Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability [Biochemistry]

The RecQ-like helicase BLM cooperates with topoisomerase IIIα, RMI1, and RMI2 in a heterotetrameric complex (the “Bloom syndrome complex”) for dissolution of double Holliday junctions, key intermediates in homologous recombination. Mutations in any component of the Bloom syndrome complex can cause genome instability and a highly cancer-prone disorder called Bloom...

Source: Proceedings of the National Academy of Sciences - February 3, 2022 Category: Science Authors: Charlotte Hodson, Jason K. K. Low, Sylvie van Twest, Samuel E. Jones, Paolo Swuec, Vincent Murphy, Kaima Tsukada, Matthew Fawkes, Rohan Bythell–Douglas, Adelina Davies, Jessica K. Holien, Julienne J. O’Rourke, Benȷamin L. Parker, Astri Tags: Biochemistry Biological Sciences Source Type: research