Bilateral insufficiency hip fractures after bariatric surgery
We present the first case of bilateral insufficiency hip fracture after years of bariatric surgery. Although this is a long-term and rare complication, with the high number of gastric bypass performed in the past years, the number of these cases could increase with time. Moreover, it is important as an undiagnosed hip fracture can cause a displacement that could need an arthroplasty, with all the complications that entails. For that reason, this long-term complication highlights the need to reevaluate the optimal follow-up of these patients and the importance to continue monitoring metabolic bone diseases in the prevention...
Source: Osteoporosis International - December 23, 2016 Category: Orthopaedics Source Type: research

Birmingham epidermolysis severity score and vitamin D status are associated with low BMD in children with epidermolysis bullosa
AbstractSummaryBone status impairment represents a complication of generalized forms of epidermolysis bullosa (EB); however, the prevalence and the main determinants of this event in localized forms remain poorly defined. Birmingham epidermolysis bullosa severity (BEBS) score and 25-hydroxyvitamin D levels are strongly associated with low bone mass, suggesting that vitamin D may play a potential beneficial role in bone health. Further longitudinal studies are needed in order to confirm this hypothesis.IntroductionBone status impairment represents a complication of generalized forms of EB; thus, we aimed to estimate the pre...
Source: Osteoporosis International - December 23, 2016 Category: Orthopaedics Source Type: research

Teriparatide treatment in a heart transplant patient with a chronic kidney disease and a low-turnover bone disease: a case report
AbstractLow-turnover bone disease is a complication of chronic kidney disease and a long-term steroid therapy. Currently, the only bone anabolic treatment available is teriparatide (TPTD). So far, no data exist in heart transplant patients, and only one single case with histomorphometric analysis of a dialysis patient with a low-turnover bone disease has been published. The current report shows the effect of a 1-year TPTD therapy in a cardiac transplant patient with 10 vertebral and 3 peripheral fractures who had developed a chronic kidney failure while receiving triple immunosuppressive therapy. A transiliac bone biopsy f...
Source: Osteoporosis International - December 17, 2016 Category: Orthopaedics Source Type: research

Bone marrow sFRP5 level is negatively associated with bone formation markers
AbstractSummarySecreted frizzled-related protein 5 (sFRP5) level in bone marrow environment is inversely correlated with bone formation markers, suggesting that it decreases bone mass by inhibiting bone formation. Besides, it functions in a local fashion when regulating bone metabolism. sFRP5 may be a target when developing anti-osteoporotic agents.IntroductionThe purpose of the study is to investigate the relationship between bone marrow sFRP5 level and bone turnover state.MethodsEighty-three total knee arthroplasty patients were enrolled in this study. Data were collected prospectively and reviewed retrospectively. Lumba...
Source: Osteoporosis International - December 17, 2016 Category: Orthopaedics Source Type: research

Optimum dose of vitamin D for disease prevention in older people: BEST-D trial of vitamin D in primary care
ConclusionsAfter accounting for average 70% compliance in long-term trials, doses of 4000  IU vitamin D3 daily may be required to achieve plasma 25(OH)D levels associated with lowest disease risk in observational studies. (Source: Osteoporosis International)
Source: Osteoporosis International - December 16, 2016 Category: Orthopaedics Source Type: research

Reviewers 2016
(Source: Osteoporosis International)
Source: Osteoporosis International - December 16, 2016 Category: Orthopaedics Source Type: research

Age-related reference curves of volumetric bone density, structure, and biomechanical parameters adjusted for weight and height in a population of healthy women: an HR-pQCT study
AbstractSummaryIn a cross-sectional cohort of 450 healthy women aged 20 to 85  years, data on the density, structure, and strength of the distal radius and tibia were obtained using high-resolution peripheral quantitative computed tomography (HR-pQCT) and were adjusted for age, weight, and height. Age-dependent patterns of change differed between the sites and between the tr abecular and cortical compartments. In postmenopausal women, the trabecular bone remained relatively stable at the distal tibia, but the cortical compartment changed significantly. Cortical porosity exhibited a very weak correlation with stiffness...
Source: Osteoporosis International - December 15, 2016 Category: Orthopaedics Source Type: research

