Correction to: Long-term safety and clinical performance of kyphoplasty and SpineJack ® procedures in the treatment of osteoporotic vertebral compression fractures: a pilot, monocentric, investigator-initiated study
The author list was incomplete. The complete list of authors is the following: D. Noriega, F. Rodr ίguez-Monsalve, R. Ramajo, I.Sánchez-Lite, B. Toribio, F. Ardura. The corresponding author regrets sincerely this error. The original article got update. (Source: Osteoporosis International)
Source: Osteoporosis International - January 18, 2019 Category: Orthopaedics Source Type: research

Treatment with zoledronic acid subsequent to odanacatib prevents bone loss in postmenopausal women with osteoporosis
AbstractSummaryTreatment with zoledronic acid 5  mg maintained bone turnover markers in the premenopausal range, increased lumbar spine bone mineral density, and maintained hip bone mineral density in women previously treated with odanacatib 50 mg weekly.IntroductionThe development of odanacatib (ODN), a cathepsin K inhibitor, for treatment of osteoporosis was discontinued due to an increased risk of cardiovascular events. As the treatment is considered reversible, participants from the LOFT trial in Aarhus, Denmark, were offered treatment with zoledronic acid (ZOL).MethodsSixty-seven postmenopausal women were tr...
Source: Osteoporosis International - January 17, 2019 Category: Orthopaedics Source Type: research

Dairy- and supplement-based calcium intake in adulthood and vertebral dimensions in midlife —the Northern Finland Birth Cohort 1966 Study
AbstractSummaryAmong a representative sample of 1064 Northern Finns, we studied the association of dairy- and supplement-based calcium intake in adulthood with vertebral size in midlife. Inadequate calcium intake (
Source: Osteoporosis International - January 17, 2019 Category: Orthopaedics Source Type: research

Changes in middle ear transmission characteristics secondary to altered bone remodelling
ConclusionsThere is a detrimental impact of reduction in bone mineral density on middle ear transmission characteristics which may go unnoticed initially. Treatment of osteoporosis may potentially mitigate hearing loss from middle ear fractures due to reduced bone mineral density. Absence of significant air-bone gap with the presence of reduced middle ear resonance frequency may be early signs of reduced BMD. (Source: Osteoporosis International)
Source: Osteoporosis International - January 16, 2019 Category: Orthopaedics Source Type: research

25(OH) vitamin D and functional outcomes in older adults admitted to rehabilitation units: the safari study
AbstractSummaryVitamin D (25(OH)D) deficiency is associated with poor physical performance; little is known about its impact on geriatric rehabilitation. We found a positive non-linear relationship between 25(OH)D and functional gain, stronger in levels
Source: Osteoporosis International - January 16, 2019 Category: Orthopaedics Source Type: research

Estimates of hip fracture incidence in Japan using the National Health Insurance Claim Database in 2012 –2015
ConclusionsThe age-standardized hip fracture incidence rates indicated no significant change in females and significant increase in males in Japan from 2012 to 2015. (Source: Osteoporosis International)
Source: Osteoporosis International - January 16, 2019 Category: Orthopaedics Source Type: research

Pre-discharge prognostic factors of physical function among older adults with hip fracture surgery: a systematic review
ConclusionsOur findings highlight potentially modifiable prognostic factors that could be targeted and non-modifiable prognostic factors that could be used to identify patients who may benefit from more intensive intervention or to advise patients on their expectations on recovery. Examining the efficacies of existing interventions targeting these prognostic factors would inform future studies and whether any of such interventions could be incorporated into clinical practice. (Source: Osteoporosis International)
Source: Osteoporosis International - January 15, 2019 Category: Orthopaedics Source Type: research

Which is the best treatment of osteoporotic vertebral compression fractures: balloon kyphoplasty, percutaneous vertebroplasty, or non-surgical treatment? A Bayesian network meta-analysis
ConclusionPVP was the most effective method for improving pain, functional status, and quality of life (based on EQ-5D). BK emerged as the best intervention for decreasing the risk of subsequent vertebral fractures and re-fractures at the treated level. NST could be ranked first in reducing adjacent vertebral fractures. The future directions of OVCFs treatment will depend on the outcomes of additional and larger randomized trials in comparing BK with PVP. (Source: Osteoporosis International)
Source: Osteoporosis International - January 12, 2019 Category: Orthopaedics Source Type: research

