In silico discovery of diagnostic/vaccine candidate antigenic epitopes and a multi-epitope peptide vaccine (NaeVac) design for the brain-eating amoeba Naegleria fowleri causing human meningitis

In this study, by analyzing the N. fowleri vaccine candidate proteins (Mp2CL5, Nfa1, Nf314, proNP-A and proNP-B), it was aimed to discover diagnostic/vaccine candidate epitopes and to design a multi-epitope peptide vaccine against this pathogen. After the in silico evaluation, three prominent diagnostic/vaccine candidate epitopes (EAKDSK, LLPHIRILVY, and FYAKLLPHIRILVYS) with the highest antigenicities were discovered and a potentially highly immunogenic/antigenic multi-epitope peptide vaccine (NaeVac) was designed against the brain-eating amoeba N. fowleri causing human meningitis.PMID:38253295 | DOI:10.1016/j.gene.2024.148192

Source: Gene - January 22, 2024 Category: Genetics & Stem Cells Authors: Ahmet Efe K öseoğlu Filiz Özgül Elif Naz I şıksal Yusuf Şeflekçi Deniz T ülümen Buminhan Özgültekin G ülsüm Deniz Köseoğlu Sena Özyiğit Murat Ihlamur Ya ğmur Ekenoğlu Merdan Source Type: research