Vitamin D deficiency is associated with functional decline and falls in frail elderly women despite supplementation
We examined the impact of daily supplementation on vitamin D deficiency, function, and falls in female long-term care residents. Initial vitamin D deficiency was associated with greater functional decline and increased fall risk despite guideline-recommended supplementation, highlighting the importance of preventing vitamin D deficiency in frail elderly.IntroductionInstitute of Medicine (IOM) guidelines recommend 800  IU vitamin D daily for older adults and maintaining serum 25-hydroxyvitamin D [25(OH) D] above 20 ng/ml for optimal skeletal health. The adequacy of IOM guidelines for sustaining function and reduci...
Source: Osteoporosis International - December 15, 2016 Category: Orthopaedics Source Type: research

Vertebral cross-sectional area: an orphan phenotype with potential implications for female spinal health
AbstractA high priority in imaging-based research is the identification of the structural basis that confers greater risk for spinal disorders. New evidence indicates that factors related to sex influence the fetal development of the axial skeleton. Girls are born with smaller vertebral cross-sectional area compared to boys —a sexual dimorphism that is present throughout life and independent of body size. The smaller female vertebra is associated with greater flexibility of the spine that could represent the human adaptation to fetal load. It also likely contributes to the higher prevalence of spinal deformities, suc...
Source: Osteoporosis International - December 14, 2016 Category: Orthopaedics Source Type: research

Retreatment with teriparatide: our experience in three patients with severe secondary osteoporosis
AbstractTeriparatide is a drug for the treatment of osteoporosis which is licensed for use for up to 24  months. There is little experience with retreatment. The aim of this study was to evaluate, in three patients with severe secondary osteoporosis, the response to a second cycle of teriparatide regarding bone mineral density (BMD) and osteocalcin.Case 1: A 62-year-old woman with multiple vertebral fractures has received corticoids for a long time. After starting teriparatide, her BMD and osteocalcin increased. She then received ibandronate for 3  years but her BMD declined. After a second treatment with teripar...
Source: Osteoporosis International - December 14, 2016 Category: Orthopaedics Source Type: research

Habitual levels of higher, but not medium or low, impact physical activity are positively related to lower limb bone strength in older women: findings from a population-based study using accelerometers to classify impact magnitude
ConclusionsDespite their rarity, habitual levels of higher impacts were positively associated with lower limb bone size and strength, whereas equivalent relationships were not seen for low or medium impacts. (Source: Osteoporosis International)
Source: Osteoporosis International - December 13, 2016 Category: Orthopaedics Source Type: research

The impact of the new National Bone Health Alliance (NBHA) diagnostic criteria on the prevalence of osteoporosis in the USA
AbstractSummaryWe evaluated the prevalence of osteoporosis using the osteoporosis diagnostic criteria developed by the National Bone Health Alliance (NBHA), which includes qualified fractures, FRAX score in addition to bone mineral density (BMD). The expanded definition increases the prevalence compared to BMD alone definitions; however, it may better identify those at elevated fracture risk.PurposeThe purpose of this paper is to estimate the prevalence of osteoporosis in US adults ≥50 years using the NBHA osteoporosis diagnostic criteria.MethodsUtilizing 2005 –2008 data of the National Health and Nutrition E...
Source: Osteoporosis International - December 13, 2016 Category: Orthopaedics Source Type: research

Vertebral fracture assessment by dual X-ray absorptiometry
(Source: Osteoporosis International)
Source: Osteoporosis International - December 12, 2016 Category: Orthopaedics Source Type: research

Vertebral fracture assessment by dual X-ray absorptiometry: reply to comments by Fechtenbaum et al.
(Source: Osteoporosis International)
Source: Osteoporosis International - December 12, 2016 Category: Orthopaedics Source Type: research

