Proceedings of the National Academy of Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Hierarchical timescales in the neocortex: Mathematical mechanism and biological insights [Applied Mathematics]
A cardinal feature of the neocortex is the progressive increase of the spatial receptive fields along the cortical hierarchy. Recently, theoretical and experimental findings have shown that the temporal response windows also gradually enlarge, so that early sensory neural circuits operate on short timescales whereas higher-association areas are capable of... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 2, 2022 Category: Science Authors: Songting Li, Xiao-Jing Wang Tags: Applied Mathematics, Neuroscience Biological Sciences Source Type: research

Loss of TET reprograms Wnt signaling through impaired demethylation to promote lung cancer development [Genetics]
Oncogenic imbalance of DNA methylation is well recognized in cancer development. The ten-eleven translocation (TET) family of dioxygenases, which facilitates DNA demethylation, is frequently dysregulated in cancers. How such dysregulation contributes to tumorigenesis remains poorly understood, especially in solid tumors which present infrequent mutational incidence of TET genes. Here, we... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 2, 2022 Category: Science Authors: Qin Xu, Chao Wang, Jia-Xin Zhou, Zhi-Mei Xu, Juan Gao, Pengfei Sui, Colum P. Walsh, Hongbin Ji, Guo-Liang Xu Tags: Genetics Biological Sciences Source Type: research

In This Issue [This Week in PNAS]
ENVIRONMENTAL SCIENCES Short-beaked echidna on Kangaroo Island, South Australia. Image credit: Peter Hastwell (EchidnaCSI, Adelaide, SA). Citizen science aids efforts to conserve echidnas The short-beaked echidna (Tachyglossus aculeatus ssp.), an iconic egg-laying mammal native to Australia, lives in diverse and often-remote environments. Although some regional populations are well explored, a... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 1, 2022 Category: Science Tags: In This Issue This Week in PNAS Source Type: research

Polymorphism in peptide self-assembly visualized [Biophysics and Computational Biology]
The spontaneous formation of well-defined supramolecular structures, based on precisely located, finely balanced, and weak, relative to kT, interactions among the assembling subunits, is a useful definition of self-assembly. The recognition that proteins could spontaneously refold from their denatured states (1), demonstrating that the information required to assemble the tertiary... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 1, 2022 Category: Science Authors: Matthew Tirrell Tags: Biophysics and Computational Biology, Commentaries Commentary Source Type: research

Countering obesity with eosinophils and sympathetic fat [Immunology and Inflammation]
In addition to being the main energy storage depot of the body, adipose tissue plays a key role in metabolic homeostasis and hormone production (1). Dysregulation of adipose tissue due to inflammation, obesity, hypoxia, and other conditions results in a host of metabolic alterations that drive the obesity-associated diseases (1).... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 1, 2022 Category: Science Authors: Maureen A. Cox Tags: Immunology and Inflammation, Commentaries Commentary Source Type: research