Viruses, Vol. 16, Pages 455: Acalculous Cholecystitis in COVID-19 Patients: A Narrative Review
stos Savopoulos
Acute acalculous cholecystitis (AAC) represents cholecystitis without gallstones, occurring in approximately 5–10% of all cases of acute cholecystitis in adults. Several risk factors have been recognized, while infectious diseases can be a cause of cholecystitis in otherwise healthy people. Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has spread worldwide, leading to an unprecedented pandemic. The virus enters cells through the binding of the spike protein to angiotensin-converting enzyme 2 (ACE2) receptors expressed ...
Source: Viruses - March 15, 2024 Category: Virology Authors: Evanthia Thomaidou Eleni Karlafti Matthaios Didagelos Kalliopi Megari Eleni Argiriadou Karolina Akinosoglou Daniel Paramythiotis Christos Savopoulos Tags: Review Source Type: research
Viruses, Vol. 16, Pages 453: Recent Molecular Characterization of Porcine Rotaviruses Detected in China and Their Phylogenetic Relationships with Human Rotaviruses
ang
Xiaowen Li
Bin Zhou
Porcine rotavirus A (PoRVA) is an enteric pathogen capable of causing severe diarrhea in suckling piglets. Investigating the prevalence and molecular characteristics of PoRVA in the world, including China, is of significance for disease prevention. In 2022, a total of 25,768 samples were collected from 230 farms across China, undergoing porcine RVA positivity testing. The results showed that 86.52% of the pig farms tested positive for porcine RVA, with an overall positive rate of 51.15%. Through the genetic evolution analysis of VP7, VP4 and VP6 genes, it was revealed that G9 is the predomin...
Source: Viruses - March 14, 2024 Category: Virology Authors: Mengli Qiao Meizhen Li Yang Li Zewei Wang Zhiqiang Hu Jie Qing Jiapei Huang Junping Jiang Yaqin Jiang Jinyong Zhang Chunliu Gao Chen Yang Xiaowen Li Bin Zhou Tags: Article Source Type: research
Viruses, Vol. 16, Pages 450: Small Molecules for the Treatment of Long-COVID-Related Vascular Damage and Abnormal Blood Clotting: A Patent-Based Appraisal
iano Altomare
People affected by COVID-19 are exposed to, among others, abnormal clotting and endothelial dysfunction, which may result in deep vein thrombosis, cerebrovascular disorders, and ischemic and non-ischemic heart diseases, to mention a few. Treatments for COVID-19 include antiplatelet (e.g., aspirin, clopidogrel) and anticoagulant agents, but their impact on morbidity and mortality has not been proven. In addition, due to viremia-associated interconnected prothrombotic and proinflammatory events, anti-inflammatory drugs have also been investigated for their ability to mitigate against immune dysregulation du...
Source: Viruses - March 14, 2024 Category: Virology Authors: Francesco Samarelli Giovanni Graziano Nicola Gambacorta Elisabetta Anna Graps Francesco Leonetti Orazio Nicolotti Cosimo Damiano Altomare Tags: Perspective Source Type: research
Viruses, Vol. 16, Pages 451: Interferons in Viral Infections
yay
Interferons (IFNs) are cytokines that inhibit viral replication in host cells by triggering innate immune responses through the transcriptional induction of various IFN-stimulated genes (ISGs) [...] (Source: Viruses)
Source: Viruses - March 14, 2024 Category: Virology Authors: Pracheta Sengupta Saurabh Chattopadhyay Tags: Editorial Source Type: research
Viruses, Vol. 16, Pages 452: Comparative Analysis of Cytomegalovirus Gastrointestinal Disease in Immunocompetent and Immunocompromised Patients
Conclusions: GI bleeding is the most common manifestation and prognostic factor in both groups. Early diagnosis and effective antiviral therapy can significantly reduce in-hospital mortality. (Source: Viruses)
Source: Viruses - March 14, 2024 Category: Virology Authors: Pai-Jui Yeh Ren-Chin Wu Yung-Kuan Tsou Chien-Ming Chen Cheng-Tang Chiu Chien-Chang Chen Ming-Wei Lai Yu-Bin Pan Puo-Hsien Le Tags: Article Source Type: research
Viruses, Vol. 16, Pages 448: Viral Epitope Scanning Reveals Correlation between Seasonal HCoVs and SARS-CoV-2 Antibody Responses among Cancer and Non-Cancer Patients
West
Charles Wood
Seasonal coronaviruses (HCoVs) are known to contribute to cross-reactive antibody (Ab) responses against SARS-CoV-2. While these responses are predictable due to the high homology between SARS-CoV-2 and other CoVs, the impact of these responses on susceptibility to SARS-CoV-2 infection in cancer patients is unclear. To investigate the influence of prior HCoV infection on anti-SARS-CoV-2 Ab responses among COVID-19 asymptomatic individuals with cancer and controls without cancers, we utilized the VirScan technology in which phage immunoprecipitation and sequencing (PhIP-seq) of longitudinal plasma sa...