Novel mutations in the SEC24D gene in Chinese families with autosomal recessive osteogenesis imperfecta
ConclusionsWe discovered two novel compoundSEC24D mutations of autosomal recessive OI patients. Our study extended both the phenotypic and the genotypic spectrum of the autosomal recessive OI patients withSEC24D mutations. (Source: Osteoporosis International)
Source: Osteoporosis International - December 10, 2016 Category: Orthopaedics Source Type: research

Comparison of peripheral quantitative computed tomography forearm bone density versus DXA in rheumatoid arthritis patients and controls
AbstractSummaryRheumatoid arthritis (RA) has been associated with osteoporosis. Quantitative computed tomography (QCT) is capable of assessing bone density and composition. We found lower bone density in RA compared to controls. Age and RA duration influenced bone density. QCT may be useful to assess bone metabolism in RA.IntroductionRA is associated with generalized and periarticular osteoporosis. In addition to DXA that determines areal bone mineral density (BMD), peripheral QCT also detects volumetric BMD. QCT differentiates between total, trabecular, and cortical BMD. Here, we compared DXA and QCT in RA patients and he...
Source: Osteoporosis International - December 10, 2016 Category: Orthopaedics Source Type: research

Efficacy and safety of osteoporosis medications in a rat model of late-stage chronic kidney disease accompanied by secondary hyperparathyroidism and hyperphosphatemia
ConclusionsBP is safe and effective for the treatment of bone disorders in stage 4 CKD rats. Intermittent TPD therapy showed an anabolic action on bone even under SHPT conditions without having an adverse effect on mineral metabolism in late-stage CKD. (Source: Osteoporosis International)
Source: Osteoporosis International - December 8, 2016 Category: Orthopaedics Source Type: research

Calcium-41: a technology for monitoring changes in bone mineral
AbstractThe rare, long-lived radiotracer,41Ca, measured by accelerator mass spectrometry in the urine or serum following incorporation into the bone provides an ultra-sensitive tool to assess changes in bone calcium balance in response to an intervention. Changes in bone balance can be followed for years with one small dose that is both radiologically and biologically non-invasive. Sequential interventions can be compared, with greater precision than they can with biochemical markers of bone turnover and with greater power than with bone densitometry. This method is especially useful to screen interventions over a period o...
Source: Osteoporosis International - December 7, 2016 Category: Orthopaedics Source Type: research

Dual-energy X-ray absorptiometry and fracture prediction in patients with spinal cord injuries and disorders
ConclusionThe majority (over 80%) of individuals with a SCI have osteopenia or osteoporosis. DXA-derived measurements at the hip, but not the lumbar spine, predict fracture risk in persons with a SCI. WHO-derived bone density categories may be useful in classifying fracture risk in persons with a SCI. (Source: Osteoporosis International)
Source: Osteoporosis International - December 6, 2016 Category: Orthopaedics Source Type: research

Adherence to the 2006 American Heart Association ’s Diet and Lifestyle Recommendations for cardiovascular disease risk reduction is associated with bone mineral density in older Chinese
AbstractSummaryThis cross-sectional study investigated the association between the modified 2006 American Heart Association Diet and Lifestyle Recommendations (AHA-DLR) and bone mineral density in Chinese adults. We found that better adherence to the AHA-DLR associated with higher bone mineral density (BMD) at multiple sites.IntroductionAccumulating evidence shows that cardiovascular disease (CVD) and osteoporosis are associated with each other, yet little research has focused on whether strategies to reduce CVD risk could also benefit bone health. We aimed to assess the association between adherence to the modified 2006 A...
Source: Osteoporosis International - December 6, 2016 Category: Orthopaedics Source Type: research

Can the alendronate dosage be altered when combined with high-frequency loading in osteoporosis treatment?
ConclusionsThe bone anabolic potency of HF loading was overruled by the ALN dosages applied in the present study. Further altering the ALN dosage combined with robust mechanical stimuli needs to be considered in osteoporosis research and eventually therapy. (Source: Osteoporosis International)
Source: Osteoporosis International - December 5, 2016 Category: Orthopaedics Source Type: research

