Atypical femur fractures: a survey of current practices in orthopedic surgery
AbstractSummaryThe results of a self-administered online survey demonstrate that orthopedic surgeons ’ management practices for AFF are variable. These data will inform the development of clinical practice guidelines.IntroductionWe aimed to determine current AFF treatment practices of orthopedic surgeons to inform clinical practice guideline development.MethodsA self-administered online survey was developed and sequentially posted on the Orthopaedic Trauma Association (OTA) website from July to August 2015 and the Canadian Orthopaedic Association (COA) website from December 2015 to January 2016. Level of confidence i...
Source: Osteoporosis International - August 2, 2017 Category: Orthopaedics Source Type: research

Use of dipeptidyl peptidase-4 inhibitors and risk of bone fracture in patients with type 2 diabetes in Germany —A retrospective analysis of real-world data
AbstractSummaryIn type 2 diabetes patients treated in German primary care practices, the use of dipeptidyl peptidase-4 inhibitor (DPP4i) in combination with metformin was associated with a significant decrease in the risk of developing bone fractures compared to metformin monotherapy.IntroductionThe goal of this study was to analyze the impact of dipeptidyl peptidase-4 inhibitor (DPP4i) use on the risk of bone fracture in patients diagnosed with type 2 diabetes mellitus (T2DM) in Germany.MethodsPatients with an initial prescription of metformin between 2008 and 2014 from 1262 German general practitioner practices were sele...
Source: Osteoporosis International - July 24, 2017 Category: Orthopaedics Source Type: research

Increased blood cadmium levels were not associated with increased fracture risk but with increased total mortality in women: the Malm ö Diet and Cancer Study
This study aimed to investigate if high levels of blood cadmium at baseline were associated with increased fracture risk during follow-up in middle-aged women. No increased fracture risk was observed during follow-up, but women with higher levels of cadmium had an increased overall mortality.IntroductionExposure to high levels ofcadmium has been associated with an increased fracture risk. The aim was to investigate a perceived association between low levels of blood cadmium (B-Cd) at baseline and risk of first incident fracture.MethodsFrom the population-based Malm ö Diet and Cancer Study Cardiovascular cohort, 2920 m...
Source: Osteoporosis International - July 24, 2017 Category: Orthopaedics Source Type: research

Association between bone mineral density, muscle strength, and vitamin D status in patients with myasthenia gravis: a cross-sectional study
AbstractSummaryMyasthenia gravis (MG) patients had low proximal hip BMD, which could be explained by reduced muscle strength, elevated bone resorption markers, vitamin D deficiency, and increased PTH levels in those with MG compared to controls.IntroductionMuscle strength is closely correlated with bone mineral density (BMD) and vitamin D status. Here, we evaluated muscle strength, BMD, and vitamin D status in a large sample of Chinese patients with MG.MethodsIn this cross-sectional survey, 86 patients with MG without glucocorticoid treatment and 86 healthy controls were included. Serum levels of 25-hydroxyvitamin D [25OHD...
Source: Osteoporosis International - July 24, 2017 Category: Orthopaedics Source Type: research

Meta-analysis of hypertension and osteoporotic fracture risk in women and men
In this study, a systematic review of relevant published articles was conducted to verify the association between hypertension and osteoporotic fracture risk in women and men.MethodsPubMed (1953_October 5th, 2016) and Embase (1974_October 5th, 2016) were systematically searched for relevant articles. Odds ratios (ORs) and confidence intervals (CIs) were derived using random effect models. Categorical, subgroup, heterogeneity, publication bias, and meta-regression analyses were conducted.ResultsWe analyzed 10 articles encompassing 28 independent studies, 1,430,431 participants, and 148,048 osteoporotic fracture cases. The r...
Source: Osteoporosis International - July 24, 2017 Category: Orthopaedics Source Type: research

Oral contraceptive use and fracture risk —a retrospective study of 12,970 women in the UK
ConclusionsThe present study revealed that women without bone fractures were significantly more likely to have had exposure to combined oral contraception, especially where the duration of intake was at least 5  years. (Source: Osteoporosis International)
Source: Osteoporosis International - July 24, 2017 Category: Orthopaedics Source Type: research

