The effects of person-centered or other supportive interventions in older women with osteoporotic vertebral compression fractures —a systematic review of the literature
AbstractVertebral compression fracture (VCF) is a common fragility fracture and the starting point of a lasting, painful, disabling condition. The aim was to summarize evidence of person-centered/non-medical interventions supporting women with VCF. Results show small numbers of studies with only probable effect on function, pain, QoL, fear of falling, and psychological symptoms. The vertebral compression fracture (VCF) caused by osteoporosis is the third most common fragility fracture worldwide. Previously, it was believed that the pain caused by VCF was self-subsiding within weeks or a few months post-fracture. However, t...
Source: Osteoporosis International - June 6, 2017 Category: Orthopaedics Source Type: research

Circulating levels of dickkopf-1, osteoprotegerin and sclerostin are higher in old compared with young men and women and positively associated with whole-body bone mineral density in older adults
This study aims to investigate the relationship between whole-body bone mineral density (WBMD) and levels of circulating factors with known roles in bone remodelling during ‘healthy’ ageing.MethodsWBMD and fasting plasma concentrations of dickkopf-1, fibroblast growth factor-23, osteocalcin, osteoprotegerin, osteopontin and sclerostin were measured in 272 older subjects (69 to 81  years; 52% female) and 171 younger subjects (18–30 years; 53% female).ResultsWBMD was lower in old than young. Circulating osteocalcin was lower in old compared with young, while dickkopf-1, osteoprotegerin and scleros...
Source: Osteoporosis International - June 5, 2017 Category: Orthopaedics Source Type: research

Effect of recent spinal cord injury on the OPG/RANKL system and its relationship with bone loss and the response to denosumab therapy
ConclusionsRANKL levels are increased after SCI and related to BMD loss at the proximal femur, becoming undetectable after denosumab treatment. The effect of denosumab on preventing sublesional bone loss, especially in patients with undetectable levels during treatment, suggests a contributory role of RANKL in this process. (Source: Osteoporosis International)
Source: Osteoporosis International - June 4, 2017 Category: Orthopaedics Source Type: research

Bone mineral density at femoral neck and lumbar spine in adults with type 1 diabetes: a meta-analysis and review of the literature
ConclusionFemoral neck and lumbar spine BMD were modestly lower in adults with T1D compared to controls. However, this modest reduction in femoral neck and lumbar spine BMD cannot explain much higher observed fracture risk in adults with T1D. (Source: Osteoporosis International)
Source: Osteoporosis International - June 3, 2017 Category: Orthopaedics Source Type: research

Patient education in osteoporosis prevention: a systematic review focusing on methodological quality of randomised controlled trials
AbstractSummaryThis review summarizes evidence regarding the effects of patient education in osteoporosis prevention and treatment. The included studies reveal mixed results on a variety of endpoints. Methodological improvem ent of future RCTs (e.g. with regard to randomization and duration of follow-up) might yield more conclusive evidence on the effects of patient education in osteoporosisIntroduction This review aims to evaluate the effects of patient education on osteoporosis prevention and treatment results.MethodsMultiple databases including PubMed and Embase were searched until February 2016. Randomised controlled t...
Source: Osteoporosis International - June 1, 2017 Category: Orthopaedics Source Type: research

“I do not have time. Is there a handout I can use?”: combining physicians’ needs and behavior change theory to put physical activity evidence into practice
ConclusionsKey barriers to PA guideline implementation among physicians include knowledge on where to refer or what to say, access to pragmatic programs or resources, and things that influence motivation, such as competing priorities or lack of incentives. Future work will report on the development and evaluation of knowledge translation interventions informed by the barriers. (Source: Osteoporosis International)
Source: Osteoporosis International - June 1, 2017 Category: Orthopaedics Source Type: research

