Viruses, Vol. 16, Pages 142: Prevention of Viral Hepatitis and HIV Infection among People Who Inject Drugs: A Systematic Review and Meta-Analysis
This study aimed to explore the current evidence on preventing blood-borne virus infections among people who inject drugs (PWID). We conducted a comprehensive search across three databases (PubMed, Embase, Cochrane Library) for relevant articles published in English between 2014 and 2023. We followed the Preferred Reporting Items for Systematic Reviews and Meta Analysis (PRISMA) guidelines, assessed the quality of the paper using the revised Cochrane Risk of Bias Tool (ROB 2), and conducted a meta-analysis using RevMan 5.3. Completing the harm reduction program (HRP) participation and receiving all three vaccine doses resu...
Source: Viruses - January 18, 2024 Category: Virology Authors: Yen-Ju Chen Yu-Chen Lin Meng-Tien Wu Jenn-Yuan Kuo Chun-Hsiang Wang Tags: Systematic Review Source Type: research

Viruses, Vol. 16, Pages 143: High-Density Lipoprotein Particles and Torque Teno Virus in Stable Outpatient Kidney Transplant Recipients
The objective of this study was to analyze TTV loads and HDL parameters in serum samples collected at least one year post-transplantation from 656 stable outpatient kidney transplant recipients (KTRs), enrolled in the TransplantLines Food and Nutrition Cohort (Groningen, the Netherlands). Plasma HDL particles and subfractions were measured using nuclear magnetic resonance spectroscopy. Serum TTV load was measured using a quantitative real-time polymerase chain reaction. Associations between HDL parameters and TTV load were examined using univariable and multivariable linear regression. The median age was 54.6 [IQR: 44.6 to...
Source: Viruses - January 18, 2024 Category: Virology Authors: Jip Jonker Caecilia S. E. Doorenbos Daan Kremer Edmund J. Gore Hubert G. M. Niesters Coretta van Leer-Buter Philippe Bourgeois Margery A. Connelly Robin P. F. Dullaart Stefan P. Berger Jan-Stephan F. Sanders Stephan J. L. Bakker Tags: Article Source Type: research

Viruses, Vol. 16, Pages 135: Non-Polio Enteroviruses Isolated by Acute Flaccid Paralysis Surveillance Laboratories in the Russian Federation in 1998 & ndash;2021: Distinct Epidemiological Features of Types
Viruses, Vol. 16, Pages 135: Non-Polio Enteroviruses Isolated by Acute Flaccid Paralysis Surveillance Laboratories in the Russian Federation in 1998–2021: Distinct Epidemiological Features of Types Viruses doi: 10.3390/v16010135 Authors: Olga E. Ivanova Tatiana P. Eremeeva Nadezhda S. Morozova Yulia M. Mikhailova Liubov I. Kozlovskaya Olga Y. Baikova Armen K. Shakaryan Alexandr Y. Krasota Ekaterina A. Korotkova Elizaveta V. Yakovchuk Elena Y. Shustova Alexander N. Lukashev More than 100 types of non-polio enteroviruses (NPEVs) are ubiquitous in the human population and cause a variet...
Source: Viruses - January 18, 2024 Category: Virology Authors: Olga E. Ivanova Tatiana P. Eremeeva Nadezhda S. Morozova Yulia M. Mikhailova Liubov I. Kozlovskaya Olga Y. Baikova Armen K. Shakaryan Alexandr Y. Krasota Ekaterina A. Korotkova Elizaveta V. Yakovchuk Elena Y. Shustova Alexander N. Lukashev Tags: Article Source Type: research

Viruses, Vol. 16, Pages 133: Herpesviridae, Neurodegenerative Disorders and Autoimmune Diseases: What Is the Relationship between Them?
o Alzheimer’s disease and Parkinson’s disease represent the most common forms of cognitive impairment. Multiple sclerosis is a chronic inflammatory disease of the central nervous system responsible for severe disability. An aberrant immune response is the cause of myelin destruction that covers axons in the brain, spinal cord, and optic nerves. Systemic lupus erythematosus is an autoimmune disease characterized by alteration of B cell activation, while Sjögren’s syndrome is a heterogeneous autoimmune disease characterized by altered immune responses. The etiology o...
Source: Viruses - January 17, 2024 Category: Virology Authors: Maria Antonia De Francesco Tags: Review Source Type: research

