Safety, tolerability and immunogenicity of a novel 24-valent pneumococcal vaccine in toddlers: A phase 1 randomized controlled trial
CONCLUSIONS: In 12-15-month-old toddlers, a single dose of Pn-MAPS24v showed an acceptable safety profile, regardless of dose level; AEs were reported at similar frequencies by Pn-MAPS24v and PCV13 recipients. Pn-MAPS24v elicited IgG and OPA responses to all common and most unique serotypes. These results support further clinical evaluation in infants.PMID:38360475 | DOI:10.1016/j.vaccine.2024.02.001 (Source: Vaccine)
Source: Vaccine - February 15, 2024 Category: Allergy & Immunology Authors: Dorota Borys Richard Rupp Ronald Smulders Gurunadh R Chichili Laura L Kovanda Vicki Santos Frank Malinoski George Siber Richard Malley Shite Sebastian Source Type: research
Immunization with a whole cell vaccine reduces pneumococcal nasopharyngeal density and shedding, and middle ear infection in mice
Vaccine. 2024 Feb 12:S0264-410X(24)00131-2. doi: 10.1016/j.vaccine.2024.01.104. Online ahead of print.ABSTRACTPneumococcal Conjugate Vaccines (PCVs) have substantially reduced the burden of disease caused by Streptococcus pneumoniae (the pneumococcus). However, protection is limited to vaccine serotypes, and when administered to children who are colonized with pneumococci at the time of vaccination, immune responses to the vaccine are blunted. Here, we investigate the potential of a killed whole cell pneumococcal vaccine (WCV) to reduce existing pneumococcal carriage and mucosal disease when given therapeutically to infant...
Source: Vaccine - February 13, 2024 Category: Allergy & Immunology Authors: Jayne Manning Sam Manna Eileen M Dunne Viktoria Bongcaron Casey L Pell Natalie L Patterson Sacha D Kuil Poshmaal Dhar David Goldblatt E Kim Mulholland Paul V Licciardi Roy M Robins-Browne Richard Malley Odilia Wijburg Catherine Satzke Source Type: research
Cost-effectiveness analysis of vaccination strategies against meningococcal disease for children under nine years of age in China
Volume 20, Issue 1, December 2024 . (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - February 13, 2024 Category: Allergy & Immunology Authors: Haonan ZhangHaijun ZhangHai Fanga School of Public Health, Peking University, Beijing, Chinab China Center for Health Development Studies, Peking University, Beijing, Chinac Department of International Health, Johns Hopkins Bloomberg School of Public Heal Source Type: research
United States Physicians' Knowledge, Attitudes, and Practices Regarding Meningococcal Vaccination for Healthy Adolescents and Young Adults
This study investigated United States physicians' knowledge , attitudes, and practices regarding recommending MenB and MenACWY vaccines to non-high-risk older adolescents and young adults. (Source: Journal of Adolescent Health)
Source: Journal of Adolescent Health - February 13, 2024 Category: Child Development Authors: Oscar Herrera-Restrepo, Suvapun Bunniran, Tiffany Mond, Eric Davenport, Jinyi Wang, Carolyn Sweeney, Gary S. Marshall Tags: Original article Source Type: research
Minimal interval for the administration of a pneumococcal polysaccharide vaccine following the administration of a pneumococcal conjugate vaccine
Vaccine. 2024 Feb 12:S0264-410X(24)00163-4. doi: 10.1016/j.vaccine.2024.02.023. Online ahead of print.NO ABSTRACTPMID:38346915 | DOI:10.1016/j.vaccine.2024.02.023 (Source: Vaccine)
Source: Vaccine - February 12, 2024 Category: Allergy & Immunology Authors: Philippe De Wals Micha ël Desjardins Source Type: research
Disparities in Influenza, Pneumococcal, COVID-19 Vaccine Coverage in High-Risk Adults 19-64 Years of Age in Southeastern Minnesota, 2010-2021
Chest. 2024 Feb 9:S0012-3692(24)00145-4. doi: 10.1016/j.chest.2024.01.049. Online ahead of print.ABSTRACTBACKGROUND: Despite effective vaccines against influenza, pneumococcus and COVID-19, uptake has been suboptimal.RESEARCH QUESTION: While disparities in vaccination by race and ethnicity have been observed, what is the role of other sociodemographic in US vaccine uptake?STUDY DESIGN AND METHODS: We conducted a population-based study using Rochester Epidemiology Project (REP), a comprehensive medical records linkage system, to assess effects of sociodemographic factors including race, ethnicity, individual-level socioecon...