Bone texture analysis using CT-simulation scans to individuate risk parameters for radiation-induced insufficiency fractures
This study deals with the role of texture analysis as a predictive factor of radiation-induced insufficiency fractures in patients undergoing pelvic radiation.IntroductionThis study aims to assess the texture analysis (TA) of computed tomography (CT) simulation scans as a predictive factor of insufficiency fractures (IFs) in patients with pelvic malignancies undergoing radiation therapy (RT).MethodsWe performed an analysis of patients undergoing pelvic RT from January 2010 to December 2014, 24 of whom had developed pelvic bone IFs. We analyzed CT-simulation images using ImageJ macro software and selected two regions of int...
Source: Osteoporosis International - June 1, 2017 Category: Orthopaedics Source Type: research

Identification of vertebral fractures: a moderately severe solution?
(Source: Osteoporosis International)
Source: Osteoporosis International - June 1, 2017 Category: Orthopaedics Source Type: research

Quantitative analysis of efficacy and associated factors of calcium intake on bone mineral density in postmenopausal women
ConclusionCalcium intake can effectively postpone the tendency of BMD decrease in postmenopausal women. An increased calcium dose contributes to the shortening of the onset time. Considering the drug-acting rate and safety into account, menopausal women can be administered with a rational dose of 1200  mg/day to reduce bone loss. (Source: Osteoporosis International)
Source: Osteoporosis International - June 1, 2017 Category: Orthopaedics Source Type: research

Imminent fracture risk
AbstractThe clinical significance of osteoporosis is in the occurrence of fractures and re-fractures. The main risk factor of sustaining a fracture is a previous one, but a recent fracture is a better fracture risk factor than fracture history. The role of the recency of fracture has been shown for both vertebral and non-vertebral fracture risk. This imminent risk is explained by both bone-related factors (underlying osteoporosis) and fall-related factors (including those related to postfracture care). Such a short-term increased risk has been shown also in patients initiating corticosteroids and in frail osteoporotic subj...
Source: Osteoporosis International - June 1, 2017 Category: Orthopaedics Source Type: research

Effect of single-dose dexamethasone on acute phase response following zoledronic acid: a randomized controlled trial
ConclusionsA single dose of dexamethasone 4  mg does not influence the incidence or severity of APR following first exposure to ZOL.Trial registrationACTRN12615000794505 (Source: Osteoporosis International)
Source: Osteoporosis International - June 1, 2017 Category: Orthopaedics Source Type: research

Unmasking romosozumab: response to commentsby Uzoigwe et al.
(Source: Osteoporosis International)
Source: Osteoporosis International - June 1, 2017 Category: Orthopaedics Source Type: research

Risk of fragility fracture among patients with sarcoidosis: a population-based study 1976 –2013
ConclusionPatients with sarcoidosis have an increased risk of fragility fracture which is primarily driven by the higher incidence of distal forearm fracture. (Source: Osteoporosis International)
Source: Osteoporosis International - June 1, 2017 Category: Orthopaedics Source Type: research

Unmasking romosozumab
(Source: Osteoporosis International)
Source: Osteoporosis International - June 1, 2017 Category: Orthopaedics Source Type: research

Erratum to: Cost-effectiveness analysis of once-yearly injection of zoledronic acid for the treatment of osteoporosis in Japan
(Source: Osteoporosis International)
Source: Osteoporosis International - June 1, 2017 Category: Orthopaedics Source Type: research

The effects of a patient activation intervention on smoking and excessive drinking cessations: results from the PAADRN randomized controlled trial
ConclusionAn individually tailored DXA result letter accompanied by an educational brochure did not lead to smoking or excessive drinking cessations in patients who received DXA.Trial Registration:clinicaltrials.gov identifier NCT01507662. (Source: Osteoporosis International)
Source: Osteoporosis International - June 1, 2017 Category: Orthopaedics Source Type: research

Higher milk intake increases fracture risk: confounding or true association?
(Source: Osteoporosis International)
Source: Osteoporosis International - June 1, 2017 Category: Orthopaedics Source Type: research