Chronic hyponatremia and association with osteoporosis among a large racially/ethnically diverse population
AbstractSummaryChronic hyponatremia may contribute to decreased bone density. We studied 341,003 men and women who underwent DXA testing and observed that individuals with chronic hyponatremia (sodium
Source: Osteoporosis International - January 11, 2019 Category: Orthopaedics Source Type: research

Bone turnover markers to explain changes in lumbar spine BMD with abaloparatide and teriparatide: results from ACTIVE
AbstractSummaryEarly PINP changes correlate with 18-month lumbar spine BMD changes and the correlation was greater with abaloparatide versus teriparatide. The uncoupling index was similar between the two agents.IntroductionWe evaluated the relationship between early PINP changes and subsequent changes in spine BMD following abaloparatide and teriparatide treatments. We also explored the use of an “uncoupling index” (UI), the balance between bone formation and bone resorption, which we hypothesised would be similar in response to these treatment groups.MethodsBlood samples were taken for measurement of bone turn...
Source: Osteoporosis International - January 11, 2019 Category: Orthopaedics Source Type: research

Primary lactase deficiency and bone mineral density in postmenopausal women
(Source: Osteoporosis International)
Source: Osteoporosis International - January 11, 2019 Category: Orthopaedics Source Type: research

Epidemiology of osteonecrosis among older adults in Sweden
ConclusionsOsteonecrosis was approximately 10 times more common than a small number of previous population-based studies have suggested. The strongest risk factors for osteonecrosis were dialysis, hip fracture, osteomyelitis, and solid organ transplantation, but only hip fractures could have contributed substantially to the disease burden. (Source: Osteoporosis International)
Source: Osteoporosis International - January 9, 2019 Category: Orthopaedics Source Type: research

A systematic review and meta-analysis of the effect of bisphosphonate drug holidays on bone mineral density and osteoporotic fracture risk
ConclusionsBisphosphonate discontinuation may be considered for women who do not have low hip BMD after 3 to 5  years of initial treatment, while women who have low hip BMD may benefit from treatment continuation. (Source: Osteoporosis International)
Source: Osteoporosis International - January 8, 2019 Category: Orthopaedics Source Type: research

Obesity, bone density relative to body weight and prevalent vertebral fracture at age 62  years: the Newcastle thousand families study
AbstractSummaryObesity increases the likelihood of prevalent vertebral fracture (VF) in men and women at age 62 years. The higher absolute bone mineral density (BMD) observed in obese individuals is disproportionate to body weight, and this may partly explain the greater prevalence of VF in this group.IntroductionObesity is a global epidemic, and there remains uncertainty over the effect of obesity on skeletal health, particularly in the context of osteoporosis. The aim of this study was to investigate associations of body mass index (BMI) and obesity with BMD and prevalent VF in men and women aged 62 years.MethodsThree hu...
Source: Osteoporosis International - January 8, 2019 Category: Orthopaedics Source Type: research

Correspondence in response to OSIN-D-18-00831 quantifying imminent risk
(Source: Osteoporosis International)
Source: Osteoporosis International - January 7, 2019 Category: Orthopaedics Source Type: research

Bone metabolism markers are associated with neck circumference in adult Arab women
AbstractSummaryThe study aimed to determine whether neck circumference is associated with bone metabolism markers among adult Arab women and found modest but significant associations with bone resorption markers, suggesting that neck circumference, a surrogate measure of upper subcutaneous fat, influences bone turnover expression among adult females.IntroductionBody fat distribution is associated with decreased bone resorption and neck circumference (NC), a surrogate measure for upper body fat, has never been tested as a marker that can reflect bone turnover. This is the first study aimed to analyze the associations betwee...
Source: Osteoporosis International - January 6, 2019 Category: Orthopaedics Source Type: research

Clinical utility of bone turnover markers in monitoring the withdrawal of treatment with oral bisphosphonates in postmenopausal osteoporosis
AbstractSummaryBone markers may be useful to monitor response to treatment withdrawal in osteoporosis. We used two criteria for investigating the change in BTMs after withdrawal of bisphosphonate treatment. A larger increase in BTMs was associated with greater bone loss. Bone markers may be useful in monitoring of patients taking a pause from treatment.IntroductionMeasurement of bone turnover markers (BTMs) may be useful to monitor offset of treatment with bisphosphonates (BP) in osteoporosis. We assessed the effect of withdrawal of BP treatment by comparing the changes in BTMs and total hip (TH) bone density (BMD).Methods...
Source: Osteoporosis International - January 6, 2019 Category: Orthopaedics Source Type: research

