Viruses, Vol. 16, Pages 358: Genetics of H5N1 and H5N8 High-Pathogenicity Avian Influenza Viruses Isolated in Japan in Winter 2021 & ndash;2022
Viruses, Vol. 16, Pages 358: Genetics of H5N1 and H5N8 High-Pathogenicity Avian Influenza Viruses Isolated in Japan in Winter 2021–2022 Viruses doi: 10.3390/v16030358 Authors: Junki Mine Yoshihiro Takadate Asuka Kumagai Saki Sakuma Ryota Tsunekuni Kohtaro Miyazawa Yuko Uchida In winter 2021–2022, H5N1 and H5N8 high-pathogenicity avian influenza (HPAI) viruses (HPAIVs) caused serious outbreaks in Japan: 25 outbreaks of HPAI at poultry farms and 107 cases in wild birds or in the environment. Phylogenetic analyses divided H5 HPAIVs isolated in Japan in the winter of 2021&nda...
Source: Viruses - February 26, 2024 Category: Virology Authors: Junki Mine Yoshihiro Takadate Asuka Kumagai Saki Sakuma Ryota Tsunekuni Kohtaro Miyazawa Yuko Uchida Tags: Brief Report Source Type: research

Viruses, Vol. 16, Pages 359: Molecular Profile of Variants Potentially Associated with Severe Forms of COVID-19 in Amazonian Indigenous Populations
The objective of the study is to investigate genetic variants present in the genes AQP3, ARHGAP27, ELF5L, IFNAR2, LIMD1, OAS1 and UPK1A, selected due to their association with the severity of COVID-19, in a sample of indigenous people from the Brazilian Amazon in order to describe potential new and already studied variants. We performed the complete sequencing of the exome of 64 healthy indigenous people from the Brazilian Amazon. The allele frequency data of the population were compared with data from other continental populations. A total of 66 variants present in the seven genes studied were identified, including a vari...
Source: Viruses - February 26, 2024 Category: Virology Authors: Rita de C ássia Calderaro Coelho Carlliane Lima e Lins Pinto Martins Lucas Favacho Pastana Juliana Carla Gomes Rodrigues Kaio Evandro Cardoso Aguiar Amanda de Nazar é Cohen-Paes Laura Patr ícia Albarello Gellen Francisco Cezar Aquino de Moraes Maria Cl Tags: Article Source Type: research

Viruses, Vol. 16, Pages 356: Editorial for SARS-CoV-2 and COVID-19 Topical Collection
n A previously unknown coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was isolated in Wuhan, China in December 2019, from a patient with a respiratory disease linked to potential contact with wild animals [...] (Source: Viruses)
Source: Viruses - February 25, 2024 Category: Virology Authors: Luis Martinez-Sobrido Fernando Almaz án Tags: Editorial Source Type: research

Viruses, Vol. 16, Pages 354: Tixagevimab/Cilgavimab: Still a Valid Prophylaxis against COVID-19 New Variants?
Conclusions: Tixagevimab/cilgavimab efficacy wanes against novel subvariants. This underscores the critical need for ongoing adaptation and vigilance in prophylactic strategies to effectively counter the dynamic and unpredictable nature of the COVID-19 pandemic. (Source: Viruses)
Source: Viruses - February 25, 2024 Category: Virology Authors: Anna Gidari Samuele Sabbatini Sabrina Bastianelli Sara Pierucci Chiara Busti Elisabetta Svizzeretto Andrea Tommasi Carlo Pallotto Elisabetta Schiaroli Daniela Francisci Tags: Brief Report Source Type: research

Viruses, Vol. 16, Pages 355: Identification of Mycoviruses in the Pathogens of Fragrant Pear Valsa Canker from Xinjiang in China
In this study, 199 isolates were obtained from diseased branches of fragrant pear in the main production areas of Xinjiang. Among them, 134 belonged to Valsa spp., identified using morphological and molecular biological techniques, in which V. mali was the dominant species. The mycoviruses in Valsa spp. were further identified using metatranscriptomic sequencing and RT-PCR. The results revealed that a total of seven mycoviruses were identified, belonging to Botourmiaviridae, Endornaviridae, Fusariviridae, Hypoviridae, Mitoviridae, and Narnaviridae, among which Phomopsis longicolla hypovirus (PlHV) was dominant in all the s...
Source: Viruses - February 25, 2024 Category: Virology Authors: Chenguang Zhang Xiaoya Zheng Zhanjiang Tie Hui Xi Mai Shi Yanjun Ma Wenbin Chen Yingjie Mi Rui Yang Sifeng Zhao Xuekun Zhang Tags: Article Source Type: research