Vertebral fracture in postmenopausal Chinese women: a population-based study
ConclusionThis study is from a true random sample of postmenopausal women in urban China with high response rate. The prevalence of vertebral fractures in postmenopausal women in Beijing increases from 13% under age 60 to over 50% by age 80  years. A model with seven clinical risk factors with or without BMD is better than simple models and may guide the use of spine x-rays to identify women with vertebral fractures. More than half an hour of outdoor activity might correlate with lower risk of vertebral fracture in this population. (Source: Osteoporosis International)
Source: Osteoporosis International - May 30, 2017 Category: Orthopaedics Source Type: research

Association of adiposity indices with bone density and bone turnover in the Chinese population
ConclusionBMI, fat mass, and lean mass are proved to be beneficial for BMD in both males and postmenopausal females. SFA is negatively associated with BMD and positively correlated with osteocalcin in postmenopausal females. (Source: Osteoporosis International)
Source: Osteoporosis International - May 29, 2017 Category: Orthopaedics Source Type: research

Statin treatment and healthy adherer effects
(Source: Osteoporosis International)
Source: Osteoporosis International - May 29, 2017 Category: Orthopaedics Source Type: research

Statin use does not protect from fractures: the healthy adherer effect is a plausible explanation in observational studies
(Source: Osteoporosis International)
Source: Osteoporosis International - May 29, 2017 Category: Orthopaedics Source Type: research

Sedentary behaviour and bone health in children, adolescents and young adults: a systematic review
AbstractSedentary behaviour (SB) is increasing in Western societies and some studies suggest a deleterious effect of SB on bone. The aim of this systematic review was to examine the association between SB and bone health in children, adolescents and young adults. Electronic databases (PubMed, MEDLINE, PsycINFO and Science Citation Index) were searched for relevant articles up to January 9, 2017. Studies were included when results on bone health (e.g. strength, mass and structure) and either subjectively (questionnaires) or objectively (accelerometry) measured SB were reported in healthy participants ≤24 years. Two ...
Source: Osteoporosis International - May 26, 2017 Category: Orthopaedics Source Type: research

Clinical, radiographic and biochemical characteristics of adult hypophosphatasia
ConclusionAdult HPP presents with a wide range of clinical symptoms and is not associated with low bone mass in general. PLP seems to be a good marker for disease severity in adult patients as its level is correlated with the occurrence of fractures and number of symptoms. (Source: Osteoporosis International)
Source: Osteoporosis International - May 25, 2017 Category: Orthopaedics Source Type: research

Assessing the feasibility of the Effectiveness of Discontinuing Bisphosphonates trial: a pilot study
ConclusionsAdministrative procedures of the EDGE study were generally feasible, with minimal disruption to clinic flow. In this convenience sample, participant recruitment was suboptimal across most practice sites. Accounting for low treatment arm adherence, a comprehensive recruitment approach will be needed to effectively achieve the scientific goals of the EDGE study. (Source: Osteoporosis International)
Source: Osteoporosis International - May 24, 2017 Category: Orthopaedics Source Type: research

Retrospective evaluation of serum CTX levels after denosumab discontinuation in patients with or without prior exposure to bisphosphonates
ConclusionThe higher CTX levels occurring after Dmab discontinuation in patients who have received multiple injections may be prevented by prior exposure to BPs. This observation may be related to the persistent effects of BPs on bone that prevent the resorbing activity of newly formed osteoclasts when RANK Ligand is no more antagonized. (Source: Osteoporosis International)
Source: Osteoporosis International - May 24, 2017 Category: Orthopaedics Source Type: research

Examining the treatment gap and risk of subsequent fractures among females with a fragility fracture in the US Medicare population
ConclusionsDemographics and clinical characteristics were strong predictors of osteoporosis medication use. In the US Medicare population, osteoporosis treatment significantly reduced the risk of fragility fractures. (Source: Osteoporosis International)
Source: Osteoporosis International - May 23, 2017 Category: Orthopaedics Source Type: research

