Twenty-four months of follow-up in women with rebound-associated vertebral fractures after discontinuation of denosumab: a single-centre case series
ConclusionIn this series of patients with RAVFs, we did not observe any new fractures and the BMD remained stable after 24  months of RT. Future studies are needed to evaluate the most suitable treatment approach after RAVFs but these preliminary data suggest that all denosumab, zoledronate and teriparatide might be adequate options. (Source: Osteoporosis International)
Source: Osteoporosis International - September 13, 2023 Category: Orthopaedics Source Type: research

A novel fracture liaison service using digital health: impact on mortality in hospitalized elderly osteoporotic fracture patients
ConclusionsA new FLS model implementation assisted by DH can effectively reduce ACM among elderly patients with OP fractures requiring surgery. In future investigations, we recommend examining the scalability of this model. (Source: Osteoporosis International)
Source: Osteoporosis International - September 12, 2023 Category: Orthopaedics Source Type: research

Effect of SGLT2 inhibitors on fractures, BMD, and bone metabolism markers in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
AbstractThis meta-analysis aims to evaluate the impact of Sodium Glucose Transporter 2 (SGLT2) inhibitors on fractures, bone mineral density (BMD), and bone metabolism markers in type 2 diabetes mellitus (T2DM) patients.  Pooled relative risk (RR) with 95% confidence interval (CI) assessed the relationship between SGLT2 inhibitors and fracture risk. Weighted mean difference (WMD) with 95% CI explored the correlation between SGLT2 inhibitors and BMD, as well as bone metabolism markers. A total of 20 randomised cont rolled trials (RCTs) involving 12,764 patients were analysed. No significant association emerged between SGL...
Source: Osteoporosis International - September 11, 2023 Category: Orthopaedics Source Type: research

Author response to letter to editor OSIN-D-23-00809: ALDH2 polymorphism rs671 and alcohol consumption: possible explanatory factors for race/ethnic differences in bone density
(Source: Osteoporosis International)
Source: Osteoporosis International - September 11, 2023 Category: Orthopaedics Source Type: research

ALDH2 polymorphism rs671 and alcohol consumption: possible explanatory factors for race/ethnic differences in bone density
(Source: Osteoporosis International)
Source: Osteoporosis International - September 11, 2023 Category: Orthopaedics Source Type: research

Effect of SGLT2 inhibitors on fractures, BMD, and bone metabolism markers in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
AbstractThis meta-analysis aims to evaluate the impact of Sodium Glucose Transporter 2 (SGLT2) inhibitors on fractures, bone mineral density (BMD), and bone metabolism markers in type 2 diabetes mellitus (T2DM) patients.  Pooled relative risk (RR) with 95% confidence interval (CI) assessed the relationship between SGLT2 inhibitors and fracture risk. Weighted mean difference (WMD) with 95% CI explored the correlation between SGLT2 inhibitors and BMD, as well as bone metabolism markers. A total of 20 randomised cont rolled trials (RCTs) involving 12,764 patients were analysed. No significant association emerged between SGL...
Source: Osteoporosis International - September 11, 2023 Category: Orthopaedics Source Type: research

Author response to letter to editor OSIN-D-23-00809: ALDH2 polymorphism rs671 and alcohol consumption: possible explanatory factors for race/ethnic differences in bone density
(Source: Osteoporosis International)
Source: Osteoporosis International - September 11, 2023 Category: Orthopaedics Source Type: research

ALDH2 polymorphism rs671 and alcohol consumption: possible explanatory factors for race/ethnic differences in bone density
(Source: Osteoporosis International)
Source: Osteoporosis International - September 11, 2023 Category: Orthopaedics Source Type: research

External validation of a convolutional neural network algorithm for opportunistically detecting vertebral fractures in routine CT scans
ConclusionThe algorithm demonstrated excellent performance in the identification of vertebral fractures in a cohort of chest and abdominal CT scans of Chinese patients ≥50 years.Graphical abstract (Source: Osteoporosis International)
Source: Osteoporosis International - September 7, 2023 Category: Orthopaedics Source Type: research

A study on whether deep learning models based on CT images for bone density classification and prediction can be used for opportunistic osteoporosis screening
ConclusionUsing deep learning neural networks to process opportunistic CT scan images of the body can accurately predict bone density values and perform bone density three-classification diagnosis, which can reduce the radiation risk, economic consumption, and time consumption brought by specialized bone density measurement, expand the scope of osteoporosis screening, and have broad application prospects. (Source: Osteoporosis International)
Source: Osteoporosis International - September 5, 2023 Category: Orthopaedics Source Type: research

Bone mineral density is associated with composite dietary antioxidant index among US adults: results from NHANES
ConclusionsCDAI serves as a comprehensive tool for evaluating the overall antioxidant capacity of antioxidants in diets. Additionally, our study shows a positive correlation between CDAI and BMD, which indicates that the combined intake of dietary antioxidants may help reduce the risk of osteoporosis in adults. (Source: Osteoporosis International)
Source: Osteoporosis International - September 4, 2023 Category: Orthopaedics Source Type: research