Viruses, Vol. 16, Pages 357: Wild Bird-Origin H6N2 Influenza Virus Acquires Enhanced Pathogenicity after Single Passage in Mice
This study demonstrated that the H6N2 subtype wild bird-origin AIV easily acquired the mammalian adaptation. The monitoring and evaluation of H6 wild bird-origin AIV should be strengthened. (Source: Viruses)
Source: Viruses - February 25, 2024 Category: Virology Authors: Siqi Tang Bing Han Chaofan Su Hailing Li Shiyuchen Zhao Haoyu Leng Yali Feng Ying Zhang Tags: Article Source Type: research

Viruses, Vol. 16, Pages 352: Cordycepin Inhibits Enterovirus A71 Replication and Protects Host Cell from Virus-Induced Cytotoxicity through Adenosine Action Pathway
In this study, the potency and role of cordycepin treatment on EV-A71 infection were investigated. Results demonstrated that cordycepin treatment significantly reduced the viral load and viral ribonucleic acid (RNA) level in EV-A71-infected Vero cells. In addition, EV-A71-mediated cytotoxicity was significantly inhibited in the presence of cordycepin in a dose-dependent manner. The protective effect can also be extended to Caco-2 intestinal cells, as evidenced by the higher median tissue culture infectious dose (TCID50) values in the cordycepin-treated groups. Furthermore, cordycepin inhibited EV-A71 replication by acting ...
Source: Viruses - February 24, 2024 Category: Virology Authors: Yi-Ping Lee Chun-Keung Yu Tak-Wah Wong Li-Ching Chen Bu-Miin Huang Tags: Article Source Type: research

Viruses, Vol. 16, Pages 353: Cross-Species Transmission Potential of H4 Avian Influenza Viruses in China: Epidemiological and Evolutionary Study
an Wang Yuelong Shu H4 avian influenza viruses (AIVs) have been widely detected in live poultry markets in China. However, the potential public health impact of H4 AIVs remains largely uncertain. Here, we fully analyzed the distribution and phylogenetic relationship of H4 AIVs in China. We obtained 31 isolates of H4 viruses in China during 2009–2022 through surveillance in poultry-associated environments, such as live poultry markets and poultry farms. Genomic sequence analysis together with publicly available data revealed that frequent reassortment and introduction of H4 AIV from wild birds to poultry...
Source: Viruses - February 24, 2024 Category: Virology Authors: Shuxia Lin Ye Zhang Jiaying Yang Lei Yang Xiyan Li Hong Bo Jia Liu Min Tan Wenfei Zhu Dayan Wang Yuelong Shu Tags: Article Source Type: research

Viruses, Vol. 16, Pages 350: Negevirus Piura Suppresses Zika Virus Replication in Mosquito Cells
reen T. Long We investigated the interaction between the insect-specific virus, Piura virus (PIUV), and the arbovirus Zika virus (ZIKV) in Aedes albopictus cells. We performed coinfection experiments in C6/36 cells. Piura virus (Cor 33 strain, Colombia) and ZIKV (PRVABC58 strain, Puerto Rico) were co-inoculated into C6/36 cells using two multiplicity of infection (MOI) combinations: 0.1 for both viruses and 1.0 for ZIKV, 0.1 for PIUV. Wells were infected in triplicate with either PIUV and ZIKV coinfection, ZIKV-only, or PIUV-only. Mock infected cells served as control wells. The cell suspension was collected daily 7 da...
Source: Viruses - February 24, 2024 Category: Virology Authors: Val éria L. Carvalho Dhani Prakoso Erika R. Schwarz Tracey D. Logan Bruno Tardelli Diniz Nunes Sarah E. Beachboard Maureen T. Long Tags: Article Source Type: research

Viruses, Vol. 16, Pages 351: Risk of Severe COVID-19-Related Outcomes among Patients with Cirrhosis: A Population-Based Cohort Study in Canada
Naveed Z. Janjua We assessed the association between cirrhosis and severe COVID-19-related outcomes among people with laboratory-diagnosed COVID-19 infection in British Columbia, Canada. We used data from the British Columbia (BC) COVID-19 Cohort, a population-based cohort that integrates data on all individuals tested for COVID-19, with data on hospitalizations, medical visits, emergency room visits, prescription drugs, chronic conditions, and deaths in the Canadian province of BC. We included all individuals aged ≥18 who tested positive for SARS-CoV-2 by real-time reverse transcription-polymerase chain rea...
Source: Viruses - February 24, 2024 Category: Virology Authors: H éctor Alexander Velásquez García Prince A. Adu Ada Okonkwo-Dappa Jean Damascene Makuza Georgine Cua Mawuena Binka James Wilton Hind Sbihi Naveed Z. Janjua Tags: Article Source Type: research