Alendronate after denosumab discontinuation in women previously exposed to bisphosphonates was not effective in preventing the risk of spontaneous multiple vertebral fractures: two case reports
We report two cases of postmenopausal women, previously exposed to bisphosphonates, treated with alendronate at denosumab discontinuation. Alendronate was ineffective to avoid spontaneous clinical vertebral fractures. They presented three and nine spontaneous vertebral fractures 8 and 12  months after denosumab discontinuation, respectively. Ineffectiveness of alendronate was attributed to insufficient control of the rebound as assessed by B-crosslaps measures in the first case, and partially to the high risk of fractures in the later. In both situations, the increased fracture ris k may have favoured these new fractu...
Source: Osteoporosis International - January 6, 2019 Category: Orthopaedics Source Type: research

High-intensity exercise did not cause vertebral fractures and improves thoracic kyphosis in postmenopausal women with low to very low bone mass: the LIFTMOR trial
AbstractSummaryOur aim was to assess risk of vertebral fracture during high-intensity resistance and impact training (HiRIT) for postmenopausal women with low bone mass. HiRIT did not induce vertebral fracture, as evidenced by a reduction in kyphosis following 8  months of training and a lack of change in vertebral morphology.IntroductionThe LIFTMOR trial demonstrated a novel, HiRIT program notably improved bone mass in postmenopausal women with osteopenia and osteoporosis. While no clinical signs or symptoms of vertebral crush fracture were evident during the trial, anecdotal feedback suggests that concerns about saf...
Source: Osteoporosis International - January 5, 2019 Category: Orthopaedics Source Type: research

The relationship between sarcopenia and fragility fracture —a systematic review
SummarySarcopenia is a common geriatric syndrome characterized by progressive decrease of muscle mass and function leading to an increased risk of physical disability, poor quality of life, and mortality. Increasing evidence shows that sarcopenia is related with fragility fractures. This systematic review aimed to summarize the following: (1) the prevalence of sarcopenia in patients with fragility fracture and (2) the associated risk factors for fragility fracture in patients with sarcopenia. Literature search was conducted in PubMed and Cochrane databases. Studies with the prevalence of sarcopenia in elderly patients with...
Source: Osteoporosis International - January 4, 2019 Category: Orthopaedics Source Type: research

Cost-effectiveness of implementing guidelines for the treatment of glucocorticoid-induced osteoporosis in Japan
ConclusionsThe cost-effectiveness of preventive alendronate therapy for postmenopausal women with osteopenia or osteoporosis using GC is sensitive to age, BMD, GC dose, and the presence of previous fracture. Our analysis suggested that the treatment indication for postmenopausal women with osteopenia or osteoporosis using GC in the current Japanese clinical guidelines is likely to be cost-effective except for the limited patients who are at low risk for fracture. (Source: Osteoporosis International)
Source: Osteoporosis International - January 4, 2019 Category: Orthopaedics Source Type: research

Lower grip strength and dynamic body balance in women with distal radial fractures
ConclusionsWomen with DRF demonstrated lower grip strength and dynamic body balancing ability. Lower grip strength and dynamic body balancing ability were identified as significant risk factors in women with DRF, suggesting that these may be useful screening tools to assess fracture risk. (Source: Osteoporosis International)
Source: Osteoporosis International - January 4, 2019 Category: Orthopaedics Source Type: research

Mortality risk reduction differs according to bisphosphonate class: a 15-year observational study
ConclusionCompared to no treatment, nitrogen but not non-nitrogen bisphosphonates appear to be associated with better survival. (Source: Osteoporosis International)
Source: Osteoporosis International - January 3, 2019 Category: Orthopaedics Source Type: research