Spinal radiographs in those with back pain —when are they appropriate to diagnose vertebral fractures?
AbstractThe presence of an osteoporotic vertebral fracture improves fracture risk assessment and may change management, so it is vital for healthcare professionals to assess patients for the presence or absence of these fractures. This may be particularly important in the presence of back pain. However, the correlation between low back symptoms and spinal imaging results is poor and the pathophysiology of most low back pain is not known, leading to a common conclusion that spinal radiographs are not appropriate for the assessment of back pain. For individual patients with back pain, spinal radiographs should be considered ...
Source: Osteoporosis International - July 24, 2017 Category: Orthopaedics Source Type: research

Impact of pioglitazone on bone mineral density and bone marrow fat content
ConclusionsPioglitazone use for 12  months compared with placebo is associated with significant increase in BM fat content at the femoral neck, accompanied by a small but significant decrease in total hip BMD. (Source: Osteoporosis International)
Source: Osteoporosis International - July 22, 2017 Category: Orthopaedics Source Type: research

Osteosarcopenia: where bone, muscle, and fat collide
AbstractAs the world ’s population ages, the prevalence of chronic diseases increases. Sarcopenia and osteoporosis are two conditions that are associated with aging, with similar risk factors that include genetics, endocrine function, and mechanical factors. Additionally, bone and muscle closely interact with each oth er not only anatomically, but also chemically and metabolically. Fat infiltration, a phenomenon observed in age-related bone and muscle loss, is highly prevalent and more severe in sarcopenic and osteoporotic subjects. Clinically, when individuals suffer a combination of both disorders, negative out com...
Source: Osteoporosis International - July 22, 2017 Category: Orthopaedics Source Type: research

Clinical performance of an updated trabecular bone score (TBS) algorithm in men and women: the Manitoba BMD cohort
AbstractSummaryThis is the first study to directly compare the original and recently updated versions of the trabecular bone score (TBS) algorithm. We confirmed improved performance of the new algorithm, especially among men.IntroductionLumbar spine trabecular bone score (TBS) predicts major osteoporotic fractures (MOFs) and hip fractures (HFs) independent of bone density. The original TBS algorithm (version 1; [TBS-v1]) was optimized for women of average body size. Limitations were identified when used in men or extremes of body mass index (BMI). The current study evaluates an updated TBS algorithm (version 2; [TBS-v2]) m...
Source: Osteoporosis International - July 21, 2017 Category: Orthopaedics Source Type: research

Sideways fall-induced impact force and its effect on hip fracture risk: a review
ConclusionsThe analysis of the gathered data revealed that there is a need to develop modified biomechanical models for more accurate prediction of the impact force and appropriately adopt them in hip fracture risk assessment tools in order to achieve a better precision in identifying high-risk patients.Graphical abstractImpact force to the hip induced in sideways falls is affected by many parameters and may remarkably vary from subject to subject (Source: Osteoporosis International)
Source: Osteoporosis International - July 20, 2017 Category: Orthopaedics Source Type: research

Patterns of alcohol consumption and risk of falls in older adults: a prospective cohort study
ConclusionBoth moderate drinking and the MDP were associated with a lower risk of falls and injurious falls in older adults. However, sound advice on alcohol consumption should balance risks and benefits. (Source: Osteoporosis International)
Source: Osteoporosis International - July 19, 2017 Category: Orthopaedics Source Type: research

Gene mutation spectrum and genotype-phenotype correlation in a cohort of Chinese osteogenesis imperfecta patients revealed by targeted next generation sequencing
ConclusionWe revealed the gene mutation spectrum in Chinese OI patients, and novel mutations identified here expanded the mutation catalog and genotype and phenotype relationships among OI patients. (Source: Osteoporosis International)
Source: Osteoporosis International - July 19, 2017 Category: Orthopaedics Source Type: research

Diversity in fall characteristics hampers effective prevention: the precipitants, the environment, the fall and the injury
AbstractSummaryFalls among the elderly are common and characteristics may differ between injurious and non-injurious falls. Among 887 older Australian women followed for 1.6  years, 32% fell annually. Only 8.5% resulted in fracture and/or hospital admission. The characteristics of those falls are indistinguishable from those not coming to medical attention.IntroductionThe precipitants and environment of all falls occurring among a large cohort of older Caucasian women were categorised by injury status to determine if the characteristics differed between injurious and non-injurious falls.MethodsAmong 887 Australian wom...
Source: Osteoporosis International - July 19, 2017 Category: Orthopaedics Source Type: research

