Viruses, Vol. 16, Pages 477: Predicting Natural Evolution in the RBD Region of the Spike Glycoprotein of SARS-CoV-2 by Machine Learning
This study investigates the effectiveness of the “ML-Guided Design Correctly Predicts Combinatorial Effects Strategy” compared to the “ML-Guided Design Correctly Predicts Natural Evolution Prediction Strategy”. To enhance machine learning, we created a timestamping algorithm and two auxiliary programs using advanced techniques to rapidly process extensive data, surpassing batch sequencing capabilities. This study not only advances machine learning in guiding protein evolution but also holds potential for forecasting future viruses and vaccine development. (Source: Viruses)
Source: Viruses - March 20, 2024 Category: Virology Authors: Yiheng Liu Zitong He Liyiyang Jia Yiwei Xue Yuxuan Du Huiwen Tan Xianzhi Zhang Yu Ji Yigang Tong Haijun Xu Luo Liu Tags: Article Source Type: research
Viruses, Vol. 16, Pages 476: Epidemiological and Genetic Characterization of Coxsackievirus A6-Associated Hand, Foot, and Mouth Disease in Gwangju, South Korea, in 2022
In conclusion, circulating EV types should be continuously monitored to understand pathogen emergence and evolution during the post-pandemic era. (Source: Viruses)
Source: Viruses - March 20, 2024 Category: Virology Authors: Ji-Eun Lee Min-Ji Kim Mi-Hyeon Lim Sue-Ji Han Jin-Yeong Kim Soo-Hoo Kim Yi-Duen Ha Gyung-Li Gang Yoon-Seok Chung Jung-Mi Seo Tags: Communication Source Type: research
Viruses, Vol. 16, Pages 478: Bacteriophage & ndash;Host Interactions and the Therapeutic Potential of Bacteriophages
Viruses, Vol. 16, Pages 478: Bacteriophage–Host Interactions and the Therapeutic Potential of Bacteriophages
Viruses doi: 10.3390/v16030478
Authors:
Leon M. T. Dicks
Wian Vermeulen
Healthcare faces a major problem with the increased emergence of antimicrobial resistance due to over-prescribing antibiotics. Bacteriophages may provide a solution to the treatment of bacterial infections given their specificity. Enzymes such as endolysins, exolysins, endopeptidases, endosialidases, and depolymerases produced by phages interact with bacterial surfaces, cell wall components, and exopolysaccharides, and may ev...
Source: Viruses - March 20, 2024 Category: Virology Authors: Leon M. T. Dicks Wian Vermeulen Tags: Review Source Type: research
Viruses, Vol. 16, Pages 479: Predicting Vaccine Effectiveness for Hospitalization and Symptomatic Disease for Novel SARS-CoV-2 Variants Using Neutralizing Antibody Titers
ick
The emergence of new virus variants, including the Omicron variant (B.1.1.529) of SARS-CoV-2, can lead to reduced vaccine effectiveness (VE) and the need for new vaccines or vaccine doses if the extent of immune evasion is severe. Neutralizing antibody titers have been shown to be a correlate of protection for SARS-CoV-2 and other pathogens, and could be used to quickly estimate vaccine effectiveness for new variants. However, no model currently exists to provide precise VE estimates for a new variant against severe disease for SARS-CoV-2 using robust datasets from several populations. We developed predictive model...
Source: Viruses - March 20, 2024 Category: Virology Authors: Billy J. Gardner A. Marm Kilpatrick Tags: Article Source Type: research
Viruses, Vol. 16, Pages 480: Parvovirus B19 Outbreak in Israel: Retrospective Molecular Analysis from 2010 to 2023
This study presents an analysis of the epidemiological trends of parvovirus B19 (B19V) in Israel from 2010 to 2023, with particular emphasis on the outbreak in 2023. The analysis utilized molecular diagnostic data from individual patients obtained at the Central Virology Laboratory. Between 2010 and 2022, 8.5% of PCR-tested samples were positive for B19V, whereas in 2023, this percentage surged to 31% of PCR-tested samples. Throughout the study period, annual cycles consistently peaked in early spring/summer, with the most recent prominent outbreak occurring in 2016. Predominantly, diagnoses were made in children and women...
Source: Viruses - March 20, 2024 Category: Virology Authors: Orna Mor Marina Wax Shoshana-Shani Arami Maya Yitzhaki Or Kriger Oran Erster Neta S. Zuckerman Tags: Brief Report Source Type: research
Viruses, Vol. 16, Pages 481: The Effect of Global Spread, Epidemiology, and Control Strategies on the Evolution of the GI-19 Lineage of Infectious Bronchitis Virus
This study leverages this scenario to explore how different environments may influence virus evolution. Through the analysis of the complete S1 sequence, four datasets were identified, comprising strains of monophyletic clades circulating in different continents or countries (e.g., Asia vs. Europe and China vs. Thailand), indicative of single introduction events and independent evolution. The population dynamics and evolutionary rate variation over time, as well as the presence and intensity of selective pressures, were estimated and compared across these datasets. Since the lineage origin (approximately in the mid-20th ce...
