Viruses, Vol. 16, Pages 345: Viroporins Manipulate Cellular Powerhouses and Modulate Innate Immunity
°rez Viruses have a wide repertoire of molecular strategies that focus on their replication or the facilitation of different stages of the viral cycle. One of these strategies is mediated by the activity of viroporins, which are multifunctional viral proteins that, upon oligomerization, exhibit ion channel properties with mild ion selectivity. Viroporins facilitate multiple processes, such as the regulation of immune response and inflammasome activation through the induction of pore formation in various cell organelle membranes to facilitate the escape of ions and the alteration of intracellular homeostasis. Viroporins...
Source: Viruses - February 23, 2024 Category: Virology Authors: Leticia Cedillo-Barr ón Julio Garc ía-Cordero Giovani Visoso-Carvajal Mois és León-Juárez Tags: Review Source Type: research

Viruses, Vol. 16, Pages 346: Cytomegalovirus Diseases of the Gastrointestinal Tract in Immunocompetent Patients: A Narrative Review
This study aims to provide a comprehensive summary of the current evidence regarding presentations, diagnostics, management, risk assessment, and outcomes in immunocompetent patients with CMV GI disease. A thorough literature search of English publications up to April 2022 was conducted across electronic databases to identify relevant articles, with eligible case series selected for detailed analysis. The majority of immunocompetent patients affected by CMV GI disease are typically elderly, critically ill, or burdened with comorbidities that compromise immunity. Clinical presentations range from subtle symptoms to severe s...
Source: Viruses - February 23, 2024 Category: Virology Authors: Pai-Jui Yeh Ren-Chin Wu Chyi-Liang Chen Cheng-Tang Chiu Ming-Wei Lai Chien-Chang Chen Cheng-Hsun Chiu Yu-Bin Pan Wey-Ran Lin Puo-Hsien Le Tags: Review Source Type: research

Viruses, Vol. 16, Pages 347: Retreatment with HBV siRNA Results in Additional Reduction in HBV Antigenemia and Immune Stimulation in the AAV-HBV Mouse Model
Conclusions: Retreatment induced an additional decline in HBsAg levels, reaching undetectable levels when baseline HBsAg levels were 3log10 or less. This correlated with T-cell activation and upregulation of Trem2. (Source: Viruses)
Source: Viruses - February 23, 2024 Category: Virology Authors: Ellen Van Van Gulck N ádia Conceição-Neto Liese Aerts Wim Pierson Lore Verschueren Mara Vleeschouwer Vinod Krishna Isabel N ájera Frederik Pauwels Tags: Article Source Type: research

Viruses, Vol. 16, Pages 341: A Specific Pattern of Routine Cerebrospinal Fluid Parameters Might Help to Identify Cases of West Nile Virus Neuroinvasive Disease
Conclusions: Cases with WNV ME showed a specific pattern of routine CSF parameters and demographic data that allowed for their identification with good accuracy. These findings might help to guide the diagnostic workup in cases with viral ME, in particular allowing the timely identification of cases with ME due to WNV. (Source: Viruses)
Source: Viruses - February 22, 2024 Category: Virology Authors: Johann Otto Pelz Christoph M √ľhlberg Isabel Friedrich Lorenz Weidhase Silke Zimmermann Melanie Maier Corinna Pietsch Tags: Brief Report Source Type: research

Viruses, Vol. 16, Pages 333: Post-Vaccination Sero-Monitoring of Peste des Petits Ruminants in Sheep and Goats in Karnataka: Progress towards PPR Eradication in India
This study was conducted from January to March 2023 to assess seroconversion in post-vaccinated goats and sheep at the epidemiological unit (epi-unit) level, aligning with the World Organisation for Animal Health (WOAH) and the Food and Agriculture Organization (FAO) guidelines in the PPR Global Control and Eradication Strategy (GCES). Before vaccination, 3466 random serum samples were collected from small ruminants of three age groups (6–12 months, 1–2 years, and >2 years) across 116 epi-units, spanning 82 taluks in 28 districts. Post-vaccination sero-monitoring included 1102 serum s...
Source: Viruses - February 22, 2024 Category: Virology Authors: Vinayagamurthy Balamurugan Rakshit Ojha Kirubakaran Vinod Kumar Anand Asha Suhail Ashraf Annett Helcita Dsouza Archana Pal Prajakta Prashant Bokade Shakuntala Krishnaiah Harshitha Ramchandra Deshpande Mahadevappa Swathi Kuralayanapalya Puttahonnappa Sures Tags: Article Source Type: research