Source: Chest - February 11, 2024 Category: Respiratory Medicine Authors: Jamie R Felzer Amy Montgomery Allison M LeMahieu Lila J Finney Rutten Young J Juhn Chung-Il Wi Robert M Jacobson Cassie C Kennedy Source Type: research
Neighborhood-level disadvantages increase risk for invasive pneumococcal disease
CONCLUSIONS: ADI is a risk factor for IPD in younger adults. Community-level socioeconomic risk factors should be considered when developing prevention strategies such as increasing vaccine uptake in high risk population to reduce the disease burden of IPD.PMID:38340982 | DOI:10.1016/j.amjms.2024.02.002 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - February 10, 2024 Category: General Medicine Authors: Daniel Minassian Liang Shan Chaoling Dong Arzoo N Charania Carlos J Orihuela Chao He Source Type: research
Surveillance of pneumococcal serotypes in adults hospitalised with acute lower respiratory tract infection in Bristol, UK
DISCUSSION: Among adults hospitalised with respiratory infection, pneumococcus is an important pathogen across all subgroups, including CAP+/RAD- and NP-LRTI. Despite 20-years of PPV23 use in adults ≥ 65-years and herd protection due to 17-years of PCV use in infants, vaccine-serotype pneumococcal disease still causes a significant proportion of LRTI adult hospitalizations. Direct adult vaccination with high-valency PCVs may reduce pneumococcal disease burden.PMID:38336560 | DOI:10.1016/j.vaccine.2024.02.007 (Source: Vaccine)
Source: Vaccine - February 9, 2024 Category: Allergy & Immunology Authors: Catherine Hyams Maria Lahuerta Christian Theilacker Jade King David Adegbite Serena McGuinness Charli Grimes James Campling Jo Southern Michael W Pride Elizabeth Begier Nick Maskell Jennifer Oliver Luis Jodar Bradford D Gessner Adam Finn AvonCAP Research Source Type: research
The potential impact of PCV-13, PCV-15 and PCV-20 vaccines in Colombia
CONCLUSION: Introducing PCV-20 for children and PCV-20 along with a PPSV-23 booster in adults may reduce IPD frequency in all ages in Colombia. The inclusion of non-covered serotypes is required for future vaccines.PMID:38336559 | DOI:10.1016/j.vaccine.2024.01.086 (Source: Vaccine)
Source: Vaccine - February 9, 2024 Category: Allergy & Immunology Authors: Cristian C Serrano-Mayorga Elsa D Ib áñez-Prada Juan M Restrepo-Mart ínez Esteban Garcia-Gallo Sara Duque David Felipe Severiche-Bueno Diego Fernando Severiche-Bueno Sandra Gomez Hern án Vargas Luis Felipe Reyes Source Type: research
Establishment of Safety Monitoring System for Vaccines Not Included in the National Immunization Program in Korea
CONCLUSION: We are establishing the first safety monitoring system for selected non-NIP vaccines in Korea since September 2022 and report its progress as of July 2023. However, continuous government support is essential for its maintenance and improvement.PMID:38317446 | PMC:PMC10843970 | DOI:10.3346/jkms.2024.39.e45 (Source: J Korean Med Sci)
Source: J Korean Med Sci - February 6, 2024 Category: General Medicine Authors: Eliel Nham Jin Gu Yoon Min Joo Choi Yu Bin Seo Jacob Lee Won Suk Choi Hakjun Hyun Hye Seong Ji Yun Noh Joon Young Song Woo Joo Kim Hee Jin Cheong Source Type: research
Establishment of Safety Monitoring System for Vaccines Not Included in the National Immunization Program in Korea
