The Yun/Prohibitin complex regulates adult Drosophila intestinal stem cell proliferation through the transcription factor E2F1 [Developmental Biology]

Stem cells constantly divide and differentiate to maintain adult tissue homeostasis, and uncontrolled stem cell proliferation leads to severe diseases such as cancer. How stem cell proliferation is precisely controlled remains poorly understood. Here, from an RNA interference (RNAi) screen in adult Drosophila intestinal stem cells (ISCs), we identify a...

Source: Proceedings of the National Academy of Sciences - February 3, 2022 Category: Science Authors: Hang Zhao, Lin Shi, Zhengran Li, Ruiyan Kong, Xuejing Ren, Rui Ma, Lemei Jia, Meifang Ma, Shan Lu, Ran Xu, Richard Binari, Jian-Hua Wang, Meng-qiu Dong, Norbert Perrimon, Zhouhua Li Tags: Developmental Biology Biological Sciences Source Type: research