Source: Viruses - March 20, 2024 Category: Virology Authors: Giovanni Franzo Giulia Faustini Claudia Maria Tucciarone Francesca Poletto Francesca Tonellato Mattia Cecchinato Matteo Legnardi Tags: Article Source Type: research
Viruses, Vol. 16, Pages 468: Host-like RNA Elements Regulate Virus Translation
Fox
Viruses are obligate, intracellular parasites that co-opt host cell machineries for propagation. Critical among these machineries are those that translate RNA into protein and their mechanisms of control. Most regulatory mechanisms effectuate their activity by targeting sequence or structural features at the RNA termini, i.e., at the 5′ or 3′ ends, including the untranslated regions (UTRs). Translation of most eukaryotic mRNAs is initiated by 5′ cap-dependent scanning. In contrast, many viruses initiate translation at internal RNA regions at internal ribosome entry sites (I...
Source: Viruses - March 20, 2024 Category: Virology Authors: Debjit Khan Paul L. Fox Tags: Review Source Type: research
Viruses, Vol. 16, Pages 469: Trends of Hepatitis A Virus Infection in Poland: Assessing the Potential Impact of the COVID-19 Pandemic and War in Ukraine
This study analyzed trends of HAV infections in Poland according to socio-demographic features in the years 2009–2022 and assessed the potential impact of the COVID-19 pandemic (2020–2023) and the migration of war refugees from Ukraine (since February 2022). In 2009–2022, 7115 new cases of HAV infection were diagnosed in Poland, especially among men (66.4%) and in urban areas (77.4%). Infections among men were most common at the age of 25–34 (median rate 0.43 per 105) and in women aged 15–24 (median rate 0.39 per 105). Analysis of the 14-year frequency o...
Source: Viruses - March 20, 2024 Category: Virology Authors: Piotr Rzymski Dorota Zar ębska-Michaluk Agnieszka Genowska Piotr Tyszko Birute Strukcinskiene Robert Flisiak Tags: Article Source Type: research
Viruses, Vol. 16, Pages 470: Development and Validation of Three Triplex Real-Time RT-PCR Assays for Typing African Horse Sickness Virus: Utility for Disease Control and Other Laboratory Applications
Agüero
The African horse sickness virus (AHSV) belongs to the Genus Orbivirus, family Sedoreoviridae, and nine serotypes of the virus have been described to date. The AHSV genome is composed of ten linear segments of double-stranded (ds) RNA, numbered in decreasing size order (Seg-1 to Seg-10). Genome segment 2 (Seg-2) encodes outer-capsid protein VP2, the most variable AHSV protein and the primary target for neutralizing antibodies. Consequently, Seg-2 determines the identity of the virus serotype. An African horse sickness (AHS) outbreak in an AHS-free status country requires identifying the serotype as soon as poss...
Source: Viruses - March 20, 2024 Category: Virology Authors: Rub én Villalba Cristina Tena-Tom ás Mar ía José Ruano Marta Valero-Lorenzo Ana L ópez-Herranz Cristina Cano-G ómez Montserrat Ag üero Tags: Article Source Type: research
Viruses, Vol. 16, Pages 467: Assessing the Clinical Impact of the SARS-CoV-2 Gamma Variant on Intensive Care Unit Admissions: Insights from a Reference Hospital in Northeastern Brazil
a Ferreira Costa
Zaquer Suzana Costa-Ferro
Clarissa Araújo Gurgel Rocha
Silvia Inês Sardi
Gúbio Soares
Ana Verena Almeida Mendes
Bruno Solano de Freitas Souza
The global challenge posed by the prolonged COVID-19 pandemic underscores the critical need for ongoing genomic surveillance to identify emerging variants and formulate effective public health strategies. This retrospective observational study, conducted in a reference hospital in Northeast Brazil and comprising 2116 cases, employed PCR genotyping together with epidemiological data to elucidate the impact of the Gamma variant during its emergence, ...