One and two-year persistence with different anti-osteoporosis medications: a retrospective cohort study
AbstractSummaryAdherence to anti-osteoporosis medications is poor. We carried out a cohort study using a real-world population database to estimate the persistence of anti-osteoporosis drugs. Unadjusted 2-year persistence ranged from 10.3 to 45.4%. Denosumab users had a 40% lower risk of discontinuation at 2  years compared to alendronate users.PurposeThe purpose of this study was to estimate real-world persistence amongst incident users of anti-osteoporosis medications.MethodsThis is a retrospective cohort using data from anonymised records and dispensation data (www.sidiap.org). Eligibility comprised the following: ...
Source: Osteoporosis International - July 16, 2017 Category: Orthopaedics Source Type: research

Fracture risk reduction with use of dipeptidyl peptidase-4 inhibitors: is there immortal time bias?
(Source: Osteoporosis International)
Source: Osteoporosis International - July 13, 2017 Category: Orthopaedics Source Type: research

Fracture risk reduction with use of dipeptidyl peptidase-4 inhibitors: response to Driessen et al.
(Source: Osteoporosis International)
Source: Osteoporosis International - July 13, 2017 Category: Orthopaedics Source Type: research

Abdominal obesity and risk of hip fracture: a meta-analysis of prospective studies
AbstractSummaryWe conducted a meta-analysis to qualitatively summarize the evidence of the association between abdominal obesity and hip fracture risk. The results indicated that abdominal obesity as measured by waist circumference and waist-hip ratio might be associated with an increased risk of hip fracture.IntroductionEpidemiological investigations evaluating the association of abdominal obesity with hip fracture risk have yielded conflicting results. Therefore, a meta-analysis was conducted to qualitatively summarize the evidence of the associations between waist circumference, waist-hip ratio, and hip circumference an...
Source: Osteoporosis International - July 12, 2017 Category: Orthopaedics Source Type: research

Spine fracture prevalence in a nationally representative sample of US women and men aged ≥40 years: results from the National Health and Nutrition Examination Survey (NHANES) 2013–2014---supplementary presentation
AbstractSpine fracture prevalence is similar in men and women, increasing from
Source: Osteoporosis International - July 10, 2017 Category: Orthopaedics Source Type: research

Long-term follow-up in osteogenesis imperfecta type VI
ConclusionsPatients with OI type VI who received intravenous bisphosphonate treatment during growth had an increase in lumbar spine areal BMD, a higher final height z-score, and presented some reshaping of vertebral bodies. More effective treatment modalities are clearly required in OI type VI. (Source: Osteoporosis International)
Source: Osteoporosis International - July 9, 2017 Category: Orthopaedics Source Type: research

Targeted spine strengthening exercise and posture training program to reduce hyperkyphosis in older adults: results from the study of hyperkyphosis, exercise, and function (SHEAF) randomized controlled trial
ConclusionsSpine-strengthening exercise and posture training over 6  months reduced kyphosis compared to control. Our randomized controlled trial results suggest that a targeted kyphosis-specific exercise program may be an effective treatment option for older adults with hyperkyphosis.Trial registration number and name of trial registerClinicalTrials.gov; identifier NCT01751685 (Source: Osteoporosis International)
Source: Osteoporosis International - July 8, 2017 Category: Orthopaedics Source Type: research

Are more trials of calcium supplements really needed?
(Source: Osteoporosis International)
Source: Osteoporosis International - July 7, 2017 Category: Orthopaedics Source Type: research

Are more trials of calcium supplements really needed? A response to Bolland et al.
(Source: Osteoporosis International)
Source: Osteoporosis International - July 7, 2017 Category: Orthopaedics Source Type: research

Bone mineral density in adults with Down syndrome
This study analyzed data of bone mineral density (BMD) from a large cohort of adults with Down syndrome (DS). BMD was found to decrease with age more rapidly in these subjects than in the general population, exposing adults with DS to an increased risk of osteoporosis and bone fracture.IntroductionDown syndrome (DS) in adulthood presents with a high prevalence of osteoporosis. However, in DS, bone mineral density (BMD) can be underestimated due to short stature. Furthermore, the rate of age-related decline in BMD and its association with gender in DS has been rarely evaluated or compared with the general population. The pr...
Source: Osteoporosis International - July 6, 2017 Category: Orthopaedics Source Type: research