Compressive loading of the murine tibia reveals site-specific micro-scale differences in adaptation and maturation rates of bone
AbstractSummaryLoading increases bone mass and strength in a site-specific manner; however, possible effects of loading on bone matrix composition have not been evaluated. Site-specific structural and material properties of mouse bone were analyzed on the macro- and micro/molecular scale in the presence and absence of axial loading. The response of bone to load is heterogeneous, adapting at molecular, micro-, and macro-levels.IntroductionOsteoporosis is a degenerative disease resulting in reduced bone mineral density, structure, and strength. The overall aim was to explore the hypothesis that changes in loading environment...
Source: Osteoporosis International - December 5, 2016 Category: Orthopaedics Source Type: research

Bone loss at the distal femur and proximal tibia in persons with spinal cord injury: imaging approaches, risk of fracture, and potential treatment options
This article will discuss the risk of fracture at the knee in persons with SCI, imaging methods to acquire and quantify BMD at the distal femur and proximal tibia, and treatment options available for prophylaxis against or reversal of osteoporosis in individuals with SCI. (Source: Osteoporosis International)
Source: Osteoporosis International - December 5, 2016 Category: Orthopaedics Source Type: research

Associations between serum vitamin E concentration and bone mineral density in the US elderly population
AbstractSummaryMixed findings regarding effects of vitamin E on bone metabolism existed. We were the first to find a negative association between serum α-tocopherol concentration and bone mineral density in the US elderly population. Using vitamin E supplement as α-tocopherol to promote bone health was not warranted at this time.IntroductionThe aim of the study is to examine the associations between serum vitamin E ( α-tocopherol and γ-tocopherol) status and bone mineral density (BMD) among the US elderly population.MethodsWe used data from the National Health and Nutrition Examination Survey (NHANE...
Source: Osteoporosis International - December 1, 2016 Category: Orthopaedics Source Type: research

Retraction to: Nitrate use and changes in bone mineral density: the Canadian Multicentre Osteoporosis Study
(Source: Osteoporosis International)
Source: Osteoporosis International - December 1, 2016 Category: Orthopaedics Source Type: research

Statement of concern re: The effects of organic nitrates on osteoporosis: a systematic review
(Source: Osteoporosis International)
Source: Osteoporosis International - December 1, 2016 Category: Orthopaedics Source Type: research

Visit-to-visit variation of fasting plasma glucose is a predictor of hip fracture in older persons with type 2 diabetes: the Taiwan Diabetes Study
ConclusionsThus, the present study demonstrated the importance of glucose stability for fracture prevention in older persons with type 2 diabetes. Future studies should be conducted to explore whether reduction in glucose oscillation in older adults with diabetes mellitus can reduce the risk of hip fracture. (Source: Osteoporosis International)
Source: Osteoporosis International - November 23, 2016 Category: Orthopaedics Source Type: research

Evaluation of trabecular bone score in patients with a distal radius fracture
ConclusionsTBS was not different between women with a DRF and those without a history of osteoporotic fracture, suggesting that TBS measured at the lumbar spine does not reflect early microarchitectural changes of the distal radius. Only total hip BMD is associated with the risk of DRF in Korean women. (Source: Osteoporosis International)
Source: Osteoporosis International - November 23, 2016 Category: Orthopaedics Source Type: research

Vitamin D deficiency and seasonal variation over the years in S ão Paulo, Brazil
We report very high prevalence of vitamin D deficiency in a large database of Brazilian subjects and show seasonal and reciprocal relationship between vitamin D and parathyroid hormone (PTH) over the years in this tropical area.IntroductionWe aim to examine the prevalence of vitamin D deficiency, characterize the temporal relationship between 25-hydroxyvitamin D levels (25(OH)D) and intact PTH (iPTH) according to seasons, and investigate potential associations between 25(OH)D levels and extra-skeletal outcomes in a Brazilian population.MethodsWe retrospectively determined population weekly mean concentrations of unpaired 2...
Source: Osteoporosis International - November 23, 2016 Category: Orthopaedics Source Type: research

