Proceedings of the National Academy of Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Rapid basal melting of the Greenland Ice Sheet from surface meltwater drainage [Earth, Atmospheric, and Planetary Sciences]
Subglacial hydrologic systems regulate ice sheet flow, causing acceleration or deceleration, depending on hydraulic efficiency and the rate at which surface meltwater is delivered to the bed. Because these systems are rarely observed, ice sheet basal drainage represents a poorly integrated and uncertain component of models used to predict sea... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 22, 2022 Category: Science Authors: Tun Jan Young, Poul Christoffersen, Marion Bougamont, Slawek M. Tulaczyk, Bryn Hubbard, Kenneth D. Mankoff, Keith W. Nicholls, Craig L. Stewart Tags: Earth, Atmospheric, and Planetary Sciences Physical Sciences Source Type: research

Growing impact of wildfire on western US water supply [Environmental Sciences]
Streamflow often increases after fire, but the persistence of this effect and its importance to present and future regional water resources are unclear. This paper addresses these knowledge gaps for the western United States (WUS), where annual forest fire area increased by more than 1,100% during 1984 to 2020. Among... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 22, 2022 Category: Science Authors: A. Park Williams, Ben Livneh, Karen A. McKinnon, Winslow D. Hansen, Justin S. Mankin, Benjamin I. Cook, Jason E. Smerdon, Arianna M. Varuolo-Clarke, Nels R. Bjarke, Caroline S. Juang, Dennis P. Lettenmaier Tags: Environmental Sciences Physical Sciences Source Type: research

Ultrafast photooxidation of protein-bound anionic flavin radicals [Chemistry]
The photophysical properties of anionic semireduced flavin radicals are largely unknown despite their importance in numerous biochemical reactions. Here, we studied the photoproducts of these intrinsically unstable species in five different flavoprotein oxidases where they can be stabilized, including the well-characterized glucose oxidase. Using ultrafast absorption and fluorescence spectroscopy, we... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 18, 2022 Category: Science Authors: Bo Zhuang, Rivo Ramodiharilafy, Ursula Liebl, Alexey Aleksandrov, Marten H. Vos Tags: Biophysics and Computational Biology, Chemistry Biological Sciences Source Type: research

Network modeling predicts personalized gene expression and drug responses in valve myofibroblasts cultured with patient sera [Systems Biology]
Aortic valve stenosis (AVS) patients experience pathogenic valve leaflet stiffening due to excessive extracellular matrix (ECM) remodeling. Numerous microenvironmental cues influence pathogenic expression of ECM remodeling genes in tissue-resident valvular myofibroblasts, and the regulation of complex myofibroblast signaling networks depends on patient-specific extracellular factors. Here, we combined a manually curated... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 18, 2022 Category: Science Authors: Jesse D. Rogers, Brian A. Aguado, Kelsey M. Watts, Kristi S. Anseth, William J. Richardson Tags: Systems Biology Biological Sciences Source Type: research

Reversible dougong structured receptor-ligand recognition for building dynamic extracellular matrix mimics [Applied Physical Sciences]
Dynamic biomaterials excel at recapitulating the reversible interlocking and remoldable structure of the extracellular matrix (ECM), particularly in manipulating cell behaviors and adapting to tissue morphogenesis. While strategies based on dynamic chemistries have been extensively studied for ECM-mimicking dynamic biomaterials, biocompatible molecular means with biogenicity are still rare. Here, we... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 18, 2022 Category: Science Authors: Wenbo He, Jiaxiang Bai, Xu Chen, Di Suo, Shenghao Wang, Qianping Guo, Weiling Yin, Dechun Geng, Miao Wang, Guoqing Pan, Xin Zhao, Bin Li Tags: Applied Physical Sciences Source Type: research

Atomic-scale probing of heterointerface phonon bridges in nitride semiconductor [Physics]
Interface phonon modes that are generated by several atomic layers at the heterointerface play a major role in the interface thermal conductance for nanoscale high-power devices such as nitride-based high-electron-mobility transistors and light-emitting diodes. Here we measure the local phonon spectra across AlN/Si and AlN/Al interfaces using atomically resolved vibrational... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 18, 2022 Category: Science Authors: Yue-Hui Li, Rui-Shi Qi, Ruo-Chen Shi, Jian-Nan Hu, Zhe-Tong Liu, Yuan-Wei Sun, Ming-Qiang Li, Ning Li, Can-Li Song, Lai Wang, Zhi-Biao Hao, Yi Luo, Qi-Kun Xue, Xu-Cun Ma, Peng Gao Tags: Physics Physical Sciences Source Type: research

Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients [Immunology and Inflammation]
Cytomegalovirus (CMV) infection is associated with graft rejection in renal transplantation. Memory-like natural killer (NK) cells expressing NKG2C and lacking FcεRIγ are established during CMV infection. Additionally, CD8+ T cells expressing NKG2C have been observed in some CMV-seropositive patients. However, in vivo kinetics detailing the development and differentiation of these... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 18, 2022 Category: Science Authors: Kenichi Ishiyama, Janice Arakawa-Hoyt, Oscar A. Aguilar, Izabella Damm, Parhom Towfighi, Tara Sigdel, Stanley Tamaki, Joel Babdor, Matthew H. Spitzer, Elaine F. Reed, Minnie M. Sarwal, Lewis L. Lanier, CMV Systems Immunobiology Group Tags: Immunology and Inflammation Biological Sciences Source Type: research

