Damaged bone microarchitecture by Trabecular Bone Score (TBS) and low appendicular muscle mass: main risk factors for vertebral and non-vertebral fractures in women with long-standing rheumatoid arthritis
ConclusionIn women with long-term RA, markers of fractures differed between distinct skeletal sites (vertebral and non-vertebral). The magnitude of association of bone/muscle parameters with fracture (TBS for VF and appendicular muscle mass for NVF) was greater than that of the association between RA activity and fracture. TBS seems to have greater discriminative power than BMD to identify subjects with VF in long-standing RA. (Source: Osteoporosis International)
Source: Osteoporosis International - January 25, 2024 Category: Orthopaedics Source Type: research
Establishing consensus recommendations for long-term osteoporosis care for patients who have attended an Australian fracture liaison service: a Delphi study
ConclusionWe found clear consensus among experts in many key areas of FLS integration with primary care. While experts agreed that primary care is the most appropriate setting for long-term osteoporosis care, overall confidence in primary care systems to achieve this was low. The role of (and responsibility for) adherence monitoring in a resource-limited setting remains to be defined. (Source: Osteoporosis International)
Source: Osteoporosis International - January 25, 2024 Category: Orthopaedics Source Type: research
Damaged bone microarchitecture by Trabecular Bone Score (TBS) and low appendicular muscle mass: main risk factors for vertebral and non-vertebral fractures in women with long-standing rheumatoid arthritis
ConclusionIn women with long-term RA, markers of fractures differed between distinct skeletal sites (vertebral and non-vertebral). The magnitude of association of bone/muscle parameters with fracture (TBS for VF and appendicular muscle mass for NVF) was greater than that of the association between RA activity and fracture. TBS seems to have greater discriminative power than BMD to identify subjects with VF in long-standing RA. (Source: Osteoporosis International)
Source: Osteoporosis International - January 25, 2024 Category: Orthopaedics Source Type: research
Average daily glucocorticoid dose, number of prescription days, and cumulative dose in the initial 90 days of glucocorticoid therapy are associated with subsequent hip and clinical vertebral fracture risk: a retrospective cohort study using a nationwide health insurance claims database in Japan
ConclusionsGC exposure in the initial 90 days of GC therapy was dose-dependently associated with hip and clinical vertebral fracture risk. GC may increase fracture risk with lower doses for shorter durations than previously reported.SummaryFracture risk assessment three months after glucocorticoid (GC) therapy initiation is recommended. We found that GC exposure in the initial 90 days of GC therapy at lower daily doses for shorter durations than previously reported were significantly and dose-dependently associated with fracture risk using a nationwide health insurance claims database. (Source: Osteoporosis International)
Source: Osteoporosis International - January 24, 2024 Category: Orthopaedics Source Type: research
Comparison of radiological and functional outcomes of conservative treatment with teriparatide and denosumab in thoracolumbar osteoporotic vertebral fracture
ConclusionsTeriparatide and denosumab, despite of their different pharmacological mechanisms, showed similar radiological deformation and functional outcomes in the conservative treatment of TL-OVF. However, teriparatide showed a significantly higher incidence of fracture union with paravertebral bone bridge formation. (Source: Osteoporosis International)
Source: Osteoporosis International - January 23, 2024 Category: Orthopaedics Source Type: research
A new hip fracture risk index derived from FEA-computed proximal femur fracture loads and energies-to-failure
ConclusionsThe global FEA-computed fracture risk index increased hip fracture risk prediction accuracy in males. (Source: Osteoporosis International)
Source: Osteoporosis International - January 22, 2024 Category: Orthopaedics Source Type: research
Selective estrogen receptor modulators (SERMs) with vitamin D composite agent can prevent fracture better than SERMs treatment: based on the National Health Claims Database 2017 –2019
ConclusionThe risk of osteoporotic fractures, especially hip fractures, was lower in the SERM + VitD group than in the SERMs group. Therefore, the composite agent of SERMs and vitamin D can be considered as a viable option for postmenopausal women with a relatively low fracture risk. (Source: Osteoporosis International)
Source: Osteoporosis International - January 19, 2024 Category: Orthopaedics Source Type: research
Opportunistically identifiable vertebral fractures on routine radiological imaging predict mortality: observational cohort study
ConclusionSubjects with VF available for identification on routine CT scans face a substantially increased risk of death. Opportunistic identification and reporting of VF is important to identify these patients to allow intervention if indicated. (Source: Osteoporosis International)
Source: Osteoporosis International - January 18, 2024 Category: Orthopaedics Source Type: research
A meta-analysis of previous falls and subsequent fracture risk in cohort studies
ConclusionsA previous self-reported fall confers an increased risk of fracture that is largely independent of BMD. Previous falls should be considered as an additional risk factor in future iterations of FRAX to improve fracture risk prediction. (Source: Osteoporosis International)
Source: Osteoporosis International - January 17, 2024 Category: Orthopaedics Source Type: research