Lower extremity insufficiency fractures: an underappreciated manifestation of endogenous Cushing ’s syndrome
This report describes the presence of lower extremity insufficiency fractures in 10 women prior to the clinical and biochemical diagnosis of endogenous Cushing ’s syndrome (CS). Osteoporosis is a well-recognized complication of overt CS resulting in a high rate of vertebral and other fractures. After institutional review board (IRB) approval, we did a retrospective chart review of patients with lower extremity (LE) insufficiency fractures (IF) and CS. Th is chart review found 10 women in whom LE-IF preceded the diagnosis of endogenous CS. Low bone density was found in all but one patient. The CS was considered to be ...
Source: Osteoporosis International - November 23, 2016 Category: Orthopaedics Source Type: research

Applying ethnic-specific bone mineral density T-scores to Chinese women in the USA
This study examines BMD classification by ethnic T-scores for Chinese women.MethodsUsing BMD data in a Northern California healthcare population, Chinese women aged 50 –79 years were compared to age-matched white women (1:5 ratio), with femoral neck (FN), total hip (TH), and lumbar spine (LS) T-scores calculated using Caucasian versus Chinese American reference data.ResultsComparing 4039 Chinese and 20,195 white women (44.8  % age 50–59 years, 37.5 % age 60–69 years, 17.7 % age 70–79 years), Chinese women had lower BMD T-scores at the FN, TH, and LS (median T-score...
Source: Osteoporosis International - November 23, 2016 Category: Orthopaedics Source Type: research

Visceral fat measured by DXA is associated with increased risk of non-spine fractures in nonobese elderly women: a population-based prospective cohort analysis from the S ão Paulo Ageing & amp; Health (SPAH) Study
ConclusionThis study suggests a potential negative effect of visceral adiposity on bone health in nonobese women. (Source: Osteoporosis International)
Source: Osteoporosis International - November 23, 2016 Category: Orthopaedics Source Type: research

Effect of intravenous zoledronic acid infusion on electrocardiographic parameters in patients with osteoporosis
ConclusionsZA infusion did not affect P wave dispersion both at the immediate post-infusion period and 1  month after infusion. QT values were significantly increased early after ZA infusion; however, there were no significant differences in parameters reflecting disparity of ventricular recovery times and transmural dispersion of ventricular repolarization. Based on these observations, it may be sugg ested that ZA infusion did not have any short- or long-term effect on any parameter that might be associated with the tendency for atrial fibrillation or ventricular arrhythmias. (Source: Osteoporosis International)
Source: Osteoporosis International - November 23, 2016 Category: Orthopaedics Source Type: research

Zoledronate treatment has different effects in mouse strains with contrasting baseline bone mechanical phenotypes
ConclusionThese data may support the concept that properties of the bone geometry and/or tissue at the time of treatment initiation play a role in determining the bone ’s mechanical response to zoledronate treatment. (Source: Osteoporosis International)
Source: Osteoporosis International - November 23, 2016 Category: Orthopaedics Source Type: research

Predictors of bone mineral density testing among older women on Medicare
ConclusionsInterventions to increase DXA use should target the characteristics that were observed here to be negatively associated with such screening. (Source: Osteoporosis International)
Source: Osteoporosis International - November 23, 2016 Category: Orthopaedics Source Type: research

Patient-activation and guideline-concordant pharmacological treatment after bone density testing: the PAADRN randomized controlled trial
AbstractSummaryPatients often do not know or understand their bone density test results, and pharmacological treatment rates are low. In a clinical trial of 7749 patients, we used a tailored patient-activation result letter accompanied by a bone health brochure to improve appropriate pharmacological treatment. Treatment rates, however, did not improve.IntroductionPatients often do not know or understand their dual-energy x-ray absorptiometry (DXA) test results, which may lead to suboptimal care. We tested whether usual care augmented by a tailored patient-activation DXA result letter accompanied by an educational brochure ...
Source: Osteoporosis International - November 23, 2016 Category: Orthopaedics Source Type: research