Is the association between hip fractures and seasonality modified by influenza vaccination? An ecological study
AbstractSummaryOsteoporotic hip fractures in 4344 patients were more common during winter. Lower temperatures were associated with higher rates of fracture only in those not vaccinated for influenza. Influenza outbreaks increased the risk of hip fractures. Further studies are needed to assess whether influenza vaccination can prevent hip fractures.IntroductionWinter seasonality of osteoporotic hip fracture incidence has been demonstrated, yet the explanation for the association is lacking. We hypothesize that the seasonality of osteoporotic hip fracture can be explained by an association between hip fractures and seasonal ...
Source: Osteoporosis International - May 23, 2017 Category: Orthopaedics Source Type: research

Hip fractures or femoral fractures?
(Source: Osteoporosis International)
Source: Osteoporosis International - May 22, 2017 Category: Orthopaedics Source Type: research

Increased risk of hip fracture among spouses —evidence of a homogamy effect: response to comments by Minkov
(Source: Osteoporosis International)
Source: Osteoporosis International - May 22, 2017 Category: Orthopaedics Source Type: research

Sustainable affordability of Otago exercise in the US healthcare system
(Source: Osteoporosis International)
Source: Osteoporosis International - May 18, 2017 Category: Orthopaedics Source Type: research

Sustainable affordability of Otago exercise in the US healthcare system: response to Liu et al.
(Source: Osteoporosis International)
Source: Osteoporosis International - May 18, 2017 Category: Orthopaedics Source Type: research

Response to Sabour: Dual-energy X-ray absorptiometry and fracture prediction in patients with spinal cord injuries and disorders: methodological issues
(Source: Osteoporosis International)
Source: Osteoporosis International - May 15, 2017 Category: Orthopaedics Source Type: research

The role of adipokines as prognostic factors of one-year mortality in hip fracture patients
This study investigated the impact of anthropometric parameters, adiponectin, leptin, homeostatic model assessment for insulin resistance (HOMA-IR), beta-isomerised C-terminal telopeptide of collagen type I ( β-CTX), and routine biochemical tests on one-year mortality in hip fracture patients. We found that male patients with high adiponectin, leptin, and β-CTX levels had a 5-fold increase in all-cause one-year mortality.IntroductionSeveral predictors of one-year hip fracture mortality have been identified including advanced age, male sex, low bone mineral density, and preexisting comorbidities. However, the impa...
Source: Osteoporosis International - May 13, 2017 Category: Orthopaedics Source Type: research

Dual-energy X-ray absorptiometry and fracture prediction in patients with spinal cord injuries and disorders: methodological issues
(Source: Osteoporosis International)
Source: Osteoporosis International - May 13, 2017 Category: Orthopaedics Source Type: research

Bone density, microarchitecture, and material strength in chronic kidney disease patients at the time of kidney transplantation
AbstractSummaryBone health is assessed by bone mineral density (BMD). Other techniques such as trabecular bone score and microindentation could improve the risk of fracture ’s estimation. Our chronic kidney disease (CKD) patients presented worse bone health (density, microarchitecture, mechanical properties) than controls. More than BMD should be done to evaluate patients at risk of fracture.IntroductionBMD measured by dual-energy X-ray absorptiometry (DXA) is used to assess bone health in end-stage renal disease (ESRD) patients. Recently, trabecular bone score (TBS) and microindentation that can measure microarchite...
Source: Osteoporosis International - May 11, 2017 Category: Orthopaedics Source Type: research

The association between serum uric acid level and the risk of fractures: a systematic review and meta-analysis
AbstractControversy has arisen in regarding the association between serum uric acid (UA) and fracture risk. Therefore, we conducted a systemic review and meta-analysis by pooling estimate of five prospective studies (29,110 participants). Results showed that an increased serum UA level is associated with a lower risk of fracture. Numerous studies have demonstrated that high serum UA is a relevant risk factor for a wide variety of diseases, whereas new understanding in serum uric acid follows recent reports demonstrating a protective role of UA in health status. However, the association between serum UA and fracture remains...
Source: Osteoporosis International - May 9, 2017 Category: Orthopaedics Source Type: research