Source: Viruses - March 13, 2024 Category: Virology Authors: Salum J. Lidenge Dicle Yalcin Sydney J. Bennett Owen Ngalamika Brenda B. Kweyamba Chacha J. Mwita For Yue Tso Julius Mwaiselage John T. West Charles Wood Tags: Article Source Type: research
Viruses, Vol. 16, Pages 444: The Prevalence of Tick-Borne Encephalitis Virus in Wild Rodents Captured in Tick-Borne Encephalitis Foci in Highly Endemic Lithuania
This study shows that wild rodents are suitable sentinel animals to confirm TBEV foci. In addition, the study results demonstrate that sample cultivation in cell culture is a highly efficient method for increasing TBEV viral load to detectable quantities. (Source: Viruses)
Source: Viruses - March 13, 2024 Category: Virology Authors: Evelina Simkute Arnoldas Pautienius Juozas Grigas Marina Sidorenko Jana Radzijevskaja Algimantas Paulauskas Arunas Stankevicius Tags: Article Source Type: research
Viruses, Vol. 16, Pages 445: Porcine Deltacoronavirus Occurrence in the United States Breeding Herds since Its Emergence in 2014
Corzo
PDCoV, an enveloped RNA virus, causes atrophic enteritis in neonatal piglets, leading to diarrhea, malabsorption, dehydration, and death. The study aims to fill the gap in the current epidemiological information about PDCoV in the U.S. pig population after its emergence in 2014. Data from the Morrison Swine Health Monitoring Project (MSHMP) between January 2015 and December 2023 were analyzed, representing approximately 60% of the U.S. breeding herd. Participating herds report weekly PDCoV health status. In total, 244 PDCoV outbreaks occurred in 186 sites from 22 production systems across 16 states. Case counts p...
Source: Viruses - March 13, 2024 Category: Virology Authors: Mariana Kikuti Catalina Picasso-Risso Cesar A. Corzo Tags: Brief Report Source Type: research
Viruses, Vol. 16, Pages 447: Immune System Deficiencies Do Not Alter SARS-CoV-2 Evolutionary Rate but Favour the Emergence of Mutations by Extending Viral Persistence
This study suggests that a compromised immune system alone does not affect SARS-CoV-2 within-host genomic variability. (Source: Viruses)
Source: Viruses - March 13, 2024 Category: Virology Authors: Laura Manuto Martina Bado Marco Cola Elena Vanzo Maria Antonello Giorgia Mazzotti Monia Pacenti Giampaolo Cordioli Lolita Sasset Anna Maria Cattelan Stefano Toppo Enrico Lavezzo Tags: Article Source Type: research
Viruses, Vol. 16, Pages 446: SARS-CoV-2-Specific Immune Responses in Vaccination and Infection during the Pandemic in 2020 & ndash;2022
Viruses, Vol. 16, Pages 446: SARS-CoV-2-Specific Immune Responses in Vaccination and Infection during the Pandemic in 2020–2022
Viruses doi: 10.3390/v16030446
Authors:
Wakana Inoue
Yuta Kimura
Shion Okamoto
Takuto Nogimori
Akane Sakaguchi-Mikami
Takuya Yamamoto
Yasuko Tsunetsugu-Yokota
To gain insight into how immunity develops against SARS-CoV-2 from 2020 to 2022, we analyzed the immune response of a small group of university staff and students who were either infected or vaccinated. We investigated the levels of receptor-binding domain (RBD)-specific and nucleocapsid (N)-specific IgG and IgA...
Source: Viruses - March 13, 2024 Category: Virology Authors: Wakana Inoue Yuta Kimura Shion Okamoto Takuto Nogimori Akane Sakaguchi-Mikami Takuya Yamamoto Yasuko Tsunetsugu-Yokota Tags: Article Source Type: research
Viruses, Vol. 16, Pages 449: The Accumulation of Phenyllactic Acid Impairs Host Glutamine Metabolism and Inhibits African Swine Fever Virus Replication: A Novel Target for the Development of Anti-ASFV Drugs
This study aimed to investigate the impact of glucose and glutamine metabolic dynamics on the rate of ASFV replication. Our findings demonstrate that ASFV infection favors using glutamine as a metabolic fuel to facilitate self-replication. ASFV replication can be substantially inhibited by blocking glutamine metabolism. The metabolomics analysis of the host cell after late-stage ASFV infection revealed a significant disruption of normal glutamine metabolic pathways due to the abundant expression of PLA (phenyllactic acid). Pretreatment with PLA also inhibited ASFV proliferation and glutamine consumption following infection...