Teriparatide improves volumetric bone mineral density and fine bone structure in the UIV+1 vertebra, and reduces bone failure type PJK after surgery for adult spinal deformity
This study sought to determine whether teriparatide (TP) is an effective prophylactic against PJK type 2 (vertebral fracture) in surgically treated patients with adult spinal deformity (ASD).MethodsForty-three patients who started TP therapy immediately after surgery and 33 patients who did not receive TP were enrolled in this prospective case series. These patients were female, over 50, surgically treated for ASD, and followed for at least 2  years. Preoperative and postoperative standing whole-spine X-rays and dual-energy X-ray absorptiometry scans, and multidetector CT images obtained before and 6 months after...
Source: Osteoporosis International - November 23, 2016 Category: Orthopaedics Source Type: research

Hip fracture registries: utility, description, and comparison
ConclusionThe recording of HF cases in different countries improves knowledge about handling this condition and its quality of care, while at the same time reducing clinical variability, optimizing efficiency, improving outcomes, and reducing costs. The debate on the variables that should be recorded is timely, such as organizing how to collect each measurement, and even trying to unify the national and international registries or using a current proposal such as the one from the Fragility Fracture Network. (Source: Osteoporosis International)
Source: Osteoporosis International - November 21, 2016 Category: Orthopaedics Source Type: research

Osteonecrosis of the jaw (ONJ) and atypical femoral fracture (AFF) in an osteoporotic patient chronically treated with bisphosphonates
AbstractThe aim of the study is to report the rare association of two complications of long-term treatment of osteoporosis with bisphosphonates in the same Caucasian elderly patient. A female patient of Italian descent, age 87  years, consulted in February 2013. She had a history of osteoporosis and had taken alendronate weekly for 7 years (1999–2006). Due to low back pain, an orthopedist had indicated i.v. zoledronic acid, 5 mg/year for 3 years (2006–2008). She received occasional supplements of ergocalciferol. I n 2009, she suffered a fall and sustained a subtrochanteric fracture of the le...
Source: Osteoporosis International - November 20, 2016 Category: Orthopaedics Source Type: research

Association of circulating dipeptidyl-peptidase 4 levels with osteoporotic fracture in postmenopausal women
ConclusionsDPP4 may be associated with OF by at least partly mediating the bone turnover rate. Circulating DPP4 levels may be a potential biomarker that could increase the predictive power of current fracture risk assessment models. (Source: Osteoporosis International)
Source: Osteoporosis International - November 19, 2016 Category: Orthopaedics Source Type: research

Impact of body mass index on risk of acute kidney injury and mortality in elderly patients undergoing hip fracture surgery
ConclusionsObese patients were at increased risk of AKI compared with normal-weight patients. Among patients with and without postoperative AKI, overweight and obesity were not associated with mortality. Compared to normal-weight patients, underweight patients had elevated mortality for up to 1  year after hip fracture surgery irrespective of the presence of AKI. The absolute mortality risks were higher in all BMI groups with the presence of AKI. (Source: Osteoporosis International)
Source: Osteoporosis International - November 19, 2016 Category: Orthopaedics Source Type: research

Increased CD14+ and decreased CD14 − populations of monocytes 48 h after zolendronic acid infusion in breast cancer patients
ConclusionsOur results provide evidence supporting the hypothesis that bisphosphonate administration modifies the monocyte-mediated immune response. An increase of CD14+ peripheral blood monocyte (PBMC) populations along with a decrease of CD14 − PBMC populations has been recorded. The latter finding is in accordance with limited—currently existing—evidence and warrants further elucidation. (Source: Osteoporosis International)
Source: Osteoporosis International - November 17, 2016 Category: Orthopaedics Source Type: research

Trends in hip fracture rates in Taiwan: a nationwide study from 1996 to 2010
ConclusionsWhile LOS shortened gradually since 1996, the absolute number of hip fractures in Taiwan continues to rise. There is still room for improvement in reducing mortality due to hip fractures. (Source: Osteoporosis International)
Source: Osteoporosis International - November 17, 2016 Category: Orthopaedics Source Type: research

Clinical fracture risk evaluated by hierarchical agglomerative clustering
ConclusionsUnsupervised HAC presents a novel technology to improve patient characteristics in bone disease beyond traditional T-score-based diagnosis. Technological and validation limitations need to be overcome to improve its use in internal medicine. Current DXA scan indication guidelines could be further improved by clustering algorithms. (Source: Osteoporosis International)
Source: Osteoporosis International - November 16, 2016 Category: Orthopaedics Source Type: research

