Genetic analysis of cancer drivers reveals cohesin and CTCF as suppressors of PD-L1 [Genetics]

Immune evasion is a significant contributor to tumor evolution, and the immunoinhibitory axis PD-1/PD-L1 is a frequent mechanism employed to escape tumor immune surveillance. To identify cancer drivers involved in immune evasion, we performed a CRISPR-Cas9 screen of tumor suppressor genes regulating the basal and interferon (IFN)-inducible cell surface levels...

Source: Proceedings of the National Academy of Sciences - February 11, 2022 Category: Science Authors: Ena Oreskovic, Emily C. Wheeler, Kristen E. Mengwasser, Eric Fujimura, Timothy D. Martin, Zuzana Tothova, Stephen J. Elledge Tags: Genetics Biological Sciences Source Type: research