Short-term effects of extracorporeal shock wave therapy on bone mineral density in postmenopausal osteoporotic patients
This study evaluated the short-term effectiveness of extracorporeal shock wave therapy (ESWT) on bone mineral density (BMD).MethodsA total of 64 postmenopausal osteoporotic patients were recruited and randomized into 3 groups in 2015. Groups A (n = 20) and B (n = 21) patients received a single-session of low- or high-energy flux density (EFD) ESWT in the left hip, respectively, whereas group C (n = 23) patients served as controls without the ESWT treatment. All patients self-administered alendronate sodium tablets orally for a year. The BMD of the lumbar spine (L2-L4), femoral neck, great tube...
Source: Osteoporosis International - July 6, 2017 Category: Orthopaedics Source Type: research

Does regional loss of bone density explain low trauma distal forearm fractures in men (the Mr F study)?
This study found that these men have lower bone mineral density at the forearm itself, as well as the hip and spine, and has shown that forearm bone mineral density is the best predictor of wrist fracture.IntroductionMen with distal forearm fractures have reduced bone density at the lumbar spine and hip sites, an increased risk of osteoporosis and a higher incidence of further fractures. The aim of this case-control study was to investigate whether or not there is a regional loss of bone mineral density (BMD) at the forearm between men with and without distal forearm fractures.MethodsSixty-one men with low trauma distal fo...
Source: Osteoporosis International - July 6, 2017 Category: Orthopaedics Source Type: research

Marginal structural model to evaluate the association between cumulative osteoporosis medication and infection using claims data
ConclusionsThe discrepancy of effect estimates for overall but not serious infection comparing unweighted models and MSM suggested analyses of composite outcomes with a wide range of disease severity may be more susceptible to time-varying confounding. (Source: Osteoporosis International)
Source: Osteoporosis International - July 6, 2017 Category: Orthopaedics Source Type: research

Osteoporosis exercise knowledge and education in medicine and nursing: response to comments by Nguyen
(Source: Osteoporosis International)
Source: Osteoporosis International - July 6, 2017 Category: Orthopaedics Source Type: research

Osteoporosis exercise knowledge and education in medicine and nursing
(Source: Osteoporosis International)
Source: Osteoporosis International - July 6, 2017 Category: Orthopaedics Source Type: research

Validation of FRAX and the impact of self-reported falls among elderly in a general population: the HUNT study, Norway
AbstractSummaryFracture Risk Assessment Tool (FRAX) without bone mineral density (BMD) for hip fracture prediction was validated in a Norwegian population 50 –90 years. Fracture risk increased with higher FRAX score, and the observed number of hip fractures agreed well with the predicted number, except for the youngest and oldest men.Self-reported fall was an independent risk factor for fracture in women.IntroductionThe primary aim was to validate FRAX without BMD for hip fracture prediction in a Norwegian population of men and women 50 –90 years. Secondary, to study whether information of falls could...
Source: Osteoporosis International - July 1, 2017 Category: Orthopaedics Source Type: research

Economic burden of osteoporosis-related hip fracture in Asia: a systematic review
ConclusionThere is a paucity of burden of illness studies of osteoporosis in the Asian region. For the few available studies, there was a lack of standardization in methodological approach in evaluating the economic burden of the disease. There is a need to encourage more quality burden of illness studies of osteoporosis to inform policymakers in healthcare planning. (Source: Osteoporosis International)
Source: Osteoporosis International - June 22, 2017 Category: Orthopaedics Source Type: research

Association between obesity and femoral neck strength according to age, sex, and fat distribution
We examined total fat mass (TFM) and percentage fat mass (pFM) as indicators of total obesity and truncal fat mass (TrFM) as an indicator of abdominal obesity. We calculated the composite indices of FN strength and anthropometric clinical indicators of abdominal obesity.ResultsTFM, pFM, and TrFM were negatively associated with the composite indices, irrespective of age and sex (P 
Source: Osteoporosis International - June 22, 2017 Category: Orthopaedics Source Type: research

Functional block of IL-17 cytokine promotes bone healing by augmenting FOXO1 and ATF4 activity in cortical bone defect model
ConclusionOverall, our study demonstrates bone healing and regeneration potential of neutralizing IL-17 antibody in osteoporotic fractures. (Source: Osteoporosis International)
Source: Osteoporosis International - June 22, 2017 Category: Orthopaedics Source Type: research

