A comprehensive meta-analysis of risk factors associated with osteosarcopenic obesity: a closer look at gender, lifestyle and comorbidities
ConclusionsOur study underscored the substantial role of female gender, physical inactivity, and hypertension in the development of OSO, whilst suggesting a strong link between OSO and frailty. These findings emphasize the importance of early risk factor identification and targeted interventions in these groups. Further research is warranted to decode the complex pathophysiological interplay and devise effective prevention and management strategies. (Source: Osteoporosis International)
Source: Osteoporosis International - January 15, 2024 Category: Orthopaedics Source Type: research

Association between fatty liver index and controlled attenuation parameters as markers of metabolic dysfunction-associated fatty liver disease and bone mineral density: observational and two-sample Mendelian randomization studies
ConclusionNo causal effect of MAFLD and hepatic steatosis on BMD was observed in this study, while some metabolic factors were correlated with BMD. This has important implications for understanding the relationship between fatty liver disease and BMD, which may help direct the clinical management of MAFLD patients with osteoporosis.Graphical Abstract (Source: Osteoporosis International)
Source: Osteoporosis International - January 15, 2024 Category: Orthopaedics Source Type: research

A comprehensive meta-analysis of risk factors associated with osteosarcopenic obesity: a closer look at gender, lifestyle and comorbidities
ConclusionsOur study underscored the substantial role of female gender, physical inactivity, and hypertension in the development of OSO, whilst suggesting a strong link between OSO and frailty. These findings emphasize the importance of early risk factor identification and targeted interventions in these groups. Further research is warranted to decode the complex pathophysiological interplay and devise effective prevention and management strategies. (Source: Osteoporosis International)
Source: Osteoporosis International - January 15, 2024 Category: Orthopaedics Source Type: research

Association between fatty liver index and controlled attenuation parameters as markers of metabolic dysfunction-associated fatty liver disease and bone mineral density: observational and two-sample Mendelian randomization studies
ConclusionNo causal effect of MAFLD and hepatic steatosis on BMD was observed in this study, while some metabolic factors were correlated with BMD. This has important implications for understanding the relationship between fatty liver disease and BMD, which may help direct the clinical management of MAFLD patients with osteoporosis.Graphical Abstract (Source: Osteoporosis International)
Source: Osteoporosis International - January 15, 2024 Category: Orthopaedics Source Type: research

Trajectories of oral bisphosphonate use after hip fractures: a population-based cohort study
ConclusionTwo-thirds of patients demonstrated good adherence to oral bisphosphonates over 12  months following hip fracture. Efforts to further increase post-discharge antiresorptive use should be sex-specific and address possible persistent uncertainty around delaying treatment initiation. (Source: Osteoporosis International)
Source: Osteoporosis International - January 10, 2024 Category: Orthopaedics Source Type: research

Health-related quality of life in osteoporosis: a systematic review of measurement properties of the QUALEFFO-41
AbstractThe 41-item Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO-41) is a widely used and freely available patient-reported outcome measure (PROM). However, data on its reliability, validity, and responsiveness remain unclear. Therefore, this study aimed to systematically review the measurement properties of the QUALEFFO-41. A systematic search of MEDLINE, EBSCOhost, and Cochrane Library from their inception up to December 2022 was performed. Data were extracted, and the methodological quality of each measurement property was evaluated according to the COnsensus-based Standards for th...
Source: Osteoporosis International - January 9, 2024 Category: Orthopaedics Source Type: research

Comment on: Bone density and fracture risk factors in ankylosing spondylitis: a meta-analysis
(Source: Osteoporosis International)
Source: Osteoporosis International - January 8, 2024 Category: Orthopaedics Source Type: research

Prevalence of denosumab-induced hypocalcemia: a retrospective observational study of patients routinely monitored with ionized calcium post-injection
ConclusionsDenosumab-induced hypocalcemia is a prevalent adverse event, which occurs independently of the number of injections. However, severe hypocalcemia is a rare occurrence, and severe renal failure and nutritional status appear to be important predictive factors. Magnesium and phosphate might add value in the pre-injection risk assessment; however, this observation needs to be confirmed in larger cohorts. (Source: Osteoporosis International)
Source: Osteoporosis International - January 1, 2024 Category: Orthopaedics Source Type: research

Establish and validate the reliability of predictive models in bone mineral density by deep learning as examination tool for women
ConclusionWhile FRAX with BMD could be more precise in estimating the fracture risk, DL-based models were validated to slightly reduce the number of under- and over-treated patients when no BMD measurements were available. The validated models could be used to screen for patients at a high risk of fracture and osteoporosis. (Source: Osteoporosis International)
Source: Osteoporosis International - January 1, 2024 Category: Orthopaedics Source Type: research

Multiple brown tumors: a bone complication due to long-term untreated pseudohypoparathyroidism
We describe the case of a 33-year-old woman, referred for the diagnostic evaluation of lytic bone lesions of the lower limbs, in the context of asymptomatic pseudohypoparathyroidism. She had been treated with alfacalcidol and calcium during her childhood. Treatment was discontinued at the age of 18 years old because of the lack of symptoms. A femur biopsy revealed a lesion rich in giant cells, without malignancy, consistent with a brown tumor. Laboratory tests showed a parathyroid level at 1387 pg/ml (14 –50). Whole-body Fluorocholine PET/CT revealed hypermetabolism of bone lesions. The final diagnosis was brown tumors r...
Source: Osteoporosis International - January 1, 2024 Category: Orthopaedics Source Type: research

Development and usability of a decision aid to initiate anti-osteoporosis medication treatment in patients visiting the fracture liaison service with a recent fracture
ConclusionProfessionals and persons with osteoporosis were supportive of the proposed DA and its usability. The DA could help in a shared decision-making process between patients and HCPs. (Source: Osteoporosis International)
Source: Osteoporosis International - January 1, 2024 Category: Orthopaedics Source Type: research

The effect of starting metformin on bone mineral density among women with type 2 diabetes in the Study of Women ’s Health Across the Nation (SWAN)
ConclusionsWomen in the mid-life starting metformin had longitudinal changes in BMD very similar to other women not starting metformin. (Source: Osteoporosis International)
Source: Osteoporosis International - January 1, 2024 Category: Orthopaedics Source Type: research