Proceedings of the National Academy of Sciences 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.A dominant negative variant of RAB5B disrupts maturation of surfactant protein B and surfactant protein C [Genetics]
Pathogenic variants in surfactant proteins SP-B and SP-C cause surfactant deficiency and interstitial lung disease. Surfactant proteins are synthesized as precursors (proSP-B, proSP-C), trafficked, and processed via a vesicular-regulated secretion pathway; however, control of vesicular trafficking events is not fully understood. Through the Undiagnosed Diseases Network, we evaluated a child... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 4, 2022 Category: Science Authors: Huiyan Huang, Jiehong Pan, David R. Spielberg, Neil A. Hanchard, Daryl A. Scott, Lindsay C. Burrage, Hongzheng Dai, David Murdock, Jill A. Rosenfeld, Ariz Mohammad, Tao Huang, Anika G. Lindsey, Hyori Kim, Jian Chen, Avinash Ramu, Stephanie A. Morrison, Za Tags: Genetics Biological Sciences Source Type: research
Epigenetic state determines inflammatory sensing in neuroblastoma [Medical Sciences]
Immunotherapy has revolutionized cancer treatment, but many cancers are not impacted by currently available immunotherapeutic strategies. Here, we investigated inflammatory signaling pathways in neuroblastoma, a classically “cold” pediatric cancer. By testing the functional response of a panel of 20 diverse neuroblastoma cell lines to three different inflammatory stimuli, we found... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 4, 2022 Category: Science Authors: Adam J. Wolpaw, Liron D. Grossmann, Jessica L. Dessau, May M. Dong, Bailey J. Aaron, Patricia A. Brafford, Darya Volgina, Guillem Pascual-Pasto, Alba Rodriguez-Garcia, Yasin Uzun, Marie Arsenian-Henriksson, Daniel J. Powell Jr., Kristopher R. Bosse, Andre Tags: Medical Sciences Biological Sciences Source Type: research
A hyperpromiscuous antitoxin protein domain for the neutralization of diverse toxin domains [Microbiology]
Toxin–antitoxin (TA) gene pairs are ubiquitous in microbial chromosomal genomes and plasmids as well as temperate bacteriophages. They act as regulatory switches, with the toxin limiting the growth of bacteria and archaea by compromising diverse essential cellular targets and the antitoxin counteracting the toxic effect. To uncover previously uncharted TA... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 4, 2022 Category: Science Authors: Tatsuaki Kurata, Chayan Kumar Saha, Jessica A. Buttress, Toomas Mets, Tetiana Brodiazhenko, Kathryn J. Turnbull, Ololade F. Awoyomi, Sofia Raquel Alves Oliveira, Steffi Jimmy, Karin Ernits, Maxence Delannoy, Karina Persson, Tanel Tenson, Henrik Strahl, Va Tags: Microbiology Biological Sciences Source Type: research
Soft colloids for complex interfacial assemblies [Physics]
The design of complex materials and the formation of specific patterns often arise from the properties of the individual building blocks. In this respect, colloidal systems offer a unique opportunity because nowadays, they can be synthesized in the laboratory with many different shapes and features. Hence, an appropriate choice of... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 4, 2022 Category: Science Authors: Fabrizio Camerin, Emanuela Zaccarelli Tags: Physics, Commentaries Commentary Source Type: research
In vivo oxidation by thioredoxin regulates chloroplast enzymes activity [Plant Biology]
Thioredoxins (Trxs) are proteins that can receive or donate electrons via reduction or oxidation, respectively, of their redox-active cysteine pair, converting a disulfide to thiol or vice versa. They are involved in multiple biological processes throughout all kingdoms of life, modulating the activity of enzymes that function, for example, in... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 3, 2022 Category: Science Authors: Alizee Malnoe Tags: Plant Biology, Commentaries Commentary Source Type: research
Electrostatic influence on IL-1 transport through the GSDMD pore [Biophysics and Computational Biology]
A variety of signals, including inflammasome activation, trigger the formation of large transmembrane pores by gasdermin D (GSDMD). There are primarily two functions of the GSDMD pore, to drive lytic cell death, known as pyroptosis, and to permit the release of leaderless interleukin-1 (IL-1) family cytokines, a process that does... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 3, 2022 Category: Science Authors: Wen Jun Xie, Shiyu Xia, Arieh Warshel, Hao Wu Tags: Biophysics and Computational Biology Biological Sciences Source Type: research
Arabidopsis TBP-ASSOCIATED FACTOR 12 ortholog NOBIRO6 controls root elongation with unfolded protein response cofactor activity [Plant Biology]
Plant root growth is indeterminate but continuously responds to environmental changes. We previously reported on the severe root growth defect of a double mutant in bZIP17 and bZIP28 (bz1728) modulating the unfolded protein response (UPR). To elucidate the mechanism by which bz1728 seedlings develop a short root, we obtained a... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 3, 2022 Category: Science Authors: June-Sik Kim, Yuki Sakamoto, Fuminori Takahashi, Michitaro Shibata, Kaoru Urano, Sachihiro Matsunaga, Kazuko Yamaguchi-Shinozaki, Kazuo Shinozaki Tags: Inaugural Articles, Plant Biology Biological Sciences Source Type: research
Opinion: Wastewater analysis can be a powerful public health tool—if it’s done sensibly [Microbiology]