Viruses, Vol. 16, Pages 134: Structural and Functional Disparities within the Human Gut Virome in Terms of Genome Topology and Representative Genome Selection
ury Zhang Circularity confers protection to viral genomes where linearity falls short, thereby fulfilling the form follows function aphorism. However, a shift away from morphology-based classification toward the molecular and ecological classification of viruses is currently underway within the field of virology. Recent years have seen drastic changes in the International Committee on Taxonomy of Viruses’ operational definitions of viruses, particularly for the tailed phages that inhabit the human gut. After the abolition of the order Caudovirales, these tailed phages are best defined as members of the...
Source: Viruses - January 17, 2024 Category: Virology Authors: Veldsman Yang Zhang Huang Chowdhury Zhang Tags: Article Source Type: research

Viruses, Vol. 16, Pages 131: Influenza A Virus and Acetylation: The Picture Is Becoming Clearer
n Influenza A virus (IAV) is one of the most circulated human pathogens, and influenza disease, commonly known as the flu, remains one of the most recurring and prevalent infectious human diseases globally. IAV continues to challenge existing vaccines and antiviral drugs via its ability to evolve constantly. It is critical to identify the molecular determinants of IAV pathogenesis to understand the basis of flu severity in different populations and design improved antiviral strategies. In recent years, acetylation has been identified as one of the determinants of IAV pathogenesis. Acetylation was originally discovered ...
Source: Viruses - January 17, 2024 Category: Virology Authors: Matloob Husain Tags: Perspective Source Type: research

Viruses, Vol. 16, Pages 132: Systematic Genomic Surveillance of SARS-CoV-2 at Xiamen International Airport and the Port of Xiamen Reveals the Importance of Incoming Travelers in Lineage Diversity
This study focuses on the surveillance of imported SARS-CoV-2 variants among travelers entering Xiamen International Airport and the Port of Xiamen from February to August 2023. A total of 97 imported SARS-CoV-2 sequences among travelers from 223 cases collected from 12 different countries and regions were identified by real-time RT-PCR. Next-generation sequencing was used to generate high-quality complete sequences for phylogenetic and population dynamic analysis. The study revealed a dominant shift in variant distribution, in which the XBB subvariant (XBB.1.5, XBB.1.16, XBB.1.9, XBB.2.3, and EG.5.1) accounted for approxi...
Source: Viruses - January 17, 2024 Category: Virology Authors: Ruiluan You Ruotong Wu Xijing Wang Rao Fu Ningshao Xia Yixin Chen Kunyu Yang Junyu Chen Tags: Article Source Type: research

Viruses, Vol. 16, Pages 129: Chloride Intracellular Channel Protein 1 (CLIC1) Is a Critical Host Cellular Factor for Influenza A Virus Replication
Conclusions: This study suggests that CLIC1 is involved in later stages of IAV replication. Further investigation should clarify mechanism(s) for the development of anti-IAV drugs targeting CLIC1 protein. (Source: Viruses)
Source: Viruses - January 16, 2024 Category: Virology Authors: Mahamud-ur Rashid Kevin M. Coombs Tags: Article Source Type: research

Viruses, Vol. 16, Pages 130: Equine Rotavirus A under the One Health Lens: Potential Impacts on Public Health
Parreño Group A rotaviruses are a well-known cause of viral gastroenteritis in infants and children, as well as in many mammalian species and birds, affecting them at a young age. This group of viruses has a double-stranded, segmented RNA genome with high genetic diversity linked to point mutations, recombination, and, importantly, reassortment. While initial molecular investigations undertaken in the 1900s suggested host range restriction among group A rotaviruses based on the fact that different gene segments were distributed among different animal species, recent molecular surveillance and genome constellation geno...
Source: Viruses - January 16, 2024 Category: Virology Authors: Mariano Carossino Maria Aldana Vissani Maria E. Barrandeguy Udeni B. R. Balasuriya Viviana Parre ño Tags: Review Source Type: research

Viruses, Vol. 16, Pages 126: Characteristics of Respiratory Syncytial Virus Infections in Children in the Post-COVID Seasons: A Northern Italy Hospital Experience
Conclusions: The clinical presentation of RSV in the two post-COVID seasons suggests that the pathophysiology of the virus did not change across these two years. Further studies are needed to continuously monitor RSV to support an effective prevention strategy. (Source: Viruses)
Source: Viruses - January 16, 2024 Category: Virology Authors: Davide Treggiari Chiara Pomari Giorgio Zavarise Chiara Piubelli Fabio Formenti Francesca Perandin Tags: Brief Report Source Type: research

