Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN [Biophysics and Computational Biology]

High-fidelity replication of the large RNA genome of coronaviruses (CoVs) is mediated by a 3′-to-5′ exoribonuclease (ExoN) in nonstructural protein 14 (nsp14), which excises nucleotides including antiviral drugs misincorporated by the low-fidelity viral RNA-dependent RNA polymerase (RdRp) and has also been implicated in viral RNA recombination and resistance to innate...

Source: Proceedings of the National Academy of Sciences - February 14, 2022 Category: Science Authors: Nicholas H. Moeller, Ke Shi, Ozlem Demir, Christopher Belica, Suraȷit Banerȷee, Lulu Yin, Cameron Durfee, Rommie E. Amaro, Hideki Aihara Tags: Biophysics and Computational Biology, Coronavirus (COVID-19) Biological Sciences Source Type: research