Proceedings of the National Academy of Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Stabilizing selection on Atlantic cod supergenes through a millennium of extensive exploitation [Ecology]
Life on Earth has been characterized by recurring cycles of ecological stasis and disruption, relating biological eras to geological and climatic transitions through the history of our planet. Due to the increasing degree of ecological abruption caused by human influences many advocate that we now have entered the geological era... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 14, 2022 Category: Science Authors: Marte Sodeland, Sissel Jentoft, Per Erik Jorde, Morten Mattingsdal, Jon Albretsen, Alf Ring Kleiven, Ann–Elin Waroy Synnes, Sigurd Heiberg Espeland, Esben Moland Olsen, Carl Andre, Nils Chr. Stenseth, Halvor Knutsen Tags: Ecology Biological Sciences Source Type: research

Ultrahigh-pressure disordered eight-coordinated phase of Mg2GeO4: Analogue for super-Earth mantles [Earth, Atmospheric, and Planetary Sciences]
In this study, we have investigated magnesium germanate to 275 GPa and over 2,000 K using a laser-heated diamond anvil cell combined with in situ synchrotron X-ray diffraction and density functional theory... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 14, 2022 Category: Science Authors: Rajkrishna Dutta, Sally June Tracy, R. E. Cohen, Francesca Miozzi, Kai Luo, Jing Yang, Pamela C. Burnley, Dean Smith, Yue Meng, Stella Chariton, Vitali B. Prakapenka, Thomas S. Duffy Tags: Earth, Atmospheric, and Planetary Sciences Physical Sciences Source Type: research

Selective memory retrieval can revive forgotten memories [Psychological and Cognitive Sciences]
Humans remember less and less of what was encoded as more and more time passes. Selective retrieval can interrupt such time-dependent forgetting, enhancing recall not only of the retrieved but also of the nonretrieved information. The recall enhancement has been attributed to context retrieval and the idea that selective retrieval... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 14, 2022 Category: Science Authors: Karl–Heinz T. Bauml, Lukas Trissl Tags: Psychological and Cognitive Sciences Social Sciences Source Type: research

Pharmaceutical pollution of the world’s rivers [Environmental Sciences]
Environmental exposure to active pharmaceutical ingredients (APIs) can have negative effects on the health of ecosystems and humans. While numerous studies have monitored APIs in rivers, these employ different analytical methods, measure different APIs, and have ignored many of the countries of the world. This makes it difficult to quantify... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 14, 2022 Category: Science Authors: John L. Wilkinson, Alistair B. A. Boxall, Dana W. Kolpin, Kenneth M. Y. Leung, Racliffe W. S. Lai, Cristobal Galban–Malagon, Aiko D. Adell, Julie Mondon, Marc Metian, Robert A. Marchant, Aleȷandra Bouzas–Monroy, Aida Cuni–Sanchez, Tags: Environmental Sciences Physical Sciences Source Type: research

More comprehensive sex education reduced teen births: Quasi-experimental evidence [Social Sciences]
Women in the United States are much more likely to become mothers as teens than those in other rich countries. Teen births are particularly likely to be reported as unintended, leading to debate over whether better information on sex and contraception might lead to reductions in teen births. We contribute... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 14, 2022 Category: Science Authors: Nicholas D. E. Mark, Lawrence L. Wu Tags: Social Sciences Source Type: research

Mitochondrial dysfunction and oxidative stress contribute to cognitive and motor impairment in FOXP1 syndrome [Genetics]
In this study, we used a Foxp1+/− mouse model to address whether cognitive and motor deficits in FOXP1 syndrome are associated with mitochondrial... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 14, 2022 Category: Science Authors: Jing Wang, Henning Frohlich, Felipe Bodaleo Torres, Rangel Leal Silva, Gernot Poschet, Amit Agarwal, Gudrun A. Rappold Tags: Genetics Biological Sciences Source Type: research

MadR mediates acyl CoA-dependent regulation of mycolic acid desaturation in mycobacteria [Microbiology]
Mycobacterium tuberculosis has a lipid-rich cell envelope that is remodeled throughout infection to enable adaptation within the host. Few transcriptional regulators have been characterized that coordinate synthesis of mycolic acids, the major cell wall lipids of mycobacteria. Here, we show that the mycolic acid desaturase regulator (MadR), a transcriptional repressor... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 14, 2022 Category: Science Authors: Charlotte Cooper, Eliza J. R. Peterson, Rebeca Bailo, Min Pan, Albel Singh, Patrick Moynihan, Makoto Nakaya, Nagatoshi Fujiwara, Nitin Baliga, Apoorva Bhatt Tags: Microbiology Biological Sciences Source Type: research

Glacial isostatic adjustment directed incision of the Channeled Scabland by Ice Age megafloods [Earth, Atmospheric, and Planetary Sciences]
During the last deglaciation, dozens of glacial outburst floods—among the largest known floods on Earth—scoured the Channeled Scabland landscape of eastern Washington. Over this same period, deformation of the Earth’s crust in response to the growth and decay of ice sheets changed the topography by hundreds of meters. Here, we... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 14, 2022 Category: Science Authors: Tamara Pico, Scott R. David, Isaac J. Larsen, Alan C. Mix, Karin Lehnigk, Michael P. Lamb Tags: Earth, Atmospheric, and Planetary Sciences Physical Sciences Source Type: research