Diagnosis, prevention, and treatment of bone fragility in people living with HIV: a position statement from the Swiss Association against Osteoporosis
AbstractLife expectancy of people living with HIV (PLWH) is reaching similar length as in the general population. Accordingly, age-related comorbidities, including osteoporosis, are increasing. Fracture risk is higher and increases approximately 10  years earlier in PLWH. Classical risk factors of bone fragility are highly prevalent in PLWH but factors specific for HIV infection itself and the type of antiretroviral therapy (ART) (triple combination antiretroviral therapy) regimen (especially tenofovir and protease inhibitors) also contribute to bone loss. The majority of bone loss occurs during virus activity and at ...
Source: Osteoporosis International - January 2, 2019 Category: Orthopaedics Source Type: research

Pulsed electromagnetic fields: promising treatment for osteoporosis
AbstractOsteoporosis (OP) is considered to be a well-defined disease which results in high morbidity and mortality. In patients diagnosed with OP, low bone mass and fragile bone strength have been demonstrated to significantly increase risk of fragility fractures. To date, various anabolic and antiresorptive therapies have been applied to maintain healthy bone mass and strength. Pulsed electromagnetic fields (PEMFs) are employed to treat patients suffering from delayed fracture healing and nonunions. Although PEMFs stimulate osteoblastogenesis, suppress osteoclastogenesis, and influence the activity of bone marrow mesenchy...
Source: Osteoporosis International - January 2, 2019 Category: Orthopaedics Source Type: research

Correction to: Notch in skeletal physiology and disease
Table 2 of the original article was incorrect. The correct table is shown below. (Source: Osteoporosis International)
Source: Osteoporosis International - January 1, 2019 Category: Orthopaedics Source Type: research

Comparison of hospitalised trends, treatment cost and health outcomes of fall-related hip fracture for people aged ≥ 65 years living in residential aged care and the community
ConclusionsRACF residents are a vulnerable cohort of older people who experience worse health outcomes and survival post-hip fracture than older people living in the community. Whether access to individualised hip fracture rehabilitation for RACF residents could improve their health outcomes should be examined. (Source: Osteoporosis International)
Source: Osteoporosis International - December 19, 2018 Category: Orthopaedics Source Type: research

Health-related quality of life in children with osteogenesis imperfecta: a large-sample study
AbstractSummaryIn this large-sample study, we demonstrated that osteogenesis imperfecta (OI) significantly impaired the quality of life (QoL) in children. Moderate/severe OI patients had worse QoL scores than patients with mild OI. Furthermore, the QoL for OI patients was correlated with the presence of pathogenic gene mutations.IntroductionOsteogenesis imperfecta (OI) is a hereditary disease characterized by multiple fragility fractures and progressive skeletal deformities. No detailed investigations about the quality of life (QoL) have been carried out in a large sample of patients with OI. We evaluated the QoL and its i...
Source: Osteoporosis International - December 19, 2018 Category: Orthopaedics Source Type: research

Comments on Kanis et al.: Characteristics of recurrent fractures
(Source: Osteoporosis International)
Source: Osteoporosis International - December 18, 2018 Category: Orthopaedics Source Type: research

Osteoporosis risk of the subjects with isolated lactase enzyme deficiency
(Source: Osteoporosis International)
Source: Osteoporosis International - December 18, 2018 Category: Orthopaedics Source Type: research

Administrative healthcare data applied to fracture risk assessment
AbstractSummaryFracture risk scores generated from population-based administrative healthcare data showed comparable or better discrimination than the Fracture Risk Assessment Tool (FRAX) scores computed without bone mineral density for predicting incident major osteoporotic fracture. Administrative data may be useful to identify individuals at high fracture risk at the population level.PurposeTo evaluate the discrimination of fracture risk scores defined using inputs available from administrative data for predicting incident major osteoporotic fracture (MOF) and hip fracture (HF) alone.MethodsUsing the Manitoba Bone Miner...
Source: Osteoporosis International - December 15, 2018 Category: Orthopaedics Source Type: research

Lean mass and lower limb muscle function in relation to hip strength, geometry and fracture risk indices in community-dwelling older women
ConclusionsLean mass and lower limb peak muscle force were associated with hip BMD and geometrical FRIs in postmenopausal women. Leg muscle strengthening exercises may therefore help prevent hip fractures in older women. (Source: Osteoporosis International)
Source: Osteoporosis International - December 14, 2018 Category: Orthopaedics Source Type: research

