Electrostatic influence on IL-1 transport through the GSDMD pore [Biophysics and Computational Biology]

A variety of signals, including inflammasome activation, trigger the formation of large transmembrane pores by gasdermin D (GSDMD). There are primarily two functions of the GSDMD pore, to drive lytic cell death, known as pyroptosis, and to permit the release of leaderless interleukin-1 (IL-1) family cytokines, a process that does...

Source: Proceedings of the National Academy of Sciences - February 3, 2022 Category: Science Authors: Wen Jun Xie, Shiyu Xia, Arieh Warshel, Hao Wu Tags: Biophysics and Computational Biology Biological Sciences Source Type: research