The coronavirus disease 2019 (COVID-19) pandemic sparked an explosion of interest in wastewater-based epidemiology (WBE; also known as wastewater monitoring or wastewater surveillance). Much has been said, in the scientific literature and popular press alike, about the public health value of tracking severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 3, 2022 Category: Science Authors: Hannah R. Safford, Karen Shapiro, Heather N. Bischel Tags: Opinions, Engineering, Microbiology, Front Matter, Coronavirus Related Source Type: research
A polarization scheme that resolves cross-peaks with transient absorption and eliminates diagonal peaks in 2D spectroscopy [Chemistry]
Two-dimensional (2D) optical spectroscopy contains cross-peaks that are helpful features for determining molecular structure and monitoring energy transfer, but they can be difficult to resolve from the much more intense diagonal peaks. Transient absorption (TA) spectra contain transitions similar to cross-peaks in 2D spectroscopy, but in most cases they are... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 3, 2022 Category: Science Authors: Kieran M. Farrell, Nan Yang, Martin T. Zanni Tags: Chemistry Physical Sciences Source Type: research
Twisted molecular wires polarize spin currents at room temperature [Chemistry]
A critical spintronics challenge is to develop molecular wires that render efficiently spin-polarized currents. Interplanar torsional twisting, driven by chiral binucleating ligands in highly conjugated molecular wires, gives rise to large near-infrared rotational strengths. The large scalar product of the electric and magnetic dipole transition moments (μ→ij⋅m→ij), which are evident... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 3, 2022 Category: Science Authors: Chih-Hung Ko, Qirong Zhu, Francesco Tassinari, George Bullard, Peng Zhang, David N. Beratan, Ron Naaman, Michael J. Therien Tags: Chemistry Physical Sciences Source Type: research
Bicarbonate-controlled reduction of oxygen by the QA semiquinone in Photosystem II in membranes [Biophysics and Computational Biology]
Photosystem II (PSII), the water/plastoquinone photo-oxidoreductase, plays a key energy input role in the biosphere. QA•−, the reduced semiquinone form of the nonexchangeable quinone, is often considered capable of a side reaction with O2, forming superoxide, but this reaction has not yet been demonstrated experimentally. Here, using chlorophyll fluorescence in... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 3, 2022 Category: Science Authors: Andrea Fantuzzi, Friederike Allgower, Holly Baker, Gemma McGuire, Wee Kii Teh, Ana P. Gamiz–Hernandez, Ville R. I. Kaila, A. William Rutherford Tags: Biochemistry Biological Sciences Source Type: research
Different {alpha}-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy [Neuroscience]
The α-synuclein protein can adopt several different conformations that cause neurodegeneration. Different α-synuclein conformers cause at least three distinct α-synucleinopathies: multiple system atrophy (MSA), dementia with Lewy bodies (DLB), and Parkinson’s disease (PD). In earlier studies, we transmitted MSA to transgenic (Tg) mice and cultured HEK cells both expressing mutant... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 3, 2022 Category: Science Authors: Jacob I. Ayers, Joanne Lee, Octovia Monteiro, Amanda L. Woerman, Ann A. Lazar, Carlo Condello, Nick A. Paras, Stanley B. Prusiner Tags: Neuroscience Biological Sciences Source Type: research
Cullin neddylation inhibitor attenuates hyperglycemia by enhancing hepatic insulin signaling through insulin receptor substrate stabilization [Physiology]
Hepatic insulin resistance is a hallmark feature of nonalcoholic fatty liver disease and type-2 diabetes and significantly contributes to systemic insulin resistance. Abnormal activation of nutrient and stress-sensing kinases leads to serine/threonine phosphorylation of insulin receptor substrate (IRS) and subsequent IRS proteasome degradation, which is a key underlying cause of... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 3, 2022 Category: Science Authors: Cheng Chen, Lijie Gu, David J. Matye, Yung-Dai Clayton, Mohammad Nazmul Hasan, Yifeng Wang, Jacob E. Friedman, Tiangang Li Tags: Physiology Biological Sciences Source Type: research
The Yun/Prohibitin complex regulates adult Drosophila intestinal stem cell proliferation through the transcription factor E2F1 [Developmental Biology]
Stem cells constantly divide and differentiate to maintain adult tissue homeostasis, and uncontrolled stem cell proliferation leads to severe diseases such as cancer. How stem cell proliferation is precisely controlled remains poorly understood. Here, from an RNA interference (RNAi) screen in adult Drosophila intestinal stem cells (ISCs), we identify a... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 3, 2022 Category: Science Authors: Hang Zhao, Lin Shi, Zhengran Li, Ruiyan Kong, Xuejing Ren, Rui Ma, Lemei Jia, Meifang Ma, Shan Lu, Ran Xu, Richard Binari, Jian-Hua Wang, Meng-qiu Dong, Norbert Perrimon, Zhouhua Li Tags: Developmental Biology Biological Sciences Source Type: research
Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability [Biochemistry]
The RecQ-like helicase BLM cooperates with topoisomerase IIIα, RMI1, and RMI2 in a heterotetrameric complex (the “Bloom syndrome complex”) for dissolution of double Holliday junctions, key intermediates in homologous recombination. Mutations in any component of the Bloom syndrome complex can cause genome instability and a highly cancer-prone disorder called Bloom... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 3, 2022 Category: Science Authors: Charlotte Hodson, Jason K. K. Low, Sylvie van Twest, Samuel E. Jones, Paolo Swuec, Vincent Murphy, Kaima Tsukada, Matthew Fawkes, Rohan Bythell–Douglas, Adelina Davies, Jessica K. Holien, Julienne J. O’Rourke, Benȷamin L. Parker, Astri Tags: Biochemistry Biological Sciences Source Type: research