D-mannose facilitates immunotherapy and radiotherapy of triple-negative breast cancer via degradation of PD-L1 [Medical Sciences]
Breast cancer is the most frequent malignancy in women worldwide, and triple-negative breast cancer (TNBC) patients have the worst prognosis and highest risk of recurrence. The therapeutic strategies for TNBC are limited. It is urgent to develop new methods to enhance the efficacy of TNBC treatment. Previous studies demonstrated that... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 18, 2022 Category: Science Authors: Ruonan Zhang, Yajing Yang, Wenjing Dong, Mingen Lin, Jing He, Xinchao Zhang, Tongguan Tian, Yunlong Yang, Kun Chen, Qun-Ying Lei, Song Zhang, Yanping Xu, Lei Lv Tags: Medical Sciences Biological Sciences Source Type: research

The mouse brain after foot shock in four dimensions: Temporal dynamics at a single-cell resolution [Neuroscience]
Acute stress leads to sequential activation of functional brain networks. A biologically relevant question is exactly which (single) cells belonging to brain networks are changed in activity over time after acute stress across the entire brain. We developed a preprocessing and analytical pipeline to chart whole-brain immediate early genes’ expression—as... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 18, 2022 Category: Science Authors: Valeria Bonapersona, Heike Schuler, Ruth Damsteegt, Youri Adolfs, R. Jeroen Pasterkamp, Martiȷn P. van den Heuvel, Marian Joels, R. Angela Sarabdȷitsingh Tags: Neuroscience Biological Sciences Source Type: research

Fully learnable deep wavelet transform for unsupervised monitoring of high-frequency time series [Engineering]
High-frequency (HF) signals are ubiquitous in the industrial world and are of great use for monitoring of industrial assets. Most deep-learning tools are designed for inputs of fixed and/or very limited size and many successful applications of deep learning to the industrial context use as inputs extracted features, which are... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 18, 2022 Category: Science Authors: Gabriel Michau, Gaetan Frusque, Olga Fink Tags: Engineering Physical Sciences Source Type: research

Kelp-forest dynamics controlled by substrate complexity [Ecology]
The factors that determine why ecosystems exhibit abrupt shifts in state are of paramount importance for management, conservation, and restoration efforts. Kelp forests are emblematic of such abruptly shifting ecosystems, transitioning from kelp-dominated to urchin-dominated states around the world with increasing frequency, yet the underlying processes and mechanisms that control... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 18, 2022 Category: Science Authors: Zachary Randell, Michael Kenner, Joseph Tomoleoni, Julie Yee, Mark Novak Tags: Ecology Biological Sciences Source Type: research

Rag GTPases regulate cellular amino acid homeostasis [Cell Biology]
Amino acids are essential sources for synthesizing proteins, being precursors for hormones/neurotransmitters and key anaplerotic metabolites for the tricarboxylic acid cycle and gluconeogenesis. While mammalian cells can synthesize the majority of amino acids from other metabolic intermediates, among the 20 proteinogenic l-amino acids, 9 amino acids are required to be... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 17, 2022 Category: Science Authors: Ken Inoki, Kun-Liang Guan Tags: Cell Biology, Commentaries Commentary Source Type: research

The m6A reader YTHDC2 is essential for escape from KSHV SOX-induced RNA decay [Microbiology]
The role of N6-methyladenosine (m6A) modifications has increasingly been associated with a diverse set of roles in modulating viruses and influencing the outcomes of viral infection. Here, we report that the landscape of m6A deposition is drastically shifted during Kaposi’s sarcoma–associated herpesvirus (KSHV) lytic infection for both viral and host... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 17, 2022 Category: Science Authors: Daniel Macveigh-Fierro, Angelina Cicerchia, Ashley Cadorette, Vasudha Sharma, Mandy Muller Tags: Microbiology Biological Sciences Source Type: research

Definition of a mouse microglial subset that regulates neuronal development and proinflammatory responses in the brain [Immunology and Inflammation]
Expression of Itgax (encoding the CD11c surface protein) and Spp1 (encoding osteopontin; OPN) has been associated with activated microglia that can develop in healthy brains and some neuroinflammatory disorders. However, whether CD11c and OPN expression is a consequence of microglial activation or represents a portion of the genetic program expressed... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 17, 2022 Category: Science Authors: Xianli Shen, Yiguo Qiu, Andrew E. Wight, Hye-Jung Kim, Harvey Cantor Tags: Immunology and Inflammation Biological Sciences Source Type: research

Ghost mitochondria drive metastasis through adaptive GCN2/Akt therapeutic vulnerability [Cell Biology]
Cancer metabolism, including in mitochondria, is a disease hallmark and therapeutic target, but its regulation is poorly understood. Here, we show that many human tumors have heterogeneous and often reduced levels of Mic60, or Mitofilin, an essential scaffold of mitochondrial structure. Despite a catastrophic collapse of mitochondrial integrity, loss of... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 17, 2022 Category: Science Authors: Jagadish C. Ghosh, Michela Perego, Ekta Agarwal, Irene Bertolini, Yuan Wang, Aaron R. Goldman, Hsin-Yao Tang, Andrew V. Kossenkov, Catherine J. Libby, Lucia R. Languino, Edward F. Plow, Annamaria Morotti, Luisa Ottobrini, Marco Locatelli, David W. Speiche Tags: Cell Biology Biological Sciences Source Type: research