Viruses, Vol. 16, Pages 348: HBcAb Positivity as a Risk Factor for Missing HIV RNA Undetectability after the 3TC+DTG Switch
In this study, a comparison analysis was conducted between HBcAb-positive and -negative PLWH regarding HIV-RNA suppression, considering: (1): Target Not Detected (TND) < 20 cp/mL; (2) Target Detected (TD) < 20 cp/mL; and (3) Detectable > 20 cp/mL and <50 cp/mL and >50 copies/mL. A total of 267 patients on 2DR with 3TC-DTG were included. In comparison to HBcAb-negative, HBcAb-positive patients were older (45 years [35–54]) and had a lower CD4+ nadir (248 vs. 349 cells/mmc, p = 0.007). No difference in the maintenance of virological suppression was present ...
Source: Viruses - February 23, 2024 Category: Virology Authors: Vincenzo Malagnino Tiziana Mulas Elisabetta Teti Monica Basso Mario Giobbia Nicholas Geremia Giuliana Battagin Yasmine Abi Aad Jean-Paul Vincensini Marco Iannetta Saverio Giuseppe Parisi Loredana Sarmati Karine Lacombe Tags: Brief Report Source Type: research

Viruses, Vol. 16, Pages 349: Identification of a Potential Entry-Fusion Complex Based on Sequence Homology of African Swine Fever and Vaccinia Virus
In this study, we explored the possibility of an analogous ASFV EFC by identifying ten candidate proteins exhibiting structural similarities with VACV EFC proteins. This could reveal key functions of these ASFV proteins, drawing attention to shared features between the two virus families, suggesting the potential existence of an ASFV entry-fusion complex. (Source: Viruses)
Source: Viruses - February 23, 2024 Category: Virology Authors: Jes ús Urquiza Miguel Ángel Cuesta-Geijo Isabel Garc ía-Dorival Óscar Fernández Ana del Puerto Jos é Fernando Díaz Covadonga Alonso Tags: Article Source Type: research

Viruses, Vol. 16, Pages 342: Intra-Host Evolution Analyses in an Immunosuppressed Patient Supports SARS-CoV-2 Viral Reservoir Hypothesis
n-Lepage Catherine Bourassa Alexandra Tauzin Simon Grandjean Lapierre Nicolas Chomont Andrés Finzi Daniel E. Kaufmann Morgan Craig Julie G. Hussin Throughout the SARS-CoV-2 pandemic, several variants of concern (VOCs) have been identified, many of which share recurrent mutations in the spike glycoprotein’s receptor-binding domain (RBD). This region coincides with known epitopes and can therefore have an impact on immune escape. Protracted infections in immunosuppressed patients have been hypothesized to lead to an enrichment of such mutations and therefore drive evolution towards VOCs. He...
Source: Viruses - February 23, 2024 Category: Virology Authors: Dominique Fournelle Fatima Mostefai Elsa Brunet-Ratnasingham Rapha ël Poujol Jean-Christophe Grenier Jos é Héctor Gálvez Am élie Pagliuzza In ès Levade Sandrine Moreira Mehdi Benlarbi Guillaume Beaudoin-Bussi ères Gabrielle Gendron-Lepage Catherine Tags: Article Source Type: research

Viruses, Vol. 16, Pages 343: Multiple Infections with Viruses of the Family Tymoviridae in Czech Grapevines
This study focused on the viruses of the Tymoviridae family that infect grapevines in the Czech Republic. Complete sequences of GFkV (grapevine fleck virus) and GRGV (grapevine red globe virus) from the genus Maculavirus and GRVFV (grapevine rupestris vein feathering virus) and GSyV-1 (grapevine Syrah virus 1) from the genus Marafivirus were obtained using high-throughput sequencing of small RNAs and total RNAs. Mixed infections with these viruses were observed, as well as several variants of these viruses in the same plant. Phylogenetic analysis showed the position of the newly obtained virus isolates within the Tymovirid...
Source: Viruses - February 23, 2024 Category: Virology Authors: Marcela Kom ínková Karima Ben Mansour Petr Kom ínek Jana Bro žová Radom íra Střalková Tags: Article Source Type: research

Viruses, Vol. 16, Pages 344: Does the Recovery of Respiratory Viruses Impact Pulmonary Function at Baseline and 1-, 6-, and 12-Month Follow-Up in People Living with HIV and Pneumonia?
lma Vanessa Rueda The frequency of respiratory viruses in people living with HIV (PLHIV) and their impact on lung function remain unclear. We aimed to determine the frequency of respiratory viruses in bronchoalveolar lavage and induced sputum samples in PLHIV and correlate their presence with lung function. A prospective cohort of adults hospitalized in Medellín between September 2016 and December 2018 included three groups: group 1 = people diagnosed with HIV and a diagnosis of community-acquired pneumonia (CAP), group 2 = HIV, and group 3 = CAP. People were followed up with at months 1, 6, and 12. Clin...
Source: Viruses - February 23, 2024 Category: Virology Authors: Iv án Arturo Rodríguez-Sabogal Ruth Cabrera Diana Marin Lucelly Lopez Yudy Aguilar Gustavo Gomez Katherine Pe ña-Valencia Will Ria ño L ázaro Vélez Yoav Keynan Zulma Vanessa Rueda Tags: Article Source Type: research