumococcal vaccination recommendations, confidence in recommending vaccines, total number of pneumococcal vaccinations given, and estimated pneumococcal vaccination rate for adults with asthma. The validity of conclusions drawn from our data were limited because of discordant numbers of survey...
Source: Military Medicine - March 30, 2024 Category: International Medicine & Public Health Authors: Curtis S Pacheco Joseph A Baxter Daniel Steigelman Source Type: research

Effects of PCV10 and PCV13 on pneumococcal serotype 6C disease, carriage, and antimicrobial resistance
CONCLUSIONS: In contrast to PCV10, PCV13 vaccination consistently protected against 6C IPD and NPC in children, and provided some level of indirect protection to adults, supporting that serotype 6A but not 6B provides cross-protection to 6C. Vaccine policy makers and regulators should consider the effects of serotype 6A-containing PCVs against serotype 6C disease in their decisions.PMID:38553292 | DOI:10.1016/j.vaccine.2024.03.065 (Source: Vaccine)
Source: Vaccine - March 29, 2024 Category: Allergy & Immunology Authors: Lindsay R Grant Germaine Hanquet Ingrid T Sep úlveda-Pachón Christian Theilacker Marc Baay Mary P E Slack Luis Jodar Bradford D Gessner Source Type: research

Effects of PCV10 and PCV13 on pneumococcal serotype 6C disease, carriage, and antimicrobial resistance
CONCLUSIONS: In contrast to PCV10, PCV13 vaccination consistently protected against 6C IPD and NPC in children, and provided some level of indirect protection to adults, supporting that serotype 6A but not 6B provides cross-protection to 6C. Vaccine policy makers and regulators should consider the effects of serotype 6A-containing PCVs against serotype 6C disease in their decisions.PMID:38553292 | DOI:10.1016/j.vaccine.2024.03.065 (Source: Vaccine)
Source: Vaccine - March 29, 2024 Category: Allergy & Immunology Authors: Lindsay R Grant Germaine Hanquet Ingrid T Sep úlveda-Pachón Christian Theilacker Marc Baay Mary P E Slack Luis Jodar Bradford D Gessner Source Type: research

Nanopore sequencing in distinguishing between wild-type and vaccine strains of Varicella-Zoster virus
CONCLUSION: This study validates that nanopore sequencing is a reliable method for differentiating between the wild-type and vaccine strains of VZV. Its ability to produce long-read sequences is remarkable, allowing simultaneous confirmation of known SNPs and the detection of new mutations. Nanopore sequencing can serve as a valuable tool for the swift and precise identification of wild-type and vaccine strains and has potential applications in future VZV surveillance.PMID:38548526 | DOI:10.1016/j.vaccine.2024.03.046 (Source: Vaccine)
Source: Vaccine - March 28, 2024 Category: Allergy & Immunology Authors: Yuto Fukuda Takako Suzuki Ken-Ichi Iwata Kazunori Haruta Makoto Yamaguchi Yuka Torii Atsushi Narita Hideki Muramatsu Yoshiyuki Takahashi Jun-Ichi Kawada Source Type: research

Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD
This study also found significant associations of various infections with the risk of AD, but not with the risks of other dementias. This indicates that vulnerability to infections may play a more significant role in AD than in other types of dementia, which warrants further investigation.PMID:38548241 | DOI:10.1016/j.exger.2024.112411 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 28, 2024 Category: Geriatrics Authors: Svetlana Ukraintseva Arseniy P Yashkin Igor Akushevich Konstantin Arbeev Hongzhe Duan Galina Gorbunova Eric Stallard Anatoliy Yashin Source Type: research

Nanopore sequencing in distinguishing between wild-type and vaccine strains of Varicella-Zoster virus
CONCLUSION: This study validates that nanopore sequencing is a reliable method for differentiating between the wild-type and vaccine strains of VZV. Its ability to produce long-read sequences is remarkable, allowing simultaneous confirmation of known SNPs and the detection of new mutations. Nanopore sequencing can serve as a valuable tool for the swift and precise identification of wild-type and vaccine strains and has potential applications in future VZV surveillance.PMID:38548526 | DOI:10.1016/j.vaccine.2024.03.046 (Source: Herpes)
Source: Herpes - March 28, 2024 Category: Infectious Diseases Authors: Yuto Fukuda Takako Suzuki Ken-Ichi Iwata Kazunori Haruta Makoto Yamaguchi Yuka Torii Atsushi Narita Hideki Muramatsu Yoshiyuki Takahashi Jun-Ichi Kawada Source Type: research

Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD
This study also found significant associations of various infections with the risk of AD, but not with the risks of other dementias. This indicates that vulnerability to infections may play a more significant role in AD than in other types of dementia, which warrants further investigation.PMID:38548241 | DOI:10.1016/j.exger.2024.112411 (Source: Herpes)
Source: Herpes - March 28, 2024 Category: Infectious Diseases Authors: Svetlana Ukraintseva Arseniy P Yashkin Igor Akushevich Konstantin Arbeev Hongzhe Duan Galina Gorbunova Eric Stallard Anatoliy Yashin Source Type: research

Nanopore sequencing in distinguishing between wild-type and vaccine strains of Varicella-Zoster virus
CONCLUSION: This study validates that nanopore sequencing is a reliable method for differentiating between the wild-type and vaccine strains of VZV. Its ability to produce long-read sequences is remarkable, allowing simultaneous confirmation of known SNPs and the detection of new mutations. Nanopore sequencing can serve as a valuable tool for the swift and precise identification of wild-type and vaccine strains and has potential applications in future VZV surveillance.PMID:38548526 | DOI:10.1016/j.vaccine.2024.03.046 (Source: Vaccine)
Source: Vaccine - March 28, 2024 Category: Allergy & Immunology Authors: Yuto Fukuda Takako Suzuki Ken-Ichi Iwata Kazunori Haruta Makoto Yamaguchi Yuka Torii Atsushi Narita Hideki Muramatsu Yoshiyuki Takahashi Jun-Ichi Kawada Source Type: research

Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD
This study also found significant associations of various infections with the risk of AD, but not with the risks of other dementias. This indicates that vulnerability to infections may play a more significant role in AD than in other types of dementia, which warrants further investigation.PMID:38548241 | DOI:10.1016/j.exger.2024.112411 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 28, 2024 Category: Geriatrics Authors: Svetlana Ukraintseva Arseniy P Yashkin Igor Akushevich Konstantin Arbeev Hongzhe Duan Galina Gorbunova Eric Stallard Anatoliy Yashin Source Type: research

Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD
This study also found significant associations of various infections with the risk of AD, but not with the risks of other dementias. This indicates that vulnerability to infections may play a more significant role in AD than in other types of dementia, which warrants further investigation.PMID:38548241 | DOI:10.1016/j.exger.2024.112411 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 28, 2024 Category: Geriatrics Authors: Svetlana Ukraintseva Arseniy P Yashkin Igor Akushevich Konstantin Arbeev Hongzhe Duan Galina Gorbunova Eric Stallard Anatoliy Yashin Source Type: research