Viruses, Vol. 16, Pages 127: Functional Impacts of Epitranscriptomic m6A Modification on HIV-1 Infection
Li Wu Epitranscriptomic RNA modifications play a crucial role in the posttranscriptional regulation of gene expression. N6-methyladenosine (m6A) is the most prevalent internal modification of eukaryotic RNA and plays a pivotal role in RNA fate. RNA m6A modification is regulated by a group of cellular proteins, methyltransferases (writers) and demethylases (erasers), which add and remove the methyl group from adenosine, respectively. m6A modification is recognized by a group of cellular RNA-binding proteins (readers) that specifically bind to m6A-modified RNA, mediating effects on RNA stability, splicing, transport, a...
Source: Viruses - January 16, 2024 Category: Virology Authors: Stacia Phillips Tarun Mishra Siyu Huang Li Wu Tags: Review Source Type: research

Viruses, Vol. 16, Pages 128: Current Progress of Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) Vaccine Development
U. Jung SFTSV is an emerging tick-borne virus causing hemorrhagic fever with a case fatality rate (CFR) that can reach up to 27%. With endemic infection in East Asia and the recent spread of the vector tick to more than 20 states in the United States, the SFTSV outbreak is a globally growing public health concern. However, there is currently no targeted antiviral therapy or licensed vaccine against SFTSV. Considering the age-dependent SFTS pathogenesis and disease outcome, a sophisticated vaccine development approach is required to safeguard the elderly population from lethal SFTSV infection. Given the recent emergence...
Source: Viruses - January 16, 2024 Category: Virology Authors: Dokyun Kim Chih-Jen Lai Inho Cha Jae U. Jung Tags: Review Source Type: research

Viruses, Vol. 16, Pages 124: Update of Natural Products and Their Derivatives Targeting Epstein & ndash;Barr Infection
Viruses, Vol. 16, Pages 124: Update of Natural Products and Their Derivatives Targeting Epstein–Barr Infection Viruses doi: 10.3390/v16010124 Authors: Rosamaria Pennisi Paola Trischitta Marianna Costa Assunta Venuti Maria Pia Tamburello Maria Teresa Sciortino Epstein–Barr (EBV) is a human γ-herpesvirus that undergoes both a productive (lytic) cycle and a non-productive (latent) phase. The virus establishes enduring latent infection in B lymphocytes and productive infection in the oral mucosal epithelium. Like other herpesviruses, EBV expresses its genes in a coordinat...
Source: Viruses - January 15, 2024 Category: Virology Authors: Rosamaria Pennisi Paola Trischitta Marianna Costa Assunta Venuti Maria Pia Tamburello Maria Teresa Sciortino Tags: Review Source Type: research

Viruses, Vol. 16, Pages 125: Development of Stable Infectious cDNA Clones of Tomato Black Ring Virus Tagged with Green Fluorescent Protein
wska Tomato black ring virus (TBRV) is a member of the Nepovirus genus in the Secoviridae family, which infects a wide range of important crop species worldwide. In this work, we constructed four cDNA infectious clones of the TBRV tagged with the green fluorescent protein (TBRV-GFP), which varied in (i) the length of the sequences flanking the GFP insert, (ii) the position of the GFP insert within the RNA2 polyprotein, and (iii) the addition of a self-cutting 2A protein. The presence of the GFP coding sequence in infected plants was verified by RT-PCR, while the infectivity and stability of the constructs were verified...
Source: Viruses - January 15, 2024 Category: Virology Authors: Aleksandra Zarzy ńska-Nowak Julia Minicka Przemys ław Wieczorek Beata Hasi ów-Jaroszewska Tags: Article Source Type: research

Viruses, Vol. 16, Pages 123: Navigating Evolving Challenges in Blood Safety
m Blood safety remains a paramount public health concern, and health authorities maintain a high level of vigilance to prevent transfusion-transmitted infections (TTIs) [...] (Source: Viruses)
Source: Viruses - January 15, 2024 Category: Virology Authors: Mahmoud Reza Pourkarim Tags: Editorial Source Type: research