Are bilateral decubitus views necessary in assessing for vertebral compression fractures using DXA vertebral fracture assessment?
This study aims to assess the differences in VFA diagnostic accuracy for right and left lateral decubitus views and the effect of scoliosis.MethodsOne hundred fourteen postmenopausal women received right and left lateral thoracolumbar spine dual-energy VFA and radiography. Cobb angles were measured from the posteroanterior absorptiometry image, and lumbar spine radiography was the standard reference for vertebral fracture and also provides the levels investigated. McNemar ’s test was used to compare accuracy between the two decubitus position and Fisher’s exact test was used for patients with and without scolio...
Source: Osteoporosis International - May 9, 2017 Category: Orthopaedics Source Type: research

Undisturbed local bone formation capacity in patients with atypical femoral fractures: a case series
ConclusionsNew bone formation occurred within a time frame that appears normal for healing of cortical bone defects. This suggests that the capacity to form new bone is intact. (Source: Osteoporosis International)
Source: Osteoporosis International - May 4, 2017 Category: Orthopaedics Source Type: research

A translational approach from an animal model identifies CD80 as a candidate gene for the study of bone phenotypes in postmenopausal women
This study represented a translational study that first compared gene expression of B cells of BM from ovariectomized and control mice, and then analyzed some of the differentially expressed genes in women. Results showed novel genetic associations with bone phenotypes and points to theCD80 gene as relevant in postmenopausal bone loss.IntroductionOsteoporosis is a multifactorial disease with a strong genetic component. However, to date, research into osteoporosis has only been able to explain a small part of its heritability. Moreover, several components of the immune system are involved in the regulation of bone metabolis...
Source: Osteoporosis International - May 2, 2017 Category: Orthopaedics Source Type: research

Comparison of total, free and bioavailable 25-OH vitamin D determinations to evaluate its biological activity in healthy adults: the LabOscat study
AbstractSummaryDetermination of different forms of 25-OHD (total, free and bioavailable) in healthy young women does not offer additional advantages over standard 25-OHDT for evaluating vitamin D deficiency. In these subjects 25-OHDT values
Source: Osteoporosis International - May 2, 2017 Category: Orthopaedics Source Type: research

Bone material strength index as measured by impact microindentation is low in patients with fractures irrespective of fracture site
ConclusionOur data demonstrate that BMSi is low in fracture patients with low bone mass, irrespective of whether they sustained a vertebral fracture or a non-vertebral fracture. (Source: Osteoporosis International)
Source: Osteoporosis International - May 2, 2017 Category: Orthopaedics Source Type: research

Greater yogurt consumption is associated with increased bone mineral density and physical function in older adults
AbstractSummaryIn this cohort of community dwelling older adults (>60  years), we observed significant positive associations between the frequencies of yogurt intake with measures of bone density, bone biomarkers, and indicators of physical function. Improving yogurt intakes could be a valuable health strategy for maintaining bone health in older adults.IntroductionThe associations of yogurt intakes with bone health and frailty in older adults are not well documented. The aim was to investigate the association of yogurt intakes with bone mineral density (BMD), bone biomarkers, and physical function in 4310 Irish ad...
Source: Osteoporosis International - May 1, 2017 Category: Orthopaedics Source Type: research

Preceding and subsequent high- and low-trauma fracture patterns —a 13-year epidemiological study in females and males in Austria
ConclusionsPreceding high-trauma fractures increase the risk of future low-trauma non-vertebral fractures including hip. For each patient with a fracture, regardless of the severity of the trauma, osteoporosis should be taken into clinical consideration. (Source: Osteoporosis International)
Source: Osteoporosis International - April 13, 2017 Category: Orthopaedics Source Type: research