Source: Viruses - March 20, 2024 Category: Virology Authors: Carolina Kymie Vasques Nonaka Adlas Michel de Jesus Ribeiro Gisele Vieira Rocha Helena Souza da Hora Ant ônio Augusto Fonseca Junior Fernanda de Mac êdo Lima Iasmin Nogueira Bastos Samara Alves Sa Teles Thamires Gomes Lopes Weber Vanessa Ferreira Costa Tags: Article Source Type: research
Viruses, Vol. 16, Pages 471: Investigation of the Correlation between Enterovirus Infection and the Climate Factor Complex Including the Ping-Year Factor and El Ni & ntilde;o-Southern Oscillation in Taiwan
This study aimed to determine the relationship between these two CFCs and the incidence of enterovirus infection. Children aged 15 years and younger with enterovirus infection and/or EVSC were enrolled between 2007 and 2022. Each year was categorized into a ping-year or non-ping-year according to the PYF. Poisson regression was used to evaluate the associations between the PYF, ENSO, and the incidence of enterovirus infection. Compared to the ping-year group, the incidence rate of enterovirus infection, the incidence rate of EVSC, and the ratio of EVSC in the non-ping-year group were 1.24, 3.38, and 2.73 times higher, resp...
Source: Viruses - March 20, 2024 Category: Virology Authors: Hsueh-Wen Yu Chia-Hsuan Kuan Liang-Wei Tseng Hsing-Yu Chen Meg-Yen Tsai Yu-Sheng Chen Tags: Article Source Type: research
Viruses, Vol. 16, Pages 466: Susceptibility of Mediterranean Buffalo (Bubalus bubalis) Following Experimental Infection with Lumpy Skin Disease Virus
This study highlights that the sensitivity of ELISA and VNT may differ between animal species and further studies are needed to investigate the epidemiological role of water buffalo. (Source: Viruses)
Source: Viruses - March 19, 2024 Category: Virology Authors: Elisabetta Di Felice Chiara Pinoni Emanuela Rossi Giorgia Amatori Elisa Mancuso Federica Iapaolo Angela Taraschi Giovanni Di Teodoro Guido Di Donato Gaetano Federico Ronchi Maria Teresa Mercante Mauro Di Ventura Daniela Morelli Federica Monaco Tags: Article Source Type: research
Viruses, Vol. 16, Pages 464: Brincidofovir Effectively Inhibits Proliferation of Pseudorabies Virus by Disrupting Viral Replication
Xiangru Wang
Pseudorabies is an acute and febrile infectious disease caused by pseudorabies virus (PRV), a member of the family Herpesviridae. Currently, PRV is predominantly endemoepidemic and has caused significant economic losses among domestic pigs. Other animals have been proven to be susceptible to PRV, with a mortality rate of 100%. In addition, 30 human cases of PRV infection have been reported in China since 2017, and all patients have shown severe neurological symptoms and eventually died or developed various neurological sequelae. In these cases, broad-spectrum anti-herpesvirus drugs and integrated treatm...
Source: Viruses - March 18, 2024 Category: Virology Authors: Huihui Guo Qingyun Liu Dan Yang Hao Zhang Yan Kuang Yafei Li Huanchun Chen Xiangru Wang Tags: Article Source Type: research
Viruses, Vol. 16, Pages 465: Detection of Acipenser European Iridovirus (AcIV-E) in Sturgeon Farms in Northern Italy between 2021 & ndash;2023
Viruses, Vol. 16, Pages 465: Detection of Acipenser European Iridovirus (AcIV-E) in Sturgeon Farms in Northern Italy between 2021–2023
Viruses doi: 10.3390/v16030465
Authors:
Fabio Bondavalli
Dáša Schleicherová
Paolo Pastorino
Davide Mugetti
Claudio Pedron
Marino Prearo
Sturgeon farming is rapidly expanding in Europe, where Italy ranks first in farmed caviar production. A major threat to sturgeon health in captivity is infection with Acipenser European Iridovirus (AcIV-E), a viral disease definitively identified in 2016. Here we present data on the occurrence of AcIV-E in 482 sturgeons (age &...
Source: Viruses - March 18, 2024 Category: Virology Authors: Fabio Bondavalli D áša Schleicherová Paolo Pastorino Davide Mugetti Claudio Pedron Marino Prearo Tags: Communication Source Type: research
Viruses, Vol. 16, Pages 463: Acalculous Cholecystitis as a Complication of Primary Epstein-Barr Virus Infection: A Case-Based Scoping Review of the Literature
olina Akinosoglou
Primary Epstein-Barr virus (EBV) infection manifests with diverse clinical symptoms, occasionally resulting in severe complications. This scoping review investigates the rare occurrence of acute acalculous cholecystitis (AAC) in the context of primary EBV infection, with a focus on understanding its prevalence, clinical features, and underlying mechanisms. The study also explores EBV infection association with Gilbert syndrome, a condition that potentially exacerbates the clinical picture. Additionally, a case report of an 18-year-old female presenting with AAC and ascites secondary to EBV infection e...
Source: Viruses - March 18, 2024 Category: Virology Authors: Aristotelis Tsiakalos Georgios Schinas Aggelos Karatzaferis Emmanouil Angelos Rigopoulos Christos Pappas Eleni Polyzou Effrosyni Dimopoulou George Dimopoulos Karolina Akinosoglou Tags: Review Source Type: research