Cytosolic proteome profiling of monocytes for male osteoporosis
AbstractSummaryIn male Caucasians with discordant hip bone mineral density (BMD), we applied the subcellular separation and proteome profiling to investigate the monocytic cytosol. Three BMD-associated proteins (ALDOA, MYH14, and Rap1B) were identified based on multiple omics evidence, and they may influence the pathogenic mechanisms of osteoporosis by regulating the activities of monocytes.IntroductionOsteoporosis is a serious public health problem, leading to significant mortality not only in aging females but also in males. Peripheral blood monocytes (PBMs) play important roles in bone metabolism by acting as precursors...
Source: Osteoporosis International - November 14, 2016 Category: Orthopaedics Source Type: research

High mortality in younger patients with major osteoporotic fractures
ConclusionsYoung individuals with hip and humerus fractures have a significantly increased mortality risk after their injury relative to the general population. The results of our study suggest that this may be in part due to a high prevalence of alcohol excess. (Source: Osteoporosis International)
Source: Osteoporosis International - November 14, 2016 Category: Orthopaedics Source Type: research

Gait speed and one-leg standing time each add to the predictive ability of FRAX
AbstractSummaryGait speed or one-leg standing time (OLST) as additional predictors in FRAX. Population 351 elderly women followed 10  years. Both could improve predictions. The area under curve (AUC) for FRAX is 0.59, OLST is 0.69 and gait speed is 0.71. The net reclassification index (NRI) for classification to highest risk quartile or lowest three quartiles was 0.24 for gait speed and non-significant for OLST.IntroductionThe risk of falls and bone strength are two main determinants of hip fracture risk. The fracture risk assessment tool FRAX, however, lacks direct measures of fall risk1. A short OLST and a slow gait...
Source: Osteoporosis International - November 14, 2016 Category: Orthopaedics Source Type: research

Steroid therapy and the risk of osteonecrosis in SARS patients: a dose-response meta-analysis
AbstractSummaryThis meta-analysis synthesized current evidence from 10 trials to evaluate the association between steroid therapy and osteonecrosis incidence in patients with severe acute respiratory syndrome (SARS). Our results suggest that higher cumulative doses and longer treatment durations of steroids are more likely to lead to the development of osteonecrosis in SARS patients.IntroductionThe link between steroid treatment and the risk of osteonecrosis in SARS patients remains unknown. The present meta-analysis aimed to examine the dose-response association between steroid therapy and osteonecrosis incidence in SARS ...
Source: Osteoporosis International - November 14, 2016 Category: Orthopaedics Source Type: research

Diverging results of areal and volumetric bone mineral density in Down syndrome
ConclusionsAreal BMD is reduced in DS, but it seems to be related to the smaller body and skeletal size. In fact, the estimated volumetric BMD is similar in patients with DS and in control individuals. Furthermore, people with DS have normal bone microarchitecture. (Source: Osteoporosis International)
Source: Osteoporosis International - November 12, 2016 Category: Orthopaedics Source Type: research

Effect of high-dose cholecalciferol (vitamin D 3 ) on bone and body composition in children and young adults with HIV infection: a randomized, double-blind, placebo-controlled trial
The objective of this paper was to determine the impact of high-dose daily cholecalciferol (vitamin D3) supplementation on body composition and bone density, structure, and strength in children and young adults with perinatally acquired (PHIV) or behaviorally acquired (BHIV) HIV infection.MethodsParticipants were randomized to receive vitamin D3 supplementation (7000  IU/day) or placebo for 12 months. Serum 25-hydroxyvitamin D [25(OH)D] concentrations, dual energy X-ray absorptiometry (DXA) of the whole body and lumbar spine, and peripheral quantitative computed tomography (pQCT) of tibia sites were acquired at 0...
Source: Osteoporosis International - November 11, 2016 Category: Orthopaedics Source Type: research