Different {alpha}-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy [Neuroscience]

The α-synuclein protein can adopt several different conformations that cause neurodegeneration. Different α-synuclein conformers cause at least three distinct α-synucleinopathies: multiple system atrophy (MSA), dementia with Lewy bodies (DLB), and Parkinson’s disease (PD). In earlier studies, we transmitted MSA to transgenic (Tg) mice and cultured HEK cells both expressing mutant...

Source: Proceedings of the National Academy of Sciences - February 3, 2022 Category: Science Authors: Jacob I. Ayers, Joanne Lee, Octovia Monteiro, Amanda L. Woerman, Ann A. Lazar, Carlo Condello, Nick A. Paras, Stanley B. Prusiner Tags: Neuroscience Biological Sciences Source Type: research