Selective estrogen receptor modulators (SERMs) with vitamin D composite agent can prevent fracture better than SERMs treatment: based on the National Health Claims Database 2017 –2019
ConclusionThe risk of osteoporotic fractures, especially hip fractures, was lower in the SERM + VitD group than in the SERMs group. Therefore, the composite agent of SERMs and vitamin D can be considered as a viable option for postmenopausal women with a relatively low fracture risk. (Source: Osteoporosis International)
Source: Osteoporosis International - January 19, 2024 Category: Orthopaedics Source Type: research
Opportunistically identifiable vertebral fractures on routine radiological imaging predict mortality: observational cohort study
ConclusionSubjects with VF available for identification on routine CT scans face a substantially increased risk of death. Opportunistic identification and reporting of VF is important to identify these patients to allow intervention if indicated. (Source: Osteoporosis International)
Source: Osteoporosis International - January 18, 2024 Category: Orthopaedics Source Type: research
A meta-analysis of previous falls and subsequent fracture risk in cohort studies
ConclusionsA previous self-reported fall confers an increased risk of fracture that is largely independent of BMD. Previous falls should be considered as an additional risk factor in future iterations of FRAX to improve fracture risk prediction. (Source: Osteoporosis International)
Source: Osteoporosis International - January 17, 2024 Category: Orthopaedics Source Type: research
A comprehensive meta-analysis of risk factors associated with osteosarcopenic obesity: a closer look at gender, lifestyle and comorbidities
ConclusionsOur study underscored the substantial role of female gender, physical inactivity, and hypertension in the development of OSO, whilst suggesting a strong link between OSO and frailty. These findings emphasize the importance of early risk factor identification and targeted interventions in these groups. Further research is warranted to decode the complex pathophysiological interplay and devise effective prevention and management strategies. (Source: Osteoporosis International)
Source: Osteoporosis International - January 15, 2024 Category: Orthopaedics Source Type: research
Association between fatty liver index and controlled attenuation parameters as markers of metabolic dysfunction-associated fatty liver disease and bone mineral density: observational and two-sample Mendelian randomization studies
ConclusionNo causal effect of MAFLD and hepatic steatosis on BMD was observed in this study, while some metabolic factors were correlated with BMD. This has important implications for understanding the relationship between fatty liver disease and BMD, which may help direct the clinical management of MAFLD patients with osteoporosis.Graphical Abstract (Source: Osteoporosis International)
Source: Osteoporosis International - January 15, 2024 Category: Orthopaedics Source Type: research
A comprehensive meta-analysis of risk factors associated with osteosarcopenic obesity: a closer look at gender, lifestyle and comorbidities
ConclusionsOur study underscored the substantial role of female gender, physical inactivity, and hypertension in the development of OSO, whilst suggesting a strong link between OSO and frailty. These findings emphasize the importance of early risk factor identification and targeted interventions in these groups. Further research is warranted to decode the complex pathophysiological interplay and devise effective prevention and management strategies. (Source: Osteoporosis International)
Source: Osteoporosis International - January 15, 2024 Category: Orthopaedics Source Type: research
Association between fatty liver index and controlled attenuation parameters as markers of metabolic dysfunction-associated fatty liver disease and bone mineral density: observational and two-sample Mendelian randomization studies
ConclusionNo causal effect of MAFLD and hepatic steatosis on BMD was observed in this study, while some metabolic factors were correlated with BMD. This has important implications for understanding the relationship between fatty liver disease and BMD, which may help direct the clinical management of MAFLD patients with osteoporosis.Graphical Abstract (Source: Osteoporosis International)
Source: Osteoporosis International - January 15, 2024 Category: Orthopaedics Source Type: research
Trajectories of oral bisphosphonate use after hip fractures: a population-based cohort study
ConclusionTwo-thirds of patients demonstrated good adherence to oral bisphosphonates over 12 months following hip fracture. Efforts to further increase post-discharge antiresorptive use should be sex-specific and address possible persistent uncertainty around delaying treatment initiation. (Source: Osteoporosis International)
Source: Osteoporosis International - January 10, 2024 Category: Orthopaedics Source Type: research
Health-related quality of life in osteoporosis: a systematic review of measurement properties of the QUALEFFO-41
AbstractThe 41-item Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO-41) is a widely used and freely available patient-reported outcome measure (PROM). However, data on its reliability, validity, and responsiveness remain unclear. Therefore, this study aimed to systematically review the measurement properties of the QUALEFFO-41. A systematic search of MEDLINE, EBSCOhost, and Cochrane Library from their inception up to December 2022 was performed. Data were extracted, and the methodological quality of each measurement property was evaluated according to the COnsensus-based Standards for th...
Source: Osteoporosis International - January 9, 2024 Category: Orthopaedics Source Type: research
