Epigenetic state determines inflammatory sensing in neuroblastoma [Medical Sciences]

Immunotherapy has revolutionized cancer treatment, but many cancers are not impacted by currently available immunotherapeutic strategies. Here, we investigated inflammatory signaling pathways in neuroblastoma, a classically “cold” pediatric cancer. By testing the functional response of a panel of 20 diverse neuroblastoma cell lines to three different inflammatory stimuli, we found...

Source: Proceedings of the National Academy of Sciences - February 4, 2022 Category: Science Authors: Adam J. Wolpaw, Liron D. Grossmann, Jessica L. Dessau, May M. Dong, Bailey J. Aaron, Patricia A. Brafford, Darya Volgina, Guillem Pascual-Pasto, Alba Rodriguez-Garcia, Yasin Uzun, Marie Arsenian-Henriksson, Daniel J. Powell Jr., Kristopher R. Bosse, Andre Tags: Medical Sciences Biological Sciences Source Type: research