Proton pump inhibitors and risk of hip fracture: a meta-analysis of observational studies
AbstractSummaryWe performed a meta-analysis of relevant studies to quantify the magnitude of the association between proton pump inhibitors (PPIs) and risk of hip fracture. Patients with PPIs had a greater risk of hip fracture than those without PPI therapy (RR 1.20, 95% CI 1.14 –1.28,p 
Source: Osteoporosis International - December 12, 2018 Category: Orthopaedics Source Type: research

Combination therapy with parathyroid hormone analogs and antiresorptive agents for osteoporosis: a systematic review and meta-analysis of randomized controlled trials
This study aimed to estimate the effectiveness and safety of this combination therapy for osteoporosis. MEDLINE, EMBASE, and Cochrane Library were searched from inception to May 1, 2018, including randomized controlled trials (RCTs) with a duration of at least 6  months on adults with osteoporosis treated with combination therapy versus monotherapy. Outcomes included fractures, bone mineral density (BMD) changes, and adverse events. A meta-analysis was performed using a random-effect model, to estimate risk ratios (RRs) for fractures, and mean differences (MDs) for BMD changes. A total of 19 RCTs and 2177 patients wer...
Source: Osteoporosis International - December 11, 2018 Category: Orthopaedics Source Type: research

Correction to: Age-related normative values of trabecular bone score (TBS) for Japanese women: the Japanese Population-based Osteoporosis (JPOS) study
I have, as the Principal Investigator of this study, identified an error in the computation of TBS values in the JPOS cohort, which resulted in the publication of incorrect TBS absolute values [1]. This error was linked to the calibration process for calculating standardized TBS values in the R&D TBS. (Source: Osteoporosis International)
Source: Osteoporosis International - December 11, 2018 Category: Orthopaedics Source Type: research

Comparison of the efficacy between once-monthly oral ibandronate and risedronate among Korean women with osteoporosis: a nationwide population-based study
ConclusionsOnce-monthly ibandronate (150  mg) shows better anti-fracture efficacy than once-monthly risedronate (150 mg). However, further large-scale studies are required to confirm our findings and to determine site-specific differences, especially regarding the vertebral and hip areas. (Source: Osteoporosis International)
Source: Osteoporosis International - December 8, 2018 Category: Orthopaedics Source Type: research

Vertebral fractures cascade: potential causes and risk factors
ConclusionThe results of this retrospective study showed that only half of VFC occurred in patients with a secondary cause of osteoporosis. Prospective studies are needed to further explore the determinants of this severe complication of osteoporosis. (Source: Osteoporosis International)
Source: Osteoporosis International - December 5, 2018 Category: Orthopaedics Source Type: research

Vigorous physical activity patterns affect bone growth during early puberty in boys
This study aims to analyze the impact of participation in vigorous physical activity as it can promote a healthy bone development. Adolescents who increased their participation in vigorous physical activity showed higher improvements in bone parameters compared to those who did not, which highlights the relevance of vigorous physical activity engagement.IntroductionThe main purpose of the study was to analyze the effects of different patterns of vigorous physical activity (VPA) on bone development.MethodsOne-week accelerometry registers and dual-energy X-ray absorptiometry scans at the whole body, hip, and lumbar spine of ...
Source: Osteoporosis International - November 23, 2018 Category: Orthopaedics Source Type: research

Impact of prescription drugs on second fragility fractures among US Medicare patients
ConclusionDiscontinuing high-risk drugs after fracture was not generally protective against subsequent fractures. Preventing the addition of new medications may result in greater improvements in post-fracture care. (Source: Osteoporosis International)
Source: Osteoporosis International - November 23, 2018 Category: Orthopaedics Source Type: research

Skeletal status assessment by quantitative ultrasound and bone densitometry in children with different renal conditions
ConclusionsSkeletal status assessment in children and adolescents with different renal conditions should not be based on single diagnostic approach. DXA scanning, performed at lumbar spine, is potentially more appropriate to reveal disturbances secondary to long-term GC therapy, whereas TB-DXA is highly effective in the identification of skeletal disturbances related to decreased kidney function. QUS at hand phalanges seems to be a useful diagnostic means in CKD with diminished GFR but insufficient to detect GC-related disturbances. (Source: Osteoporosis International)
Source: Osteoporosis International - November 23, 2018 Category: Orthopaedics Source Type: research