Increased risk of incident osteoporosis and osteoporotic fracture in tuberculosis patients: a population-based study in a tuberculosis-endemic area
In this study, we found significantly higher incidence rates of osteoporosis (Adjusted hazard ratio (AHR) 1.82) and osteoporotic fracture (AHR 2.33) in tuberculosis patients than matched cohorts, which suggest that osteoporosis screening should be considered in tuberculosis patients’ follow-up program. The aim of this study is to determine the occurrence of incident osteoporosis in patients w ho completed anti-tuberculosis (TB) treatment.IntroductionChronic inflammatory disorders are associated with an increased risk of osteoporosis. Although TB is an infectious disease characterized by systemic inflammatory respo...
Source: Osteoporosis International - April 13, 2017 Category: Orthopaedics Source Type: research

The associations between serum 25-hydroxyvitamin D level and the risk of total fracture and hip fracture
ConclusionsOur study suggests that low serum 25(OH) vitamin D level is associated with increased risks of total and hip fractures. In the analyzed studies, the per SD decrease in serum 25(OH) vitamin D level was associated with the hip fracture risk but not with the total fracture risk. (Source: Osteoporosis International)
Source: Osteoporosis International - April 13, 2017 Category: Orthopaedics Source Type: research

Evaluation of bone mineral density and microarchitectural parameters by DXA and HR-pQCT in 37 children and adults with X-linked hypophosphatemic rickets
AbstractSummaryIn X-linked hypophosphatemic (XLH) rickets, dual-energy X-ray absorptiometry (DXA) measurements must be analyzed with caution. High-resolution peripheral quantitative computed tomography (HR-pQCT) analysis suggested that XLH primarily affects the cancellous compartment, with the tibia more affected than the radius. Effective treatment of XLH appears to positively affect bone mineralization, mainly in the bone cortex.IntroductionThe purpose of this study is to evaluate bone mineral density (BMD) and microarchitecture in 37 patients (13 children and 24 adults) with XLH confirmed byPHEX mutations from a tertiar...
Source: Osteoporosis International - April 13, 2017 Category: Orthopaedics Source Type: research

Standardizing 25-hydroxyvitamin D data from the HunMen cohort
AbstractSummaryStandardization of 25-hydroxyvitamin D (25OHD) values is still a challenge. We propose standardization by correction of the measured 25OHD values using the linear regression bias from the National Institute of Standards and Technology (NIST) ‘total’ target values reported by Vitamin D External Quality Assessment Scheme (DEQAS). Our approach could perhaps be a practical solution to the anomaly surrounding non-standardized 25OHD values.IntroductionStandardization of 25OHD values is still a challenge. We propose standardization by correction of the measured 25OHD values using the linear regression e...
Source: Osteoporosis International - April 13, 2017 Category: Orthopaedics Source Type: research

Significant improvement of bone mineral density and bone turnover markers by denosumab therapy in bisphosphonate-unresponsive patients: response to comments
(Source: Osteoporosis International)
Source: Osteoporosis International - April 13, 2017 Category: Orthopaedics Source Type: research

Skeletal effects of vitamin D deficiency among patients with primary hyperparathyroidism
AbstractSummaryLittle is known about the association between vitamin D deficiency and the skeletal phenotypes in primary hyperparathyroidism (PHPT) patients. A low 25-hydroxyvitamin D level was associated with a low bone mineral density and deteriorated hip geometry in women with PHPT in an Asian population where vitamin D deficiency is prevalent.IntroductionFew studies have examined the effect of vitamin D deficiency on the bone health of primary hyperparathyroidism (PHPT) patients.MethodsWe investigated the skeletal effects of vitamin D deficiency in 79 PHPT patients by assessing bone mineral density (BMD), the trabecula...
Source: Osteoporosis International - April 13, 2017 Category: Orthopaedics Source Type: research

Cost effective measures to standardize serum 25(OH)D values from completed studies
(Source: Osteoporosis International)
Source: Osteoporosis International - April 13, 2017 Category: Orthopaedics Source Type: research