Source: Viruses - March 13, 2024 Category: Virology Authors: Junfei Dai Xusheng Ma Ashenafi Kiros Wubshet Qian Li Xiaofen Shang Zhikuan Luo Jianan Liu Zhiyu Li Mingxia Li Yujie Song Lijun Guo Jie Zhang Haixue Zheng Tags: Article Source Type: research
Viruses, Vol. 16, Pages 442: Natural Adeno-Associated Virus Serotypes and Engineered Adeno-Associated Virus Capsid Variants: Tropism Differences and Mechanistic Insights
mas Weber
Today, adeno-associated virus (AAV)-based vectors are arguably the most promising in vivo gene delivery vehicles for durable therapeutic gene expression. Advances in molecular engineering, high-throughput screening platforms, and computational techniques have resulted in a toolbox of capsid variants with enhanced performance over parental serotypes. Despite their considerable promise and emerging clinical success, there are still obstacles hindering their broader use, including limited transduction capabilities, tissue/cell type-specific tropism and penetration into tissues through anatomical barriers, off-ta...
Source: Viruses - March 12, 2024 Category: Virology Authors: Estrella Lopez-Gordo Kyle Chamberlain Jalish Mahmud Riyad Erik Kohlbrenner Thomas Weber Tags: Review Source Type: research
Viruses, Vol. 16, Pages 443: The Medicinal Phage & mdash;Regulatory Roadmap for Phage Therapy under EU Pharmaceutical Legislation
Viruses, Vol. 16, Pages 443: The Medicinal Phage—Regulatory Roadmap for Phage Therapy under EU Pharmaceutical Legislation
Viruses doi: 10.3390/v16030443
Authors:
Timo Faltus
Bacteriophage therapy is a promising approach to treating bacterial infections. Research and development of bacteriophage therapy is intensifying due to the increase in antibiotic resistance and the faltering development of new antibiotics. Bacteriophage therapy uses bacteriophages (phages), i.e., prokaryotic viruses, to specifically target and kill pathogenic bacteria. The legal handling of this type of therapy raises several questio...
Source: Viruses - March 12, 2024 Category: Virology Authors: Timo Faltus Tags: Article Source Type: research
Viruses, Vol. 16, Pages 435: Understanding the Impact of COVID-19 on Roma Vulnerable Communities in Western Romania: Insights and Predictive Factors from a Retrospective Study
Conclusions: Higher rates of ICU admissions, severe symptomatology, and distinct laboratory biomarker profiles among Roma patients emphasize the critical importance of personalized care strategies and targeted interventions to mitigate the disproportionate burden of COVID-19 on vulnerable communities. CRP values at admission have had a clear impact as a risk assessment biomarker for Roma patients, while the significance of IL-6, HDL, and 25-OHD should also not be overlooked in these patients. (Source: Viruses)
Source: Viruses - March 12, 2024 Category: Virology Authors: Ionut Dragos Capraru Catalin Marian Dan Dumitru Vulcanescu Sonia Tanasescu Tiberiu Liviu Dragomir Teodora Daniela Marti Casiana Boru Cecilia Roberta Avram Monica Susan Cristian Sebastian Vlad Tags: Article Source Type: research
Viruses, Vol. 16, Pages 436: Exogenous Application of dsRNA for Protection against Tomato Leaf Curl New Delhi Virus
aura Miozzi
Tomato leaf curl New Delhi virus (ToLCNDV) is an emerging plant pathogen, fast spreading in Asian and Mediterranean regions, and is considered the most harmful geminivirus of cucurbits in the Mediterranean. ToLCNDV infects several plant and crop species from a range of families, including Solanaceae, Cucurbitaceae, Fabaceae, Malvaceae and Euphorbiaceae. Up to now, protection from ToLCNDV infection has been achieved mainly by RNAi-mediated transgenic resistance, and non-transgenic fast-developing approaches are an urgent need. Plant protection by the delivery of dsRNAs homologous to a pathogen target sequenc...
Source: Viruses - March 12, 2024 Category: Virology Authors: Fulco Frascati Silvia Rotunno Gian Paolo Accotto Emanuela Noris Anna Maria Vaira Laura Miozzi Tags: Article Source Type: research
