Comparison of Endoscopic Facet Joint Denervation to the Percutaneous Technique Regarding Efficacy in Patients With Low Back Pain: A Randomized Controlled Trial
Study Design. This was a single-center prospective randomized controlled study. Objective. The aim was to compare the efficacy of endoscopic facet joint denervation (FJD) with that of the percutaneous technique in terms of pain, functional disability, and quality of life in patients with low back pain (LBP). Summary of Background Data. Different controlled studies in patients with LBP have shown short-term benefits from percutaneous FJD. Observational studies have demonstrated that endoscopic FJD may be more effective. As the superiority of the endoscopic technique has not been clearly demonstrated in pre...
Source: Spine - August 18, 2022 Category: Orthopaedics Tags: Randomized Trial Source Type: research

Are the Definitions of Low Back Pain Holding Back the Entire Field?
No abstract available (Source: The Back Letter)
Source: The Back Letter - August 18, 2022 Category: Orthopaedics Tags: Articles Source Type: research

Is “Usual Care” a Meaningful Intervention in Studies of Low Back Pain?
No abstract available (Source: The Back Letter)
Source: The Back Letter - August 18, 2022 Category: Orthopaedics Tags: Articles Source Type: research

The Nrf2 antioxidant defense system in intervertebral disc degeneration: Molecular insights
Exp Mol Med. 2022 Aug 17. doi: 10.1038/s12276-022-00829-6. Online ahead of print.ABSTRACTIntervertebral disc degeneration (IDD) is a common degenerative musculoskeletal disorder and is recognized as a major contributor to discogenic lower back pain. However, the molecular mechanisms underlying IDD remain unclear, and therapeutic strategies for IDD are currently limited. Oxidative stress plays pivotal roles in the pathogenesis and progression of many age-related diseases in humans, including IDD. Nuclear factor E2-related factor 2 (Nrf2) is a master antioxidant transcription factor that protects cells against oxidative stre...
Source: Molecular Medicine - August 17, 2022 Category: Molecular Biology Authors: Qian Xiang Yongzhao Zhao Jialiang Lin Shuai Jiang Weishi Li Source Type: research

Association of Patient Race and Ethnicity With Differences in Opioid Prescribing by Primary Care Physicians for Older Adults With New Low Back Pain
CONCLUSIONS AND RELEVANCE: This cross-sectional study found that from 2007 to 2014, primary care physicians prescribed opioids for new low back pain more often to White patients than to patients of racial and ethnic minority groups. These results suggest that there may have been unequal treatment of pain by physicians when less was known about the morbidity associated with opioid use.PMID:35977182 | PMC:PMC8796941 | DOI:10.1001/jamahealthforum.2021.2333 (Source: Pain Physician)
Source: Pain Physician - August 17, 2022 Category: Anesthesiology Authors: Dan P Ly Source Type: research

The Nrf2 antioxidant defense system in intervertebral disc degeneration: Molecular insights
Exp Mol Med. 2022 Aug 17. doi: 10.1038/s12276-022-00829-6. Online ahead of print.ABSTRACTIntervertebral disc degeneration (IDD) is a common degenerative musculoskeletal disorder and is recognized as a major contributor to discogenic lower back pain. However, the molecular mechanisms underlying IDD remain unclear, and therapeutic strategies for IDD are currently limited. Oxidative stress plays pivotal roles in the pathogenesis and progression of many age-related diseases in humans, including IDD. Nuclear factor E2-related factor 2 (Nrf2) is a master antioxidant transcription factor that protects cells against oxidative stre...
Source: Molecular Medicine - August 17, 2022 Category: Molecular Biology Authors: Qian Xiang Yongzhao Zhao Jialiang Lin Shuai Jiang Weishi Li Source Type: research

The Nrf2 antioxidant defense system in intervertebral disc degeneration: Molecular insights
Experimental & Molecular Medicine, Published online: 17 August 2022; doi:10.1038/s12276-022-00829-6Insights into the activity of a protein that regulates gene expression and protects cells against oxidative stress could yield novel treatments for lower back pain. Intervertebral disc degeneration (IDD) is a common cause of lower back pain, but the molecular mechanisms underlying IDD are unclear, meaning treatment options are limited. Oxidative stress is implicated in IDD, and scientists have begun exploring the role of nuclear factor E2-related factor 2 (Nrf2), a master regulator of the body’s antioxidant responses, i...
Source: Experimental and Molecular Medicine - August 17, 2022 Category: Molecular Biology Authors: Qian Xiang Yongzhao Zhao Jialiang Lin Shuai Jiang Weishi Li Source Type: research

Test Yourself Answer: A 22-year-old female with a 2-year history of progressive right lower back pain
(Source: Skeletal Radiology)
Source: Skeletal Radiology - August 16, 2022 Category: Radiology Source Type: research

