Periprosthetic fractures are osteoporotic fractures: missed opportunities for osteoporosis diagnosis
ConclusionPeriprosthetic fractures are osteoporosis-related. They occur in older adults, often female, and result from falls; BMD, when assessed, is low. Data available at the time of PPFx often allows osteoporosis diagnosis; this should prompt evaluation and pharmacologic treatment consideration. (Source: Osteoporosis International)
Source: Osteoporosis International - April 1, 2024 Category: Orthopaedics Source Type: research
Correction to: Semi-automatic proximal humeral trabecular bone density assessment tool: technique application and clinical validation
(Source: Osteoporosis International)
Source: Osteoporosis International - April 1, 2024 Category: Orthopaedics Source Type: research
Factors influencing the measurement of sagittal spinopelvic alignment in patients with vertebral fractures
(Source: Osteoporosis International)
Source: Osteoporosis International - March 29, 2024 Category: Orthopaedics Source Type: research
Metformin treatment reduces the incidence of osteoporosis: a two-sample Mendelian randomized study
ConclusionsThis study indicated that metformin treatment is significantly associated with a reduction in the risk of OP, fracture and higher LS-BMD, FN-BMD, and eBMD. However, there was no significant association with FA-BMD. (Source: Osteoporosis International)
Source: Osteoporosis International - March 27, 2024 Category: Orthopaedics Source Type: research
The significance of recent fracture location for imminent risk of hip and vertebral fractures —a nationwide cohort study on older adults in Sweden
This study found that most recent fracture sites were associated with an increased risk of both hip and vertebral fracture, a finding that may impact the design of secondary prevention programs.BackgroundHip and vertebral fractures are the most serious in terms of associated morbidity, mortality, and societal costs. There is limited evidence as to which fracture types are associated with the highest risk for subsequent hip and vertebral fractures. This study aims to explore the dependency of imminent hip and vertebral fracture risk on the site of the recent index fracture.MethodsConducted as a nationwide retrospective coho...
Source: Osteoporosis International - March 23, 2024 Category: Orthopaedics Source Type: research
The relationship between bone strain index, bone mass, microarchitecture and mechanical behavior in human vertebrae: an ex vivo study
ConclusionThe BSI was significantly correlated with the microarchitecture and mechanical behavior of L3 vertebrae, and these associations remained statistically significant regardless of aBMD. (Source: Osteoporosis International)
Source: Osteoporosis International - March 23, 2024 Category: Orthopaedics Source Type: research
Deprescribing bisphosphonates for older adults with dementia: perspectives of caregivers
ConclusionConversations grounded in caregiver experiences and “what matters most” may help optimize fracture prevention treatment for older adults with dementia. (Source: Osteoporosis International)
Source: Osteoporosis International - March 21, 2024 Category: Orthopaedics Source Type: research
Hypophosphatasia: presentation and response to asfotase alfa
ConclusionHPP treatment with AA in individuals with both pediatric and adult-onset forms resulted in significant subjective improvement in musculoskeletal and cognitive manifestations in addition to patients ’ quality of life. The drug was well tolerated in 6 patients. 1 patient discontinued therapy because of minor adverse effects with myalgias. (Source: Osteoporosis International)
Source: Osteoporosis International - March 21, 2024 Category: Orthopaedics Source Type: research
Systematic review and meta-analysis of preoperative predictors for early mortality following hip fracture surgery
This study aimed to identify predictors for early mortality following hip fracture surgery. Cohort studies examining independent preoperative predictors for mortality following hip fracture surgery were identified through a systematic search on Scopus and PubMed. Predictors for 30-day mortality were the primary outcome, and predictors for mortality within 1 year were secondary outcomes. Primary outcomes were analysed with random-effects meta-analyses. Confidence in the cumulative evidence was assessed using the GRADE criteria. Secondary outcomes were synthesised narratively. Thirty-three cohort studies involving 462,699 pa...
Source: Osteoporosis International - March 21, 2024 Category: Orthopaedics Source Type: research
Correction to: Determination of the combined effects of asian herbal medicine with calcium and/or vitamin D supplements on bone mineral density in primary osteoporosis: A systematic review and meta-analysis
(Source: Osteoporosis International)
Source: Osteoporosis International - March 21, 2024 Category: Orthopaedics Source Type: research
Bone mineral density, turnover, and microarchitecture assessed by second-generation high-resolution peripheral quantitative computed tomography in patients with Sheehan ’s syndrome
ConclusionLow areal BMD (aBMD) is highly prevalent in SS as compared to age- and BMI-matched controls. However, there were no significant differences in bone microarchitectural measurements, except for tibial cortical vBMD, which was lower in adequately treated SS patients. (Source: Osteoporosis International)
Source: Osteoporosis International - March 20, 2024 Category: Orthopaedics Source Type: research
The comments on manuscript entitled ‘Major osteoporosis fracture prediction in type 2 diabetes: a derivation and comparison study’
(Source: Osteoporosis International)
Source: Osteoporosis International - March 20, 2024 Category: Orthopaedics Source Type: research
The yield of routine laboratory examination in osteoporosis evaluation in primary care
ConclusionsWe identified a low prevalence of laboratory abnormalities in a primary care population of older women and the majority of these findings had no medical consequences. (Source: Osteoporosis International)
Source: Osteoporosis International - March 18, 2024 Category: Orthopaedics Source Type: research
Correction: Hypophosphatasia diagnosis: current state of the art and proposed diagnostic criteria for children and adults
(Source: Osteoporosis International)
Source: Osteoporosis International - March 18, 2024 Category: Orthopaedics Source Type: research
Letters to the Editor for “Association between dental diseases and oral hygiene care and the risk of vertebral fracture: a nationwide cohort study”
(Source: Osteoporosis International)
Source: Osteoporosis International - March 14, 2024 Category: Orthopaedics Source Type: research