Coupled CH4 production and oxidation support CO2 supersaturation in a tropical flood pulse lake (Tonle Sap Lake, Cambodia) [Environmental Sciences]
Carbon dioxide (CO2) supersaturation in lakes and rivers worldwide is commonly attributed to terrestrial–aquatic transfers of organic and inorganic carbon (C) and subsequent, in situ aerobic respiration. Methane (CH4) production and oxidation also contribute CO2 to freshwaters, yet this remains largely unquantified. Flood pulse lakes and rivers in the tropics... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 14, 2022 Category: Science Authors: Benjamin Lloyd Miller, Gordon William Holtgrieve, Mauricio Eduardo Arias, Sophorn Uy, Phen Chheng Tags: Ecology, Environmental Sciences Biological Sciences Source Type: research

Biome boundary maintained by intense belowground resource competition in world’s thinnest-rooted plant community [Ecology]
We examined two hypotheses: 1) Thin-rooted plant strategies might be favored in biomes with low soil resources; and 2) these strategies may act, along with fire, to... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 14, 2022 Category: Science Authors: Mingzhen Lu, William J. Bond, Efrat Sheffer, Michael D. Cramer, Adam G. West, Nicky Allsopp, Edmund C. February, Samson Chimphango, Zeqing Ma, Jasper A. Slingsby, Lars O. Hedin Tags: Ecology Biological Sciences Source Type: research

Diverse methylotrophic methanogenic archaea cause high methane emissions from seagrass meadows [Ecology]
Marine coastlines colonized by seagrasses are a net source of methane to the atmosphere. However, methane emissions from these environments are still poorly constrained, and the underlying processes and responsible microorganisms remain largely unknown. Here, we investigated methane turnover in seagrass meadows of Posidonia oceanica in the Mediterranean Sea. The... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 14, 2022 Category: Science Authors: Sina Schorn, Soeren Ahmerkamp, Emma Bullock, Miriam Weber, Christian Lott, Manuel Liebeke, Gaute Lavik, Marcel M. M. Kuypers, Jon S. Graf, Jana Milucka Tags: Ecology Biological Sciences Source Type: research

Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN [Biophysics and Computational Biology]
High-fidelity replication of the large RNA genome of coronaviruses (CoVs) is mediated by a 3′-to-5′ exoribonuclease (ExoN) in nonstructural protein 14 (nsp14), which excises nucleotides including antiviral drugs misincorporated by the low-fidelity viral RNA-dependent RNA polymerase (RdRp) and has also been implicated in viral RNA recombination and resistance to innate... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 14, 2022 Category: Science Authors: Nicholas H. Moeller, Ke Shi, Ozlem Demir, Christopher Belica, Suraȷit Banerȷee, Lulu Yin, Cameron Durfee, Rommie E. Amaro, Hideki Aihara Tags: Biophysics and Computational Biology, Coronavirus (COVID-19) Biological Sciences Source Type: research

Environmental outcomes of the US Renewable Fuel Standard [Sustainability Science]
The Renewable Fuel Standard (RFS) specifies the use of biofuels in the United States and thereby guides nearly half of all global biofuel production, yet outcomes of this keystone climate and environmental regulation remain unclear. Here we combine econometric analyses, land use observations, and biophysical models to estimate the realized... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 14, 2022 Category: Science Authors: Tyler J. Lark, Nathan P. Hendricks, Aaron Smith, Nicholas Pates, Seth A. Spawn-Lee, Matthew Bougie, Eric G. Booth, Christopher J. Kucharik, Holly K. Gibbs Tags: Environmental Sciences, Sustainability Science Physical Sciences Source Type: research

Genetic analysis of cancer drivers reveals cohesin and CTCF as suppressors of PD-L1 [Genetics]
Immune evasion is a significant contributor to tumor evolution, and the immunoinhibitory axis PD-1/PD-L1 is a frequent mechanism employed to escape tumor immune surveillance. To identify cancer drivers involved in immune evasion, we performed a CRISPR-Cas9 screen of tumor suppressor genes regulating the basal and interferon (IFN)-inducible cell surface levels... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 11, 2022 Category: Science Authors: Ena Oreskovic, Emily C. Wheeler, Kristen E. Mengwasser, Eric Fujimura, Timothy D. Martin, Zuzana Tothova, Stephen J. Elledge Tags: Genetics Biological Sciences Source Type: research

Reversible lysine fatty acylation of an anchoring protein mediates adipocyte adrenergic signaling [Biochemistry]
N-myristoylation on glycine is an irreversible modification that has long been recognized to govern protein localization and function. In contrast, the biological roles of lysine myristoylation remain ill-defined. We demonstrate that the cytoplasmic scaffolding protein, gravin-α/A kinase–anchoring protein 12, is myristoylated on two lysine residues embedded in its carboxyl-terminal protein... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 11, 2022 Category: Science Authors: Rushita A. Bagchi, Emma L. Robinson, Tianjing Hu, Ji Cao, Jun Young Hong, Charles A. Tharp, Hanan Qasim, Kathleen M. Gavin, Julie Pires da Silva, Jennifer L. Major, Bradley K. McConnell, Edward Seto, Hening Lin, Timothy A. McKinsey Tags: Biochemistry Biological Sciences Source Type: research