Tumor-induced osteomalacia: experience from a South American academic center
ConclusionsThe clinical presentation, delay time to diagnosis, FGF23 diagnostic sensitivity and histopathology in this first series of South American patients is similar to those described in other populations. The success of localization by somatostatin analog-based imaging, suggests this may the optimal imaging modality. (Source: Osteoporosis International)
Source: Osteoporosis International - June 22, 2017 Category: Orthopaedics Source Type: research

Case report: fast reversal of severe osteoporosis after correction of excessive levothyroxine treatment and long-term follow-up
ConclusionExcessive TSH suppression contributed to the secondary osteoporosis in this patient; BMD normalized after dose reduction of levothyroxine and no fractures occurred during 23 years ’ follow-up. Some patients develop severe osteoporosis if they are over-substituted with levothyroxine, and decent follow-up of patients with levothyroxine supplementation is mandatory. (Source: Osteoporosis International)
Source: Osteoporosis International - June 22, 2017 Category: Orthopaedics Source Type: research

Hip fracture incidence and social deprivation: results from a French ecological study
AbstractSummaryThe association between socioeconomic status (SES) and hip fracture (HF) incidence was analyzed in France in 2008. In men and women, a decrease in HF incidence was observed as the social deprivation index increased. This result may be partly due to the protective effect of increasing body weight against HF.IntroductionRegional variations in hip fracture (HF) incidence exist worldwide. Reasons for these variations remain unknown. As regional variations have also been observed for socioeconomic status, we analyzed the association between socioeconomic deprivation (SED) and HF incidence in France in 2008.Method...
Source: Osteoporosis International - June 22, 2017 Category: Orthopaedics Source Type: research

The relationship between cumulative lifetime ultraviolet radiation exposure, bone mineral density, falls risk and fractures in older adults
ConclusionsBG grade demonstrated beneficial associations with fracture outcomes in females and BMD in younger males independent of current 25-hydroxyvitamin D. These data support the concept that cumulative ultraviolet radiation exposure is an important determinant of skeletal health. The association with vertebral deformities in males may reflect outdoor physical trauma in younger life. (Source: Osteoporosis International)
Source: Osteoporosis International - June 22, 2017 Category: Orthopaedics Source Type: research

Cortical microstructure compensates for smaller bone size in young Caribbean Hispanic versus non-Hispanic white men
ConclusionIn conclusion, greater cortical thickness and density as well as lower cortical porosity tend to compensate for smaller bone size in Hispanic men, leading to similar mechanical competence compared with white men. (Source: Osteoporosis International)
Source: Osteoporosis International - June 22, 2017 Category: Orthopaedics Source Type: research

Defining hip fracture with claims data: outpatient and provider claims matter
ConclusionsWhen ascertaining hip fractures, a definition using outpatient and provider claims identified 11% more fractures than a definition with only inpatient claims. Future studies should publish their definition of fracture and specify if diagnostic codes from contiguous fracture sites were used. (Source: Osteoporosis International)
Source: Osteoporosis International - June 22, 2017 Category: Orthopaedics Source Type: research

Use of systemic glucocorticoids and the risk of major osteoporotic fractures in patients with sarcoidosis
This study revealed the risk of major osteoporotic fracture in patients with sarcoidosis exposed to glucocorticoids. Current use of glucocorticoids was associated with a risk of fracture, with no difference between patients with and without sarcoidosis. Sarcoidosis per se was not associated with an increased fracture risk.IntroductionSarcoidosis is a multi-organ, chronic inflammatory, granulomatous disorder that most frequently affects the lungs, lymph nodes, skin, eyes, and liver, but may occur in any organ, including the bones. While oral glucocorticoids (GCs) are commonly used as initial treatment, little is known about...
Source: Osteoporosis International - June 21, 2017 Category: Orthopaedics Source Type: research

Use of CTX-I and PINP as bone turnover markers: National Bone Health Alliance recommendations to standardize sample handling and patient preparation to reduce pre-analytical variability
ConclusionThe successful adoption of standardized sample handling and patient preparation recommendations necessitates the close collaboration of various stakeholders at the global stage, including the reagent manufacturers, the laboratories, the medical community, and the regulatory agencies. (Source: Osteoporosis International)
Source: Osteoporosis International - June 19, 2017 Category: Orthopaedics Source Type: research