Test Yourself Question: A 22-year-old female with a 2-year history of progressive right lower back pain
(Source: Skeletal Radiology)
Source: Skeletal Radiology - August 16, 2022 Category: Radiology Source Type: research

Tubiechong :A review on ethnomedicinal uses, bioactive chemical constituents and pharmacological activities
CONCLUSION: Tubiechong is an important insect medicine with the effect of promoting blood circulation and removing blood stasis, which has been used in traditional Chinese medicine for thousands of years for the treatment of trauma and abdominal lumps, and has now been clinically extended to the treatment of a variety of diseases. Its multiple pharmacological activities indicate that it has great potential for development and application. However, its chemical constituents with pharmacological activity require further excavation and detailed study. In addition, the in-depth molecular pharmacological mechanisms deserve furt...
Source: Herpes - August 16, 2022 Category: Infectious Diseases Authors: Xiang Fu Bing-Hao Shao Xue Wei Hui-Hui Wang Xing Chen Tian-Tian Zhao Chun-Mei Wang Source Type: research

IJERPH, Vol. 19, Pages 10135: Associations of Central Sensitization-Related Symptoms with Low Back Pain-Related Factors and Work Status in Caregivers
in Murata Low back pain (LBP) is associated with psychological factors and central sensitization-related symptoms (CSSs). The relationship between CSSs, LBP-related factors, and work status in caregivers remain unclear. This multicentre, collaborative, cross-sectional study aimed to determine the association between CSS severity, LBP-related factors, and work status in caregivers with LBP. We measured LBP intensity, pain duration, pain sites, CSSs (using the Central Sensitization Inventory-9: CSI-9), psychological factors (using the Pain Catastrophizing and Pain Self-Efficacy scales), and work status (interference, amo...
Source: International Journal of Environmental Research and Public Health - August 16, 2022 Category: Environmental Health Authors: Hayato Shigetoh Teppei Abiko Michie Ohyama Eiji Sakata Shin Murata Tags: Article Source Type: research

IJERPH, Vol. 19, Pages 10145: Biopsychosocial Factors for Chronicity in Individuals with Non-Specific Low Back Pain: An Umbrella Review
This study summarizes up-to-date and high-level research evidence on the biopsychosocial prognostic factors of outcomes in adults with non-specific low back pain at follow-up. An umbrella review was carried out. PubMed, the Cochrane Database of Systematic Reviews, Web of Science, PsycINFO, CINAHL Plus and PEDro were searched for studies published between 1 January 2008 and 20 March 2020. Two reviewers independently screened abstracts and full texts, extracted data and assessed review quality. Fifteen systematic reviews met the eligibility criteria; all were deemed reliable according to our criteria. There were five prognos...
Source: International Journal of Environmental Research and Public Health - August 16, 2022 Category: Environmental Health Authors: Emilia Otero-Ketterer Cecilia Pe ñacoba-Puente Carina Ferreira Pinheiro-Araujo Juan Antonio Valera-Calero Ricardo Ortega-Santiago Tags: Systematic Review Source Type: research

Prevalence of low back pain in India: A systematic review and meta-analysis
CONCLUSION: The point, annual, and lifetime prevalence rates of LBP in the Indian population is higher compared to global and other ethnic populations affecting a large proportion of the population, especially among women, rural population and in elementary workers. The findings of this study can be the basis for formulating policy regarding the prevention and treatment of LBP in a large part of the global population.PMID:35964222 | DOI:10.3233/WOR-205300 (Source: Work)
Source: Work - August 14, 2022 Category: Occupational Health Authors: Gautam M Shetty Shikha Jain Harshad Thakur Kriti Khanna Source Type: research

Prevalence of low back pain in India: A systematic review and meta-analysis
CONCLUSION: The point, annual, and lifetime prevalence rates of LBP in the Indian population is higher compared to global and other ethnic populations affecting a large proportion of the population, especially among women, rural population and in elementary workers. The findings of this study can be the basis for formulating policy regarding the prevention and treatment of LBP in a large part of the global population.PMID:35964222 | DOI:10.3233/WOR-205300 (Source: Work)
Source: Work - August 14, 2022 Category: Occupational Health Authors: Gautam M Shetty Shikha Jain Harshad Thakur Kriti Khanna Source Type: research

Prevalence of low back pain in India: A systematic review and meta-analysis
CONCLUSION: The point, annual, and lifetime prevalence rates of LBP in the Indian population is higher compared to global and other ethnic populations affecting a large proportion of the population, especially among women, rural population and in elementary workers. The findings of this study can be the basis for formulating policy regarding the prevention and treatment of LBP in a large part of the global population.PMID:35964222 | DOI:10.3233/WOR-205300 (Source: Work)
Source: Work - August 14, 2022 Category: Occupational Health Authors: Gautam M Shetty Shikha Jain Harshad Thakur Kriti Khanna Source Type: research