Bone fragility after spinal cord injury: reductions in stiffness and bone mineral at the distal femur and proximal tibia as a function of time
ConclusionsAfter SCI, individuals experienced rapid and profound reductions in bone stiffness and bone mineral at the knee. FE models predicted similar reductions to axial and torsional stiffness, suggesting that both failure modes may be clinically relevant. Importantly, CT-derived measures of bone mineral alone underpredicted the impacts of SCI, compared to FE-derived measures of stiffness.Trial registrationClinicalTrials.gov (NCT01225055, NCT02325414) (Source: Osteoporosis International)
Source: Osteoporosis International - November 23, 2018 Category: Orthopaedics Source Type: research

Menstrual and reproductive factors and risk of vertebral fractures in Japanese women: the Japan Public Health Center-based prospective (JPHC) study
ConclusionsMenstrual and reproductive factors, corresponding to the effect of reproductive hormonal disturbance on bone metabolism, might affect the risk of later-life vertebral fractures. (Source: Osteoporosis International)
Source: Osteoporosis International - November 23, 2018 Category: Orthopaedics Source Type: research

The burden of musculoskeletal disorders in Mexico at national and state level, 1990 –2016: estimates from the global burden of disease study 2016
ConclusionMSK conditions are an important cause of premature mortality and disability. Researcher engagement and cross-sectorial actions to address the burden of MSK disorders are essential. (Source: Osteoporosis International)
Source: Osteoporosis International - November 23, 2018 Category: Orthopaedics Source Type: research

Osteogenesis imperfecta and the teeth, eyes, and ears —a study of non-skeletal phenotypes in adults
ConclusionAlthough significant health problems outside the skeleton are frequent in adult patients with OI, the patients are not consistently monitored and treated for their symptoms. Clinicians treating adult patients with OI should be aware of non-skeletal health issues and consider including regular interdisciplinary check-ups in the management plan for adult OI patients. (Source: Osteoporosis International)
Source: Osteoporosis International - November 23, 2018 Category: Orthopaedics Source Type: research

Bone mineral density in osteoporotic patients with pyogenic vertebral osteomyelitis: effect of early versus late treatment for osteoporosis
ConclusionsEarly bisphosphonate treatment within 6  weeks after PVO diagnosis (group A) was significantly associated with superior outcome in femoral BMD at 2-year follow-up, compared to that with late treatment (groups B and C). (Source: Osteoporosis International)
Source: Osteoporosis International - November 23, 2018 Category: Orthopaedics Source Type: research

Effects of virtual tube current reduction and sparse sampling on MDCT-based femoral BMD measurements
ConclusionsOur simulations, which still require clinical validation, indicate that reductions down to  ultra-low tube currents have a significant impact on MDCT-based femoral BMD measurements. In contrast, the application of sparse-sampled MDCT seems a promising future clinical option that may enable a significant reduction of the radiation dose without considerable changes of BMD values. (Source: Osteoporosis International)
Source: Osteoporosis International - November 23, 2018 Category: Orthopaedics Source Type: research

Tight control: a new therapeutic strategy in the management of osteoporotic patients
ConclusionOur findings suggest that adopting tight control as a new therapeutic strategy might be justified in the osteoporosis management. In fact, a greater improvement of BMD can be achieved by treatment according to these principles. (Source: Osteoporosis International)
Source: Osteoporosis International - November 23, 2018 Category: Orthopaedics Source Type: research

Socioeconomic status and risk of osteoporotic fractures and the use of DXA scans: data from the Danish population-based ROSE study
ConclusionThe study found no differences in risk of osteoporotic fractures depending on socioeconomic status. However, women with further or higher education as well as higher income are more often DXA-scanned. (Source: Osteoporosis International)
Source: Osteoporosis International - November 21, 2018 Category: Orthopaedics Source Type: research

Long waiting time before tooth extraction may increase delayed wound healing in elderly Japanese
ConclusionsA long waiting time before tooth extraction may be a risk factor for delayed wound healing beyond 8  weeks after extraction in patients aged ≥ 60 years. (Source: Osteoporosis International)
Source: Osteoporosis International - November 20, 2018 Category: Orthopaedics Source Type: research

Association between malnutrition –inflammation score and risk of subsequent self-reported bone fractures in prevalent kidney transplant recipients
ConclusionThe MIS is independently associated with new clinically detected bone fractures in prevalent KTR. (Source: Osteoporosis International)
Source: Osteoporosis International - November 19, 2018 Category: Orthopaedics Source Type: research