CONCLUSION: We are establishing the first safety monitoring system for selected non-NIP vaccines in Korea since September 2022 and report its progress as of July 2023. However, continuous government support is essential for its maintenance and improvement.PMID:38317446 | PMC:PMC10843970 | DOI:10.3346/jkms.2024.39.e45 (Source: Herpes)
Source: Herpes - February 6, 2024 Category: Infectious Diseases Authors: Eliel Nham Jin Gu Yoon Min Joo Choi Yu Bin Seo Jacob Lee Won Suk Choi Hakjun Hyun Hye Seong Ji Yun Noh Joon Young Song Woo Joo Kim Hee Jin Cheong Source Type: research
Establishment of Safety Monitoring System for Vaccines Not Included in the National Immunization Program in Korea
CONCLUSION: We are establishing the first safety monitoring system for selected non-NIP vaccines in Korea since September 2022 and report its progress as of July 2023. However, continuous government support is essential for its maintenance and improvement.PMID:38317446 | PMC:PMC10843970 | DOI:10.3346/jkms.2024.39.e45 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - February 6, 2024 Category: Biomedical Science Authors: Eliel Nham Jin Gu Yoon Min Joo Choi Yu Bin Seo Jacob Lee Won Suk Choi Hakjun Hyun Hye Seong Ji Yun Noh Joon Young Song Woo Joo Kim Hee Jin Cheong Source Type: research
Establishment of Safety Monitoring System for Vaccines Not Included in the National Immunization Program in Korea
CONCLUSION: We are establishing the first safety monitoring system for selected non-NIP vaccines in Korea since September 2022 and report its progress as of July 2023. However, continuous government support is essential for its maintenance and improvement.PMID:38317446 | PMC:PMC10843970 | DOI:10.3346/jkms.2024.39.e45 (Source: J Korean Med Sci)
Source: J Korean Med Sci - February 6, 2024 Category: General Medicine Authors: Eliel Nham Jin Gu Yoon Min Joo Choi Yu Bin Seo Jacob Lee Won Suk Choi Hakjun Hyun Hye Seong Ji Yun Noh Joon Young Song Woo Joo Kim Hee Jin Cheong Source Type: research
Establishment of Safety Monitoring System for Vaccines Not Included in the National Immunization Program in Korea
CONCLUSION: We are establishing the first safety monitoring system for selected non-NIP vaccines in Korea since September 2022 and report its progress as of July 2023. However, continuous government support is essential for its maintenance and improvement.PMID:38317446 | PMC:PMC10843970 | DOI:10.3346/jkms.2024.39.e45 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - February 6, 2024 Category: Biomedical Science Authors: Eliel Nham Jin Gu Yoon Min Joo Choi Yu Bin Seo Jacob Lee Won Suk Choi Hakjun Hyun Hye Seong Ji Yun Noh Joon Young Song Woo Joo Kim Hee Jin Cheong Source Type: research
Establishment of Safety Monitoring System for Vaccines Not Included in the National Immunization Program in Korea
CONCLUSION: We are establishing the first safety monitoring system for selected non-NIP vaccines in Korea since September 2022 and report its progress as of July 2023. However, continuous government support is essential for its maintenance and improvement.PMID:38317446 | PMC:PMC10843970 | DOI:10.3346/jkms.2024.39.e45 (Source: J Korean Med Sci)
Source: J Korean Med Sci - February 6, 2024 Category: General Medicine Authors: Eliel Nham Jin Gu Yoon Min Joo Choi Yu Bin Seo Jacob Lee Won Suk Choi Hakjun Hyun Hye Seong Ji Yun Noh Joon Young Song Woo Joo Kim Hee Jin Cheong Source Type: research
