Impact of Meningococcal ACWY Vaccination Program during 2017-18 Epidemic, Western Australia, Australia
Emerg Infect Dis. 2024 Feb;30(2):270-278. doi: 10.3201/eid3002.230144.ABSTRACTThe rising incidence of invasive meningococcal disease (IMD) caused by Neisseria meningitidis serogroup W in Western Australia, Australia, presents challenges for prevention. We assessed the effects of a quadrivalent meningococcal vaccination program using 2012-2020 IMD notification data. Notification rates peaked at 1.8/100,000 population in 2017; rates among Aboriginal and Torres Strait Islander populations were 7 times higher than for other populations. Serogroup W disease exhibited atypical manifestations and increased severity. Of 216 cases,...
Source: Emerging Infectious Diseases - January 25, 2024 Category: Infectious Diseases Authors: Krist Ewe Parveen Fathima Paul Effler Carolien Giele Peter Richmond Source Type: research
Otitis media: recent advances in otitis media vaccine development and model systems
Otitis media is an inflammatory disorder of the middle ear caused by airways-associated bacterial or viral infections. It is one of the most common childhood infections as globally more than 80% of children are diagnosed with acute otitis media by 3 years of age and it is a common reason for doctor’s visits, antibiotics prescriptions, and surgery among children. Otitis media is a multifactorial disease with various genetic, immunologic, infectious, and environmental factors predisposing children to develop ear infections. Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis are the most common cu...
Source: Frontiers in Microbiology - January 24, 2024 Category: Microbiology Source Type: research
A New Era in the Treatment of Myasthenia Gravis: Six New Medications in The Last 6 Years
This article presents a summary of the new medications approved for generalized myasthenia gravis (gMG) since 2017. Pivotal clinical trials that led to the approval of these medications and their open-label extension studies are reviewed. We also provide information on healthcare cost when available. Lastly, we propose an approach to selecting therapies.Recent FindingsSix new medications have been approved for acetylcholine receptor antibody positive gMG. These include the complement inhibitors eculizumab, ravulizumab, and zilucoplan and the neonatal Fc receptor blockers efgartigimod, efgartigimod and hyaluronidase, and ro...
Source: Current Treatment Options in Neurology - January 23, 2024 Category: Neurology Source Type: research
In silico discovery of diagnostic/vaccine candidate antigenic epitopes and a multi-epitope peptide vaccine (NaeVac) design for the brain-eating amoeba Naegleria fowleri causing human meningitis
In this study, by analyzing the N. fowleri vaccine candidate proteins (Mp2CL5, Nfa1, Nf314, proNP-A and proNP-B), it was aimed to discover diagnostic/vaccine candidate epitopes and to design a multi-epitope peptide vaccine against this pathogen. After the in silico evaluation, three prominent diagnostic/vaccine candidate epitopes (EAKDSK, LLPHIRILVY, and FYAKLLPHIRILVYS) with the highest antigenicities were discovered and a potentially highly immunogenic/antigenic multi-epitope peptide vaccine (NaeVac) was designed against the brain-eating amoeba N. fowleri causing human meningitis.PMID:38253295 | DOI:10.1016/j.gene.2024.148192 (Source: Gene)
Source: Gene - January 22, 2024 Category: Genetics & Stem Cells Authors: Ahmet Efe K öseoğlu Filiz Özgül Elif Naz I şıksal Yusuf Şeflekçi Deniz T ülümen Buminhan Özgültekin G ülsüm Deniz Köseoğlu Sena Özyiğit Murat Ihlamur Ya ğmur Ekenoğlu Merdan Source Type: research
Prevalence and serotype distribution of nasopharyngeal carriage of Streptococcus pneumoniae among healthy children under 5 years of age in Hainan Province, China
ConclusionsWe established the baseline of pneumococcal carriage, serotype distribution and PCV13 immunization rates among healthy children under 5 years of age in Hainan Province, prior to the introduction of PCV13 into the national immunization program. The high proportion of PCV13 serotypes suggests that PCV13 introduction will likely have a substantial impact on pneumococcal carriage in Hainan Province.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - January 19, 2024 Category: Infectious Diseases Source Type: research
Efficacy and Prolonged Safety of Haemophilus influenzae Type B Conjugate Vaccines
CONCLUSION: The Hib conjugate vaccination has shown to be extremely effective when administered to the entire population. However, changes to the immunisation protocol appear to be required in order to effectively manage invasive Hib illness.PMID:38231056 | DOI:10.2174/0118715265269877231117070051 (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - January 17, 2024 Category: Infectious Diseases Authors: Nishita Tripathi Sayali Mukherjee Source Type: research
Factors associated with shingles and pneumococcal vaccination among older Canadians
Health Rep. 2024 Jan 17;35(1):14-24. doi: 10.25318/82-003-x202400100002-eng.ABSTRACTBACKGROUND: Immunization against vaccine-preventable diseases such as shingles and pneumococcal disease is especially pertinent among older Canadians. However, vaccine uptake remains low.DATA AND METHODS: Data from the Canadian Health Survey on Seniors (CHSS) - 2019/2020 were used to examine receipt of shingles and pneumococcal vaccines among Canadians aged 65 and older living in the community. Multivariable logistic regression was used to identify individual predisposing, enabling and needs-related factors associated with receipt of each t...
Source: Health Reports - January 17, 2024 Category: International Medicine & Public Health Authors: Heather Gilmour Source Type: research