Effects of a 20-week high-intensity strength and sprint training program on tibial bone structure and strength in middle-aged and older male sprint athletes: a randomized controlled trial
ConclusionsIntensive strength and sprint training improves mid-tibia structure and strength in middle-aged and older male sprint athletes, suggesting that in the presence of high-intensity loading exercise, the adaptability of the bone structure is maintained during aging. (Source: Osteoporosis International)
Source: Osteoporosis International - June 16, 2017 Category: Orthopaedics Source Type: research

A novel large fragment deletion in PLS3 causes rare X-linked early-onset osteoporosis and response to zoledronic acid
ConclusionWe identified a large fragment deletion mutation inPLS3 for the first time and elucidated the possible mechanism of the deletion, which led to X-linked early-onset osteoporosis and multiple vertebral fractures. Our findings would enrich the etiology spectrum of this rare disease. (Source: Osteoporosis International)
Source: Osteoporosis International - June 16, 2017 Category: Orthopaedics Source Type: research

The cost of a patient activation intervention for achieving successful outcomes: results from the PAADRN randomized controlled trial
ConclusionAn individually tailored DXA result letter accompanied by an educational brochure can improve four patient-centered outcomes at a modest cost.Trial registrationclinicaltrials.gov identifier NCT01507662 (Source: Osteoporosis International)
Source: Osteoporosis International - June 15, 2017 Category: Orthopaedics Source Type: research

Atypical subtrochanteric fractures in Korean hip fracture study
ConclusionIn Korean, ASF were rare. Higher BMI and use of bisphosphonate were significant risk factors of ASF. (Source: Osteoporosis International)
Source: Osteoporosis International - June 14, 2017 Category: Orthopaedics Source Type: research

Bone density and body composition in newly licenced professional jockeys
We examined differences between BMD and body composition by gender and race type (flat or jump). Volumetric bone mineral apparent density (BMAD) of the spine and FN was also calculated to account for group differences in bone size.ResultsSeventy-nine male flat jockeys (age 18.5  ± 1.9, BMI 19.0 ± 1.4), 69 male jump (age 20.7 ± 2.0, BMI 20.6 ± 1.3) and 37 female flat jockeys (age 19.3 ± 2.0, BMI 20.8 ± 1.7) took part in this study. Spine BMD Z-scores ≤−2 for male flat, male jump and female flat jockeys were 29, 13 ...
Source: Osteoporosis International - June 13, 2017 Category: Orthopaedics Source Type: research

FRAX for fracture prediction shorter and longer than 10  years: the Manitoba BMD registry
We examined FRAX predictions over intervals shorter and longer than 10 years.MethodsUsing a population-based clinical registry for Manitoba, Canada, we identified 62,275 women and 6455 men 40  years and older with baseline dual-energy X-ray absorptiometry scans and FRAX scores. Incident MOF and hip fracture were assessed up to 15 years from population-based data. We assessed agreement between estimated fracture probability from 1 to 15 years using linearly rescaled FRAX scores and obs erved cumulative fracture probability. The gradient of risk for FRAX probability and incident fracture was examined over...
Source: Osteoporosis International - June 7, 2017 Category: Orthopaedics Source Type: research

Erratum to: Assessing the feasibility of the Effectiveness of Discontinuing Bisphosphonates trial: a pilot study
(Source: Osteoporosis International)
Source: Osteoporosis International - June 7, 2017 Category: Orthopaedics Source Type: research

Predictors of near-term fracture in osteoporotic women aged ≥65 years, based on data from the study of osteoporotic fractures
ConclusionsSeveral clinical characteristics predictive of hip and non-vertebral fracture within a 1-year follow-up period among elderly women with osteoporosis were identified, and a subset of those for hip fracture was incorporated into a risk assessment tool. Assessment of these risk factors may help guide osteoporosis treatment choices by identifying patients in whom there is urgency to treat. Additional research is needed to validate the findings of this study and the accuracy of the risk assessment tool. (Source: Osteoporosis International)
Source: Osteoporosis International - June 7, 2017 Category: Orthopaedics Source Type: research

Bone loss with antiepileptic drug therapy: a twin and sibling study
ConclusionsAED users had reduced aBMD at the hip regions. Prolonged users and EIAED users had greater aBMD loss, predicting a higher risk of bone fragility. Further prospective studies of AED effects on bone microarchitecture are needed. (Source: Osteoporosis International)
Source: Osteoporosis International - June 6, 2017 Category: Orthopaedics Source Type: research